Click here to switch to the map view.

The map label for this gene is pyrC [H]

Identifier: 116688698

GI number: 116688698

Start: 755470

End: 756564

Strand: Direct

Name: pyrC [H]

Synonym: Bcen2424_0675

Alternate gene names: 116688698

Gene position: 755470-756564 (Clockwise)

Preceding gene: 116688695

Following gene: 116688699

Centisome position: 21.68

GC content: 69.5

Gene sequence:

>1095_bases
ATGGCAAGCCCGTTCCTCACGACGCCTCCTATGACTGCCTCGAACGCTTCTTCCCCGGCGACGCTTTCGCTCGCCCGTCC
CGACGACTGGCACCTGCACCTGCGCGACGGCGACATGCTCGCCGCCGTGCTGCCGCACACCGCCCGCCAGTTCGGCCGCG
CCATCGTCATGCCGAACCTGAAGCCGCCGGTCACGACCACCGCGCAGGCGCAGGCCTATCGCGAGCGCATCCTCGCCGCG
CTGCCGGCCGGGATGACGTTCGAGCCGCTGATGACGCTGTACCTGACCGACAACACGCCGCCCGACGAAATCCGCCGCGC
GCGCGAAAGCGGCTTCGTGCACGGCGTGAAGCTGTATCCGGCAGGCGCCACGACGAATTCCGACCATGGCGTCACCGATC
TCGCGAAATGCGCGAAGACGCTCGAGGCGATGCAGGACACCGGCATGCCGCTGCTCGTGCACGGCGAGGTGACCGATGCG
TCGATCGACCTGTTCGACCGCGAGAAGGTGTTCATCGACCGCGTGATGACGCCGCTGCGCCGCGATTTCCCGGGCCTGAA
GGTCGTGTTCGAGCACATCACGACGAAGGACGCGGCCGACTACGTGCGCGATGCCGACGCGGCGCCCGGCCTGCTCGGCG
CGACGATCACCGCGCATCACCTGCTGTACAACCGCAACGCGCTGTTCGTCGGCGGGATTCGCCCGCATTACTACTGCCTG
CCGGTGCTCAAGCGCGAGACGCATCGCGTGGCGCTGGTCGAGGCCGCGACGTCGGGCAACCCGCGCTTCTTCCTCGGCAC
CGACAGCGCGCCGCATGCGCGCGACGCGAAGGAAACCGCGTGCGGCTGCGCGGGCTGCTACACGGCGCTGCACGCGCTCG
AACTGTACGCGGAAGCGTTCGACACGGCCGGCGCGCTCGACAAGCTGGAAGGGTTCGCGAGCTTCTTCGGCGCCGATTTC
TACGGGCTGCCGCGCAGCGCCGAGACGGTCACGCTGCGCCGCGAGCCGTGGGAACTGCCGCGCGAGATCCTCGCGGGCGA
TACGCCGGTCGTGCCGCTGCGCGGCGGCGAGACGATCGGCTGGAAGCTGGCGTGA

Upstream 100 bases:

>100_bases
CACCGAGCCCTGAGCGGTAAAAAGCGGATTCCGCTGGCCAAAGGCCCCGTGTTGCGGTTTGCCGTCAGTCGGCCCGCGCA
CGCGCGTTCCGGCCCCGCCG

Downstream 100 bases:

>100_bases
ACGGCGCGCCGCCGCGCGAACCCGGCCTTGCGGCCGGTCGCGCGGCGGCGGATTTTGCGCGGATCGACTGGTCCGCGCCG
TGGCTCGCGCCTTACGCGGA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MASPFLTTPPMTASNASSPATLSLARPDDWHLHLRDGDMLAAVLPHTARQFGRAIVMPNLKPPVTTTAQAQAYRERILAA
LPAGMTFEPLMTLYLTDNTPPDEIRRARESGFVHGVKLYPAGATTNSDHGVTDLAKCAKTLEAMQDTGMPLLVHGEVTDA
SIDLFDREKVFIDRVMTPLRRDFPGLKVVFEHITTKDAADYVRDADAAPGLLGATITAHHLLYNRNALFVGGIRPHYYCL
PVLKRETHRVALVEAATSGNPRFFLGTDSAPHARDAKETACGCAGCYTALHALELYAEAFDTAGALDKLEGFASFFGADF
YGLPRSAETVTLRREPWELPREILAGDTPVVPLRGGETIGWKLA

Sequences:

>Translated_364_residues
MASPFLTTPPMTASNASSPATLSLARPDDWHLHLRDGDMLAAVLPHTARQFGRAIVMPNLKPPVTTTAQAQAYRERILAA
LPAGMTFEPLMTLYLTDNTPPDEIRRARESGFVHGVKLYPAGATTNSDHGVTDLAKCAKTLEAMQDTGMPLLVHGEVTDA
SIDLFDREKVFIDRVMTPLRRDFPGLKVVFEHITTKDAADYVRDADAAPGLLGATITAHHLLYNRNALFVGGIRPHYYCL
PVLKRETHRVALVEAATSGNPRFFLGTDSAPHARDAKETACGCAGCYTALHALELYAEAFDTAGALDKLEGFASFFGADF
YGLPRSAETVTLRREPWELPREILAGDTPVVPLRGGETIGWKLA
>Mature_363_residues
ASPFLTTPPMTASNASSPATLSLARPDDWHLHLRDGDMLAAVLPHTARQFGRAIVMPNLKPPVTTTAQAQAYRERILAAL
PAGMTFEPLMTLYLTDNTPPDEIRRARESGFVHGVKLYPAGATTNSDHGVTDLAKCAKTLEAMQDTGMPLLVHGEVTDAS
IDLFDREKVFIDRVMTPLRRDFPGLKVVFEHITTKDAADYVRDADAAPGLLGATITAHHLLYNRNALFVGGIRPHYYCLP
VLKRETHRVALVEAATSGNPRFFLGTDSAPHARDAKETACGCAGCYTALHALELYAEAFDTAGALDKLEGFASFFGADFY
GLPRSAETVTLRREPWELPREILAGDTPVVPLRGGETIGWKLA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=343, Percent_Identity=56.8513119533528, Blast_Score=393, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6323452, Length=356, Percent_Identity=35.6741573033708, Blast_Score=191, Evalue=1e-49,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 39608; Mature: 39476

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPFLTTPPMTASNASSPATLSLARPDDWHLHLRDGDMLAAVLPHTARQFGRAIVMPNL
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCEEECCCC
KPPVTTTAQAQAYRERILAALPAGMTFEPLMTLYLTDNTPPDEIRRARESGFVHGVKLYP
CCCCCCCHHHHHHHHHHHHHCCCCCCHHCEEEEEECCCCCHHHHHHHHHCCCEEEEEEEE
AGATTNSDHGVTDLAKCAKTLEAMQDTGMPLLVHGEVTDASIDLFDREKVFIDRVMTPLR
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEHHCCHHHHHHHHHHHHH
RDFPGLKVVFEHITTKDAADYVRDADAAPGLLGATITAHHLLYNRNALFVGGIRPHYYCL
HCCCCHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEE
PVLKRETHRVALVEAATSGNPRFFLGTDSAPHARDAKETACGCAGCYTALHALELYAEAF
HHHHCCCCEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DTAGALDKLEGFASFFGADFYGLPRSAETVTLRREPWELPREILAGDTPVVPLRGGETIG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCEEEECCCCCCC
WKLA
EEEC
>Mature Secondary Structure 
ASPFLTTPPMTASNASSPATLSLARPDDWHLHLRDGDMLAAVLPHTARQFGRAIVMPNL
CCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCEEECCCC
KPPVTTTAQAQAYRERILAALPAGMTFEPLMTLYLTDNTPPDEIRRARESGFVHGVKLYP
CCCCCCCHHHHHHHHHHHHHCCCCCCHHCEEEEEECCCCCHHHHHHHHHCCCEEEEEEEE
AGATTNSDHGVTDLAKCAKTLEAMQDTGMPLLVHGEVTDASIDLFDREKVFIDRVMTPLR
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEHHCCHHHHHHHHHHHHH
RDFPGLKVVFEHITTKDAADYVRDADAAPGLLGATITAHHLLYNRNALFVGGIRPHYYCL
HCCCCHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEE
PVLKRETHRVALVEAATSGNPRFFLGTDSAPHARDAKETACGCAGCYTALHALELYAEAF
HHHHCCCCEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DTAGALDKLEGFASFFGADFYGLPRSAETVTLRREPWELPREILAGDTPVVPLRGGETIG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCEEEECCCCCCC
WKLA
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA