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The map label for this gene is cusR [H]

Identifier: 116690085

GI number: 116690085

Start: 2291958

End: 2292623

Strand: Reverse

Name: cusR [H]

Synonym: Bcen2424_2064

Alternate gene names: 116690085

Gene position: 2292623-2291958 (Counterclockwise)

Preceding gene: 116690086

Following gene: 116690084

Centisome position: 65.81

GC content: 69.07

Gene sequence:

>666_bases
ATGCGCATCCTGCTGATCGCGCCGCCGAATCCGCACGCGTCGCGGCTCGACAAGGCGTTTCGAGAGAGCACGCACGGCGT
CGAGCGCGTCGACGCATGGCGCGACGGCTGTTTCGCGGCGACGCAGGACCGGTTCGACGCGATCGTGATCGTCGCGACCG
ATGGCGGGGCCGCGGCGGCGATTCTCGATGAATTGCCGCGGCTCGCCGCGTCGGCCGGCGGTGCGACGATCGCCGCGATC
GTTGCCGGCACCACGTCCGCCCAGCGCGCGCGGATGCTGAACGCCGGCTGCGACGTATGTCTGGCTCATCCGTGTTCGTT
CGTCGAATTGCACGAACGGTTGCGCGCGCTGTGGCGCCGCGCGGGCATCATCGCGATGCGTGAATCGATCCGGCTCGACA
CGGCGACGCGTGCGCTCGAGGAGCAGGGCCGGCGGCTCGCGCTCAGTGCACGGGAGTTTCGCGTGGTCGAATGCCTACTG
CGCGAAGCGGGGCGGCCGGTCGGTCGGGACGCCGTGCTGCGTTATGCGTGGGACGATGCCGACATCGAACCTGAAACGGT
CAATGCGCTGGTCGTCCGGTTGCGGCGCAAGCTGGTCGCGCATGCGTTTTCCGCGCGGATCGAAACGGTTGCGCGATTCG
GCTTCCGGTTCGACACGGGCGGGTGA

Upstream 100 bases:

>100_bases
GGTTTCGCGCTGCGGATCGGCGACGCGCAGCCGGCCGGTACGGCGATCACGGTCGAATGCTGGCCGCGTTCGCTCGCATG
ACGACGCGGGAGACCGAGCG

Downstream 100 bases:

>100_bases
CGGGGCGGATATCGACGCCCGGCTGAAAGAAGCTCTTGACGGGCGGCGTGCGCAGCGCCACGCCACGCCACGCCGCGCAG
CCCGGCCCGGCCCGGCCGGC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MRILLIAPPNPHASRLDKAFRESTHGVERVDAWRDGCFAATQDRFDAIVIVATDGGAAAAILDELPRLAASAGGATIAAI
VAGTTSAQRARMLNAGCDVCLAHPCSFVELHERLRALWRRAGIIAMRESIRLDTATRALEEQGRRLALSAREFRVVECLL
REAGRPVGRDAVLRYAWDDADIEPETVNALVVRLRRKLVAHAFSARIETVARFGFRFDTGG

Sequences:

>Translated_221_residues
MRILLIAPPNPHASRLDKAFRESTHGVERVDAWRDGCFAATQDRFDAIVIVATDGGAAAAILDELPRLAASAGGATIAAI
VAGTTSAQRARMLNAGCDVCLAHPCSFVELHERLRALWRRAGIIAMRESIRLDTATRALEEQGRRLALSAREFRVVECLL
REAGRPVGRDAVLRYAWDDADIEPETVNALVVRLRRKLVAHAFSARIETVARFGFRFDTGG
>Mature_221_residues
MRILLIAPPNPHASRLDKAFRESTHGVERVDAWRDGCFAATQDRFDAIVIVATDGGAAAAILDELPRLAASAGGATIAAI
VAGTTSAQRARMLNAGCDVCLAHPCSFVELHERLRALWRRAGIIAMRESIRLDTATRALEEQGRRLALSAREFRVVECLL
REAGRPVGRDAVLRYAWDDADIEPETVNALVVRLRRKLVAHAFSARIETVARFGFRFDTGG

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=25.2212389380531, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787375, Length=147, Percent_Identity=27.891156462585, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=24.7747747747748, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24184; Mature: 24184

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLIAPPNPHASRLDKAFRESTHGVERVDAWRDGCFAATQDRFDAIVIVATDGGAAAA
CEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHH
ILDELPRLAASAGGATIAAIVAGTTSAQRARMLNAGCDVCLAHPCSFVELHERLRALWRR
HHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCEEHHCCCHHHHHHHHHHHHHHH
AGIIAMRESIRLDTATRALEEQGRRLALSAREFRVVECLLREAGRPVGRDAVLRYAWDDA
HCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHEEEECCCC
DIEPETVNALVVRLRRKLVAHAFSARIETVARFGFRFDTGG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCC
>Mature Secondary Structure
MRILLIAPPNPHASRLDKAFRESTHGVERVDAWRDGCFAATQDRFDAIVIVATDGGAAAA
CEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHH
ILDELPRLAASAGGATIAAIVAGTTSAQRARMLNAGCDVCLAHPCSFVELHERLRALWRR
HHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCEEHHCCCHHHHHHHHHHHHHHH
AGIIAMRESIRLDTATRALEEQGRRLALSAREFRVVECLLREAGRPVGRDAVLRYAWDDA
HCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHEEEECCCC
DIEPETVNALVVRLRRKLVAHAFSARIETVARFGFRFDTGG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]