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The map label for this gene is dapA [H]

Identifier: 116690116

GI number: 116690116

Start: 2326852

End: 2327754

Strand: Reverse

Name: dapA [H]

Synonym: Bcen2424_2095

Alternate gene names: 116690116

Gene position: 2327754-2326852 (Counterclockwise)

Preceding gene: 116690117

Following gene: 116690115

Centisome position: 66.81

GC content: 67.44

Gene sequence:

>903_bases
ATGGCTAACGGCACCCAAGACGGCATTCAAATCCGCGGCAGCATCCCCGCGATCGTCACCCCGATGCTCGAAGACGGCAG
TCTCGACCTGCCGGCGTTTCGCAAACTGGTCGACTGGCACATCGCGGAAGGCACCGATGCGCTCGTCGTCGTCGGTACGA
GCGGCGAGTCGGCAACGCTCAGCGTCGAAGAGCACATCCTGATGATCCGCACGGCGGTCGAGCATGCGGCGAAACGCATC
CCGATCATCGCGGGCGCGGGCGGCAATTCGACCGCCGAGGCGATCGAGCTGACGAAGCACGCGAAAGCCGTCGGCGCGGA
CGCGACGCTGCAGGTCGTGCCGTACTACAACAAGCCGACGCAGGAAGGCATGTACCGCCACTTCCGGACGATCGCCGAAG
CGGTCGACCTGCCGGTGATCCTGTACAACGTGCCGGGCCGGACGGTCGCGGACATGACGCACGAGACGACGCTGCGCCTC
GCGGAAGTCCCGGGCATCATCGGCGTGAAGGAAGCGACCGGCAACATCGATCGCGCCGCGCACCTGATCAAGGCCGCACC
GAAGCATTTCGCGATCTACAGCGGCGACGATCCGACCGCGATCGCGCTGATGCTGCTCGGCGGCCACGGCAACATCTCGG
TGACCGCGAACGTCGCGCCGCGCGCGATGAGCGAGCTGTGCCGCGCGGCGCTGGCCGGCGACGTGCAGACGGCCCGCGCG
CTGCACATGAAGCTGCTGTCGCTGCACAAGAACCTGTTCATCGAAGCGAACCCGATCCCGGTGAAGTGGGCGCTGCAGGC
GATGGGCAAGATGCAGGGCGGCATCCGGCTGCCGCTCACGGCGCTCGACGAGCGCTGCCACGATGCCGTGCGTTCGGCCC
TCGTCGAGGCCGGCGTCCTCTGA

Upstream 100 bases:

>100_bases
GGCGCGACCCCGAAGGCGGGGGCGGGAATTCCACGTTACGAACTGCCCGGCTAATCCGCTACAATCTCAACGTTTACCGG
TACACAATCAATCGCGTTTC

Downstream 100 bases:

>100_bases
TGCCGAGGCGGCCGCGTCCTGCGGCCGCCGGCTCGACCCCTGATCAACCCGCACCGGCCGGCTCCGTCCGGCGCCGCTCC
TGACGAGCGTTCTAGCAAGA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MANGTQDGIQIRGSIPAIVTPMLEDGSLDLPAFRKLVDWHIAEGTDALVVVGTSGESATLSVEEHILMIRTAVEHAAKRI
PIIAGAGGNSTAEAIELTKHAKAVGADATLQVVPYYNKPTQEGMYRHFRTIAEAVDLPVILYNVPGRTVADMTHETTLRL
AEVPGIIGVKEATGNIDRAAHLIKAAPKHFAIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSELCRAALAGDVQTARA
LHMKLLSLHKNLFIEANPIPVKWALQAMGKMQGGIRLPLTALDERCHDAVRSALVEAGVL

Sequences:

>Translated_300_residues
MANGTQDGIQIRGSIPAIVTPMLEDGSLDLPAFRKLVDWHIAEGTDALVVVGTSGESATLSVEEHILMIRTAVEHAAKRI
PIIAGAGGNSTAEAIELTKHAKAVGADATLQVVPYYNKPTQEGMYRHFRTIAEAVDLPVILYNVPGRTVADMTHETTLRL
AEVPGIIGVKEATGNIDRAAHLIKAAPKHFAIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSELCRAALAGDVQTARA
LHMKLLSLHKNLFIEANPIPVKWALQAMGKMQGGIRLPLTALDERCHDAVRSALVEAGVL
>Mature_299_residues
ANGTQDGIQIRGSIPAIVTPMLEDGSLDLPAFRKLVDWHIAEGTDALVVVGTSGESATLSVEEHILMIRTAVEHAAKRIP
IIAGAGGNSTAEAIELTKHAKAVGADATLQVVPYYNKPTQEGMYRHFRTIAEAVDLPVILYNVPGRTVADMTHETTLRLA
EVPGIIGVKEATGNIDRAAHLIKAAPKHFAIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSELCRAALAGDVQTARAL
HMKLLSLHKNLFIEANPIPVKWALQAMGKMQGGIRLPLTALDERCHDAVRSALVEAGVL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=305, Percent_Identity=25.9016393442623, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI13540533, Length=236, Percent_Identity=26.271186440678, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788823, Length=289, Percent_Identity=50.1730103806228, Blast_Score=288, Evalue=3e-79,
Organism=Escherichia coli, GI87082415, Length=300, Percent_Identity=34, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1786463, Length=243, Percent_Identity=37.8600823045267, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1789620, Length=233, Percent_Identity=30.9012875536481, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31838; Mature: 31707

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANGTQDGIQIRGSIPAIVTPMLEDGSLDLPAFRKLVDWHIAEGTDALVVVGTSGESATL
CCCCCCCCEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEE
SVEEHILMIRTAVEHAAKRIPIIAGAGGNSTAEAIELTKHAKAVGADATLQVVPYYNKPT
EHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
QEGMYRHFRTIAEAVDLPVILYNVPGRTVADMTHETTLRLAEVPGIIGVKEATGNIDRAA
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHCCHHHHEEHHHCCCCEEEECCCCCHHHHH
HLIKAAPKHFAIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSELCRAALAGDVQTARA
HHHHCCCCCEEEECCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHH
LHMKLLSLHKNLFIEANPIPVKWALQAMGKMQGGIRLPLTALDERCHDAVRSALVEAGVL
HHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ANGTQDGIQIRGSIPAIVTPMLEDGSLDLPAFRKLVDWHIAEGTDALVVVGTSGESATL
CCCCCCCEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEE
SVEEHILMIRTAVEHAAKRIPIIAGAGGNSTAEAIELTKHAKAVGADATLQVVPYYNKPT
EHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
QEGMYRHFRTIAEAVDLPVILYNVPGRTVADMTHETTLRLAEVPGIIGVKEATGNIDRAA
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHCCHHHHEEHHHCCCCEEEECCCCCHHHHH
HLIKAAPKHFAIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSELCRAALAGDVQTARA
HHHHCCCCCEEEECCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHH
LHMKLLSLHKNLFIEANPIPVKWALQAMGKMQGGIRLPLTALDERCHDAVRSALVEAGVL
HHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]