| Definition | Burkholderia cenocepacia HI2424 chromosome 1, complete sequence. |
|---|---|
| Accession | NC_008542 |
| Length | 3,483,902 |
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The map label for this gene is polS [H]
Identifier: 116690618
GI number: 116690618
Start: 2876539
End: 2877369
Strand: Reverse
Name: polS [H]
Synonym: Bcen2424_2598
Alternate gene names: 116690618
Gene position: 2877369-2876539 (Counterclockwise)
Preceding gene: 116690623
Following gene: 116690617
Centisome position: 82.59
GC content: 68.59
Gene sequence:
>831_bases ATGAGCGTTCGCTCACCTCGACCGTCGTGCAACAGAACGAACCGGAGACAGCCAGTGAGACTGGAAGACAAGGTCGCGAT CCTGACGGGCGCCGCAAGCGGCATCGGCGAGGCGGTCGCGCAACGCTATCTGGACGAGGGCGCGCGCTGCGTGCTCGTCG ACGTGAAGCCGGCAGGCGGCTCGCTCGCGCGGCTGATCGAGGCCAATCCGGGCCGCGCGGTGGCCGTCACGGCCGACGTC ACGCGCCGCGACGACATCACGCGGATCGTCGCCACGGCGGTCGAGCGCTTCGGCGGCGTCGACATCCTGTTCAACAACGC GGCGCTGTTCGACATGCGCCCGCTCCTCGATGAATCCTGGGACGTGTTCGACCGGCTGTTCTCGGTCAACGTGAAAGGGC TGTTCTTCCTGATGCAGGCGGTTGCGCAACGGATGGTCGAGCAGGGGCGCGGCGGCAAGATCGTCAACATGTCGTCGCAG GCCGGCCGCCGCGGCGAGGCGCTCGTTTCGCACTACTGCGCGACCAAGGCCGCGGTGATCAGCTATACGCAGTCGGCCGC GCTCGCGCTCGCGCCGCACCGGATCAACGTGAACGGCATCGCGCCGGGCGTGGTCGACACGCCGATGTGGGAGCAGGTCG ATGCGCTGTTCGCGCGCTACGAGAACCGGCCGCTCGGCGAGAAGAAGCGGCTCGTCGGTGAAGCCGTGCCGCTCGGCCGC ATGGGCGTGCCGGGCGACCTGACGGGCGCCGCGCTGTTCCTCGCGTCGGCCGATGCCGACTACATCACCGCCCAGACGTT GAACGTCGATGGCGGCAACTGGATGAGCTGA
Upstream 100 bases:
>100_bases CCGCCGTGCCGCAGCGCGTCATAGAAAGCCGTCACGTCGCCTTGACAGCGCGCATCGCGTATCCGATCATTCGATCACTA ACAGAGCAATTGATCGGTAG
Downstream 100 bases:
>100_bases CGTGGCGCCGCTCGCACGCGCCATCCGCCGGCCGGCCCGCGACGCAGCGGCCGCCGTCGCACGAGGAGGGCTCGCCTGAT GGCCGAGATCGTCGTCGCCG
Product: sorbitol dehydrogenase
Products: NA
Alternate protein names: L-iditol 2-dehydrogenase; Polyol dehydrogenase [H]
Number of amino acids: Translated: 276; Mature: 275
Protein sequence:
>276_residues MSVRSPRPSCNRTNRRQPVRLEDKVAILTGAASGIGEAVAQRYLDEGARCVLVDVKPAGGSLARLIEANPGRAVAVTADV TRRDDITRIVATAVERFGGVDILFNNAALFDMRPLLDESWDVFDRLFSVNVKGLFFLMQAVAQRMVEQGRGGKIVNMSSQ AGRRGEALVSHYCATKAAVISYTQSAALALAPHRINVNGIAPGVVDTPMWEQVDALFARYENRPLGEKKRLVGEAVPLGR MGVPGDLTGAALFLASADADYITAQTLNVDGGNWMS
Sequences:
>Translated_276_residues MSVRSPRPSCNRTNRRQPVRLEDKVAILTGAASGIGEAVAQRYLDEGARCVLVDVKPAGGSLARLIEANPGRAVAVTADV TRRDDITRIVATAVERFGGVDILFNNAALFDMRPLLDESWDVFDRLFSVNVKGLFFLMQAVAQRMVEQGRGGKIVNMSSQ AGRRGEALVSHYCATKAAVISYTQSAALALAPHRINVNGIAPGVVDTPMWEQVDALFARYENRPLGEKKRLVGEAVPLGR MGVPGDLTGAALFLASADADYITAQTLNVDGGNWMS >Mature_275_residues SVRSPRPSCNRTNRRQPVRLEDKVAILTGAASGIGEAVAQRYLDEGARCVLVDVKPAGGSLARLIEANPGRAVAVTADVT RRDDITRIVATAVERFGGVDILFNNAALFDMRPLLDESWDVFDRLFSVNVKGLFFLMQAVAQRMVEQGRGGKIVNMSSQA GRRGEALVSHYCATKAAVISYTQSAALALAPHRINVNGIAPGVVDTPMWEQVDALFARYENRPLGEKKRLVGEAVPLGRM GVPGDLTGAALFLASADADYITAQTLNVDGGNWMS
Specific function: Catalyzes the oxidation of D-glucitol (sorbitol) to D- fructose, galactitol to D-tagatose and of L-iditol [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=269, Percent_Identity=34.2007434944238, Blast_Score=125, Evalue=5e-29, Organism=Homo sapiens, GI32483357, Length=275, Percent_Identity=33.8181818181818, Blast_Score=124, Evalue=8e-29, Organism=Homo sapiens, GI7705925, Length=248, Percent_Identity=34.6774193548387, Blast_Score=117, Evalue=1e-26, Organism=Homo sapiens, GI59889578, Length=232, Percent_Identity=35.3448275862069, Blast_Score=117, Evalue=2e-26, Organism=Homo sapiens, GI10190704, Length=264, Percent_Identity=31.0606060606061, Blast_Score=107, Evalue=2e-23, Organism=Homo sapiens, GI19923817, Length=263, Percent_Identity=28.5171102661597, Blast_Score=105, Evalue=4e-23, Organism=Homo sapiens, GI126723750, Length=279, Percent_Identity=31.1827956989247, Blast_Score=105, Evalue=6e-23, Organism=Homo sapiens, GI5031737, Length=256, Percent_Identity=30.859375, Blast_Score=99, Evalue=4e-21, Organism=Homo sapiens, GI4758504, Length=264, Percent_Identity=29.1666666666667, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI66933014, Length=257, Percent_Identity=33.4630350194552, Blast_Score=92, Evalue=4e-19, Organism=Homo sapiens, GI40254992, Length=256, Percent_Identity=29.296875, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI31542939, Length=202, Percent_Identity=31.6831683168317, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI33667109, Length=248, Percent_Identity=31.0483870967742, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI126723191, Length=201, Percent_Identity=32.8358208955224, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI4504505, Length=195, Percent_Identity=30.7692307692308, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI83715985, Length=180, Percent_Identity=32.2222222222222, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI109715829, Length=198, Percent_Identity=32.8282828282828, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI40807363, Length=195, Percent_Identity=27.6923076923077, Blast_Score=78, Evalue=1e-14, Organism=Homo sapiens, GI20149619, Length=203, Percent_Identity=30.0492610837438, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI224922801, Length=173, Percent_Identity=31.2138728323699, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI4503817, Length=230, Percent_Identity=26.9565217391304, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI310128830, Length=200, Percent_Identity=29.5, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI310115468, Length=200, Percent_Identity=29.5, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI7706318, Length=225, Percent_Identity=28.8888888888889, Blast_Score=68, Evalue=9e-12, Organism=Homo sapiens, GI4503301, Length=261, Percent_Identity=25.6704980842912, Blast_Score=65, Evalue=5e-11, Organism=Homo sapiens, GI40254986, Length=147, Percent_Identity=30.6122448979592, Blast_Score=65, Evalue=7e-11, Organism=Escherichia coli, GI1789208, Length=256, Percent_Identity=34.765625, Blast_Score=145, Evalue=3e-36, Organism=Escherichia coli, GI87082100, Length=262, Percent_Identity=35.1145038167939, Blast_Score=127, Evalue=1e-30, Organism=Escherichia coli, GI87082160, Length=252, Percent_Identity=33.7301587301587, Blast_Score=118, Evalue=5e-28, Organism=Escherichia coli, GI1788459, Length=251, Percent_Identity=32.2709163346614, Blast_Score=117, Evalue=6e-28, Organism=Escherichia coli, GI1790717, Length=255, Percent_Identity=31.3725490196078, Blast_Score=115, Evalue=4e-27, Organism=Escherichia coli, GI1787905, Length=260, Percent_Identity=35.3846153846154, Blast_Score=114, Evalue=7e-27, Organism=Escherichia coli, GI1787335, Length=262, Percent_Identity=32.0610687022901, Blast_Score=112, Evalue=2e-26, Organism=Escherichia coli, GI1789378, Length=279, Percent_Identity=29.0322580645161, Blast_Score=102, Evalue=2e-23, Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=29.8850574712644, Blast_Score=99, Evalue=4e-22, Organism=Escherichia coli, GI1786812, Length=251, Percent_Identity=33.0677290836653, Blast_Score=92, Evalue=6e-20, Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=28.4046692607004, Blast_Score=78, Evalue=8e-16, Organism=Escherichia coli, GI2367365, Length=251, Percent_Identity=27.4900398406374, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI1787820, Length=182, Percent_Identity=29.1208791208791, Blast_Score=70, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=33.203125, Blast_Score=132, Evalue=2e-31, Organism=Caenorhabditis elegans, GI25147288, Length=256, Percent_Identity=31.640625, Blast_Score=121, Evalue=4e-28, Organism=Caenorhabditis elegans, GI17555706, Length=262, Percent_Identity=32.824427480916, Blast_Score=117, Evalue=5e-27, Organism=Caenorhabditis elegans, GI17560220, Length=278, Percent_Identity=29.8561151079137, Blast_Score=114, Evalue=6e-26, Organism=Caenorhabditis elegans, GI17560332, Length=278, Percent_Identity=30.5755395683453, Blast_Score=112, Evalue=2e-25, Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=32.8125, Blast_Score=111, Evalue=3e-25, Organism=Caenorhabditis elegans, GI17538480, Length=266, Percent_Identity=31.5789473684211, Blast_Score=106, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17562906, Length=271, Percent_Identity=29.8892988929889, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=31.3725490196078, Blast_Score=104, Evalue=6e-23, Organism=Caenorhabditis elegans, GI72000259, Length=270, Percent_Identity=29.6296296296296, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17562990, Length=275, Percent_Identity=29.0909090909091, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17544670, Length=271, Percent_Identity=29.1512915129151, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17560150, Length=276, Percent_Identity=28.9855072463768, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17562904, Length=274, Percent_Identity=29.5620437956204, Blast_Score=101, Evalue=4e-22, Organism=Caenorhabditis elegans, GI17531453, Length=278, Percent_Identity=28.0575539568345, Blast_Score=101, Evalue=4e-22, Organism=Caenorhabditis elegans, GI17560676, Length=258, Percent_Identity=32.1705426356589, Blast_Score=100, Evalue=6e-22, Organism=Caenorhabditis elegans, GI17563726, Length=276, Percent_Identity=28.6231884057971, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI193204405, Length=278, Percent_Identity=27.6978417266187, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17559104, Length=272, Percent_Identity=30.5147058823529, Blast_Score=97, Evalue=8e-21, Organism=Caenorhabditis elegans, GI17562908, Length=271, Percent_Identity=28.7822878228782, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17551412, Length=274, Percent_Identity=29.1970802919708, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI17562910, Length=274, Percent_Identity=28.4671532846715, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI115534694, Length=254, Percent_Identity=30.3149606299213, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17564282, Length=198, Percent_Identity=29.2929292929293, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17565030, Length=276, Percent_Identity=29.7101449275362, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI17538486, Length=271, Percent_Identity=28.0442804428044, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI193203117, Length=206, Percent_Identity=28.1553398058252, Blast_Score=84, Evalue=5e-17, Organism=Caenorhabditis elegans, GI193203115, Length=201, Percent_Identity=30.3482587064677, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17508895, Length=195, Percent_Identity=28.7179487179487, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17568967, Length=195, Percent_Identity=32.3076923076923, Blast_Score=80, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17508651, Length=258, Percent_Identity=27.5193798449612, Blast_Score=77, Evalue=8e-15, Organism=Caenorhabditis elegans, GI17567345, Length=200, Percent_Identity=27.5, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17538182, Length=267, Percent_Identity=26.2172284644195, Blast_Score=71, Evalue=7e-13, Organism=Caenorhabditis elegans, GI17536025, Length=278, Percent_Identity=21.5827338129496, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17561272, Length=173, Percent_Identity=26.0115606936416, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI71982365, Length=193, Percent_Identity=27.4611398963731, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI17536651, Length=267, Percent_Identity=22.4719101123595, Blast_Score=64, Evalue=9e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=193, Percent_Identity=30.0518134715026, Blast_Score=79, Evalue=7e-16, Organism=Saccharomyces cerevisiae, GI6323882, Length=206, Percent_Identity=33.9805825242718, Blast_Score=76, Evalue=5e-15, Organism=Saccharomyces cerevisiae, GI6324126, Length=264, Percent_Identity=24.2424242424242, Blast_Score=71, Evalue=2e-13, Organism=Drosophila melanogaster, GI24639444, Length=256, Percent_Identity=34.375, Blast_Score=119, Evalue=2e-27, Organism=Drosophila melanogaster, GI23397609, Length=259, Percent_Identity=34.7490347490347, Blast_Score=119, Evalue=3e-27, Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=33.2046332046332, Blast_Score=116, Evalue=1e-26, Organism=Drosophila melanogaster, GI21357041, Length=258, Percent_Identity=31.0077519379845, Blast_Score=111, Evalue=5e-25, Organism=Drosophila melanogaster, GI28571526, Length=257, Percent_Identity=31.5175097276265, Blast_Score=108, Evalue=4e-24, Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=28.6821705426357, Blast_Score=100, Evalue=2e-21, Organism=Drosophila melanogaster, GI24643142, Length=252, Percent_Identity=29.7619047619048, Blast_Score=91, Evalue=9e-19, Organism=Drosophila melanogaster, GI17737361, Length=268, Percent_Identity=27.9850746268657, Blast_Score=88, Evalue=7e-18, Organism=Drosophila melanogaster, GI281364892, Length=200, Percent_Identity=30.5, Blast_Score=87, Evalue=1e-17, Organism=Drosophila melanogaster, GI24640492, Length=189, Percent_Identity=28.042328042328, Blast_Score=85, Evalue=4e-17, Organism=Drosophila melanogaster, GI24644337, Length=207, Percent_Identity=30.9178743961353, Blast_Score=84, Evalue=1e-16, Organism=Drosophila melanogaster, GI221510726, Length=201, Percent_Identity=26.3681592039801, Blast_Score=71, Evalue=7e-13, Organism=Drosophila melanogaster, GI18859837, Length=194, Percent_Identity=29.8969072164948, Blast_Score=71, Evalue=8e-13, Organism=Drosophila melanogaster, GI24665243, Length=208, Percent_Identity=26.9230769230769, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI221331218, Length=192, Percent_Identity=28.125, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI24649181, Length=195, Percent_Identity=26.1538461538462, Blast_Score=67, Evalue=2e-11, Organism=Drosophila melanogaster, GI24665247, Length=209, Percent_Identity=26.7942583732057, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI221331216, Length=193, Percent_Identity=27.979274611399, Blast_Score=65, Evalue=7e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.14 [H]
Molecular weight: Translated: 29670; Mature: 29539
Theoretical pI: Translated: 8.83; Mature: 8.83
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSVRSPRPSCNRTNRRQPVRLEDKVAILTGAASGIGEAVAQRYLDEGARCVLVDVKPAGG CCCCCCCCCCCCCCCCCCCEECCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCC SLARLIEANPGRAVAVTADVTRRDDITRIVATAVERFGGVDILFNNAALFDMRPLLDESW HHHHHEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCEEECCHHHHCCHH DVFDRLFSVNVKGLFFLMQAVAQRMVEQGRGGKIVNMSSQAGRRGEALVSHYCATKAAVI HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHCCCHHHHHHHHHHHHHHHHH SYTQSAALALAPHRINVNGIAPGVVDTPMWEQVDALFARYENRPLGEKKRLVGEAVPLGR HHHCCCEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC MGVPGDLTGAALFLASADADYITAQTLNVDGGNWMS CCCCCCCCHHEEEEECCCCCEEEEEEEECCCCCCCC >Mature Secondary Structure SVRSPRPSCNRTNRRQPVRLEDKVAILTGAASGIGEAVAQRYLDEGARCVLVDVKPAGG CCCCCCCCCCCCCCCCCCEECCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCC SLARLIEANPGRAVAVTADVTRRDDITRIVATAVERFGGVDILFNNAALFDMRPLLDESW HHHHHEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCEEECCHHHHCCHH DVFDRLFSVNVKGLFFLMQAVAQRMVEQGRGGKIVNMSSQAGRRGEALVSHYCATKAAVI HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHCCCHHHHHHHHHHHHHHHHH SYTQSAALALAPHRINVNGIAPGVVDTPMWEQVDALFARYENRPLGEKKRLVGEAVPLGR HHHCCCEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC MGVPGDLTGAALFLASADADYITAQTLNVDGGNWMS CCCCCCCCHHEEEEECCCCCEEEEEEEECCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7551049 [H]