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The map label for this gene is rnc [H]

Identifier: 116689156

GI number: 116689156

Start: 1244629

End: 1245858

Strand: Direct

Name: rnc [H]

Synonym: Bcen2424_1134

Alternate gene names: 116689156

Gene position: 1244629-1245858 (Clockwise)

Preceding gene: 116689155

Following gene: 116689157

Centisome position: 35.73

GC content: 69.59

Gene sequence:

>1230_bases
ATGCCCTCATCCCAGTTGGAAAGCCGGCTGCGCTACGAATTTCGCAATGCGGAATTGTTGCGCCAGGCTTTGACCCATCG
CAGTCACAGTGCCACGCACAATGAACGGCTCGAGTTTCTCGGCGATTCCGTTCTGAATTGCGCGGTGGCCGCCCTTTTGT
TCCAGCGTTTCGGCAAGCTGGACGAAGGTGACCTGTCGCGCGTACGCGCCAATCTCGTCAAGCAGCAGTCGCTGTACGAA
ATTGCTCAGGCCCTGAATATCTCGGACGGCCTGCGGCTGGGCGAGGGCGAACTGCGCAGCGGCGGGTTCCGTCGCCCGTC
GATCCTCGCGGACGCGTTCGAAGCCATCATCGGGGCCGTGTTCCTCGATGGGGGCTTCGAAGCCGCCCAAGGGGTCATCA
AGCGCCTCTATATCCCGATTCTCGACCACATCGATCCGCGTACGCTCGGCAAGGACGCGAAGACGCTGCTGCAGGAATAT
CTGCAGGGGCACAAGATCGCGCTGCCGACCTATACGGTCGTCGCGACGCATGGTGCGGCGCACAATCAGCAGTTCGAGGT
CGAGTGCACGGTGCCGAAGCTGGACGTGAAGGTATCGGGCTCCGGCGCGAGCCGGCGCGCGGCCGAGCAGGCTGCCGCGA
AGAAGGCGCTCGACGAAGTGATGGCGGCCGCGCCGATGCTGGCCGCGAAGCCGAAGCGCTCGAAAAACGCGCGCGGGTCC
AAGCATGTCGAACCCGAGATCGTGCCGGGCGTGAAGGGCGTGCAGGAAGCGCTCGACCTGCGCTCGCCCGAGCGGAAGGA
ACGTGCGGCGGCGCGCGAGGCGAGGGCGGCCGGCGCGGTGCCGGCTGCCACCGCCGCGGCTGCGGCGACGGGCGCTGAAC
CGGCCGTCGCGCCGATGGCCGCGATTCGCGCGGCGCATGTCGAGCCGGCCGCGGACAAGGGCGAACGGGCGGCGAAGCCG
GCGGCCGACAAGGTTGCCGACAAACCGGCCGAGCGGCCCGACAAGGCCGCGGAGAAGCCGGCCGAGGCCGCGCCGCGCGC
AGCTGACAAGCCGGCCGGCCATGCAGCCGATCCGGCATCGTCGTCGGCCGATAAGCCTGGCGCGAGTGCCGACGCCGCCG
CGCGCACGCCTGCGCGCGCACGCGATGCCGCGGCGCCCGACGCGGACACGCCGCCCGGCGGCGCGAGCCTTGCTGCCGCG
CAGGCGCGCGTGGCCGATGCCGACCACTGA

Upstream 100 bases:

>100_bases
AACTACTTTAAGAACCAGCGGTAACACCGCCTCGTCACGCCTTTTCGTGTCCGGCCGTGCCGTTTCGGCCCGACCGGGCG
CCCGCGTTATACTCCTGCAC

Downstream 100 bases:

>100_bases
ACTGCCCAGCGATCGTGCCGCGCGCCGCGCGGCCGTTTCCGAACCTGTCTCCCAAACGATATGAACACTCCCGCTCCTAC
CGGTTTCCGTTGCGGCATGA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MPSSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANLVKQQSLYE
IAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYIPILDHIDPRTLGKDAKTLLQEY
LQGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPMLAAKPKRSKNARGS
KHVEPEIVPGVKGVQEALDLRSPERKERAAAREARAAGAVPAATAAAAATGAEPAVAPMAAIRAAHVEPAADKGERAAKP
AADKVADKPAERPDKAAEKPAEAAPRAADKPAGHAADPASSSADKPGASADAAARTPARARDAAAPDADTPPGGASLAAA
QARVADADH

Sequences:

>Translated_409_residues
MPSSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANLVKQQSLYE
IAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYIPILDHIDPRTLGKDAKTLLQEY
LQGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPMLAAKPKRSKNARGS
KHVEPEIVPGVKGVQEALDLRSPERKERAAAREARAAGAVPAATAAAAATGAEPAVAPMAAIRAAHVEPAADKGERAAKP
AADKVADKPAERPDKAAEKPAEAAPRAADKPAGHAADPASSSADKPGASADAAARTPARARDAAAPDADTPPGGASLAAA
QARVADADH
>Mature_408_residues
PSSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKLDEGDLSRVRANLVKQQSLYEI
AQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAVFLDGGFEAAQGVIKRLYIPILDHIDPRTLGKDAKTLLQEYL
QGHKIALPTYTVVATHGAAHNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPMLAAKPKRSKNARGSK
HVEPEIVPGVKGVQEALDLRSPERKERAAAREARAAGAVPAATAAAAATGAEPAVAPMAAIRAAHVEPAADKGERAAKPA
ADKVADKPAERPDKAAEKPAEAAPRAADKPAGHAADPASSSADKPGASADAAARTPARARDAAAPDADTPPGGASLAAAQ
ARVADADH

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=226, Percent_Identity=26.5486725663717, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI155030234, Length=226, Percent_Identity=26.5486725663717, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1788920, Length=203, Percent_Identity=52.7093596059113, Blast_Score=214, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI193202651, Length=197, Percent_Identity=32.48730964467, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17506883, Length=197, Percent_Identity=32.48730964467, Blast_Score=95, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6323895, Length=97, Percent_Identity=38.1443298969072, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17137682, Length=241, Percent_Identity=28.6307053941909, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 42732; Mature: 42601

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQSLYEIAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFEAAQGVIKRLYIPILDHIDPRTLGKDAKTLLQEYLQGHKIALPTYTVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCEEECCEEEEEEECCCC
HNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPMLAAKPKRSKNARGS
CCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
KHVEPEIVPGVKGVQEALDLRSPERKERAAAREARAAGAVPAATAAAAATGAEPAVAPMA
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHH
AIRAAHVEPAADKGERAAKPAADKVADKPAERPDKAAEKPAEAAPRAADKPAGHAADPAS
HHHHHHCCCCCCCCCHHCCCCHHHHHCCCCCCCCHHHCCCHHHCCCCCCCCCCCCCCCCC
SSADKPGASADAAARTPARARDAAAPDADTPPGGASLAAAQARVADADH
CCCCCCCCCCCHHHCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
PSSQLESRLRYEFRNAELLRQALTHRSHSATHNERLEFLGDSVLNCAVAALLFQRFGKL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQSLYEIAQALNISDGLRLGEGELRSGGFRRPSILADAFEAIIGAV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFEAAQGVIKRLYIPILDHIDPRTLGKDAKTLLQEYLQGHKIALPTYTVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCEEECCEEEEEEECCCC
HNQQFEVECTVPKLDVKVSGSGASRRAAEQAAAKKALDEVMAAAPMLAAKPKRSKNARGS
CCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
KHVEPEIVPGVKGVQEALDLRSPERKERAAAREARAAGAVPAATAAAAATGAEPAVAPMA
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHH
AIRAAHVEPAADKGERAAKPAADKVADKPAERPDKAAEKPAEAAPRAADKPAGHAADPAS
HHHHHHCCCCCCCCCHHCCCCHHHHHCCCCCCCCHHHCCCHHHCCCCCCCCCCCCCCCCC
SSADKPGASADAAARTPARARDAAAPDADTPPGGASLAAAQARVADADH
CCCCCCCCCCCHHHCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]