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The map label for this gene is hemC [H]

Identifier: 116690445

GI number: 116690445

Start: 2690405

End: 2691616

Strand: Reverse

Name: hemC [H]

Synonym: Bcen2424_2425

Alternate gene names: 116690445

Gene position: 2691616-2690405 (Counterclockwise)

Preceding gene: 116690447

Following gene: 116690444

Centisome position: 77.26

GC content: 70.3

Gene sequence:

>1212_bases
ATGGGTTTCCTTGGGAAAGCTCGAGTCAAAAGGAACTGCGGAAACTGCGGGAACTGCGGTCAAGCAACCAGCTACGTGCG
GCACATCCGCACAACGGCGCCGCGACCCGCGCGGAAGCAGGCCGGGCGCAGGCTCCGGGCCCGGGCGGGCCGGGGCGTGC
GTGCTACCATTGTTCGATCTTCAATCCCGTCCTTCGATGTTCCAGCAATGAATTCCGAGACCCCCGCGGCCGGGCCGCAG
CAGGCACAGCCGCCCGCGACGTTGACGATTGCTTCGCGCGAGAGCCGCCTGGCGATGTGGCAAGCCGAACATGTGCGTGA
TGCGCTGCGCAAATTATATCCAGCTTGTGACGTGAAAATCCTCGGGATGACGACGCGCGGCGATCAGATTCTCGATCGCA
CGCTGTCGAAGGTCGGCGGCAAGGGCCTGTTCGTGAAGGAACTGGAAGCCGCGCTGGCCGACGGCCGCGCCGATCTCGCC
GTGCATTCGCTGAAGGACGTGCCGATGGCGCTGCCCGACGGCTTCTCGCTCGCCGCGATCATGGAACGCGAAGACCCGCG
CGATGCCTTCGTGTCGAACGACTACGCGTCGCTCGACGCGCTGCCGGCCGGCGCGGTCGTCGGCACATCGAGCCTGCGTC
GCGAGGCGATGCTGCGGTCGCGTTATCCGCATCTCGAGGTCCTGCCGCTGCGCGGCAACCTCGACACGCGGCTCGCGAAG
CTCGACCGCGGCGACTACGCGGCGATCATCCTCGCGGCCGCCGGCCTGAAACGCCTCGGCCTCGAAGCGCGGATTCGTGC
GCTGCTCGACGTCGAGGCCAGCCCGCCCGCGGCGGGCCAGGGCGCGCTCGGCATCGAGATCGCCGCGCACCGCGACGACG
TCGCCGCGTGGCTCGCGCCGCTGCACGACCCGCAGACCGCGCTCGCGGTCGAGGCCGAGCGGATGGTGTCGCGCGCGCTC
GGCGGCAGTTGCGAGGTGCCGCTCGCCGCGCACGCGGTGTGGCGCGCGGGCGAGCTGTACCTGACGGGACGCGTGTCGAC
CACCGACGGCAAGCGCGTGCTGACGGCCGAGGAATGCGGCGCGGTCGTGACCGTCGCCGATGCGCTCGCGCTCGGCCGCG
CGGTGTCCGACGAACTCGAGGCGCAAGGCGCGCTCGACATCGTCCAGGCGCTGCTCGCGAGCTCGCAGGCCGCGGGCAAG
GGCGACGCCTGA

Upstream 100 bases:

>100_bases
ACGGCCGTTCGCGGCGGTGGCGACGGTGTCCGTCGAGGCATCGGGGGAGGGCAAGGCAGCATTGCGGCGCGCCGTACGCG
CCGATCCGGAAGACTTCACG

Downstream 100 bases:

>100_bases
TGGCGGGCGGCGCGCGCGCGTTCACCGCTGTCCTGACGCGTCCGGACGGGCAGTCCGACGCGCTTGCGGCGCAACTGGCC
GATGCCGGCTGCGACGTGCT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MGFLGKARVKRNCGNCGNCGQATSYVRHIRTTAPRPARKQAGRRLRARAGRGVRATIVRSSIPSFDVPAMNSETPAAGPQ
QAQPPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELEAALADGRADLA
VHSLKDVPMALPDGFSLAAIMEREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRSRYPHLEVLPLRGNLDTRLAK
LDRGDYAAIILAAAGLKRLGLEARIRALLDVEASPPAAGQGALGIEIAAHRDDVAAWLAPLHDPQTALAVEAERMVSRAL
GGSCEVPLAAHAVWRAGELYLTGRVSTTDGKRVLTAEECGAVVTVADALALGRAVSDELEAQGALDIVQALLASSQAAGK
GDA

Sequences:

>Translated_403_residues
MGFLGKARVKRNCGNCGNCGQATSYVRHIRTTAPRPARKQAGRRLRARAGRGVRATIVRSSIPSFDVPAMNSETPAAGPQ
QAQPPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELEAALADGRADLA
VHSLKDVPMALPDGFSLAAIMEREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRSRYPHLEVLPLRGNLDTRLAK
LDRGDYAAIILAAAGLKRLGLEARIRALLDVEASPPAAGQGALGIEIAAHRDDVAAWLAPLHDPQTALAVEAERMVSRAL
GGSCEVPLAAHAVWRAGELYLTGRVSTTDGKRVLTAEECGAVVTVADALALGRAVSDELEAQGALDIVQALLASSQAAGK
GDA
>Mature_402_residues
GFLGKARVKRNCGNCGNCGQATSYVRHIRTTAPRPARKQAGRRLRARAGRGVRATIVRSSIPSFDVPAMNSETPAAGPQQ
AQPPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELEAALADGRADLAV
HSLKDVPMALPDGFSLAAIMEREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRSRYPHLEVLPLRGNLDTRLAKL
DRGDYAAIILAAAGLKRLGLEARIRALLDVEASPPAAGQGALGIEIAAHRDDVAAWLAPLHDPQTALAVEAERMVSRALG
GSCEVPLAAHAVWRAGELYLTGRVSTTDGKRVLTAEECGAVVTVADALALGRAVSDELEAQGALDIVQALLASSQAAGKG
DA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=265, Percent_Identity=48.3018867924528, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI66933009, Length=265, Percent_Identity=48.3018867924528, Blast_Score=241, Evalue=8e-64,
Organism=Escherichia coli, GI48994974, Length=302, Percent_Identity=53.6423841059603, Blast_Score=292, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6319996, Length=319, Percent_Identity=39.4984326018809, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI20130425, Length=280, Percent_Identity=45.3571428571429, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 42575; Mature: 42444

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFLGKARVKRNCGNCGNCGQATSYVRHIRTTAPRPARKQAGRRLRARAGRGVRATIVRS
CCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECC
SIPSFDVPAMNSETPAAGPQQAQPPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKI
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEE
LGMTTRGDQILDRTLSKVGGKGLFVKELEAALADGRADLAVHSLKDVPMALPDGFSLAAI
EEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEE
MEREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRSRYPHLEVLPLRGNLDTRLAK
CCCCCCCHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHH
LDRGDYAAIILAAAGLKRLGLEARIRALLDVEASPPAAGQGALGIEIAAHRDDVAAWLAP
HCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHH
LHDPQTALAVEAERMVSRALGGSCEVPLAAHAVWRAGELYLTGRVSTTDGKRVLTAEECG
CCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEEEECCCCCEEEEHHHCC
AVVTVADALALGRAVSDELEAQGALDIVQALLASSQAAGKGDA
CEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
GFLGKARVKRNCGNCGNCGQATSYVRHIRTTAPRPARKQAGRRLRARAGRGVRATIVRS
CCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECC
SIPSFDVPAMNSETPAAGPQQAQPPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKI
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEE
LGMTTRGDQILDRTLSKVGGKGLFVKELEAALADGRADLAVHSLKDVPMALPDGFSLAAI
EEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEE
MEREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRSRYPHLEVLPLRGNLDTRLAK
CCCCCCCHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHH
LDRGDYAAIILAAAGLKRLGLEARIRALLDVEASPPAAGQGALGIEIAAHRDDVAAWLAP
HCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHH
LHDPQTALAVEAERMVSRALGGSCEVPLAAHAVWRAGELYLTGRVSTTDGKRVLTAEECG
CCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEEEECCCCCEEEEHHHCC
AVVTVADALALGRAVSDELEAQGALDIVQALLASSQAAGKGDA
CEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA