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The map label for this gene is yngJ [H]

Identifier: 116690252

GI number: 116690252

Start: 2485363

End: 2486496

Strand: Reverse

Name: yngJ [H]

Synonym: Bcen2424_2231

Alternate gene names: 116690252

Gene position: 2486496-2485363 (Counterclockwise)

Preceding gene: 116690253

Following gene: 116690251

Centisome position: 71.37

GC content: 68.34

Gene sequence:

>1134_bases
ATGGATTTCAGCTTTACCGATGAGCAGCAGCAGTTCGCCGACGCGCTGCGCCGGTATCTCGGCGAGCAATATGGCTTCGA
AGCGCGCCAGGCGATCGTGCGTAGCGATGCCGGTGTGTCGGACGCGCAGTGGCGCGCATTCACCGAACTCGGCTTGACCG
CGTTGCCCGTGCCGGACGCACAGGGCGGCTTCGGCGGCGGCCCGGTCGACATGCTGGTCGTGATGCAGGAGCTGGGCCGC
GCGCTCGTGATCGAGCCGTACTGGGCCACGGCGGTCGGCGTCGAGGCGTTGCGGATCGCCGGCTCCGGCGCAGGCGACGA
TGCCGCGCTGCTGGAGGCGGTCGCGCAAGGGCAAAAGCGCGTGGCGGTCGCATTCCACGAACCGCGGGCGCGCTACGATC
TATACGAACTCGACACGCACGCACGCGAGCAGGGCGGCACGTACCGGCTGACCGGCGCCAAGTCGGTGGTTCAGCACGGC
GCGCAGGCGCACGTGTGGATCGTGCCTGCGCGAATCGACGGTGGCGGCATCGGCCTCTTCGTCGTCGAACGCGATGCAGC
GAACACGAAGGTGGTCGACTACCGGACCATCGACGGCCAGCGTGCCGCGACGATCACGTTCGACGACACGCCGGCCCGAC
TGCTGACGGGCGGTGCGCGCGACGCGGTGGCCCTCGAGCAGATCGCCGATTACGCGACCTTCCTGCTGTGCGCGGAAGCG
GTTGGCGCGCTCGACGAGCTGAATCGCGCGACGGTCGAATATACGAAGACGCGCGAGCAGTTCGGCGTGCCGATCGCGCG
TTTTCAGGCGCTGCAGCACCGGATGGTCGACATGCTGATCCATGCCGAGCAGGCGCGTTCACTGACCTATCTCGCGGCAG
TGCGCTACGCGAACGGCGATGCCGATGCACGGCGCAAGGCCGTGTCGGCCGCGAAGGCCCGGGTCGGGGCGGCCGCGCGC
TTCGTCGGCCAGCAGGCGGTCCAATTGCACGGCGGCATGGGCGTGACCAACGAGGTGGCCGCCGCGCACCTGTTCAAACG
GCTGTCGATCATCGAGACGACGCTTGGCGATACCGATCATCACCTCGCCCGCATCACGGCGCTGCCCGATTTCGCGCAGA
CCGACGTAGCATGA

Upstream 100 bases:

>100_bases
AATTACCGGAAGACGTCGATCTACGGCGGTTCGAACGAGATCCAGAAGAACATCATCGCGCAGATGATTCTGGGGCTGTG
ATCAGGGAACGGAGACAACC

Downstream 100 bases:

>100_bases
CGGTGACGCGCGAGCGCGTCAGACAAGGAGACTTATCAGTGGGCATCAGTTACGAAGATCTGGTGGTCGGCAGTACCACC
GAAGTGGGCCGCTACACGTT

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MDFSFTDEQQQFADALRRYLGEQYGFEARQAIVRSDAGVSDAQWRAFTELGLTALPVPDAQGGFGGGPVDMLVVMQELGR
ALVIEPYWATAVGVEALRIAGSGAGDDAALLEAVAQGQKRVAVAFHEPRARYDLYELDTHAREQGGTYRLTGAKSVVQHG
AQAHVWIVPARIDGGGIGLFVVERDAANTKVVDYRTIDGQRAATITFDDTPARLLTGGARDAVALEQIADYATFLLCAEA
VGALDELNRATVEYTKTREQFGVPIARFQALQHRMVDMLIHAEQARSLTYLAAVRYANGDADARRKAVSAAKARVGAAAR
FVGQQAVQLHGGMGVTNEVAAAHLFKRLSIIETTLGDTDHHLARITALPDFAQTDVA

Sequences:

>Translated_377_residues
MDFSFTDEQQQFADALRRYLGEQYGFEARQAIVRSDAGVSDAQWRAFTELGLTALPVPDAQGGFGGGPVDMLVVMQELGR
ALVIEPYWATAVGVEALRIAGSGAGDDAALLEAVAQGQKRVAVAFHEPRARYDLYELDTHAREQGGTYRLTGAKSVVQHG
AQAHVWIVPARIDGGGIGLFVVERDAANTKVVDYRTIDGQRAATITFDDTPARLLTGGARDAVALEQIADYATFLLCAEA
VGALDELNRATVEYTKTREQFGVPIARFQALQHRMVDMLIHAEQARSLTYLAAVRYANGDADARRKAVSAAKARVGAAAR
FVGQQAVQLHGGMGVTNEVAAAHLFKRLSIIETTLGDTDHHLARITALPDFAQTDVA
>Mature_377_residues
MDFSFTDEQQQFADALRRYLGEQYGFEARQAIVRSDAGVSDAQWRAFTELGLTALPVPDAQGGFGGGPVDMLVVMQELGR
ALVIEPYWATAVGVEALRIAGSGAGDDAALLEAVAQGQKRVAVAFHEPRARYDLYELDTHAREQGGTYRLTGAKSVVQHG
AQAHVWIVPARIDGGGIGLFVVERDAANTKVVDYRTIDGQRAATITFDDTPARLLTGGARDAVALEQIADYATFLLCAEA
VGALDELNRATVEYTKTREQFGVPIARFQALQHRMVDMLIHAEQARSLTYLAAVRYANGDADARRKAVSAAKARVGAAAR
FVGQQAVQLHGGMGVTNEVAAAHLFKRLSIIETTLGDTDHHLARITALPDFAQTDVA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=371, Percent_Identity=25.8760107816712, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=26.099706744868, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4557233, Length=331, Percent_Identity=26.5861027190332, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI21361497, Length=377, Percent_Identity=24.9336870026525, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4501857, Length=365, Percent_Identity=24.6575342465753, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI187960098, Length=390, Percent_Identity=25.8974358974359, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI4557231, Length=390, Percent_Identity=25.8974358974359, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4501859, Length=370, Percent_Identity=23.5135135135135, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1786223, Length=375, Percent_Identity=24.5333333333333, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17538396, Length=371, Percent_Identity=22.911051212938, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17506239, Length=386, Percent_Identity=24.8704663212435, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=383, Percent_Identity=26.3707571801567, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508101, Length=344, Percent_Identity=24.4186046511628, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17534899, Length=341, Percent_Identity=26.9794721407625, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17569725, Length=396, Percent_Identity=25.5050505050505, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17570075, Length=386, Percent_Identity=25.3886010362694, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24646207, Length=331, Percent_Identity=25.9818731117825, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21355753, Length=332, Percent_Identity=25.9036144578313, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356377, Length=340, Percent_Identity=25.8823529411765, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24666513, Length=339, Percent_Identity=26.8436578171091, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24660351, Length=390, Percent_Identity=25.8974358974359, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 40608; Mature: 40608

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSFTDEQQQFADALRRYLGEQYGFEARQAIVRSDAGVSDAQWRAFTELGLTALPVPDA
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHCCCEEECCCCC
QGGFGGGPVDMLVVMQELGRALVIEPYWATAVGVEALRIAGSGAGDDAALLEAVAQGQKR
CCCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHEEECCCCCCHHHHHHHHHCCCCE
VAVAFHEPRARYDLYELDTHAREQGGTYRLTGAKSVVQHGAQAHVWIVPARIDGGGIGLF
EEEEEECCCCCCCHHHHCHHHHHCCCEEEECCHHHHHHCCCCEEEEEEEEEECCCCEEEE
VVERDAANTKVVDYRTIDGQRAATITFDDTPARLLTGGARDAVALEQIADYATFLLCAEA
EEEECCCCCEEEEEEECCCCEEEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
VGALDELNRATVEYTKTREQFGVPIARFQALQHRMVDMLIHAEQARSLTYLAAVRYANGD
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEHHHEEECCCC
ADARRKAVSAAKARVGAAARFVGQQAVQLHGGMGVTNEVAAAHLFKRLSIIETTLGDTDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
HLARITALPDFAQTDVA
HHEEEECCCCHHHCCCC
>Mature Secondary Structure
MDFSFTDEQQQFADALRRYLGEQYGFEARQAIVRSDAGVSDAQWRAFTELGLTALPVPDA
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHCCCEEECCCCC
QGGFGGGPVDMLVVMQELGRALVIEPYWATAVGVEALRIAGSGAGDDAALLEAVAQGQKR
CCCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHEEECCCCCCHHHHHHHHHCCCCE
VAVAFHEPRARYDLYELDTHAREQGGTYRLTGAKSVVQHGAQAHVWIVPARIDGGGIGLF
EEEEEECCCCCCCHHHHCHHHHHCCCEEEECCHHHHHHCCCCEEEEEEEEEECCCCEEEE
VVERDAANTKVVDYRTIDGQRAATITFDDTPARLLTGGARDAVALEQIADYATFLLCAEA
EEEECCCCCEEEEEEECCCCEEEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
VGALDELNRATVEYTKTREQFGVPIARFQALQHRMVDMLIHAEQARSLTYLAAVRYANGD
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEHHHEEECCCC
ADARRKAVSAAKARVGAAARFVGQQAVQLHGGMGVTNEVAAAHLFKRLSIIETTLGDTDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
HLARITALPDFAQTDVA
HHEEEECCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]