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The map label for this gene is gyaR [H]

Identifier: 116689126

GI number: 116689126

Start: 1214879

End: 1215868

Strand: Direct

Name: gyaR [H]

Synonym: Bcen2424_1103

Alternate gene names: 116689126

Gene position: 1214879-1215868 (Clockwise)

Preceding gene: 116689125

Following gene: 116689127

Centisome position: 34.87

GC content: 69.29

Gene sequence:

>990_bases
ATGCAGAAGATCCTGGTCGCGCGTCCGATCTTTCCGGACGTGATCGAACGGCTCAAGCAGTATTTCGACGTCGACTGGAA
CGACGGCGACGCGCTCGCGCCCGACGCGCTCGCCGCGCGTCTGGCCGACAAGGACGGCGCGCTGACGGCCGGCGATCCGG
TCGGCGCGGCCACGCTCGCGGCGGCGCCACGCCTGCGGGTCGTGGCGAACATGGCGGTCGGCTACAACAACTTTGACATG
GCTGCGTTCAACGCGGCGAACGTGCTCGGCACCAACACGCCCGACGTGCTGAACGAGTCGACCGCCGATTTCGGCTGGGC
GCTGATGATGGCCGCCGCGCGCCGGATCGCCGAATCGGAACACTGGCTGCGCGCCGGTCACTGGCAGAAGTGGGCGTACG
ACGGCTTTCTCGGCACCGATATCCACGGCTCGACGCTCGGCGTGATCGGGATGGGCCGCATCGGCCAGGCGCTCGCGCGC
CGCGCGCGCGGCTTCGGGATGCAGGTGATCTATCACAACCGGTCGCGGGTCGCGCCGGAGATCGAGGCCGAGCTGAATGC
CGAATACGTGTCGAAGGATGCGCTGCTCGCGCGCGCCGATCATGTCGTGCTCGTGCTGCCGTACACCCAGGAGAACCATC
ACACGATCGGCGCGGCCGAGCTCGCGAAGATGAAACCCACGGCGACGCTGACCAATATCGCGCGCGGCGGGATCGTCGAC
GATGCGGCGCTGGCCGTCGCGCTGCGCGACGGGACGATCGCCGCGGCCGGCCTCGACGTGTACGAGGGCGAGCCGAGCGT
GCATCCGGCGCTGCTCGAGGTGCCGAACGTCGTGCTGACGCCGCATATCGCGAGCGCGACCGAAAAGACCCGCCGCGCGA
TGGCGAATCTCGCTGCCGACAACCTGATCGCCGCGCTCGGCGAGGGGCCGCGTGCGGGGCAGCCGCCGAATCCGATCAAC
CCTGACGTGATCGGGAAGCCGCGCGCATGA

Upstream 100 bases:

>100_bases
GCTTTTCTTCACGGCGTAAGCTGACGTTTTTCAACCCCGAGCGGGCGGCTCCGGCGGCGCATGGCGCGCCGCGATCCGTC
CGCGGCATGCGGAGATGGCG

Downstream 100 bases:

>100_bases
CGATGACGTTGTTGCTGGCGGCGGTCGTCGTGCTGGCCGTCGCGCTCGCGGTGGCGATCGTCGCGCTCGTGCGCGGCGGC
CGCCACGACGATGCGGCCGT

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDALAARLADKDGALTAGDPVGAATLAAAPRLRVVANMAVGYNNFDM
AAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGHWQKWAYDGFLGTDIHGSTLGVIGMGRIGQALAR
RARGFGMQVIYHNRSRVAPEIEAELNAEYVSKDALLARADHVVLVLPYTQENHHTIGAAELAKMKPTATLTNIARGGIVD
DAALAVALRDGTIAAAGLDVYEGEPSVHPALLEVPNVVLTPHIASATEKTRRAMANLAADNLIAALGEGPRAGQPPNPIN
PDVIGKPRA

Sequences:

>Translated_329_residues
MQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDALAARLADKDGALTAGDPVGAATLAAAPRLRVVANMAVGYNNFDM
AAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGHWQKWAYDGFLGTDIHGSTLGVIGMGRIGQALAR
RARGFGMQVIYHNRSRVAPEIEAELNAEYVSKDALLARADHVVLVLPYTQENHHTIGAAELAKMKPTATLTNIARGGIVD
DAALAVALRDGTIAAAGLDVYEGEPSVHPALLEVPNVVLTPHIASATEKTRRAMANLAADNLIAALGEGPRAGQPPNPIN
PDVIGKPRA
>Mature_329_residues
MQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDALAARLADKDGALTAGDPVGAATLAAAPRLRVVANMAVGYNNFDM
AAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGHWQKWAYDGFLGTDIHGSTLGVIGMGRIGQALAR
RARGFGMQVIYHNRSRVAPEIEAELNAEYVSKDALLARADHVVLVLPYTQENHHTIGAAELAKMKPTATLTNIARGGIVD
DAALAVALRDGTIAAAGLDVYEGEPSVHPALLEVPNVVLTPHIASATEKTRRAMANLAADNLIAALGEGPRAGQPPNPIN
PDVIGKPRA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=253, Percent_Identity=39.1304347826087, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI23308577, Length=292, Percent_Identity=29.1095890410959, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI145580578, Length=250, Percent_Identity=35.2, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4557499, Length=250, Percent_Identity=35.2, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI145580575, Length=250, Percent_Identity=35.2, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI61743967, Length=249, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI4557497, Length=249, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI87082289, Length=325, Percent_Identity=43.0769230769231, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=28.968253968254, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1789279, Length=309, Percent_Identity=27.831715210356, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI87081824, Length=215, Percent_Identity=28.8372093023256, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=30.8196721311475, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=256, Percent_Identity=28.125, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=34.1463414634146, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320925, Length=274, Percent_Identity=30.2919708029197, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=327, Percent_Identity=28.1345565749235, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6321253, Length=307, Percent_Identity=23.7785016286645, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=144, Percent_Identity=31.25, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45551003, Length=318, Percent_Identity=38.3647798742138, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI45552429, Length=318, Percent_Identity=38.3647798742138, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI28574284, Length=318, Percent_Identity=38.3647798742138, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24585514, Length=318, Percent_Identity=38.3647798742138, Blast_Score=187, Evalue=9e-48,
Organism=Drosophila melanogaster, GI28574282, Length=318, Percent_Identity=38.3647798742138, Blast_Score=187, Evalue=9e-48,
Organism=Drosophila melanogaster, GI28574286, Length=258, Percent_Identity=39.5348837209302, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=36.9774919614148, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24585516, Length=262, Percent_Identity=34.7328244274809, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI19921140, Length=329, Percent_Identity=29.7872340425532, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI62472511, Length=252, Percent_Identity=34.1269841269841, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24646446, Length=257, Percent_Identity=33.4630350194552, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24646448, Length=257, Percent_Identity=33.4630350194552, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24646452, Length=257, Percent_Identity=33.4630350194552, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24646450, Length=257, Percent_Identity=33.4630350194552, Blast_Score=124, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34964; Mature: 34964

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDALAARLADKDGALTAGDPVGAATLA
CCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCCHHHHH
AAPRLRVVANMAVGYNNFDMAAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESE
HCCHHEEEEHHHCCCCCCCHHHCCCCHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHH
HWLRAGHWQKWAYDGFLGTDIHGSTLGVIGMGRIGQALARRARGFGMQVIYHNRSRVAPE
HHHHCCCCCCEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCEEEEEECCCCCCCH
IEAELNAEYVSKDALLARADHVVLVLPYTQENHHTIGAAELAKMKPTATLTNIARGGIVD
HHHHCCHHHHHHHHHHEECCCEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCC
DAALAVALRDGTIAAAGLDVYEGEPSVHPALLEVPNVVLTPHIASATEKTRRAMANLAAD
CCEEEEEEECCEEEEECCEEECCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
NLIAALGEGPRAGQPPNPINPDVIGKPRA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDALAARLADKDGALTAGDPVGAATLA
CCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCCHHHHH
AAPRLRVVANMAVGYNNFDMAAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESE
HCCHHEEEEHHHCCCCCCCHHHCCCCHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHH
HWLRAGHWQKWAYDGFLGTDIHGSTLGVIGMGRIGQALARRARGFGMQVIYHNRSRVAPE
HHHHCCCCCCEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCEEEEEECCCCCCCH
IEAELNAEYVSKDALLARADHVVLVLPYTQENHHTIGAAELAKMKPTATLTNIARGGIVD
HHHHCCHHHHHHHHHHEECCCEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCC
DAALAVALRDGTIAAAGLDVYEGEPSVHPALLEVPNVVLTPHIASATEKTRRAMANLAAD
CCEEEEEEECCEEEEECCEEECCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
NLIAALGEGPRAGQPPNPINPDVIGKPRA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA