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The map label for this gene is guaD [H]

Identifier: 116689041

GI number: 116689041

Start: 1125589

End: 1126908

Strand: Reverse

Name: guaD [H]

Synonym: Bcen2424_1018

Alternate gene names: 116689041

Gene position: 1126908-1125589 (Counterclockwise)

Preceding gene: 116689042

Following gene: 116689040

Centisome position: 32.35

GC content: 68.79

Gene sequence:

>1320_bases
ATGACGCAAACCGCTTTCCGTTCCCAACTGCTGACCTTCAACGGCGACCCGGCGCAATCGAGCCAGGCCACGAACTACGA
GACCGACGGGCTCCTGATCGTCGACGACGGCAAGGTCGTCGCAGCCGGCCCGTATGCGCCGCTCGCCGCGACCCTTGCGC
GCGACGCGGTGGTCCACGACCTGCGCGACAAGCTGATCGTGCCCGGCTTCATCGACACGCACATCCACTATCCGCAGACG
GACATGATCGCGTCGCCGGCGCCCGGCCTGTTGCCGTGGCTCGACAAGTACACGTTCCCGACCGAGCGCCAGTTCGGCGA
CCCCGAGCACGCGCGCGAAGTCGCCGACTTCTTCGTCGACGAACTGCTCGCGTGCGGCACGACGAGCGCACTCGTCTACT
GCACGGTGCACAAGCAGTCGGCCGATGCACTGTTCGCGGCGAGCGACGCGCGCGATCTGCGGATGATCGCGGGCAAGGTG
CTGATGGATCGCAACTGCCCCGAATTCCTGCGCGACACCGCGCAGTCGGGCTATGACGACAGCGCCGAGCTGATCGACCG
CTGGCACGGCAAGGGCCGCCAGATGTACGCGCTCACGCCGCGCTTCGCGCCGACGTCGACCGAGGCGCAGCTGGAAGCGT
GCGGCGAACTCGCGCGCCGCCATCCGGACGTGTTCGTGCAAAGCCACGTCGCGGAAAACGTCGACGAGGTGAAATGGGTG
GCCGAGCTGTTCCCCGGCCATCGCAGCTATCTCGACATCTACGACCGCTACGGGCTGCTGCGTCCGCGCGCGGTGTACGG
TCACTGCATCCATCTCGACGACGAGGATCGCCGCCGGATGGCCGAGACACGCACCGTCGTCGCGCACTGCCCGACATCCA
ACTTCTTCCTCGGCAGCGGCCTGTTCGACTTCGACAAGGCCGGCGAACATGACGTGCCGGTCACGCTCGCGACCGACGTC
GGCGGCGGCACGTCGTTCTCGATGCTGCAGACGATGAACGAGGCACACAAGGTCGCGCGGCTGTCGGGCCATCACCTGAC
CGCCACGCGGATGTTCTGGCTCGCGACGGCCGGCGCCGCGCAGGCGCTCGACCTCGCCGACACGGTCGGCACGCTCAAGC
CGCGCACCGAAGCCGACTTCGTCGTGCTCGATCCGCAGGCGACGCCGCTGCTCGCGCGCCGCACGAAGCGCGCGGAGTCG
CTCGAGGAACTGCTGTTCGCGTTCGCGCTGCTCGGCGACGACCGCGCGGTGTACCGCACCTATGCAGCCGGCGAACTCGT
GCACGAGCGCGGCGCCGCGCGCCGCCCGGCCGCCGCGTAA

Upstream 100 bases:

>100_bases
CACATCACGTGCGGCCACCGCTCGCGAAGCACCGTCGCGCCCCCGCGCGGCATCGATCGCTTTCTTCTGTTCGCCTTACC
TTGATGCAGGACCCTTCGTC

Downstream 100 bases:

>100_bases
CGTCCGCGGGTTGCCTGCGGGTTGCCTGCGGGTGCCCGTCCGGCATGCGCGGCCGCCTGGCCGCCGTGCATGCCGGCAAT
CGAAACCCTTCGGTACGCGG

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MTQTAFRSQLLTFNGDPAQSSQATNYETDGLLIVDDGKVVAAGPYAPLAATLARDAVVHDLRDKLIVPGFIDTHIHYPQT
DMIASPAPGLLPWLDKYTFPTERQFGDPEHAREVADFFVDELLACGTTSALVYCTVHKQSADALFAASDARDLRMIAGKV
LMDRNCPEFLRDTAQSGYDDSAELIDRWHGKGRQMYALTPRFAPTSTEAQLEACGELARRHPDVFVQSHVAENVDEVKWV
AELFPGHRSYLDIYDRYGLLRPRAVYGHCIHLDDEDRRRMAETRTVVAHCPTSNFFLGSGLFDFDKAGEHDVPVTLATDV
GGGTSFSMLQTMNEAHKVARLSGHHLTATRMFWLATAGAAQALDLADTVGTLKPRTEADFVVLDPQATPLLARRTKRAES
LEELLFAFALLGDDRAVYRTYAAGELVHERGAARRPAAA

Sequences:

>Translated_439_residues
MTQTAFRSQLLTFNGDPAQSSQATNYETDGLLIVDDGKVVAAGPYAPLAATLARDAVVHDLRDKLIVPGFIDTHIHYPQT
DMIASPAPGLLPWLDKYTFPTERQFGDPEHAREVADFFVDELLACGTTSALVYCTVHKQSADALFAASDARDLRMIAGKV
LMDRNCPEFLRDTAQSGYDDSAELIDRWHGKGRQMYALTPRFAPTSTEAQLEACGELARRHPDVFVQSHVAENVDEVKWV
AELFPGHRSYLDIYDRYGLLRPRAVYGHCIHLDDEDRRRMAETRTVVAHCPTSNFFLGSGLFDFDKAGEHDVPVTLATDV
GGGTSFSMLQTMNEAHKVARLSGHHLTATRMFWLATAGAAQALDLADTVGTLKPRTEADFVVLDPQATPLLARRTKRAES
LEELLFAFALLGDDRAVYRTYAAGELVHERGAARRPAAA
>Mature_438_residues
TQTAFRSQLLTFNGDPAQSSQATNYETDGLLIVDDGKVVAAGPYAPLAATLARDAVVHDLRDKLIVPGFIDTHIHYPQTD
MIASPAPGLLPWLDKYTFPTERQFGDPEHAREVADFFVDELLACGTTSALVYCTVHKQSADALFAASDARDLRMIAGKVL
MDRNCPEFLRDTAQSGYDDSAELIDRWHGKGRQMYALTPRFAPTSTEAQLEACGELARRHPDVFVQSHVAENVDEVKWVA
ELFPGHRSYLDIYDRYGLLRPRAVYGHCIHLDDEDRRRMAETRTVVAHCPTSNFFLGSGLFDFDKAGEHDVPVTLATDVG
GGTSFSMLQTMNEAHKVARLSGHHLTATRMFWLATAGAAQALDLADTVGTLKPRTEADFVVLDPQATPLLARRTKRAESL
EELLFAFALLGDDRAVYRTYAAGELVHERGAARRPAAA

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=379, Percent_Identity=33.245382585752, Blast_Score=201, Evalue=8e-52,
Organism=Escherichia coli, GI1789249, Length=416, Percent_Identity=50, Blast_Score=448, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6319963, Length=402, Percent_Identity=30.5970149253731, Blast_Score=196, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24643849, Length=452, Percent_Identity=31.4159292035398, Blast_Score=197, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 48422; Mature: 48291

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTAFRSQLLTFNGDPAQSSQATNYETDGLLIVDDGKVVAAGPYAPLAATLARDAVVHD
CCCHHHHHHHEEECCCCCCCCCCCCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHHH
LRDKLIVPGFIDTHIHYPQTDMIASPAPGLLPWLDKYTFPTERQFGDPEHAREVADFFVD
HHHCEECCCCHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
ELLACGTTSALVYCTVHKQSADALFAASDARDLRMIAGKVLMDRNCPEFLRDTAQSGYDD
HHHHCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
SAELIDRWHGKGRQMYALTPRFAPTSTEAQLEACGELARRHPDVFVQSHVAENVDEVKWV
HHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHH
AELFPGHRSYLDIYDRYGLLRPRAVYGHCIHLDDEDRRRMAETRTVVAHCPTSNFFLGSG
HHHCCCCHHHHHHHHHCCCCCCHHHEEEEEECCCHHHHHHHHHHEEEEECCCCCEEECCC
LFDFDKAGEHDVPVTLATDVGGGTSFSMLQTMNEAHKVARLSGHHLTATRMFWLATAGAA
CCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHCCCH
QALDLADTVGTLKPRTEADFVVLDPQATPLLARRTKRAESLEELLFAFALLGDDRAVYRT
HHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
YAAGELVHERGAARRPAAA
HHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TQTAFRSQLLTFNGDPAQSSQATNYETDGLLIVDDGKVVAAGPYAPLAATLARDAVVHD
CCHHHHHHHEEECCCCCCCCCCCCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHHH
LRDKLIVPGFIDTHIHYPQTDMIASPAPGLLPWLDKYTFPTERQFGDPEHAREVADFFVD
HHHCEECCCCHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
ELLACGTTSALVYCTVHKQSADALFAASDARDLRMIAGKVLMDRNCPEFLRDTAQSGYDD
HHHHCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
SAELIDRWHGKGRQMYALTPRFAPTSTEAQLEACGELARRHPDVFVQSHVAENVDEVKWV
HHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHH
AELFPGHRSYLDIYDRYGLLRPRAVYGHCIHLDDEDRRRMAETRTVVAHCPTSNFFLGSG
HHHCCCCHHHHHHHHHCCCCCCHHHEEEEEECCCHHHHHHHHHHEEEEECCCCCEEECCC
LFDFDKAGEHDVPVTLATDVGGGTSFSMLQTMNEAHKVARLSGHHLTATRMFWLATAGAA
CCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHCCCH
QALDLADTVGTLKPRTEADFVVLDPQATPLLARRTKRAESLEELLFAFALLGDDRAVYRT
HHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
YAAGELVHERGAARRPAAA
HHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]