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The map label for this gene is glxR [H]

Identifier: 116689974

GI number: 116689974

Start: 2172189

End: 2173082

Strand: Reverse

Name: glxR [H]

Synonym: Bcen2424_1953

Alternate gene names: 116689974

Gene position: 2173082-2172189 (Counterclockwise)

Preceding gene: 116689977

Following gene: 116689969

Centisome position: 62.37

GC content: 72.04

Gene sequence:

>894_bases
GTGGAAGTCGGATTTTGCGGACCGGGATTGATGGGCGCGCCGATGATTCGGCATTTGCTGGCGGCCGGGCATCGCGTCAG
CGTATGGAATCGCTCACGCGACAAGGCCGAGGCGCTGGTGAAGGACGGCGCGCAGGTGGTCGGCACGCCGCGCGAGCTGG
CCGAGCGCGTCGAGACGGTGTTCGTGTGCGTGCTCGACGGGCGTGCGGTCGGCGACGTCGTGTTCGGTGAGCACGGGCTG
CTTTCCGGCGACGCGAGCACGCGCCGCCTGCAGCGCATCGTCGATCATTCGAGCATTCCGCCCGCCGCCACGCGCGACTA
CGCGGCGCGCGCGGCCGCACTCGGGGTCGGCTGGGTCGATGCGCCGGTGTCCGGCGGCGTGCCGGGTGCACAGGCCGGCA
CGCTCGCGGTGATGGCCGGCGGCCGCGCGGCCGATCTCGACGCGGTGCGCCCGCTGATCGACACGTATGCGTCGCGCATC
ACGCACATGGGCGACGCGGGCGCGGGCCAGACGGCGAAGCTGTGCAACCAGGCGATCGTCACCGCGACGGTGACCGCGAT
CGCCGAGGCGGTCGGGCTGGCGCAGGCGAGCGGCATCGACGCCGCACGGCTGGCCGAGGCGCTCGCCGGCGGCTGGGCCG
ATTCGGTGCTGCTGCAGACGTTCGTGCCGCGCATGACGTCGGGTGGCCATCCACCGATCGGCGCGCTGAGTACATTTCAG
AAGGATGTCGATGCCATTGCCGACGCCGCGCGCGACACGGGCGCGGTGATGCCCGTGTCGGCCACCGTGCAGCAGGTGCT
GAGGCTGGGCGCCGCGCAGGGGCTCGCCGGCGCCGATTTCGCCGCGTTCATCGACATCGTGCGGCCGAACAACGGCCGTC
AGCAGGTGTCGTGA

Upstream 100 bases:

>100_bases
GTTCCGCTACGGTCCCGCTACAGCGCCGTGCGTGCCCGGCTTCTTGAGTGATAGGTATGATGGGCGGCAAGTGCAACCCA
TATCGGAGACGAGGAACATC

Downstream 100 bases:

>100_bases
CGGGCAAGCGGGGCGTGTGAATGGCAGATGGGCCGCGCGGAGGCGGCCCATCGAATGACTGGCGGATCAGCCGAGCGAGC
GGGGTGTCGTGTCGCCCGCG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MEVGFCGPGLMGAPMIRHLLAAGHRVSVWNRSRDKAEALVKDGAQVVGTPRELAERVETVFVCVLDGRAVGDVVFGEHGL
LSGDASTRRLQRIVDHSSIPPAATRDYAARAAALGVGWVDAPVSGGVPGAQAGTLAVMAGGRAADLDAVRPLIDTYASRI
THMGDAGAGQTAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTSGGHPPIGALSTFQ
KDVDAIADAARDTGAVMPVSATVQQVLRLGAAQGLAGADFAAFIDIVRPNNGRQQVS

Sequences:

>Translated_297_residues
MEVGFCGPGLMGAPMIRHLLAAGHRVSVWNRSRDKAEALVKDGAQVVGTPRELAERVETVFVCVLDGRAVGDVVFGEHGL
LSGDASTRRLQRIVDHSSIPPAATRDYAARAAALGVGWVDAPVSGGVPGAQAGTLAVMAGGRAADLDAVRPLIDTYASRI
THMGDAGAGQTAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTSGGHPPIGALSTFQ
KDVDAIADAARDTGAVMPVSATVQQVLRLGAAQGLAGADFAAFIDIVRPNNGRQQVS
>Mature_297_residues
MEVGFCGPGLMGAPMIRHLLAAGHRVSVWNRSRDKAEALVKDGAQVVGTPRELAERVETVFVCVLDGRAVGDVVFGEHGL
LSGDASTRRLQRIVDHSSIPPAATRDYAARAAALGVGWVDAPVSGGVPGAQAGTLAVMAGGRAADLDAVRPLIDTYASRI
THMGDAGAGQTAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTSGGHPPIGALSTFQ
KDVDAIADAARDTGAVMPVSATVQQVLRLGAAQGLAGADFAAFIDIVRPNNGRQQVS

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=293, Percent_Identity=27.9863481228669, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI40556376, Length=284, Percent_Identity=27.4647887323944, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786719, Length=284, Percent_Identity=36.2676056338028, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI145693186, Length=283, Percent_Identity=33.5689045936396, Blast_Score=157, Evalue=5e-40,
Organism=Escherichia coli, GI1790315, Length=291, Percent_Identity=29.2096219931272, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1789092, Length=293, Percent_Identity=25.938566552901, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17557316, Length=301, Percent_Identity=25.5813953488372, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24655230, Length=300, Percent_Identity=31, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19922568, Length=300, Percent_Identity=31, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=27.0462633451957, Blast_Score=118, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30301; Mature: 30301

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVGFCGPGLMGAPMIRHLLAAGHRVSVWNRSRDKAEALVKDGAQVVGTPRELAERVETV
CCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCHHHCCCHHHHHHHHHHE
FVCVLDGRAVGDVVFGEHGLLSGDASTRRLQRIVDHSSIPPAATRDYAARAAALGVGWVD
EEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCC
APVSGGVPGAQAGTLAVMAGGRAADLDAVRPLIDTYASRITHMGDAGAGQTAKLCNQAIV
CCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTSGGHPPIGALSTFQ
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHH
KDVDAIADAARDTGAVMPVSATVQQVLRLGAAQGLAGADFAAFIDIVRPNNGRQQVS
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MEVGFCGPGLMGAPMIRHLLAAGHRVSVWNRSRDKAEALVKDGAQVVGTPRELAERVETV
CCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCHHHCCCHHHHHHHHHHE
FVCVLDGRAVGDVVFGEHGLLSGDASTRRLQRIVDHSSIPPAATRDYAARAAALGVGWVD
EEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCC
APVSGGVPGAQAGTLAVMAGGRAADLDAVRPLIDTYASRITHMGDAGAGQTAKLCNQAIV
CCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTSGGHPPIGALSTFQ
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHH
KDVDAIADAARDTGAVMPVSATVQQVLRLGAAQGLAGADFAAFIDIVRPNNGRQQVS
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]