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The map label for this gene is hmuU [H]

Identifier: 116689372

GI number: 116689372

Start: 1488799

End: 1489839

Strand: Direct

Name: hmuU [H]

Synonym: Bcen2424_1350

Alternate gene names: 116689372

Gene position: 1488799-1489839 (Clockwise)

Preceding gene: 116689371

Following gene: 116689375

Centisome position: 42.73

GC content: 74.83

Gene sequence:

>1041_bases
ATGAGCGTGCGCGGGCAGGCGGCGCGGCTCGACATGCGCGTGGTGCTGCCGGGGCTGGCCGTGCTGCTGATCGTGTCGAT
CGTCGTGTCGGCCGCGTTCGGTCCCGCGCCGATCGCGATGCCGGCCGCGGTGCGGATCGTCGCCGCGCACGTCGCGTCGG
CGTTCGGCGGCGCCGATGCGTTTGCGGCGGCGCCGGGCAACGACAGCATCGTGTGGCTGATCCGGATGCCGCGTGCGCTG
CTGGCCGCGCTCGTCGGCGCGACGCTGGCGACGGTCGGTGTCGCGTTGCAGGCGGCGACCGCGAACCGCCTGGCCGATCC
GCACCTGCTCGGCGTAAGCGCGGGCGCGATGCTCGGCGCGATCGCGGTCACGGTGGTGGCCGGCGCGGCGTTCGGTCCGT
TCACGCTGTCGGCCGCCGCGTTTGCAGGGGCGCTCGCGGCGACCGCGTGCGTGGTCGCGCTCGCTTACCGGAGCGGCCGG
CTCGAATCGGACCGGCTGCTGCTCGCGGGCGTGTCGGTGTCGTTCATGATGGCCGCGTTCGGCAACCTGCTGCTGTATCT
CGGCGACCAGCGCGCCGCGTCGTCGGTGCTGTTCTGGATGCTCGGCGGCGTCGGGCTCGCGCGCTGGGACCTGCTGCCGG
TGCCGACCGTGTGCGCGGTGCTCGCCGGCGGCGCGCTCCATGCGCGCCGACGCGAACTGAATGCGCTGATGTCGGGCGAC
GTCGCCGCCGCGTCGCTCGGCGTGCCGAGCGCGCGGATGCGGCGCGAGGTGTTCGTCGTCGCGTCGTTCGCGACGGGCGC
GATGGTCGCGGTGAGCGGCGCGATCGGCTTCGTCGGGCTCGTGACGCCGCATCTGTGCCGTCGCGTCGTCGGCGCGGAGC
ACGGCCGGCTGCTGCCGGTCGCCGCGCTGGCCGGCGCGATCCTGCTCGTGTGGGCCGATGTCGCCGCGCGCACGCTCGCG
GCGCCGGAGGACCTGCCGATCGGCATCGTGACCGCGCTGTTCGGCAGCCTGTTCTTCGTCGCGCTGTTGCGCCGGCGCTG
A

Upstream 100 bases:

>100_bases
TGATTCCGTACGATGCCGCGACGCCCGGCCCGGAGAACGTCGCGGCGGTCGAGACGCTGGCCCGCGCGCTGTATCCGGCC
GCATTCGCCGGAGCGGCACG

Downstream 100 bases:

>100_bases
GCGAAGGCGCGGTCACGCGGGGGCGGGTAGGCGCCCGCCGCCGTTTTCATCGAAGCGGGACGACCGTGCCCGTGCCGCTG
CGGCGGCGCGCATCGGCATG

Product: transport system permease protein

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSVRGQAARLDMRVVLPGLAVLLIVSIVVSAAFGPAPIAMPAAVRIVAAHVASAFGGADAFAAAPGNDSIVWLIRMPRAL
LAALVGATLATVGVALQAATANRLADPHLLGVSAGAMLGAIAVTVVAGAAFGPFTLSAAAFAGALAATACVVALAYRSGR
LESDRLLLAGVSVSFMMAAFGNLLLYLGDQRAASSVLFWMLGGVGLARWDLLPVPTVCAVLAGGALHARRRELNALMSGD
VAAASLGVPSARMRREVFVVASFATGAMVAVSGAIGFVGLVTPHLCRRVVGAEHGRLLPVAALAGAILLVWADVAARTLA
APEDLPIGIVTALFGSLFFVALLRRR

Sequences:

>Translated_346_residues
MSVRGQAARLDMRVVLPGLAVLLIVSIVVSAAFGPAPIAMPAAVRIVAAHVASAFGGADAFAAAPGNDSIVWLIRMPRAL
LAALVGATLATVGVALQAATANRLADPHLLGVSAGAMLGAIAVTVVAGAAFGPFTLSAAAFAGALAATACVVALAYRSGR
LESDRLLLAGVSVSFMMAAFGNLLLYLGDQRAASSVLFWMLGGVGLARWDLLPVPTVCAVLAGGALHARRRELNALMSGD
VAAASLGVPSARMRREVFVVASFATGAMVAVSGAIGFVGLVTPHLCRRVVGAEHGRLLPVAALAGAILLVWADVAARTLA
APEDLPIGIVTALFGSLFFVALLRRR
>Mature_345_residues
SVRGQAARLDMRVVLPGLAVLLIVSIVVSAAFGPAPIAMPAAVRIVAAHVASAFGGADAFAAAPGNDSIVWLIRMPRALL
AALVGATLATVGVALQAATANRLADPHLLGVSAGAMLGAIAVTVVAGAAFGPFTLSAAAFAGALAATACVVALAYRSGRL
ESDRLLLAGVSVSFMMAAFGNLLLYLGDQRAASSVLFWMLGGVGLARWDLLPVPTVCAVLAGGALHARRRELNALMSGDV
AAASLGVPSARMRREVFVVASFATGAMVAVSGAIGFVGLVTPHLCRRVVGAEHGRLLPVAALAGAILLVWADVAARTLAA
PEDLPIGIVTALFGSLFFVALLRRR

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=295, Percent_Identity=37.6271186440678, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1790741, Length=297, Percent_Identity=36.026936026936, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1790740, Length=273, Percent_Identity=36.6300366300366, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786805, Length=313, Percent_Identity=32.9073482428115, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786804, Length=271, Percent_Identity=33.5793357933579, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1786347, Length=323, Percent_Identity=30.9597523219814, Blast_Score=90, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 34966; Mature: 34835

Theoretical pI: Translated: 11.79; Mature: 11.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRGQAARLDMRVVLPGLAVLLIVSIVVSAAFGPAPIAMPAAVRIVAAHVASAFGGADA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
FAAAPGNDSIVWLIRMPRALLAALVGATLATVGVALQAATANRLADPHLLGVSAGAMLGA
EEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHH
IAVTVVAGAAFGPFTLSAAAFAGALAATACVVALAYRSGRLESDRLLLAGVSVSFMMAAF
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHH
GNLLLYLGDQRAASSVLFWMLGGVGLARWDLLPVPTVCAVLAGGALHARRRELNALMSGD
HHHHEEECCCHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCC
VAAASLGVPSARMRREVFVVASFATGAMVAVSGAIGFVGLVTPHLCRRVVGAEHGRLLPV
HHHHHCCCCHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
AALAGAILLVWADVAARTLAAPEDLPIGIVTALFGSLFFVALLRRR
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVRGQAARLDMRVVLPGLAVLLIVSIVVSAAFGPAPIAMPAAVRIVAAHVASAFGGADA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
FAAAPGNDSIVWLIRMPRALLAALVGATLATVGVALQAATANRLADPHLLGVSAGAMLGA
EEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHH
IAVTVVAGAAFGPFTLSAAAFAGALAATACVVALAYRSGRLESDRLLLAGVSVSFMMAAF
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHH
GNLLLYLGDQRAASSVLFWMLGGVGLARWDLLPVPTVCAVLAGGALHARRRELNALMSGD
HHHHEEECCCHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCC
VAAASLGVPSARMRREVFVVASFATGAMVAVSGAIGFVGLVTPHLCRRVVGAEHGRLLPV
HHHHHCCCCHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
AALAGAILLVWADVAARTLAAPEDLPIGIVTALFGSLFFVALLRRR
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]