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The map label for this gene is nhaA [H]

Identifier: 116689137

GI number: 116689137

Start: 1227507

End: 1228499

Strand: Direct

Name: nhaA [H]

Synonym: Bcen2424_1115

Alternate gene names: 116689137

Gene position: 1227507-1228499 (Clockwise)

Preceding gene: 116689136

Following gene: 116689140

Centisome position: 35.23

GC content: 67.17

Gene sequence:

>993_bases
ATGGCCGACCAACCGAATTCCCCGGATTCCTCTTCCCGTCCCGACAGCCGTGAACCGAGCTGGGAGCGCGCGGCGCTCGA
GCGGATCGCGCTCGCGGCCGTCAAGGAGCAGCGTGCCGCACGGCGCTGGAAGATCTTCTTCCGCTTCGCGTTTCTCGGCG
TGTTCGTGCTGCTCGCGTTCGCGCTGATCGATTTCTCCAGCGATTCGAAGTTCTCGTCGAGCGGGCGGCATACGGCGCTC
GTGACGATCGACGGCGAGATTGCGGCGGGCGTCAACGCGAACGCCGACGACATCAACACGGCGCTCGACGCCGCGTTCGA
CGACGACGGCACGGTCGGCGTGGTGCTGCGGATCAACAGCCCGGGCGGCAGCCCGGTGCAGGCCGGCATGGTCTACGACG
AGATCCGGCGGTTGCGCGGCAAGTATCCGGACAAGCCGCTGTACGTCGTCGTGACCGACATGTGTGCGTCGGGCGGCTAT
TACATCGCGTCCGCGGCCGACAAGATCTTCGTCGACAAGGCGAGCATCGTCGGGTCGATCGGCGTGCTGATGGACGGATT
CGGCTTCACCGGGCTGATGGGCAAGCTCGGGGTCGAGCGGCGCCTGCATACGTCGGGCGAAAACAAGGGCTTCTACGATC
CGTTCTCGCCGGAAACGCCGAAGATGGACGCGCACGCGCAGGCGCTGCTCGACCAGGTGCATGCGCAGTTCATCAAGGCC
GTGAAGGATGGCCGCGGCAAGCGGCTGCACGAGACGCCCGACATGTTCTCGGGCCTGTTCTGGACCGGCGAGAAGAGCGT
CGAGCTCGGGCTCGCCGACGGCTACGGCACGACCGACACGGTCGCGCGCGACGTGCTGAAGGCGCCGGATCTGGTCGACT
ATACGGTGAAGGAAAGCCTGACGAATCGCGTCGCGCGCAAGTTCGGCGCGGCCGTCGGGGGCGCCGCGATGAAGGCGCTG
ACGGCCGGCGGCGCGTCGGTCAGCCTGCGTTGA

Upstream 100 bases:

>100_bases
CGACGAGCGCGACACGCCCGACGGCCGTGCGGTATTCTGGGTACCCGATGCCGATCTGCATCCCGCCACTCCCGCCACGA
CCGACTGACGACATCACTGC

Downstream 100 bases:

>100_bases
CGGCTGACCGCTGACGGCCGGCGACCGGCGACAATCGGCGGGCCGCGATGGCCCGCCTTTCAATTAACTGATCGCCGTTC
TTGGCATCAGTTCGCGAGCA

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MADQPNSPDSSSRPDSREPSWERAALERIALAAVKEQRAARRWKIFFRFAFLGVFVLLAFALIDFSSDSKFSSSGRHTAL
VTIDGEIAAGVNANADDINTALDAAFDDDGTVGVVLRINSPGGSPVQAGMVYDEIRRLRGKYPDKPLYVVVTDMCASGGY
YIASAADKIFVDKASIVGSIGVLMDGFGFTGLMGKLGVERRLHTSGENKGFYDPFSPETPKMDAHAQALLDQVHAQFIKA
VKDGRGKRLHETPDMFSGLFWTGEKSVELGLADGYGTTDTVARDVLKAPDLVDYTVKESLTNRVARKFGAAVGGAAMKAL
TAGGASVSLR

Sequences:

>Translated_330_residues
MADQPNSPDSSSRPDSREPSWERAALERIALAAVKEQRAARRWKIFFRFAFLGVFVLLAFALIDFSSDSKFSSSGRHTAL
VTIDGEIAAGVNANADDINTALDAAFDDDGTVGVVLRINSPGGSPVQAGMVYDEIRRLRGKYPDKPLYVVVTDMCASGGY
YIASAADKIFVDKASIVGSIGVLMDGFGFTGLMGKLGVERRLHTSGENKGFYDPFSPETPKMDAHAQALLDQVHAQFIKA
VKDGRGKRLHETPDMFSGLFWTGEKSVELGLADGYGTTDTVARDVLKAPDLVDYTVKESLTNRVARKFGAAVGGAAMKAL
TAGGASVSLR
>Mature_329_residues
ADQPNSPDSSSRPDSREPSWERAALERIALAAVKEQRAARRWKIFFRFAFLGVFVLLAFALIDFSSDSKFSSSGRHTALV
TIDGEIAAGVNANADDINTALDAAFDDDGTVGVVLRINSPGGSPVQAGMVYDEIRRLRGKYPDKPLYVVVTDMCASGGYY
IASAADKIFVDKASIVGSIGVLMDGFGFTGLMGKLGVERRLHTSGENKGFYDPFSPETPKMDAHAQALLDQVHAQFIKAV
KDGRGKRLHETPDMFSGLFWTGEKSVELGLADGYGTTDTVARDVLKAPDLVDYTVKESLTNRVARKFGAAVGGAAMKALT
AGGASVSLR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=218, Percent_Identity=32.5688073394495, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788064, Length=204, Percent_Identity=29.4117647058824, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 35369; Mature: 35238

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADQPNSPDSSSRPDSREPSWERAALERIALAAVKEQRAARRWKIFFRFAFLGVFVLLAF
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIDFSSDSKFSSSGRHTALVTIDGEIAAGVNANADDINTALDAAFDDDGTVGVVLRINS
HHHCCCCCCCCCCCCCEEEEEEECCCEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEC
PGGSPVQAGMVYDEIRRLRGKYPDKPLYVVVTDMCASGGYYIASAADKIFVDKASIVGSI
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCCEEEEECCCHHEEEHHHHHHHH
GVLMDGFGFTGLMGKLGVERRLHTSGENKGFYDPFSPETPKMDAHAQALLDQVHAQFIKA
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VKDGRGKRLHETPDMFSGLFWTGEKSVELGLADGYGTTDTVARDVLKAPDLVDYTVKESL
HHCCCCCCCCCCHHHHHCEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHH
TNRVARKFGAAVGGAAMKALTAGGASVSLR
HHHHHHHHHHHHHHHHHHHHHCCCCEEECC
>Mature Secondary Structure 
ADQPNSPDSSSRPDSREPSWERAALERIALAAVKEQRAARRWKIFFRFAFLGVFVLLAF
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIDFSSDSKFSSSGRHTALVTIDGEIAAGVNANADDINTALDAAFDDDGTVGVVLRINS
HHHCCCCCCCCCCCCCEEEEEEECCCEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEC
PGGSPVQAGMVYDEIRRLRGKYPDKPLYVVVTDMCASGGYYIASAADKIFVDKASIVGSI
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCCEEEEECCCHHEEEHHHHHHHH
GVLMDGFGFTGLMGKLGVERRLHTSGENKGFYDPFSPETPKMDAHAQALLDQVHAQFIKA
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VKDGRGKRLHETPDMFSGLFWTGEKSVELGLADGYGTTDTVARDVLKAPDLVDYTVKESL
HHCCCCCCCCCCHHHHHCEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHH
TNRVARKFGAAVGGAAMKALTAGGASVSLR
HHHHHHHHHHHHHHHHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA