Click here to switch to the map view.

The map label for this gene is ispD

Identifier: 116689964

GI number: 116689964

Start: 2158405

End: 2159115

Strand: Reverse

Name: ispD

Synonym: Bcen2424_1943

Alternate gene names: 116689964

Gene position: 2159115-2158405 (Counterclockwise)

Preceding gene: 116689969

Following gene: 116689963

Centisome position: 61.97

GC content: 71.45

Gene sequence:

>711_bases
GTGACTCCCCGACTTTTTGCCCTGATTCCCTGCGCCGGCACGGGCAGCCGTTCCGGTTCGGCCGTGCCGAAGCAATACCG
CACGCTGGCCGGCCGCGCGCTGCTGCACTACACGCTTGCCGCGTTCGACGCGTGCAGCGAGTTCGCGCAGACGCTGGTCG
TGCTCGCGCCCGACGACTCCCATTTCGATGCACGCCGCTTCGCGGGCCTGCGCTTCGCGGTGCGCCGCTGCGGCGGCGGC
TCGCGGCAGGCGTCGGTGCTCAAAGGGCTGCTGGAACTGGCCGAATTCGGCGCGACCGACCACGACTGGGTGCTGGTGCA
CGACGCCGCGCGCCCGGGCATCACGCCCGAGCTGATCCGCACGCTCGTCGCGACGCTTAAGGACGACCCGGTCGGCGGGA
TCGTCGCGCTGCCGGTGGCCGACACGCTCAAGCGGGTGCCGGCCGGCGGTGACGCGATCGCGCGCACGGAGTCGCGCGAC
GCCCTGTGGCAGGCGCAGACCCCCCAGATGTTCCGCATCGGCATGCTGCGCGAAGCGATCCTGCAGGCGCAGCGCGAAGG
GCACGACCTGACCGACGAAGCGAGCGCGATCGAATGGGCCGGCCACACGCCGCGCGTCGTGCAGGGCAGCCTGCGCAACT
TCAAGGTCACGTACCCGGAAGATTTCGCGCTCGCGGAGGCGATCCTCGCGCGCCCCGCGAACGCTTCCTGA

Upstream 100 bases:

>100_bases
ACAGGGGTGGCGTGCACGGGCGCAGCGCGGTGCGCCGGTCGAGACGAAAGACCTATTATAAAATCCGCTTCTCGATTTCA
CCTTTCCGGCGTTTCCTTTC

Downstream 100 bases:

>100_bases
CTTTCCCCCCATCTCAAACCGGATTACGCATGGATTTCAGAATCGGACAAGGCTATGACGTGCACCAGCTCGTCGAAGGG
CGCCCCCTCATCATCGGCGG

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTPRLFALIPCAGTGSRSGSAVPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVLAPDDSHFDARRFAGLRFAVRRCGGG
SRQASVLKGLLELAEFGATDHDWVLVHDAARPGITPELIRTLVATLKDDPVGGIVALPVADTLKRVPAGGDAIARTESRD
ALWQAQTPQMFRIGMLREAILQAQREGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFALAEAILARPANAS

Sequences:

>Translated_236_residues
MTPRLFALIPCAGTGSRSGSAVPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVLAPDDSHFDARRFAGLRFAVRRCGGG
SRQASVLKGLLELAEFGATDHDWVLVHDAARPGITPELIRTLVATLKDDPVGGIVALPVADTLKRVPAGGDAIARTESRD
ALWQAQTPQMFRIGMLREAILQAQREGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFALAEAILARPANAS
>Mature_235_residues
TPRLFALIPCAGTGSRSGSAVPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVLAPDDSHFDARRFAGLRFAVRRCGGGS
RQASVLKGLLELAEFGATDHDWVLVHDAARPGITPELIRTLVATLKDDPVGGIVALPVADTLKRVPAGGDAIARTESRDA
LWQAQTPQMFRIGMLREAILQAQREGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFALAEAILARPANAS

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family

Homologues:

Organism=Homo sapiens, GI157412259, Length=233, Percent_Identity=24.8927038626609, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1789104, Length=225, Percent_Identity=40.4444444444444, Blast_Score=154, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPD_BURCA (Q1BHA5)

Other databases:

- EMBL:   CP000380
- RefSeq:   YP_625973.1
- ProteinModelPortal:   Q1BHA5
- STRING:   Q1BHA5
- GeneID:   4096870
- GenomeReviews:   CP000380_GR
- KEGG:   bcn:Bcen_6136
- eggNOG:   COG1211
- HOGENOM:   HBG672839
- OMA:   FPQGAIL
- ProtClustDB:   PRK00155
- BioCyc:   BCEN331271:BCEN_6136-MONOMER
- HAMAP:   MF_00108
- InterPro:   IPR001228
- InterPro:   IPR018294
- TIGRFAMs:   TIGR00453

Pfam domain/function: PF01128 IspD

EC number: =2.7.7.60

Molecular weight: Translated: 25411; Mature: 25280

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRLFALIPCAGTGSRSGSAVPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVLAPDDS
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
HFDARRFAGLRFAVRRCGGGSRQASVLKGLLELAEFGATDHDWVLVHDAARPGITPELIR
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHH
TLVATLKDDPVGGIVALPVADTLKRVPAGGDAIARTESRDALWQAQTPQMFRIGMLREAI
HHHHHHCCCCCCCEEEECHHHHHHHCCCCCCHHHCCCCHHHHCCCCCCHHHHHHHHHHHH
LQAQREGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFALAEAILARPANAS
HHHHHCCCCCCCCHHHHHCCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TPRLFALIPCAGTGSRSGSAVPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVLAPDDS
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
HFDARRFAGLRFAVRRCGGGSRQASVLKGLLELAEFGATDHDWVLVHDAARPGITPELIR
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHH
TLVATLKDDPVGGIVALPVADTLKRVPAGGDAIARTESRDALWQAQTPQMFRIGMLREAI
HHHHHHCCCCCCCEEEECHHHHHHHCCCCCCHHHCCCCHHHHCCCCCCHHHHHHHHHHHH
LQAQREGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFALAEAILARPANAS
HHHHHCCCCCCCCHHHHHCCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA