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The map label for this gene is moeA [H]

Identifier: 116689873

GI number: 116689873

Start: 2055886

End: 2057133

Strand: Reverse

Name: moeA [H]

Synonym: Bcen2424_1852

Alternate gene names: 116689873

Gene position: 2057133-2055886 (Counterclockwise)

Preceding gene: 116689874

Following gene: 116689872

Centisome position: 59.05

GC content: 71.96

Gene sequence:

>1248_bases
ATGTCGAACCCGAATCCCGCGGCGCCGCGCGCGCCGATGCTGTCGACCGCCGAGGCGCTCGCCGCGCTGCTCGACGCCGC
GAAGCCGCTGCCCGGCGCCGAAACCGTCGCCACGCTCGACGCGCTCGGCCGCGTGCTGGCGGCCGACGTGAGCTCGCCGC
TCGACGTGCCGCCGATGCATACCAGCGCGATGGACGGCTATGCGGTGCGCGTCGCCGATTTGTTGCACGGCGATCGACGG
TTGCCGGTTTCGCAGCGCATCCCGGCCGGCCATCCGGCGCAACCGCTTGCGGCCGGCACGGCCGCGCGGATCTTCACCGG
CGCGACGGTGCCGCCCGGCGCCGACGCCGTCGTGATGCAGGAGCAGGCAGCGGCCGACGGCGACGCGGTCGAGATCCTGC
ACACGCCGAAGGCCGGTGAATGGATCACCGCGCAGGGCGCGGACATCCGCCAGGGTGCGGTGATCCTCCCGGCCGGCACG
CGGCTCACGCCGCAGGCGCTGGGTCTCGCCGCGTCGGTCGGCTGCGCGCGGTTGTCGGTCGCGCGGCGGATTCGCGTGGC
GGTGTTCTTCACCGGCGACGAACTGACGATGCCGGGCGAGCCGCTGAAGCCCGGCGCGATCTACAACTCGAACCGCTTCA
CGCTGCGCGGGCTGCTCGAGCGGCTCGGCTGCCACGTGACCGACTACGGGATCGTGCCAGACTCGCTGGCCGCGACGCGC
GACACGCTGCGCGCGGCCGCCCGCGATCACGACGTGATCCTGACGAGCGGCGGCGTGTCGGTCGGCGACGAGGATCACGT
GAAGCCGGCCGTCGAGGCCGAAGGGCGGCTCGCGCTGTGGCAGATCGCGATGAAGCCCGGCAAGCCGCTCGCGTACGGCG
CGGTGCGGCGCGGCGACGAGCGCGCCGATGCGCACTTCATCGGGCTGCCCGGCAACCCCGTCTCGAGCTTCGTCACGTTC
CTGCTGTTCGTGCGGCCGTTCCTGCTGCGCCTGTCCGGCGTGCGCGACGTCGCGCCGCGCGCGTTGTCGCTGCGTGCCGA
TTTTTCGCAGAGCAAGGGCGACCGGCGCAACGAATTCCTGCGTGCGCGCGTCAACGCAGCCGGCGGTCTCGACCTGTTCC
CGAACCAGAGCTCGGCCGTGCTGACGTCGACGGTCTGGGGCGACGGCCTGATCGACAATCCGCCGCAGCATGTGATCAGC
GCAGGCGAGACCGTGCGTTTCATCCCGTTTTCCGAATTGCTGTCGTAA

Upstream 100 bases:

>100_bases
TTCGCGCCGATTACAGTCTTCGCATGTTCGCCATATCGCGCGTCCGCGTGACGGCGTCGCTACAATGACGTATTGATTCC
AACGATCCCCGATTCCATCG

Downstream 100 bases:

>100_bases
CGCGACGGCTTCCCGAACCATGAAGATTCAACTGAAATTTTTTGCAAGCGTGCGCGAGGCGCTGGGCGTGGCCGATGAAG
AAGCCAACGTGCCGGACAGC

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSNPNPAAPRAPMLSTAEALAALLDAAKPLPGAETVATLDALGRVLAADVSSPLDVPPMHTSAMDGYAVRVADLLHGDRR
LPVSQRIPAGHPAQPLAAGTAARIFTGATVPPGADAVVMQEQAAADGDAVEILHTPKAGEWITAQGADIRQGAVILPAGT
RLTPQALGLAASVGCARLSVARRIRVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLERLGCHVTDYGIVPDSLAATR
DTLRAAARDHDVILTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAYGAVRRGDERADAHFIGLPGNPVSSFVTF
LLFVRPFLLRLSGVRDVAPRALSLRADFSQSKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPQHVIS
AGETVRFIPFSELLS

Sequences:

>Translated_415_residues
MSNPNPAAPRAPMLSTAEALAALLDAAKPLPGAETVATLDALGRVLAADVSSPLDVPPMHTSAMDGYAVRVADLLHGDRR
LPVSQRIPAGHPAQPLAAGTAARIFTGATVPPGADAVVMQEQAAADGDAVEILHTPKAGEWITAQGADIRQGAVILPAGT
RLTPQALGLAASVGCARLSVARRIRVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLERLGCHVTDYGIVPDSLAATR
DTLRAAARDHDVILTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAYGAVRRGDERADAHFIGLPGNPVSSFVTF
LLFVRPFLLRLSGVRDVAPRALSLRADFSQSKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPQHVIS
AGETVRFIPFSELLS
>Mature_414_residues
SNPNPAAPRAPMLSTAEALAALLDAAKPLPGAETVATLDALGRVLAADVSSPLDVPPMHTSAMDGYAVRVADLLHGDRRL
PVSQRIPAGHPAQPLAAGTAARIFTGATVPPGADAVVMQEQAAADGDAVEILHTPKAGEWITAQGADIRQGAVILPAGTR
LTPQALGLAASVGCARLSVARRIRVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLERLGCHVTDYGIVPDSLAATRD
TLRAAARDHDVILTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAYGAVRRGDERADAHFIGLPGNPVSSFVTFL
LFVRPFLLRLSGVRDVAPRALSLRADFSQSKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPQHVISA
GETVRFIPFSELLS

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=422, Percent_Identity=34.8341232227488, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI10880983, Length=422, Percent_Identity=34.8341232227488, Blast_Score=182, Evalue=5e-46,
Organism=Escherichia coli, GI1787049, Length=385, Percent_Identity=42.5974025974026, Blast_Score=273, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI25147659, Length=383, Percent_Identity=31.331592689295, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=360, Percent_Identity=27.5, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17136978, Length=405, Percent_Identity=35.0617283950617, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24638841, Length=405, Percent_Identity=35.0617283950617, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43562; Mature: 43431

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPNPAAPRAPMLSTAEALAALLDAAKPLPGAETVATLDALGRVLAADVSSPLDVPPMH
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TSAMDGYAVRVADLLHGDRRLPVSQRIPAGHPAQPLAAGTAARIFTGATVPPGADAVVMQ
CCCCCCHHHHHHHHHCCCCCCCHHHCCCCCCCCCCHHCCCHHHHEECCCCCCCCCEEEEE
EQAAADGDAVEILHTPKAGEWITAQGADIRQGAVILPAGTRLTPQALGLAASVGCARLSV
HHHCCCCCEEEEEECCCCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
ARRIRVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLERLGCHVTDYGIVPDSLAATR
HCEEEEEEEEECCEEECCCCCCCCCEEECCCCHHHHHHHHHHCCCEEECCCCCCHHHHHH
DTLRAAARDHDVILTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAYGAVRRGDE
HHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEHHHHHCCCC
RADAHFIGLPGNPVSSFVTFLLFVRPFLLRLSGVRDVAPRALSLRADFSQSKGDRRNEFL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEECCCCCCCCCHHHHHH
RARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPQHVISAGETVRFIPFSELLS
HHHHCCCCCCEECCCCCCCEEEEECCCCCCCCCCHHHHHCCCCEEEEECHHHHHC
>Mature Secondary Structure 
SNPNPAAPRAPMLSTAEALAALLDAAKPLPGAETVATLDALGRVLAADVSSPLDVPPMH
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TSAMDGYAVRVADLLHGDRRLPVSQRIPAGHPAQPLAAGTAARIFTGATVPPGADAVVMQ
CCCCCCHHHHHHHHHCCCCCCCHHHCCCCCCCCCCHHCCCHHHHEECCCCCCCCCEEEEE
EQAAADGDAVEILHTPKAGEWITAQGADIRQGAVILPAGTRLTPQALGLAASVGCARLSV
HHHCCCCCEEEEEECCCCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
ARRIRVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLERLGCHVTDYGIVPDSLAATR
HCEEEEEEEEECCEEECCCCCCCCCEEECCCCHHHHHHHHHHCCCEEECCCCCCHHHHHH
DTLRAAARDHDVILTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAYGAVRRGDE
HHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEHHHHHCCCC
RADAHFIGLPGNPVSSFVTFLLFVRPFLLRLSGVRDVAPRALSLRADFSQSKGDRRNEFL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEECCCCCCCCCHHHHHH
RARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPQHVISAGETVRFIPFSELLS
HHHHCCCCCCEECCCCCCCEEEEECCCCCCCCCCHHHHHCCCCEEEEECHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]