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The map label for this gene is arpR [H]

Identifier: 116690630

GI number: 116690630

Start: 2892883

End: 2893587

Strand: Direct

Name: arpR [H]

Synonym: Bcen2424_2610

Alternate gene names: 116690630

Gene position: 2892883-2893587 (Clockwise)

Preceding gene: 116690626

Following gene: 116690632

Centisome position: 83.04

GC content: 64.4

Gene sequence:

>705_bases
ATGACGGTGACGAGGGGTTGCGGACCCCATATTCACTCAAGATCGATCCAATCAGGCCTGCACATGGTCAGACGTACCAA
GGAGGAGGCGCTCGAGACGCGCAACCGCATTCTCGACGCCGCCGAACACGTGTTCTTCGAGAAAGGCGTGTCGCACACGT
CGCTCGCGGACATCGCCCAGCACGCCGGCGTGACGCGCGGCGCGATCTACTGGCATTTCGCGAACAAGAGCGAACTGTTC
GATGCGATGTTCGACCGCGTGTTCCTGCCGATCGACGAACTGAAACGGATGCCGCTCGACGCGCCGGGCGGCAATCCGCT
CGAGAAGGTGCGCCAGATCCTGATCTGGTGCCTGCTCGGCGTGCAGCGCGACCCGCAGCTGCGCCGCGTGTTCAGCATCC
TGTTCATGAAGTGCGAATACGTCGCGGACATGGAGCCGCTGCTGCAGCGCAACCGCGCGGGGATGAGCGAGGCGCTGCAC
ATGATCGACGCCGATCTCGCGGTGGCCGTGGGGCTCAAGCTGCTGCCCGAGCGGCTCGACACGTGGCGCGCGACGCTGAT
GCTGCACACGCTCGTCAGCGGGTTCGTGCGCGACATGCTGATGCTGCCCGACGAGATCGACGCCGAGCAGCATGCGGAAA
AACTCGTCGACGGCTGCTTCGACATGCTGCGCTACAGCCCGGCGATGCTGAAGGATCGCGACTGA

Upstream 100 bases:

>100_bases
ATTGTATATACATTCACGAATGTATGTAAAAAGCCCGTTTGTATTCCGCCCGCGGCCCAGTCTTACAGATTGTTACCCGC
AGCAAGCATAGCCTGTCTGC

Downstream 100 bases:

>100_bases
CCACCCGGCGCATGGCGCGCCCCGCCGCCGTCACCGTGCCGCGTCAGGCCGCCTTCGCGCGCTGCGCGCGGGCCCGCCGG
TTCGACGCGGCCACCGAATC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MTVTRGCGPHIHSRSIQSGLHMVRRTKEEALETRNRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFANKSELF
DAMFDRVFLPIDELKRMPLDAPGGNPLEKVRQILIWCLLGVQRDPQLRRVFSILFMKCEYVADMEPLLQRNRAGMSEALH
MIDADLAVAVGLKLLPERLDTWRATLMLHTLVSGFVRDMLMLPDEIDAEQHAEKLVDGCFDMLRYSPAMLKDRD

Sequences:

>Translated_234_residues
MTVTRGCGPHIHSRSIQSGLHMVRRTKEEALETRNRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFANKSELF
DAMFDRVFLPIDELKRMPLDAPGGNPLEKVRQILIWCLLGVQRDPQLRRVFSILFMKCEYVADMEPLLQRNRAGMSEALH
MIDADLAVAVGLKLLPERLDTWRATLMLHTLVSGFVRDMLMLPDEIDAEQHAEKLVDGCFDMLRYSPAMLKDRD
>Mature_233_residues
TVTRGCGPHIHSRSIQSGLHMVRRTKEEALETRNRILDAAEHVFFEKGVSHTSLADIAQHAGVTRGAIYWHFANKSELFD
AMFDRVFLPIDELKRMPLDAPGGNPLEKVRQILIWCLLGVQRDPQLRRVFSILFMKCEYVADMEPLLQRNRAGMSEALHM
IDADLAVAVGLKLLPERLDTWRATLMLHTLVSGFVRDMLMLPDEIDAEQHAEKLVDGCFDMLRYSPAMLKDRD

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=208, Percent_Identity=37.5, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1789664, Length=209, Percent_Identity=33.4928229665072, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 26709; Mature: 26577

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTRGCGPHIHSRSIQSGLHMVRRTKEEALETRNRILDAAEHVFFEKGVSHTSLADIAQ
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HAGVTRGAIYWHFANKSELFDAMFDRVFLPIDELKRMPLDAPGGNPLEKVRQILIWCLLG
HCCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
VQRDPQLRRVFSILFMKCEYVADMEPLLQRNRAGMSEALHMIDADLAVAVGLKLLPERLD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TWRATLMLHTLVSGFVRDMLMLPDEIDAEQHAEKLVDGCFDMLRYSPAMLKDRD
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCC
>Mature Secondary Structure 
TVTRGCGPHIHSRSIQSGLHMVRRTKEEALETRNRILDAAEHVFFEKGVSHTSLADIAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HAGVTRGAIYWHFANKSELFDAMFDRVFLPIDELKRMPLDAPGGNPLEKVRQILIWCLLG
HCCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
VQRDPQLRRVFSILFMKCEYVADMEPLLQRNRAGMSEALHMIDADLAVAVGLKLLPERLD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TWRATLMLHTLVSGFVRDMLMLPDEIDAEQHAEKLVDGCFDMLRYSPAMLKDRD
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]