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The map label for this gene is msrA [H]

Identifier: 116690591

GI number: 116690591

Start: 2846977

End: 2847537

Strand: Reverse

Name: msrA [H]

Synonym: Bcen2424_2571

Alternate gene names: 116690591

Gene position: 2847537-2846977 (Counterclockwise)

Preceding gene: 116690592

Following gene: 116690587

Centisome position: 81.73

GC content: 64.35

Gene sequence:

>561_bases
ATGGGGAACGAGATGCTTGAAACCGCGACGCTCGGAGGCGGGTGTTTCTGGTGCACGGAGGCCGTGTTTCTCGACGTCGA
TGGCGTGACGGCCGTCCAGTCGGGTTATGCGGGCGGCCATACGCGCAACCCTGGCTATCGCGACATCTGCGAAGGCGACA
CCGGCCACGCGGAAGTCGTCAACGTGACGTTCGATCCGGCGCGCATCGGCTATCGCGAGATCCTCGAGATCTTCTTCGCG
ACGCACGATCCGACCACGCTGAACCGGCAGGGCAACGACGTCGGCACGCAGTACCGGTCGGTCGTGTTCACGCATTCGGA
TGCGCAGCGCGACACGGCGCTCGACCTGATTGCCGAGCTCGAACGCGAACAGGTGTTCGGCCAGCCGATCGTCACGCAGG
TCGTGCCGCTCGACGGCAACTACTGGCCGGCCGAGGACTATCATCAGAACTATTACGCGCGCAACCCGGGGCAGGGCTAT
TGCTCGGTCGTGATCGGGCCGAAGCTCGCGAAATTCCGGCAGAAGTTCTCGCACCGGCTGAAGTCGCTGCGCGGCGCGTA
A

Upstream 100 bases:

>100_bases
GTGCCGCTGCCTCCCGCCTCGCGGGGCGGGCAGCGGCGATGCGAAACGATGGCGCCGGCACTGGCGTGCCGGCTGCCGTC
ATCCACGAGGGACTGATTTC

Downstream 100 bases:

>100_bases
GCGTCGGCGGCGGCGGAAACCGCGGTCACGCCGCCTCGTTGCGCCACTGTGCGCACGCGGCGGCGATTTCGCGTGCGAGC
GCGATGCACGACAGCGGCGC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MGNEMLETATLGGGCFWCTEAVFLDVDGVTAVQSGYAGGHTRNPGYRDICEGDTGHAEVVNVTFDPARIGYREILEIFFA
THDPTTLNRQGNDVGTQYRSVVFTHSDAQRDTALDLIAELEREQVFGQPIVTQVVPLDGNYWPAEDYHQNYYARNPGQGY
CSVVIGPKLAKFRQKFSHRLKSLRGA

Sequences:

>Translated_186_residues
MGNEMLETATLGGGCFWCTEAVFLDVDGVTAVQSGYAGGHTRNPGYRDICEGDTGHAEVVNVTFDPARIGYREILEIFFA
THDPTTLNRQGNDVGTQYRSVVFTHSDAQRDTALDLIAELEREQVFGQPIVTQVVPLDGNYWPAEDYHQNYYARNPGQGY
CSVVIGPKLAKFRQKFSHRLKSLRGA
>Mature_185_residues
GNEMLETATLGGGCFWCTEAVFLDVDGVTAVQSGYAGGHTRNPGYRDICEGDTGHAEVVNVTFDPARIGYREILEIFFAT
HDPTTLNRQGNDVGTQYRSVVFTHSDAQRDTALDLIAELEREQVFGQPIVTQVVPLDGNYWPAEDYHQNYYARNPGQGYC
SVVIGPKLAKFRQKFSHRLKSLRGA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=163, Percent_Identity=43.558282208589, Blast_Score=136, Evalue=9e-33,
Organism=Homo sapiens, GI208609995, Length=163, Percent_Identity=43.558282208589, Blast_Score=136, Evalue=1e-32,
Organism=Homo sapiens, GI208609993, Length=114, Percent_Identity=43.859649122807, Blast_Score=91, Evalue=4e-19,
Organism=Escherichia coli, GI1790665, Length=157, Percent_Identity=42.0382165605096, Blast_Score=125, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=149, Percent_Identity=32.8859060402685, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=161, Percent_Identity=41.6149068322981, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24664627, Length=165, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24664631, Length=167, Percent_Identity=31.7365269461078, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45553131, Length=161, Percent_Identity=31.6770186335404, Blast_Score=87, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20651; Mature: 20520

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNEMLETATLGGGCFWCTEAVFLDVDGVTAVQSGYAGGHTRNPGYRDICEGDTGHAEVV
CCCHHHHHHCCCCCHHEECCEEEEECCCCHHHHCCCCCCCCCCCCCCHHCCCCCCCEEEE
NVTFDPARIGYREILEIFFATHDPTTLNRQGNDVGTQYRSVVFTHSDAQRDTALDLIAEL
EEEECHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEEEEECCCCCHHHHHHHHHHH
EREQVFGQPIVTQVVPLDGNYWPAEDYHQNYYARNPGQGYCSVVIGPKLAKFRQKFSHRL
HHHHHCCCCCHHEEEECCCCCCCCHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHH
KSLRGA
HHHCCC
>Mature Secondary Structure 
GNEMLETATLGGGCFWCTEAVFLDVDGVTAVQSGYAGGHTRNPGYRDICEGDTGHAEVV
CCHHHHHHCCCCCHHEECCEEEEECCCCHHHHCCCCCCCCCCCCCCHHCCCCCCCEEEE
NVTFDPARIGYREILEIFFATHDPTTLNRQGNDVGTQYRSVVFTHSDAQRDTALDLIAEL
EEEECHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEEEEECCCCCHHHHHHHHHHH
EREQVFGQPIVTQVVPLDGNYWPAEDYHQNYYARNPGQGYCSVVIGPKLAKFRQKFSHRL
HHHHHCCCCCHHEEEECCCCCCCCHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHH
KSLRGA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]