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The map label for this gene is acsA [H]

Identifier: 116690212

GI number: 116690212

Start: 2442112

End: 2444094

Strand: Reverse

Name: acsA [H]

Synonym: Bcen2424_2191

Alternate gene names: 116690212

Gene position: 2444094-2442112 (Counterclockwise)

Preceding gene: 116690222

Following gene: 116690211

Centisome position: 70.15

GC content: 66.92

Gene sequence:

>1983_bases
ATGTCTGCGATTGAATCGGTTCTTCACGAAACCCGTCAGTTCGCGCCGCCCGCGGCGCTCGAGAAGACGGCGACCATTTC
CGGCATGCCGGCCTACCGCGCGCTCGTCGCCGAGGCCGAGCAGGATTACGAAGGCTTCTGGGCGCGCCTCGCGCGCGAAG
GCCTCACGTGGCACAAGCCGTTCACCAAGGTGCTCGACGAGCGCAACGCGCCGTTCTACACATGGTTCGACGACGGCGAG
CTGAACGCGTCGTACAACTGCCTCGACCGCCACGTCGAAGCCGGCAACGGCGAGCGCGTCGCGGTGATCTTCGAGGCCGA
CGACGGCACCGTCACCCGCGTCACCTATGCGGACCTGCTCGCACGCGTGTCGCGTTTCGCCAATGCGCTGAAGAAACGCG
GCATCGGCAAGGGCGATCGCGTCGTCATCTACATTCCGATGTCGATCGAAGGCATCGTCGCGATGCAGGCCTGCGCGCGC
ATCGGCGCGACGCACTCGGTCGTGTTCGGCGGCTTCTCCGCGAAATCGCTGAACGAGCGGCTCGTCGACGTCGGCGCGGT
CGCGCTGATCACCGCCGACGAGCAGGCGCGCGGCGGCAAGACGCTGCCGCTCAAGAGCATCGCCGACGAAGCGATCGCGC
TGGGCGGCTGCGAAGCGGTCAAGAGCGTGATCGTCTATCGCCGCACCGGCGGCAAGATCGACTGGCATGCGGAGCGCGAC
CTCTGGATGCATGAGCTGACCGACGGCGAATCCGACCAATGCGAGCCGACCTGGGTCGGCGCCGAGCATCCGCTGTTCAT
CCTGTATACGTCGGGCTCGACCGGCAAGCCGAAGGGCGTGCAGCACAGCACGGGCGGCTACCTGCTGTGGGCCGCGCAGA
CGATGAAGTGGACCTTCGACTGGAAACCCGACGACGTGTTCTGGTGCACGGCCGACATCGGCTGGGTCACGGGCCACACG
TACATCACCTACGGCCCGCTCGCGTGCGGCGGCACTCAGGTCGTGTTCGAAGGCGTGCCGACGTATCCGGACGCCGGCCG
CTTCTGGAAGATGATCGGCGATCACAAGGTCACCGTGTTCTACACCGCACCGACCGCGATCCGTTCGCTGATCAAGGCGG
CCGAAGCGGACGACAAGGTCCATCCGAAGAGCTATGACCTGTCGAGCCTGCGCATCATCGGCACGGTCGGCGAGCCGATC
AATCCGGAAGCGTGGATGTGGTACCACAAGCACGTCGGCCACGAGCGCTGCCCGATCGTCGACACGTGGTGGCAGACCGA
AACCGGCGGCCACATGATCACGCCGCTGCCGGGCGCGACGCCGACCGTACCGGGCTCGTGCACGCTGCCGCTGCCGGGCA
TCACGGCCGCGGTGGTCGACGAGACGGGTCAGGACGTGCCGAACGGGCAAGGCGGCATTCTGGTCGTCAAGCGCCCGTGG
CCGGCGATGATCCGCACGATCTGGGGCGACCCGGAGCGCTTCAAGAAGAGTTACTACCCGGAAGAACTCGGCGGCACGCT
CTATCTGGCCGGCGACGGCACCGTGCGCGACAAGGAGACCGGCTACTTCACGATCATGGGCCGGATCGACGACGTGCTGA
ACGTGTCGGGCCACCGGCTGGGCACGATGGAGATCGAATCGGCGCTGGTGTCGCATGAGCTGGTGGCCGAGGCGGCGGTG
GTCGGCCGTCCGGACGACACGACCGGTGAAGCGGTCGTGGCGTTCGTCGTGCTGAAGCGCTCGCGTCCGGAAGGCGAAGA
AGCGGCGGCGCTCGCGAAGACGCTGCGCGACTGGGTGGGCAAGCAGATCGGGCCGATCGCGAAGCCGAAGGACATCCGTT
TCGGCGACAACCTGCCGAAGACCCGCTCGGGCAAGATCATGCGGCGCCTGCTGCGCTCGCTCGCGAAGGGCGAGGCGATC
ACGCAGGATACGTCCACGCTCGAGAATCCGGCCATCCTCGAGCAGCTCACCGAAGTGCGCTGA

Upstream 100 bases:

>100_bases
GTGGTGGGAGACAGCGGCGCGCAGGCGCCGGCCAGGACGACGCGCGGCGCGCACGATCGCGCCGCCATGCAGAGGATTCA
TGTTCACCAAGGGGTAGTCG

Downstream 100 bases:

>100_bases
GCGCCTGCCGGTTGCGCATCTCGCGCACGAGCCCCTGCGCGGCAATCCCGATTGCCCGCGCGGGGGCTTTTTGCTACATA
ACGGCATGACCGTTCCGACC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MSAIESVLHETRQFAPPAALEKTATISGMPAYRALVAEAEQDYEGFWARLAREGLTWHKPFTKVLDERNAPFYTWFDDGE
LNASYNCLDRHVEAGNGERVAVIFEADDGTVTRVTYADLLARVSRFANALKKRGIGKGDRVVIYIPMSIEGIVAMQACAR
IGATHSVVFGGFSAKSLNERLVDVGAVALITADEQARGGKTLPLKSIADEAIALGGCEAVKSVIVYRRTGGKIDWHAERD
LWMHELTDGESDQCEPTWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFDWKPDDVFWCTADIGWVTGHT
YITYGPLACGGTQVVFEGVPTYPDAGRFWKMIGDHKVTVFYTAPTAIRSLIKAAEADDKVHPKSYDLSSLRIIGTVGEPI
NPEAWMWYHKHVGHERCPIVDTWWQTETGGHMITPLPGATPTVPGSCTLPLPGITAAVVDETGQDVPNGQGGILVVKRPW
PAMIRTIWGDPERFKKSYYPEELGGTLYLAGDGTVRDKETGYFTIMGRIDDVLNVSGHRLGTMEIESALVSHELVAEAAV
VGRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVGKQIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAI
TQDTSTLENPAILEQLTEVR

Sequences:

>Translated_660_residues
MSAIESVLHETRQFAPPAALEKTATISGMPAYRALVAEAEQDYEGFWARLAREGLTWHKPFTKVLDERNAPFYTWFDDGE
LNASYNCLDRHVEAGNGERVAVIFEADDGTVTRVTYADLLARVSRFANALKKRGIGKGDRVVIYIPMSIEGIVAMQACAR
IGATHSVVFGGFSAKSLNERLVDVGAVALITADEQARGGKTLPLKSIADEAIALGGCEAVKSVIVYRRTGGKIDWHAERD
LWMHELTDGESDQCEPTWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFDWKPDDVFWCTADIGWVTGHT
YITYGPLACGGTQVVFEGVPTYPDAGRFWKMIGDHKVTVFYTAPTAIRSLIKAAEADDKVHPKSYDLSSLRIIGTVGEPI
NPEAWMWYHKHVGHERCPIVDTWWQTETGGHMITPLPGATPTVPGSCTLPLPGITAAVVDETGQDVPNGQGGILVVKRPW
PAMIRTIWGDPERFKKSYYPEELGGTLYLAGDGTVRDKETGYFTIMGRIDDVLNVSGHRLGTMEIESALVSHELVAEAAV
VGRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVGKQIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAI
TQDTSTLENPAILEQLTEVR
>Mature_659_residues
SAIESVLHETRQFAPPAALEKTATISGMPAYRALVAEAEQDYEGFWARLAREGLTWHKPFTKVLDERNAPFYTWFDDGEL
NASYNCLDRHVEAGNGERVAVIFEADDGTVTRVTYADLLARVSRFANALKKRGIGKGDRVVIYIPMSIEGIVAMQACARI
GATHSVVFGGFSAKSLNERLVDVGAVALITADEQARGGKTLPLKSIADEAIALGGCEAVKSVIVYRRTGGKIDWHAERDL
WMHELTDGESDQCEPTWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFDWKPDDVFWCTADIGWVTGHTY
ITYGPLACGGTQVVFEGVPTYPDAGRFWKMIGDHKVTVFYTAPTAIRSLIKAAEADDKVHPKSYDLSSLRIIGTVGEPIN
PEAWMWYHKHVGHERCPIVDTWWQTETGGHMITPLPGATPTVPGSCTLPLPGITAAVVDETGQDVPNGQGGILVVKRPWP
AMIRTIWGDPERFKKSYYPEELGGTLYLAGDGTVRDKETGYFTIMGRIDDVLNVSGHRLGTMEIESALVSHELVAEAAVV
GRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVGKQIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAIT
QDTSTLENPAILEQLTEVR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=683, Percent_Identity=47.4377745241581, Blast_Score=605, Evalue=1e-173,
Organism=Homo sapiens, GI253970489, Length=696, Percent_Identity=46.551724137931, Blast_Score=600, Evalue=1e-171,
Organism=Homo sapiens, GI28416953, Length=638, Percent_Identity=46.2382445141066, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI13375727, Length=636, Percent_Identity=37.7358490566038, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI42544132, Length=532, Percent_Identity=29.1353383458647, Blast_Score=181, Evalue=3e-45,
Organism=Homo sapiens, GI122937307, Length=533, Percent_Identity=29.6435272045028, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI31982927, Length=650, Percent_Identity=25.2307692307692, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI38505220, Length=533, Percent_Identity=29.8311444652908, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI115511026, Length=594, Percent_Identity=26.9360269360269, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI58082049, Length=527, Percent_Identity=28.4629981024668, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI157311624, Length=527, Percent_Identity=27.5142314990512, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI157311622, Length=527, Percent_Identity=27.5142314990512, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI187761345, Length=396, Percent_Identity=26.7676767676768, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI187761343, Length=396, Percent_Identity=26.7676767676768, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI42544134, Length=365, Percent_Identity=25.4794520547945, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI195947378, Length=413, Percent_Identity=24.6973365617433, Blast_Score=86, Evalue=2e-16,
Organism=Escherichia coli, GI1790505, Length=632, Percent_Identity=51.2658227848101, Blast_Score=638, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=635, Percent_Identity=38.8976377952756, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1788107, Length=569, Percent_Identity=25.8347978910369, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI145693145, Length=367, Percent_Identity=25.0681198910082, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1786810, Length=558, Percent_Identity=22.0430107526882, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71982997, Length=671, Percent_Identity=44.4113263785395, Blast_Score=507, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI71983001, Length=671, Percent_Identity=44.5603576751118, Blast_Score=506, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17569507, Length=674, Percent_Identity=24.0356083086053, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17558820, Length=542, Percent_Identity=24.169741697417, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71985884, Length=414, Percent_Identity=25.6038647342995, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=578, Percent_Identity=24.9134948096886, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71994703, Length=578, Percent_Identity=24.5674740484429, Blast_Score=89, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71994690, Length=578, Percent_Identity=24.5674740484429, Blast_Score=89, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17557194, Length=564, Percent_Identity=23.936170212766, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323182, Length=643, Percent_Identity=47.7449455676516, Blast_Score=571, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319264, Length=665, Percent_Identity=46.3157894736842, Blast_Score=543, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6319699, Length=554, Percent_Identity=23.4657039711191, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24667955, Length=673, Percent_Identity=46.0624071322437, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI62472339, Length=560, Percent_Identity=50, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24667959, Length=529, Percent_Identity=49.1493383742911, Blast_Score=503, Evalue=1e-142,
Organism=Drosophila melanogaster, GI21355225, Length=645, Percent_Identity=34.8837209302326, Blast_Score=355, Evalue=6e-98,
Organism=Drosophila melanogaster, GI21355181, Length=521, Percent_Identity=24.5681381957774, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24581924, Length=551, Percent_Identity=24.3194192377495, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72336; Mature: 72205

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIESVLHETRQFAPPAALEKTATISGMPAYRALVAEAEQDYEGFWARLAREGLTWHKP
CHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
FTKVLDERNAPFYTWFDDGELNASYNCLDRHVEAGNGERVAVIFEADDGTVTRVTYADLL
HHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEHHHHH
ARVSRFANALKKRGIGKGDRVVIYIPMSIEGIVAMQACARIGATHSVVFGGFSAKSLNER
HHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
LVDVGAVALITADEQARGGKTLPLKSIADEAIALGGCEAVKSVIVYRRTGGKIDWHAERD
HHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHEEEECCCCEEEEECCCC
LWMHELTDGESDQCEPTWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFD
CHHHHCCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEEEEEC
WKPDDVFWCTADIGWVTGHTYITYGPLACGGTQVVFEGVPTYPDAGRFWKMIGDHKVTVF
CCCCCEEEEECCCCEEECCEEEEECCCCCCCCEEEEECCCCCCCCCHHHHHHCCCEEEEE
YTAPTAIRSLIKAAEADDKVHPKSYDLSSLRIIGTVGEPINPEAWMWYHKHVGHERCPIV
EECHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEHHHHHCCCCCCCEE
DTWWQTETGGHMITPLPGATPTVPGSCTLPLPGITAAVVDETGQDVPNGQGGILVVKRPW
ECCCCCCCCCEEEECCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCCCEEEEECCC
PAMIRTIWGDPERFKKSYYPEELGGTLYLAGDGTVRDKETGYFTIMGRIDDVLNVSGHRL
HHHHHHHCCCHHHHHHCCCHHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVSHELVAEAAVVGRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVG
EHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEHHHHCCCCCCHHHHHHHHHHHHHHH
KQIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAITQDTSTLENPAILEQLTEVR
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
SAIESVLHETRQFAPPAALEKTATISGMPAYRALVAEAEQDYEGFWARLAREGLTWHKP
HHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
FTKVLDERNAPFYTWFDDGELNASYNCLDRHVEAGNGERVAVIFEADDGTVTRVTYADLL
HHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEHHHHH
ARVSRFANALKKRGIGKGDRVVIYIPMSIEGIVAMQACARIGATHSVVFGGFSAKSLNER
HHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
LVDVGAVALITADEQARGGKTLPLKSIADEAIALGGCEAVKSVIVYRRTGGKIDWHAERD
HHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHEEEECCCCEEEEECCCC
LWMHELTDGESDQCEPTWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFD
CHHHHCCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEEEEEC
WKPDDVFWCTADIGWVTGHTYITYGPLACGGTQVVFEGVPTYPDAGRFWKMIGDHKVTVF
CCCCCEEEEECCCCEEECCEEEEECCCCCCCCEEEEECCCCCCCCCHHHHHHCCCEEEEE
YTAPTAIRSLIKAAEADDKVHPKSYDLSSLRIIGTVGEPINPEAWMWYHKHVGHERCPIV
EECHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEHHHHHCCCCCCCEE
DTWWQTETGGHMITPLPGATPTVPGSCTLPLPGITAAVVDETGQDVPNGQGGILVVKRPW
ECCCCCCCCCEEEECCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCCCEEEEECCC
PAMIRTIWGDPERFKKSYYPEELGGTLYLAGDGTVRDKETGYFTIMGRIDDVLNVSGHRL
HHHHHHHCCCHHHHHHCCCHHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVSHELVAEAAVVGRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVG
EHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEHHHHCCCCCCHHHHHHHHHHHHHHH
KQIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAITQDTSTLENPAILEQLTEVR
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA