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The map label for this gene is lysC [H]

Identifier: 116690095

GI number: 116690095

Start: 2303272

End: 2304525

Strand: Reverse

Name: lysC [H]

Synonym: Bcen2424_2074

Alternate gene names: 116690095

Gene position: 2304525-2303272 (Counterclockwise)

Preceding gene: 116690096

Following gene: 116690094

Centisome position: 66.15

GC content: 61.96

Gene sequence:

>1254_bases
ATGGCACTCATCGTACACAAATACGGCGGCACTTCGATGGGCTCGGTCGAGCGCATCAAGAACGTCGCGAAACGCGTCGC
AAAATGGCATCAGGCCGGGCACCAGATGGTGGTCGTGCCTTCGGCGATGTCCGGCGAAACCAACCGTCTGCTCGGTCTTG
CGAAAGAGATTTCGAGCCAGCCGAGCCCGCGTGAGCTCGACATGATCGCGTCGACCGGCGAGCAGGTCAGCGTCGGCCTG
CTGTCGATCGCGCTGCAGGAAATCGGCGTCGAGGCCGTGAGCTATGCCGGCTGGCAAGTGCCGATCAAGACGGACAGCGC
GTTTACGAAAGCACGTATTCACTCGATCGACGACGAGCGTGTGAAGGACGATCTGAACGCAGGCAAGGTCGTGATCATCA
CGGGCTTCCAGGGCGTCGATCCGGACGGCCACATCACGACGCTGGGCCGGGGCGGCTCGGACACGTCGGCGGTGGCGGTG
GCGGCTGCGCTGGGTGCCGAAGAGTGCCTGATCTATACCGACGTCGATGGCGTCTACACGACCGATCCGCGAGTCGTCGA
AGAGGCGCGCCGCCTCGACCGCGTGACGTTCGAGGAGATGCTGGAAATGGCCAGCCTCGGCTCGAAGGTCCTGCAGATCC
GCTCGGTCGAATTCGCCGGCAAATACCAGGTGAAGACGCGTGTGCTGTCGAGCCTGACCGATCCGCTGATTGCGCTCGAC
GAAGAAATGCGCTCGGGCACCCTGATTACTTTTGAAGAAGACGAGACCATGGAAAAGGCAGTCATTTCCGGCATCGCGTT
CCAGCGCGACGAAGCACGCATTGCTGTGATGGGCGTGCCCGACAAGCCGGGCATCGCATATCAGATCCTCGGCCCGGTGG
CCGATGCGAACGTCGACGTCGACATGATCATCCAGAACCAGAGCGTCGAAGGCAAGACCGACTTCACGTTCACGGTCGGC
CGCGGCGACTACCAGAAGGCGATGGACATCCTCACCAACCAGGTGCAGGGCCATGTGAGCGCCGAGCGCGTGCAGGGCGA
CCCGAAGGTGTCGAAGGTGTCGGTCGTCGGCGTCGGCATGCGTTCGCACGTGGGCGTCGCGAGCAAGATGTTCCGCACGC
TGTCGGAAGAGGGCATCAACATCCAGATGATCTCGACGTCCGAAATCAAGATTTCGGTGCTGATCGACGAGAAATACATG
GAGCTGGCCGTCCGCGCGCTGCACAAGGTATTCGAACTCGACCAGGCGTCGTGA

Upstream 100 bases:

>100_bases
TCCCCCTCGTCGTCCGTCCACAGCCACAAGCCGCGTGACCGAACGGCTACGCGGCCTGCCCAGCGCGCCCGTGCGGTTTC
TCCTCCAGTTCAGAACGACA

Downstream 100 bases:

>100_bases
ATTTTCCGTGATGCATTGAAGAAAATGCATCACGGAAATTGACGTACGGTTCGAAACCCTATATTATCTCGTTCTCGTCG
CACTGCCTCCCTGGTGCGAG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MALIVHKYGGTSMGSVERIKNVAKRVAKWHQAGHQMVVVPSAMSGETNRLLGLAKEISSQPSPRELDMIASTGEQVSVGL
LSIALQEIGVEAVSYAGWQVPIKTDSAFTKARIHSIDDERVKDDLNAGKVVIITGFQGVDPDGHITTLGRGGSDTSAVAV
AAALGAEECLIYTDVDGVYTTDPRVVEEARRLDRVTFEEMLEMASLGSKVLQIRSVEFAGKYQVKTRVLSSLTDPLIALD
EEMRSGTLITFEEDETMEKAVISGIAFQRDEARIAVMGVPDKPGIAYQILGPVADANVDVDMIIQNQSVEGKTDFTFTVG
RGDYQKAMDILTNQVQGHVSAERVQGDPKVSKVSVVGVGMRSHVGVASKMFRTLSEEGINIQMISTSEIKISVLIDEKYM
ELAVRALHKVFELDQAS

Sequences:

>Translated_417_residues
MALIVHKYGGTSMGSVERIKNVAKRVAKWHQAGHQMVVVPSAMSGETNRLLGLAKEISSQPSPRELDMIASTGEQVSVGL
LSIALQEIGVEAVSYAGWQVPIKTDSAFTKARIHSIDDERVKDDLNAGKVVIITGFQGVDPDGHITTLGRGGSDTSAVAV
AAALGAEECLIYTDVDGVYTTDPRVVEEARRLDRVTFEEMLEMASLGSKVLQIRSVEFAGKYQVKTRVLSSLTDPLIALD
EEMRSGTLITFEEDETMEKAVISGIAFQRDEARIAVMGVPDKPGIAYQILGPVADANVDVDMIIQNQSVEGKTDFTFTVG
RGDYQKAMDILTNQVQGHVSAERVQGDPKVSKVSVVGVGMRSHVGVASKMFRTLSEEGINIQMISTSEIKISVLIDEKYM
ELAVRALHKVFELDQAS
>Mature_416_residues
ALIVHKYGGTSMGSVERIKNVAKRVAKWHQAGHQMVVVPSAMSGETNRLLGLAKEISSQPSPRELDMIASTGEQVSVGLL
SIALQEIGVEAVSYAGWQVPIKTDSAFTKARIHSIDDERVKDDLNAGKVVIITGFQGVDPDGHITTLGRGGSDTSAVAVA
AALGAEECLIYTDVDGVYTTDPRVVEEARRLDRVTFEEMLEMASLGSKVLQIRSVEFAGKYQVKTRVLSSLTDPLIALDE
EMRSGTLITFEEDETMEKAVISGIAFQRDEARIAVMGVPDKPGIAYQILGPVADANVDVDMIIQNQSVEGKTDFTFTVGR
GDYQKAMDILTNQVQGHVSAERVQGDPKVSKVSVVGVGMRSHVGVASKMFRTLSEEGINIQMISTSEIKISVLIDEKYME
LAVRALHKVFELDQAS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=359, Percent_Identity=29.5264623955432, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1790455, Length=388, Percent_Identity=30.1546391752577, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790376, Length=108, Percent_Identity=34.2592592592593, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=399, Percent_Identity=27.3182957393484, Blast_Score=116, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 45156; Mature: 45025

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVHKYGGTSMGSVERIKNVAKRVAKWHQAGHQMVVVPSAMSGETNRLLGLAKEISSQ
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCC
PSPRELDMIASTGEQVSVGLLSIALQEIGVEAVSYAGWQVPIKTDSAFTKARIHSIDDER
CCCCHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHCCCEEEEECCCCCHHHHHHHCCCHHH
VKDDLNAGKVVIITGFQGVDPDGHITTLGRGGSDTSAVAVAAALGAEECLIYTDVDGVYT
HHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCEEE
TDPRVVEEARRLDRVTFEEMLEMASLGSKVLQIRSVEFAGKYQVKTRVLSSLTDPLIALD
CCHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
EEMRSGTLITFEEDETMEKAVISGIAFQRDEARIAVMGVPDKPGIAYQILGPVADANVDV
HHHCCCEEEEECCCHHHHHHHHHHHHEECCCCEEEEEECCCCCCEEEEEECCCCCCCCCE
DMIIQNQSVEGKTDFTFTVGRGDYQKAMDILTNQVQGHVSAERVQGDPKVSKVSVVGVGM
EEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEEEECH
RSHVGVASKMFRTLSEEGINIQMISTSEIKISVLIDEKYMELAVRALHKVFELDQAS
HHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALIVHKYGGTSMGSVERIKNVAKRVAKWHQAGHQMVVVPSAMSGETNRLLGLAKEISSQ
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCC
PSPRELDMIASTGEQVSVGLLSIALQEIGVEAVSYAGWQVPIKTDSAFTKARIHSIDDER
CCCCHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHCCCEEEEECCCCCHHHHHHHCCCHHH
VKDDLNAGKVVIITGFQGVDPDGHITTLGRGGSDTSAVAVAAALGAEECLIYTDVDGVYT
HHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCEEE
TDPRVVEEARRLDRVTFEEMLEMASLGSKVLQIRSVEFAGKYQVKTRVLSSLTDPLIALD
CCHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
EEMRSGTLITFEEDETMEKAVISGIAFQRDEARIAVMGVPDKPGIAYQILGPVADANVDV
HHHCCCEEEEECCCHHHHHHHHHHHHEECCCCEEEEEECCCCCCEEEEEECCCCCCCCCE
DMIIQNQSVEGKTDFTFTVGRGDYQKAMDILTNQVQGHVSAERVQGDPKVSKVSVVGVGM
EEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEEEECH
RSHVGVASKMFRTLSEEGINIQMISTSEIKISVLIDEKYMELAVRALHKVFELDQAS
HHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]