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The map label for this gene is cbbA [H]

Identifier: 116690646

GI number: 116690646

Start: 2909193

End: 2910257

Strand: Reverse

Name: cbbA [H]

Synonym: Bcen2424_2626

Alternate gene names: 116690646

Gene position: 2910257-2909193 (Counterclockwise)

Preceding gene: 116690647

Following gene: 116690645

Centisome position: 83.53

GC content: 64.69

Gene sequence:

>1065_bases
ATGCCTCTCGTATCAATGCGTCAATTGCTGGACCACGCGGCAGAGCACGGTTACGGCCTGCCGGCCTTCAACGTGAACAA
CCTGGAGCAGGTCCAGGCGATCATGGCGGCGGCGGATCAGGTCGGCGCGCCCGTGATCATGCAGGCATCGGCCGGCGCGC
GTAAGTATGCGGGCGAGCCGTTCCTGCGCCACCTGATCGAAGCGGCGGTCGAATCGTATCCGCACATCCCGGTCGTGATG
CACCAGGATCACGGCCAGTCGCCGGCCGTCTGTACGGCCGCGATCCGCAGCGGCTTCACGAGCGTGATGATGGACGGTTC
GCTCGAAGCCGACGGCAAGACGGTCGCATCGTACGAGTACAACGTCGACGTATCGCGCAAGGTCGTCGAGATGGCGCACT
CGATCGGCGTGACGGTCGAAGCCGAACTCGGCGTGCTCGGCTCGCTCGAGACGATGAAGGGCGACAAGGAGGACGGCCAC
GGCGCGGAAGGCACGATGACCCGCGAGCAGCTGCTGACCGATCCGGAGCAGGCCGCCGACTTCGTGAAGCTCACGCAGTG
CGACGCGCTCGCGATCGCGATCGGTACGTCGCACGGCGCGTACAAGTTTTCGAAGAAGCCGACGGGCGACATCCTGTCGA
TCCAGCGCATCAAGGAAATCCACGCGCGCATCCCGAACACGCACCTGGTGATGCACGGTTCGTCGTCGGTGCCGCAGGAA
CTGCTGGCCGAGATCCGCGAATTCGGCGGCGACATGAAGGAAACCTACGGCGTGCCGGTCGAGGAAATCCAAGAAGGCAT
CAAGCACGGCGTGCGCAAGATCAACATCGACACCGACCTGCGTCTGGCGATCACCGGCGCGATCCGCCGCTACCTGTTCG
AGAACCCGGGCAAGTTCGATCCGCGCGACTACCTGAAGCCCGCGCGCGAAGCCGCGAAGAAGGTGTGCGTCGACCGTTAC
CTCGCGTTCGGCTGCGAAGGCCAGGCCGGCAAGATCAAGCCAGTGTCGCTCGACAAGATCGCCGAGCAGTACAAGTCGGG
CGCGCTCGCACAGGTCGTGCGCTGA

Upstream 100 bases:

>100_bases
CTATTCGACGCTCAGCCGCGCCGCGCCGTCCCGGTTCAGAGGGGAGCGAGCGCCGCGCCGGCGTCAGGGCGCACCGGTTT
TCATTCCAAGGAGTTCCACA

Downstream 100 bases:

>100_bases
GACTGTAGTACGATTTGCCCCGCCTGGTTCTGCCGCCGGGCACGGGCTGGCCGCCCGGTCGGCCGGATTCGATCCGGCCC
CGGCAGCCGTTCCGTCCGGC

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MPLVSMRQLLDHAAEHGYGLPAFNVNNLEQVQAIMAAADQVGAPVIMQASAGARKYAGEPFLRHLIEAAVESYPHIPVVM
HQDHGQSPAVCTAAIRSGFTSVMMDGSLEADGKTVASYEYNVDVSRKVVEMAHSIGVTVEAELGVLGSLETMKGDKEDGH
GAEGTMTREQLLTDPEQAADFVKLTQCDALAIAIGTSHGAYKFSKKPTGDILSIQRIKEIHARIPNTHLVMHGSSSVPQE
LLAEIREFGGDMKETYGVPVEEIQEGIKHGVRKINIDTDLRLAITGAIRRYLFENPGKFDPRDYLKPAREAAKKVCVDRY
LAFGCEGQAGKIKPVSLDKIAEQYKSGALAQVVR

Sequences:

>Translated_354_residues
MPLVSMRQLLDHAAEHGYGLPAFNVNNLEQVQAIMAAADQVGAPVIMQASAGARKYAGEPFLRHLIEAAVESYPHIPVVM
HQDHGQSPAVCTAAIRSGFTSVMMDGSLEADGKTVASYEYNVDVSRKVVEMAHSIGVTVEAELGVLGSLETMKGDKEDGH
GAEGTMTREQLLTDPEQAADFVKLTQCDALAIAIGTSHGAYKFSKKPTGDILSIQRIKEIHARIPNTHLVMHGSSSVPQE
LLAEIREFGGDMKETYGVPVEEIQEGIKHGVRKINIDTDLRLAITGAIRRYLFENPGKFDPRDYLKPAREAAKKVCVDRY
LAFGCEGQAGKIKPVSLDKIAEQYKSGALAQVVR
>Mature_353_residues
PLVSMRQLLDHAAEHGYGLPAFNVNNLEQVQAIMAAADQVGAPVIMQASAGARKYAGEPFLRHLIEAAVESYPHIPVVMH
QDHGQSPAVCTAAIRSGFTSVMMDGSLEADGKTVASYEYNVDVSRKVVEMAHSIGVTVEAELGVLGSLETMKGDKEDGHG
AEGTMTREQLLTDPEQAADFVKLTQCDALAIAIGTSHGAYKFSKKPTGDILSIQRIKEIHARIPNTHLVMHGSSSVPQEL
LAEIREFGGDMKETYGVPVEEIQEGIKHGVRKINIDTDLRLAITGAIRRYLFENPGKFDPRDYLKPAREAAKKVCVDRYL
AFGCEGQAGKIKPVSLDKIAEQYKSGALAQVVR

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=34.6504559270517, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789526, Length=316, Percent_Identity=34.1772151898734, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788072, Length=329, Percent_Identity=29.1793313069909, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1789293, Length=357, Percent_Identity=23.8095238095238, Blast_Score=79, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38419; Mature: 38288

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVSMRQLLDHAAEHGYGLPAFNVNNLEQVQAIMAAADQVGAPVIMQASAGARKYAGEP
CCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHCCCCH
FLRHLIEAAVESYPHIPVVMHQDHGQSPAVCTAAIRSGFTSVMMDGSLEADGKTVASYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCHHHHCCCCCCCCCCEEEEEEE
NVDVSRKVVEMAHSIGVTVEAELGVLGSLETMKGDKEDGHGAEGTMTREQLLTDPEQAAD
CCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHH
FVKLTQCDALAIAIGTSHGAYKFSKKPTGDILSIQRIKEIHARIPNTHLVMHGSSSVPQE
HHHHHCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
LLAEIREFGGDMKETYGVPVEEIQEGIKHGVRKINIDTDLRLAITGAIRRYLFENPGKFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCCC
PRDYLKPAREAAKKVCVDRYLAFGCEGQAGKIKPVSLDKIAEQYKSGALAQVVR
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure 
PLVSMRQLLDHAAEHGYGLPAFNVNNLEQVQAIMAAADQVGAPVIMQASAGARKYAGEP
CHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHCCCCH
FLRHLIEAAVESYPHIPVVMHQDHGQSPAVCTAAIRSGFTSVMMDGSLEADGKTVASYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCHHHHCCCCCCCCCCEEEEEEE
NVDVSRKVVEMAHSIGVTVEAELGVLGSLETMKGDKEDGHGAEGTMTREQLLTDPEQAAD
CCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHH
FVKLTQCDALAIAIGTSHGAYKFSKKPTGDILSIQRIKEIHARIPNTHLVMHGSSSVPQE
HHHHHCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
LLAEIREFGGDMKETYGVPVEEIQEGIKHGVRKINIDTDLRLAITGAIRRYLFENPGKFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCCC
PRDYLKPAREAAKKVCVDRYLAFGCEGQAGKIKPVSLDKIAEQYKSGALAQVVR
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550527 [H]