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The map label for this gene is pcaK [H]

Identifier: 116690600

GI number: 116690600

Start: 2854567

End: 2855970

Strand: Reverse

Name: pcaK [H]

Synonym: Bcen2424_2580

Alternate gene names: 116690600

Gene position: 2855970-2854567 (Counterclockwise)

Preceding gene: 116690601

Following gene: 116690596

Centisome position: 81.98

GC content: 72.22

Gene sequence:

>1404_bases
ATGAGCACGCCCGACGCACTGAATGAACGGCCGTCGTCGATCGACATCGGCACGACGCTCGACGACGGCCCGTTCACGCT
GATGCAGCGCTGCGTGGTGCTGCTCGCCGCGCTCGCGATCGTGCTCGACGGCTTTGACGGCCAGTTGATCGGTTTCGCGA
TTCCGGTGCTGATCCGCGAGTGGGGCATCACGCGCGGTGCGTTCGCGCCGGCCGTCGCGGCGGGACTGGTCGGGATGGGT
ATCGGCAGCGCCTGCGCGGGGATCGTTGCGGACCGCTACGGCCGCCGCCAGGCCGTGATCGGCAGCGTGTTCCTGTTCGG
CATCGCGACCTGCGCGATCGGGTTCGCGCCCGACGTCGCGACGATCGCGATGCTGCGTTTTTGCGCGGGGCTCGGGATCG
GCGGCGCGCTGCCGACGGCCACGACGATGACCGCCGAATACACGCCCGCGCGGCGCCGCACGATGATGGTGACCGCGACG
ATCGTCTGCGTGCCGCTCGGCGGGATGCTGGCCGGCCTGTTCGCGCACGAGGTGCTGCCGCGCTACGGCTGGCGCGGGCT
GTTCTTCGCGGGCGGCGCGTTGCCGCTCGTGCTCGGCTTCGTGCTGGTGCGCGCGTTGCCCGAATCGCCGCGCTATCTCG
CGCGGCGCCCCGCACGCTGGCCGGAACTCGGCGCGCTGCTCGCGCGGATGCAGCGGCCGGTCGCACCGGGCACCGTGTTC
ACCGATACGAAGGACGCCCGTGCGCCGGGCAGCCGCGGCGGCTTCGGCGCGCTGTTCGCGAGCGGCCAGGCGCGCGACAC
GATCGCGCTGTGGTGCGCGTTCTTCATGTGCCTGCTCGCCGTGTACGCGGCGTTCAGCTGGTTGCCGACGATGCTCGCGG
CGAGCGGGTTGAGCGTGTCGGTCGCGGGCTCGGGCCTCACCGCGTACAACCTCGGCGGCGTGATCGGTGCGCTGCTGTGC
GCATGGGCGATCGCGCATGCGGGGTCACGCTGGCCGCTCGCGCTGTGCAGCATCGGCGGCGCGGCGAGCGCGGTATGGCT
GATGGGCGTCGATGCCAGCCGCCATACCGGCTGGCTGATCGTCGGGCTCGGTCTGCACGGGTTGTTCGTCAACGCGGTGC
AGTCGACGATGTATGCGCTGTGCGCGTACATCTATCCGACGGCCGTGCGCGCGACGGGCACCGCGAGTGCGCTCGCGTTC
GGTCGGCTCGGCGCGATCCTCAGCGCGTTCGCGGGCGCGATCGTGATCACGGCGGGCGGCGCGGGTGCGTACCTGACGAT
GCTGGCCGTCGCGATGGGGGTGGTGTGCATCGCGCTGCTCGCGATGCGGCGGCACATTCCGCGGCTGTCGCGCGCGGCGG
CGCAGCCGCGCGAAGGGGAGGCGCTCGCCCGCACGTCGTCGTGA

Upstream 100 bases:

>100_bases
CCCGGACAACCGGAGACGCCATGAAAACCATTGAATGCCGTTGTCTTGTCGCGCACCGTTCGCGCATCTTGCCGCCGCCG
CGCGGTGCATCGGAGGCCGC

Downstream 100 bases:

>100_bases
TCGTCGTGACGGCGGGCGCGTGGCGTGCGTTACAGCGTGGTGCGCACGTGCCAGAGCTCGGGGAATAGCACGACGTCGAG
CATCTTGCGCAGGTACGGCG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSTPDALNERPSSIDIGTTLDDGPFTLMQRCVVLLAALAIVLDGFDGQLIGFAIPVLIREWGITRGAFAPAVAAGLVGMG
IGSACAGIVADRYGRRQAVIGSVFLFGIATCAIGFAPDVATIAMLRFCAGLGIGGALPTATTMTAEYTPARRRTMMVTAT
IVCVPLGGMLAGLFAHEVLPRYGWRGLFFAGGALPLVLGFVLVRALPESPRYLARRPARWPELGALLARMQRPVAPGTVF
TDTKDARAPGSRGGFGALFASGQARDTIALWCAFFMCLLAVYAAFSWLPTMLAASGLSVSVAGSGLTAYNLGGVIGALLC
AWAIAHAGSRWPLALCSIGGAASAVWLMGVDASRHTGWLIVGLGLHGLFVNAVQSTMYALCAYIYPTAVRATGTASALAF
GRLGAILSAFAGAIVITAGGAGAYLTMLAVAMGVVCIALLAMRRHIPRLSRAAAQPREGEALARTSS

Sequences:

>Translated_467_residues
MSTPDALNERPSSIDIGTTLDDGPFTLMQRCVVLLAALAIVLDGFDGQLIGFAIPVLIREWGITRGAFAPAVAAGLVGMG
IGSACAGIVADRYGRRQAVIGSVFLFGIATCAIGFAPDVATIAMLRFCAGLGIGGALPTATTMTAEYTPARRRTMMVTAT
IVCVPLGGMLAGLFAHEVLPRYGWRGLFFAGGALPLVLGFVLVRALPESPRYLARRPARWPELGALLARMQRPVAPGTVF
TDTKDARAPGSRGGFGALFASGQARDTIALWCAFFMCLLAVYAAFSWLPTMLAASGLSVSVAGSGLTAYNLGGVIGALLC
AWAIAHAGSRWPLALCSIGGAASAVWLMGVDASRHTGWLIVGLGLHGLFVNAVQSTMYALCAYIYPTAVRATGTASALAF
GRLGAILSAFAGAIVITAGGAGAYLTMLAVAMGVVCIALLAMRRHIPRLSRAAAQPREGEALARTSS
>Mature_466_residues
STPDALNERPSSIDIGTTLDDGPFTLMQRCVVLLAALAIVLDGFDGQLIGFAIPVLIREWGITRGAFAPAVAAGLVGMGI
GSACAGIVADRYGRRQAVIGSVFLFGIATCAIGFAPDVATIAMLRFCAGLGIGGALPTATTMTAEYTPARRRTMMVTATI
VCVPLGGMLAGLFAHEVLPRYGWRGLFFAGGALPLVLGFVLVRALPESPRYLARRPARWPELGALLARMQRPVAPGTVFT
DTKDARAPGSRGGFGALFASGQARDTIALWCAFFMCLLAVYAAFSWLPTMLAASGLSVSVAGSGLTAYNLGGVIGALLCA
WAIAHAGSRWPLALCSIGGAASAVWLMGVDASRHTGWLIVGLGLHGLFVNAVQSTMYALCAYIYPTAVRATGTASALAFG
RLGAILSAFAGAIVITAGGAGAYLTMLAVAMGVVCIALLAMRRHIPRLSRAAAQPREGEALARTSS

Specific function: Could Be A Transporter For 3-Phenylpropionate (Hydrocinnamic Acid). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=443, Percent_Identity=25.5079006772009, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI166064021, Length=426, Percent_Identity=26.056338028169, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI213021148, Length=487, Percent_Identity=23.6139630390144, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI87081723, Length=334, Percent_Identity=32.0359281437126, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI87082231, Length=186, Percent_Identity=31.7204301075269, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786229, Length=453, Percent_Identity=23.841059602649, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788068, Length=441, Percent_Identity=22.6757369614512, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082404, Length=205, Percent_Identity=25.8536585365854, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87082159, Length=393, Percent_Identity=27.4809160305344, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788074, Length=380, Percent_Identity=23.9473684210526, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1789152, Length=407, Percent_Identity=23.3415233415233, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790463, Length=257, Percent_Identity=26.4591439688716, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=431, Percent_Identity=25.5220417633411, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19922874, Length=426, Percent_Identity=24.1784037558685, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19922616, Length=365, Percent_Identity=23.2876712328767, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48199; Mature: 48068

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPDALNERPSSIDIGTTLDDGPFTLMQRCVVLLAALAIVLDGFDGQLIGFAIPVLIRE
CCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
WGITRGAFAPAVAAGLVGMGIGSACAGIVADRYGRRQAVIGSVFLFGIATCAIGFAPDVA
HCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHH
TIAMLRFCAGLGIGGALPTATTMTAEYTPARRRTMMVTATIVCVPLGGMLAGLFAHEVLP
HHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHH
RYGWRGLFFAGGALPLVLGFVLVRALPESPRYLARRPARWPELGALLARMQRPVAPGTVF
HCCCCEEEECCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCEE
TDTKDARAPGSRGGFGALFASGQARDTIALWCAFFMCLLAVYAAFSWLPTMLAASGLSVS
ECCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VAGSGLTAYNLGGVIGALLCAWAIAHAGSRWPLALCSIGGAASAVWLMGVDASRHTGWLI
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHEEEEEECCCCCCCCEEE
VGLGLHGLFVNAVQSTMYALCAYIYPTAVRATGTASALAFGRLGAILSAFAGAIVITAGG
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEECCC
AGAYLTMLAVAMGVVCIALLAMRRHIPRLSRAAAQPREGEALARTSS
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
STPDALNERPSSIDIGTTLDDGPFTLMQRCVVLLAALAIVLDGFDGQLIGFAIPVLIRE
CCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
WGITRGAFAPAVAAGLVGMGIGSACAGIVADRYGRRQAVIGSVFLFGIATCAIGFAPDVA
HCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHH
TIAMLRFCAGLGIGGALPTATTMTAEYTPARRRTMMVTATIVCVPLGGMLAGLFAHEVLP
HHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHH
RYGWRGLFFAGGALPLVLGFVLVRALPESPRYLARRPARWPELGALLARMQRPVAPGTVF
HCCCCEEEECCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCEE
TDTKDARAPGSRGGFGALFASGQARDTIALWCAFFMCLLAVYAAFSWLPTMLAASGLSVS
ECCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VAGSGLTAYNLGGVIGALLCAWAIAHAGSRWPLALCSIGGAASAVWLMGVDASRHTGWLI
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHEEEEEECCCCCCCCEEE
VGLGLHGLFVNAVQSTMYALCAYIYPTAVRATGTASALAFGRLGAILSAFAGAIVITAGG
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEECCC
AGAYLTMLAVAMGVVCIALLAMRRHIPRLSRAAAQPREGEALARTSS
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063101 [H]