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The map label for this gene is uppS [H]

Identifier: 116690036

GI number: 116690036

Start: 2232226

End: 2233008

Strand: Reverse

Name: uppS [H]

Synonym: Bcen2424_2015

Alternate gene names: 116690036

Gene position: 2233008-2232226 (Counterclockwise)

Preceding gene: 116690037

Following gene: 116690035

Centisome position: 64.1

GC content: 66.41

Gene sequence:

>783_bases
ATGACCTATACCAGCTCTACCGTTCGCGTGCCTGACGTCGGTGTCGTGCCGCGTCACATCGCGATCATCATGGACGGCAA
TGGCCGTTGGGCGACCGAACGCCGCTTGCCGCGCGTCGCGGGGCACACCCGCGGCGTCGATGCCGTGCGGGCGGTGGTCG
AAGGCTGCGCGCGCGCCGGCGTCGAATACCTGACGCTGTTCGCGTTCAGTTCGGAAAACTGGCGCCGGCCGAACGACGAA
GTGTCGTTCCTGATGCGGCTGTTCATCACCGCGCTCGAGCGCGAAGTGGGCAAGCTGCATGCGAACGGGATCCGCCTGCG
TGTCGTCGGCGATCTCGACCGTTTCGAGCCGCGCATCCGCGAGCTGATTCGCCGCGCCGAAACCAAGACGGCGCGCAATA
CCCGTCTGACGCTCACCATCGCGGCCAACTACGGCGGGCGATGGGACATCCTGCAGGCGACGAAGAAGCTCGTCGAGCAG
GCCGTGCGCGAAGGCCGCGAGGTCGAGGTGACCGAGGACGCATTCGCGCCGCACCTGGCGATGGCCTACGCGCCGGAGCC
CGATCTCTTCATCCGCACCGGCGGCGAGCAACGCGTCAGCAACTTCCTGCTGTGGCAGCTCGCGTACGCCGAATTCTATT
TCACCGACAAGTACTGGCCGGATTTCGACGGCGCGGCACTGGCCGACGCGATGGCGTCGTATACCGAGCGCGAGCGCCGT
TTCGGGCGCACGAGTGCGCAGCTCGAACCGCAATCGCAGAACGCCGACTCCCTTTCATGCTGA

Upstream 100 bases:

>100_bases
GAAATCGACAAGCTCGTGCAGACCAAGGAAGCCGAGATCATGACGGTCTGACGACCGTCCTCGCGCGCCGCCTTCTTCCC
GCATTACTGTCTCAACGGCC

Downstream 100 bases:

>100_bases
AAACCCGTGTGATCACGGCGATCGTGATGCTGGCAGTGCTGCTGCCGGTGACGCTGTTCGCGCCGCTCGCCGGGTTCGGC
GCACTGATCGGCGTCGTGCT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTYTSSTVRVPDVGVVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRAVVEGCARAGVEYLTLFAFSSENWRRPNDE
VSFLMRLFITALEREVGKLHANGIRLRVVGDLDRFEPRIRELIRRAETKTARNTRLTLTIAANYGGRWDILQATKKLVEQ
AVREGREVEVTEDAFAPHLAMAYAPEPDLFIRTGGEQRVSNFLLWQLAYAEFYFTDKYWPDFDGAALADAMASYTERERR
FGRTSAQLEPQSQNADSLSC

Sequences:

>Translated_260_residues
MTYTSSTVRVPDVGVVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRAVVEGCARAGVEYLTLFAFSSENWRRPNDE
VSFLMRLFITALEREVGKLHANGIRLRVVGDLDRFEPRIRELIRRAETKTARNTRLTLTIAANYGGRWDILQATKKLVEQ
AVREGREVEVTEDAFAPHLAMAYAPEPDLFIRTGGEQRVSNFLLWQLAYAEFYFTDKYWPDFDGAALADAMASYTERERR
FGRTSAQLEPQSQNADSLSC
>Mature_259_residues
TYTSSTVRVPDVGVVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRAVVEGCARAGVEYLTLFAFSSENWRRPNDEV
SFLMRLFITALEREVGKLHANGIRLRVVGDLDRFEPRIRELIRRAETKTARNTRLTLTIAANYGGRWDILQATKKLVEQA
VREGREVEVTEDAFAPHLAMAYAPEPDLFIRTGGEQRVSNFLLWQLAYAEFYFTDKYWPDFDGAALADAMASYTERERRF
GRTSAQLEPQSQNADSLSC

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=231, Percent_Identity=32.4675324675325, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI45580738, Length=231, Percent_Identity=32.4675324675325, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1786371, Length=249, Percent_Identity=51.4056224899598, Blast_Score=248, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71993029, Length=228, Percent_Identity=32.8947368421053, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=223, Percent_Identity=34.9775784753363, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=226, Percent_Identity=37.6106194690265, Blast_Score=125, Evalue=8e-30,
Organism=Drosophila melanogaster, GI18857969, Length=212, Percent_Identity=34.9056603773585, Blast_Score=147, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29502; Mature: 29371

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYTSSTVRVPDVGVVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRAVVEGCARAG
CCCCCCEEECCCCCCCCCEEEEEECCCCCCCHHHCCHHHHCCCCCHHHHHHHHHHHHHCC
VEYLTLFAFSSENWRRPNDEVSFLMRLFITALEREVGKLHANGIRLRVVGDLDRFEPRIR
HHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHCCHHHH
ELIRRAETKTARNTRLTLTIAANYGGRWDILQATKKLVEQAVREGREVEVTEDAFAPHLA
HHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEECHHHCCCHHH
MAYAPEPDLFIRTGGEQRVSNFLLWQLAYAEFYFTDKYWPDFDGAALADAMASYTERERR
EEECCCCCEEEECCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHH
FGRTSAQLEPQSQNADSLSC
HCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TYTSSTVRVPDVGVVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRAVVEGCARAG
CCCCCEEECCCCCCCCCEEEEEECCCCCCCHHHCCHHHHCCCCCHHHHHHHHHHHHHCC
VEYLTLFAFSSENWRRPNDEVSFLMRLFITALEREVGKLHANGIRLRVVGDLDRFEPRIR
HHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHCCHHHH
ELIRRAETKTARNTRLTLTIAANYGGRWDILQATKKLVEQAVREGREVEVTEDAFAPHLA
HHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEECHHHCCCHHH
MAYAPEPDLFIRTGGEQRVSNFLLWQLAYAEFYFTDKYWPDFDGAALADAMASYTERERR
EEECCCCCEEEECCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHH
FGRTSAQLEPQSQNADSLSC
HCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]