BacMap

Definition	Burkholderia cenocepacia HI2424 chromosome 1, complete sequence.
Accession	NC_008542
Length	3,483,902

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The map label for this gene is hmuV [H]

Identifier: 116690474

GI number: 116690474

Start: 2726231

End: 2727049

Strand: Reverse

Name: hmuV [H]

Synonym: Bcen2424_2454

Alternate gene names: 116690474

Gene position: 2727049-2726231 (Counterclockwise)

Preceding gene: 116690475

Following gene: 116690473

Centisome position: 78.28

GC content: 71.55

Gene sequence:

>819_bases
ATGACGGGCACCGCGGCACTGAACGCCGCCGCCGGCGACCTGCACTACAGGGCCGTCGACCTGACGCTGAAGGCCGGCGC
GCGCACGTTGCTCGACCGCTTCACGCAGGCGTTCCGCCCCGGCGAGATCTGGTGCGTCGCCGGGCCGAACGGTGCGGGCA
AGACGACGCTGCTCGCCACGCTCGCGGGATTGCAGCCGCCGGCCGGCGGACACGTCGAGATCGACGGCCGGCCGCTTGCC
GCGTGGCGCCCCGAGCCACTCGCGCGGCGCCGCGCGCTGATGCCGCAGCAATTGCACGATGCGTTCAGCGCGACCGTGTT
CGACACGGTGCTGCTCAACCGCTTTCCGTATCTCGGCGGCTGGGGCTGGGAGCGCGACGACGACCGCACGGCCGCGCGCG
CTGCACTCGCGACGTTCGACCTGAGCCCGCTCGCGTCGCGCGACGTGATGTCGCTGTCGGGCGGCGAGCGGCAGCGGGTC
GCGCTGGCCGCGACGCTGTGTCAGGATGCGCCGCTGATGCTGCTCGACGAACCGCTCGCGCATCTCGACCTGCATCACCA
GATCGATTGCCTCACTGCGCTGGCCGCCTGGCTCGCGGCAGCCCCGCGCACGATATTGTTTTCGTGTCACGACCTGAATC
TCGCGCGGCGCTTCGCGACGCATGCGCTATTGCTCGACGGCCGTGGCCATGCGTCGGCCGGCCTCGTGCACGACGTGTTG
ACGCCCGAGCGCGCGAGCGACGCGTTCGGCTATCCGCTCGTGCTGATCCGCGAGAACGGCCGCGATGCGCTGCTGCCGGC
GTGGCCTGCGCGACAATGA

Upstream 100 bases:

>100_bases
CGCGTACCGCGATCGCGCCCGCGCAATTGCCGGTCGGCGTGATGACCGCGTTGATCGGCGTGCCGGTGTTCCTGTGGATG
TTGCTGAGGAGGCCGATGCG

Downstream 100 bases:

>100_bases
CCTTTCCTGTTCCGATTTTTCCGATGCGCGGCGCATGCCGCGCCCACGACCCGGCTCCTCGATGACGACTCCCACCCCAT
TCCCGCCCGCGATCGCGCCG

Product: ABC transporter related

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MTGTAALNAAAGDLHYRAVDLTLKAGARTLLDRFTQAFRPGEIWCVAGPNGAGKTTLLATLAGLQPPAGGHVEIDGRPLA
AWRPEPLARRRALMPQQLHDAFSATVFDTVLLNRFPYLGGWGWERDDDRTAARAALATFDLSPLASRDVMSLSGGERQRV
ALAATLCQDAPLMLLDEPLAHLDLHHQIDCLTALAAWLAAAPRTILFSCHDLNLARRFATHALLLDGRGHASAGLVHDVL
TPERASDAFGYPLVLIRENGRDALLPAWPARQ

Sequences:

>Translated_272_residues
MTGTAALNAAAGDLHYRAVDLTLKAGARTLLDRFTQAFRPGEIWCVAGPNGAGKTTLLATLAGLQPPAGGHVEIDGRPLA
AWRPEPLARRRALMPQQLHDAFSATVFDTVLLNRFPYLGGWGWERDDDRTAARAALATFDLSPLASRDVMSLSGGERQRV
ALAATLCQDAPLMLLDEPLAHLDLHHQIDCLTALAAWLAAAPRTILFSCHDLNLARRFATHALLLDGRGHASAGLVHDVL
TPERASDAFGYPLVLIRENGRDALLPAWPARQ
>Mature_271_residues
TGTAALNAAAGDLHYRAVDLTLKAGARTLLDRFTQAFRPGEIWCVAGPNGAGKTTLLATLAGLQPPAGGHVEIDGRPLAA
WRPEPLARRRALMPQQLHDAFSATVFDTVLLNRFPYLGGWGWERDDDRTAARAALATFDLSPLASRDVMSLSGGERQRVA
LAATLCQDAPLMLLDEPLAHLDLHHQIDCLTALAAWLAAAPRTILFSCHDLNLARRFATHALLLDGRGHASAGLVHDVLT
PERASDAFGYPLVLIRENGRDALLPAWPARQ

Specific function: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system [H]

COG id: COG1120

COG function: function code PH; ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI108773784, Length=196, Percent_Identity=27.5510204081633, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI108773782, Length=196, Percent_Identity=27.5510204081633, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI73747915, Length=216, Percent_Identity=28.7037037037037, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI9665248, Length=223, Percent_Identity=29.5964125560538, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI31657092, Length=234, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI11967969, Length=207, Percent_Identity=29.951690821256, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI105990541, Length=230, Percent_Identity=26.9565217391304, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI156105685, Length=208, Percent_Identity=30.2884615384615, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1786345, Length=237, Percent_Identity=34.5991561181435, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1786803, Length=240, Percent_Identity=34.5833333333333, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1790739, Length=227, Percent_Identity=35.6828193832599, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788002, Length=230, Percent_Identity=36.0869565217391, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786253, Length=219, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789873, Length=220, Percent_Identity=31.8181818181818, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI87081709, Length=221, Percent_Identity=28.0542986425339, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1789891, Length=281, Percent_Identity=29.8932384341637, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1788225, Length=215, Percent_Identity=29.7674418604651, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787712, Length=186, Percent_Identity=30.6451612903226, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786872, Length=183, Percent_Identity=30.0546448087432, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1789032, Length=205, Percent_Identity=29.7560975609756, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787029, Length=192, Percent_Identity=30.7291666666667, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790544, Length=205, Percent_Identity=30.2439024390244, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87081834, Length=192, Percent_Identity=31.25, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1786698, Length=191, Percent_Identity=27.7486910994764, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1786563, Length=203, Percent_Identity=29.5566502463054, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787112, Length=216, Percent_Identity=29.6296296296296, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787143, Length=232, Percent_Identity=25.8620689655172, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788165, Length=213, Percent_Identity=29.5774647887324, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI87082267, Length=228, Percent_Identity=26.3157894736842, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI87081791, Length=174, Percent_Identity=31.6091954022989, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788450, Length=207, Percent_Identity=28.5024154589372, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786703, Length=199, Percent_Identity=30.6532663316583, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789751, Length=208, Percent_Identity=30.7692307692308, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788761, Length=213, Percent_Identity=28.6384976525822, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790467, Length=194, Percent_Identity=28.8659793814433, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788210, Length=201, Percent_Identity=28.3582089552239, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87082268, Length=202, Percent_Identity=28.7128712871287, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786319, Length=145, Percent_Identity=29.6551724137931, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787972, Length=202, Percent_Identity=28.7128712871287, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786398, Length=232, Percent_Identity=26.7241379310345, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787089, Length=197, Percent_Identity=29.4416243654822, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1786653, Length=221, Percent_Identity=27.1493212669683, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789593, Length=198, Percent_Identity=30.3030303030303, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787164, Length=204, Percent_Identity=33.8235294117647, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17555800, Length=223, Percent_Identity=27.3542600896861, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539902, Length=255, Percent_Identity=29.0196078431373, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17511077, Length=224, Percent_Identity=27.2321428571429, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533592, Length=243, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565938, Length=194, Percent_Identity=28.3505154639175, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17558664, Length=183, Percent_Identity=30.0546448087432, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI85724864, Length=213, Percent_Identity=28.6384976525822, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24580555, Length=213, Percent_Identity=28.6384976525822, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI85816269, Length=213, Percent_Identity=28.6384976525822, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24580553, Length=213, Percent_Identity=28.6384976525822, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24650855, Length=206, Percent_Identity=27.6699029126214, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24650853, Length=206, Percent_Identity=27.6699029126214, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281362751, Length=206, Percent_Identity=27.6699029126214, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR015863
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 29335; Mature: 29204

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGTAALNAAAGDLHYRAVDLTLKAGARTLLDRFTQAFRPGEIWCVAGPNGAGKTTLLAT
CCCCCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHH
LAGLQPPAGGHVEIDGRPLAAWRPEPLARRRALMPQQLHDAFSATVFDTVLLNRFPYLGG
HHCCCCCCCCEEEECCEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCC
WGWERDDDRTAARAALATFDLSPLASRDVMSLSGGERQRVALAATLCQDAPLMLLDEPLA
CCCCCCCCHHHHHHHHHHCCCCCCCCCCHHCCCCCCHHHHHHHHHHHCCCCEEEECCCHH
HLDLHHQIDCLTALAAWLAAAPRTILFSCHDLNLARRFATHALLLDGRGHASAGLVHDVL
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHEEEEECCCCCCCCHHHHHC
TPERASDAFGYPLVLIRENGRDALLPAWPARQ
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TGTAALNAAAGDLHYRAVDLTLKAGARTLLDRFTQAFRPGEIWCVAGPNGAGKTTLLAT
CCCCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHH
LAGLQPPAGGHVEIDGRPLAAWRPEPLARRRALMPQQLHDAFSATVFDTVLLNRFPYLGG
HHCCCCCCCCEEEECCEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCC
WGWERDDDRTAARAALATFDLSPLASRDVMSLSGGERQRVALAATLCQDAPLMLLDEPLA
CCCCCCCCHHHHHHHHHHCCCCCCCCCCHHCCCCCCHHHHHHHHHHHCCCCEEEECCCHH
HLDLHHQIDCLTALAAWLAAAPRTILFSCHDLNLARRFATHALLLDGRGHASAGLVHDVL
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHEEEEECCCCCCCCHHHHHC
TPERASDAFGYPLVLIRENGRDALLPAWPARQ
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA