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The map label for this gene is estB [H]

Identifier: 116690609

GI number: 116690609

Start: 2866762

End: 2867958

Strand: Reverse

Name: estB [H]

Synonym: Bcen2424_2589

Alternate gene names: 116690609

Gene position: 2867958-2866762 (Counterclockwise)

Preceding gene: 116690611

Following gene: 116690608

Centisome position: 82.32

GC content: 72.26

Gene sequence:

>1197_bases
ATGTCATCACTGCCTGTCACCGCCCGCCGCGCCGAACCGGATGCCGCGCTGCGCGCCCGGCTCGATGCCGTGCTCGACCG
CGCGCTGGCCGATGCGCGCGCGGTCGGCGCGGTCGTGCTGGTCGCGCGCGACGGCGAATTGCGTTATGCACGCGCGGCCG
GGCTGGCCGATCGCGAAGCCGGCACGCCGATGCGCGAGGACACGCTGTTCCGGCTCGCGTCGGTATCCAAGCCGATCGTG
ACGGCCGCCGCGATGCGGCTGGTCGCGGCATCGAAGATCGGGCTCGACGAGCCGGTCGCGCGCTGGCTGCCCGCGTTCAC
GCCGACGCTCGCGGACGGCACGCCGGCGAACATCACGCTGCGGCATCTGCTGTCGCACACGGCCGGGCTCGGCTATCGCT
TTCTCGAAGCCGACGCCGACGGCCCGTATGCACGCGCGGGCGTGTCCGACGGGATGGATCGCGCGAGCCTGTCGCTCGCC
GAGAACGTGCGGCGCATCGCCGGCGTGCCGCTGCAGTTCGCGCCCGGCACGTCGTGGGGCTACTCGCTTGCGACCGACGT
GGTCGGCGCGCTGATCGAGGCGGTCGACGGCCGCCCGCTCGCCGACGCCGTGGCGGCGCTCGTGACGACGCCGCTCGGGA
TGGCCGACACGGCATTTTTCACGCATGACGCGGCGCGTCTGGCGACGCCTTACGTCAGCACGCCCGACGTGCCGCGCCGG
ATGGCGGACGACGATCTCGTGCCGGTGTTCGACGGCACGGTCGGTATCCGCTTCGAGCCGGCGCGCGCGTTCGACGCGAC
CGCGTGGCCGTCGGGCGGCGCGGGCATGGTCGGCACCGCGCACGATTGCCTGACGCTGCTCGATACGCTGCGCACGGGCC
TCGACGGCTGGCTCGCACCGCGCTGGATCGACGAGATGGCGCGGGTGCAGCCGGGCGCGCACGACTTGCCGGATGCGCCG
GGATTCGGTTTCGGACTCGGTTTTTCCGTGCTGCATGACCCGGTGGCCGCGCAATCGCCGGAGTCGGTCGGCACCTGGCG
CTGGGGCGGTGCGTACGGGCATGCGTGGTTCGTCGACCGCGCAGCCGGGCTGACGGTCGTCGCACTGACCAATACGTTAT
ACGAAGGGATGCACGGGCGCATCGTCACCGACGTGCGCGATGCGGTGTATGGCATCGACGACCGGAGCGCGGCATGA

Upstream 100 bases:

>100_bases
TGCGGACACCCATGTCCGGAGTGTCCGGAACTCTAACCCGATTTTTCTTCTCGTGCCGGCTCCCTACGATGGGCGTTCCT
TCACTGTTCGAGGTCACGCC

Downstream 100 bases:

>100_bases
GCGAGTGCGTATCCGTCTCCGACCGCGCTGTCGATCGTGCGGCAGATTCGTCCGCGCCGGCTCGTGCACGTCTGCCCGTC
GCGAACCTGTTCGCGCTGGC

Product: beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSSLPVTARRAEPDAALRARLDAVLDRALADARAVGAVVLVARDGELRYARAAGLADREAGTPMREDTLFRLASVSKPIV
TAAAMRLVAASKIGLDEPVARWLPAFTPTLADGTPANITLRHLLSHTAGLGYRFLEADADGPYARAGVSDGMDRASLSLA
ENVRRIAGVPLQFAPGTSWGYSLATDVVGALIEAVDGRPLADAVAALVTTPLGMADTAFFTHDAARLATPYVSTPDVPRR
MADDDLVPVFDGTVGIRFEPARAFDATAWPSGGAGMVGTAHDCLTLLDTLRTGLDGWLAPRWIDEMARVQPGAHDLPDAP
GFGFGLGFSVLHDPVAAQSPESVGTWRWGGAYGHAWFVDRAAGLTVVALTNTLYEGMHGRIVTDVRDAVYGIDDRSAA

Sequences:

>Translated_398_residues
MSSLPVTARRAEPDAALRARLDAVLDRALADARAVGAVVLVARDGELRYARAAGLADREAGTPMREDTLFRLASVSKPIV
TAAAMRLVAASKIGLDEPVARWLPAFTPTLADGTPANITLRHLLSHTAGLGYRFLEADADGPYARAGVSDGMDRASLSLA
ENVRRIAGVPLQFAPGTSWGYSLATDVVGALIEAVDGRPLADAVAALVTTPLGMADTAFFTHDAARLATPYVSTPDVPRR
MADDDLVPVFDGTVGIRFEPARAFDATAWPSGGAGMVGTAHDCLTLLDTLRTGLDGWLAPRWIDEMARVQPGAHDLPDAP
GFGFGLGFSVLHDPVAAQSPESVGTWRWGGAYGHAWFVDRAAGLTVVALTNTLYEGMHGRIVTDVRDAVYGIDDRSAA
>Mature_397_residues
SSLPVTARRAEPDAALRARLDAVLDRALADARAVGAVVLVARDGELRYARAAGLADREAGTPMREDTLFRLASVSKPIVT
AAAMRLVAASKIGLDEPVARWLPAFTPTLADGTPANITLRHLLSHTAGLGYRFLEADADGPYARAGVSDGMDRASLSLAE
NVRRIAGVPLQFAPGTSWGYSLATDVVGALIEAVDGRPLADAVAALVTTPLGMADTAFFTHDAARLATPYVSTPDVPRRM
ADDDLVPVFDGTVGIRFEPARAFDATAWPSGGAGMVGTAHDCLTLLDTLRTGLDGWLAPRWIDEMARVQPGAHDLPDAPG
FGFGLGFSVLHDPVAAQSPESVGTWRWGGAYGHAWFVDRAAGLTVVALTNTLYEGMHGRIVTDVRDAVYGIDDRSAA

Specific function: Acts on short-chain (C4-C6) fatty acid esters and triglycerides, including tertiary alcohol esters. Activity on p- nitrophenyl esters is generally higher than on o-nitrophenyl esters. Lacks beta-lactamase activity; it hydrolyzes the ester bond of cephalos

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-A beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI26051231, Length=115, Percent_Identity=34.7826086956522, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI26051233, Length=115, Percent_Identity=34.7826086956522, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI87082101, Length=398, Percent_Identity=24.6231155778894, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17550934, Length=198, Percent_Identity=30.3030303030303, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR000871 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: NA

Molecular weight: Translated: 41934; Mature: 41803

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLPVTARRAEPDAALRARLDAVLDRALADARAVGAVVLVARDGELRYARAAGLADREA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEHHHHCCCCCCCC
GTPMREDTLFRLASVSKPIVTAAAMRLVAASKIGLDEPVARWLPAFTPTLADGTPANITL
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCHHHH
RHLLSHTAGLGYRFLEADADGPYARAGVSDGMDRASLSLAENVRRIAGVPLQFAPGTSWG
HHHHHHHCCCCEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCC
YSLATDVVGALIEAVDGRPLADAVAALVTTPLGMADTAFFTHDAARLATPYVSTPDVPRR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCHHHHCCCCCCCCCCCHH
MADDDLVPVFDGTVGIRFEPARAFDATAWPSGGAGMVGTAHDCLTLLDTLRTGLDGWLAP
HCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCH
RWIDEMARVQPGAHDLPDAPGFGFGLGFSVLHDPVAAQSPESVGTWRWGGAYGHAWFVDR
HHHHHHHHCCCCCCCCCCCCCCCHHCCHHHHHCCHHCCCCCCCCCEECCCCCCCHHEEHH
AAGLTVVALTNTLYEGMHGRIVTDVRDAVYGIDDRSAA
CCCEEEEEEHHHHHHCCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SSLPVTARRAEPDAALRARLDAVLDRALADARAVGAVVLVARDGELRYARAAGLADREA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEHHHHCCCCCCCC
GTPMREDTLFRLASVSKPIVTAAAMRLVAASKIGLDEPVARWLPAFTPTLADGTPANITL
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCHHHH
RHLLSHTAGLGYRFLEADADGPYARAGVSDGMDRASLSLAENVRRIAGVPLQFAPGTSWG
HHHHHHHCCCCEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCC
YSLATDVVGALIEAVDGRPLADAVAALVTTPLGMADTAFFTHDAARLATPYVSTPDVPRR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCHHHHCCCCCCCCCCCHH
MADDDLVPVFDGTVGIRFEPARAFDATAWPSGGAGMVGTAHDCLTLLDTLRTGLDGWLAP
HCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCH
RWIDEMARVQPGAHDLPDAPGFGFGLGFSVLHDPVAAQSPESVGTWRWGGAYGHAWFVDR
HHHHHHHHCCCCCCCCCCCCCCCHHCCHHHHHCCHHCCCCCCCCCEECCCCCCCHHEEHH
AAGLTVVALTNTLYEGMHGRIVTDVRDAVYGIDDRSAA
CCCEEEEEEHHHHHHCCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11472796; 11847270 [H]