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The map label for this gene is clpP

Identifier: 116689944

GI number: 116689944

Start: 2138393

End: 2139046

Strand: Reverse

Name: clpP

Synonym: Bcen2424_1923

Alternate gene names: 116689944

Gene position: 2139046-2138393 (Counterclockwise)

Preceding gene: 116689945

Following gene: 116689943

Centisome position: 61.4

GC content: 63.46

Gene sequence:

>654_bases
ATGATCACTCGCGCTGAATTGCTGGACATGCTTGCTTCGAACGCGCCGCAGGGTTTCGAGGCGCAAGCGCTGGGGCTGGT
GCCGATCGTCGTCGAAACGAGCGGCCGCGGCGAGCGTTCGTACGATATCTATTCGCGTCTCCTGAAGGAGCGCCTGGTGT
TCATGGTCGGCGAAGTGAACGACCAGACCGCCAACCTCGTGGTCGCGCAATTGCTGTTCCTCGAGAGCGAGAATCCCGAC
AAGGACATCAGCCTCTACATCAACAGCCCGGGCGGCTCGGTGTCGGCCGGGATGGCGATCTACGACACGATGCAGTTCAT
CAAGCCGGACGTGTCGACCCTGTGCATGGGCCTCGCGGCCAGCATGGGCGCGTTCCTGCTCGCGTCGGGTGCGAAGGGCA
AGCGCTTCGCGCTGCCGAATTCGCGCGTGATGATTCACCAGCCGCTCGGCGGCGCGCGCGGCCAGGCATCCGACATCGAG
ATCCAGGCACGCGAGATCCTCTACCTGAAGGAACGGCTGAACAACCTGCTCGCGCAACACACGGGCCAGGACGTCGAACG
CATCGCGCGCGACACCGACCGTGATAACTTCATGTCGAGCGAGGACGCGAAGGCGTACGGGCTGATCGACCAGGTGTTGT
TGAAGCGCCCGTGA

Upstream 100 bases:

>100_bases
CGCACGCCGTTTTTACGTCAAGCGCACGGTTGCCATTAATATGGCGATTGAGCGGGCGGCTTCCTTCCGTTCAATTTTCC
ATTCGAACAAGGTTCATTGA

Downstream 100 bases:

>100_bases
GTTTAAACGGGGTGCCGCCCCGATTCGGGCCGGCGCCCTCAAACGTCCCGAGTGCCCTGAGCATCTGCGGCAAGCGCATC
CAGCCGGCTCCGGTCGCGCC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MITRAELLDMLASNAPQGFEAQALGLVPIVVETSGRGERSYDIYSRLLKERLVFMVGEVNDQTANLVVAQLLFLESENPD
KDISLYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAASMGAFLLASGAKGKRFALPNSRVMIHQPLGGARGQASDIE
IQAREILYLKERLNNLLAQHTGQDVERIARDTDRDNFMSSEDAKAYGLIDQVLLKRP

Sequences:

>Translated_217_residues
MITRAELLDMLASNAPQGFEAQALGLVPIVVETSGRGERSYDIYSRLLKERLVFMVGEVNDQTANLVVAQLLFLESENPD
KDISLYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAASMGAFLLASGAKGKRFALPNSRVMIHQPLGGARGQASDIE
IQAREILYLKERLNNLLAQHTGQDVERIARDTDRDNFMSSEDAKAYGLIDQVLLKRP
>Mature_217_residues
MITRAELLDMLASNAPQGFEAQALGLVPIVVETSGRGERSYDIYSRLLKERLVFMVGEVNDQTANLVVAQLLFLESENPD
KDISLYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAASMGAFLLASGAKGKRFALPNSRVMIHQPLGGARGQASDIE
IQAREILYLKERLNNLLAQHTGQDVERIARDTDRDNFMSSEDAKAYGLIDQVLLKRP

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=196, Percent_Identity=58.1632653061224, Blast_Score=246, Evalue=1e-65,
Organism=Escherichia coli, GI1786641, Length=196, Percent_Identity=69.3877551020408, Blast_Score=298, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=54.8387096774194, Blast_Score=219, Evalue=7e-58,
Organism=Drosophila melanogaster, GI20129427, Length=194, Percent_Identity=55.6701030927835, Blast_Score=242, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_BURCA (Q1BH85)

Other databases:

- EMBL:   CP000380
- RefSeq:   YP_625993.1
- ProteinModelPortal:   Q1BH85
- SMR:   Q1BH85
- STRING:   Q1BH85
- MEROPS:   S14.001
- GeneID:   4096756
- GenomeReviews:   CP000380_GR
- KEGG:   bcn:Bcen_6156
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   PRK00277
- BioCyc:   BCEN331271:BCEN_6156-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23751; Mature: 23751

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 121-121 ACT_SITE 146-146

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITRAELLDMLASNAPQGFEAQALGLVPIVVETSGRGERSYDIYSRLLKERLVFMVGEVN
CCCHHHHHHHHHCCCCCCCCCHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCC
DQTANLVVAQLLFLESENPDKDISLYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAA
CHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
SMGAFLLASGAKGKRFALPNSRVMIHQPLGGARGQASDIEIQAREILYLKERLNNLLAQH
HHHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
TGQDVERIARDTDRDNFMSSEDAKAYGLIDQVLLKRP
CCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MITRAELLDMLASNAPQGFEAQALGLVPIVVETSGRGERSYDIYSRLLKERLVFMVGEVN
CCCHHHHHHHHHCCCCCCCCCHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCC
DQTANLVVAQLLFLESENPDKDISLYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAA
CHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
SMGAFLLASGAKGKRFALPNSRVMIHQPLGGARGQASDIEIQAREILYLKERLNNLLAQH
HHHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
TGQDVERIARDTDRDNFMSSEDAKAYGLIDQVLLKRP
CCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA