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The map label for this gene is edd [H]

Identifier: 116688683

GI number: 116688683

Start: 733738

End: 735594

Strand: Direct

Name: edd [H]

Synonym: Bcen2424_0660

Alternate gene names: 116688683

Gene position: 733738-735594 (Clockwise)

Preceding gene: 116688681

Following gene: 116688684

Centisome position: 21.06

GC content: 68.87

Gene sequence:

>1857_bases
ATGACGTCGCTGCACCCCACCCTGGCGAAGGTCACCGAACGCGTGATCGTCCGCAGCCAATCGACCCGTTCCGCCTATCT
GCAGCGCATCGACGGCGCGCAAGGCAAGTTCCCGGCACGCGGCGCGCTGTCGTGCGCGAACCTCGCGCACGGCTTCGCGG
GCCTCGAGGGCAACGACAAGTTCGCGATCAAGGCGATCCGCGAGCCGAACATCGGCATCGTGTCCTCGTACAACGAGATG
CTGTCCGCGCACGCGCCGTACAAGGATTTCCCCGAAATCATCAAGGCGGCCGCGCGCGAGAACGGCGGGGTCGCGCAGTT
CGCGGGCGGCGTGCCGGCGATGTGCGACGGCGTCACGCAGGGCAACCCGGGGATGGAGCTGTCGCTGTTCTCGCGCGAGG
CGATCGCGATGGGCACGGCGATCGCGCTCACGCACAACATGTTCGACGCGGCGCTCTGCCTCGGCATCTGCGACAAGATC
GTGCCGGGCCTCTTGATCGGCGCGCTGCAGTTCGGCCACCTGCCGACGATCTTCGTGCCGGCCGGCCCGATGACGAGCGG
CCTGTCGAACGACGACAAGGCGAAGATCCGCCAGCAGTTCGCGACCGGCCAGGTCGGCCGCGACGCGCTGCTCGAAGCCG
AATCGGCTGCATATCACGGCCACGGCACCTGCACGTTCTACGGCACCGCGAACAGCAACCAGATGCTGATGGAGCTGATG
GGGCTGCACCTGCCGGGCTCGGCCTTCGTTCATCCGCATACGCCGCTGCGCACCGCGCTGACGGCCGAGGCCGCGCGCCG
CGTGCTTGACCTGACCGTCGAGCGCGGTCACTACACGCCGATCGGCCATGTGATCGACGAAAAGGCGATCGTCAACGGCA
TCGTCGCGCTGCTCGCGACGGGCGGCTCGACCAACCACACGCTGCACTTGGTCGCGATCGCGCGCGCGGCCGGCATCCTG
ATCGACTGGAACGACTTCGACGAGCTGTCTGCCGTCGTGCCGCTGCTCGCGAAGATCTACCCGAACGGCAAGGCCGACGT
GAACCATTTCCACGCGGCAGGCGGTGTCGCGTTCCTGGTACGCAACCTGCTCGAAGGCGGGCTGCTGCACGAGGACGTGA
CGACGGTCGCAGGCAAGGGGCTTGCGCACTACACGAAGGAGCCGAAGCTGATCGACGGCAAGCTGACGTGGGTCGACGGC
GCGGCCGAGAGCCACGACACGAAGGTGCTGCGCGGCATTCGCGACCCGTTCCAGCCGGACGGCGGTCTGCGCCTGATGCA
GGGCCGGCTCGGCCGCGGCGTGATCAAGATCTCGGCGGTCGCGCCGGAGCACCGCAAGGTGACGGCGCCCGCGATCGTGT
TCGACTCGCAGGAAGCCGTGCAGGAAGCGTTCGATCGCGGCGAACTGAAGCGCGATTTCGTCGCGGTGGTGCGCTTCCAG
GGCGCGCGCGCCAACGGCATGCCCGAGCTGCACCGTTTGACGCCGCTGCTCGGCGTGCTGCAGGATCAGGGCTTCCACGT
TGCGCTGGTGACCGACGGCCGCATGTCGGGCGCATCGGGCAAGGTGCCGGCCGTGATCCACGTGTCGCCGGAGGCGCTGC
TGGCCGGCCCGATCGGCAAGGTGAAGACGGGCGACATGCTCGTGATCGACGCCGAAGCCGGCGTGCTCGACATCGAGGTC
GACGACGCCGAGTGGCACGCGCGCCCGGTCGCGCAGCCGCGGCACCAGGCCGAGAACGAAGTCGGTTTCGGGCGCGAACT
GTTCGGCGTGTTCCGCGCGGCCGCGGCGCCGGCCGAGCAGGGCGCATCGGTTTTCGGGACGCTGGTCGGCGAAACGGCCG
CTCACGTCACCGCATGA

Upstream 100 bases:

>100_bases
TTGTAGTTTTTCTACTAGACTGCCTTCGTTCGATCGACGAAGCTCGACCGTCCCTACGATTCCAACCGCCGGTGTCGGCC
GGCATACAGGAGCGCCCAGC

Downstream 100 bases:

>100_bases
ATTTCAAGGAGCCAATTCAATGAAGACGATTGCTGAAATCGTGAAGCTGGGCCCGGTCATTCCGGTGCTCGCATTCGACT
CGGTCGAGCAGGGCGAAAAC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MTSLHPTLAKVTERVIVRSQSTRSAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGNDKFAIKAIREPNIGIVSSYNEM
LSAHAPYKDFPEIIKAAARENGGVAQFAGGVPAMCDGVTQGNPGMELSLFSREAIAMGTAIALTHNMFDAALCLGICDKI
VPGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
GLHLPGSAFVHPHTPLRTALTAEAARRVLDLTVERGHYTPIGHVIDEKAIVNGIVALLATGGSTNHTLHLVAIARAAGIL
IDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLVRNLLEGGLLHEDVTTVAGKGLAHYTKEPKLIDGKLTWVDG
AAESHDTKVLRGIRDPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQEAFDRGELKRDFVAVVRFQ
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLAGPIGKVKTGDMLVIDAEAGVLDIEV
DDAEWHARPVAQPRHQAENEVGFGRELFGVFRAAAAPAEQGASVFGTLVGETAAHVTA

Sequences:

>Translated_618_residues
MTSLHPTLAKVTERVIVRSQSTRSAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGNDKFAIKAIREPNIGIVSSYNEM
LSAHAPYKDFPEIIKAAARENGGVAQFAGGVPAMCDGVTQGNPGMELSLFSREAIAMGTAIALTHNMFDAALCLGICDKI
VPGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
GLHLPGSAFVHPHTPLRTALTAEAARRVLDLTVERGHYTPIGHVIDEKAIVNGIVALLATGGSTNHTLHLVAIARAAGIL
IDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLVRNLLEGGLLHEDVTTVAGKGLAHYTKEPKLIDGKLTWVDG
AAESHDTKVLRGIRDPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQEAFDRGELKRDFVAVVRFQ
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLAGPIGKVKTGDMLVIDAEAGVLDIEV
DDAEWHARPVAQPRHQAENEVGFGRELFGVFRAAAAPAEQGASVFGTLVGETAAHVTA
>Mature_617_residues
TSLHPTLAKVTERVIVRSQSTRSAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGNDKFAIKAIREPNIGIVSSYNEML
SAHAPYKDFPEIIKAAARENGGVAQFAGGVPAMCDGVTQGNPGMELSLFSREAIAMGTAIALTHNMFDAALCLGICDKIV
PGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELMG
LHLPGSAFVHPHTPLRTALTAEAARRVLDLTVERGHYTPIGHVIDEKAIVNGIVALLATGGSTNHTLHLVAIARAAGILI
DWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLVRNLLEGGLLHEDVTTVAGKGLAHYTKEPKLIDGKLTWVDGA
AESHDTKVLRGIRDPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQEAFDRGELKRDFVAVVRFQG
ARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLAGPIGKVKTGDMLVIDAEAGVLDIEVD
DAEWHARPVAQPRHQAENEVGFGRELFGVFRAAAAPAEQGASVFGTLVGETAAHVTA

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=58.8039867109634, Blast_Score=716, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=585, Percent_Identity=31.1111111111111, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI2367371, Length=480, Percent_Identity=31.6666666666667, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1786464, Length=505, Percent_Identity=30.8910891089109, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322476, Length=500, Percent_Identity=30, Blast_Score=187, Evalue=5e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 65372; Mature: 65240

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLHPTLAKVTERVIVRSQSTRSAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGNDK
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
FAIKAIREPNIGIVSSYNEMLSAHAPYKDFPEIIKAAARENGGVAQFAGGVPAMCDGVTQ
EEEEEECCCCCCEEECHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHCCCCC
GNPGMELSLFSREAIAMGTAIALTHNMFDAALCLGICDKIVPGLLIGALQFGHLPTIFVP
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCEECCCEEEEEEECCCCCHHHHHHH
GLHLPGSAFVHPHTPLRTALTAEAARRVLDLTVERGHYTPIGHVIDEKAIVNGIVALLAT
CCCCCCCCEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCC
GGSTNHTLHLVAIARAAGILIDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLV
CCCCCCEEEEEEEEHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
RNLLEGGLLHEDVTTVAGKGLAHYTKEPKLIDGKLTWVDGAAESHDTKVLRGIRDPFQPD
HHHHCCCCCHHHHHHHHCCCHHHHCCCCCEECCEEEEECCCCCCHHHHHHHHHCCCCCCC
GGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQEAFDRGELKRDFVAVVRFQ
CCCEEECCCCCCCEEEEEEECCCCCCEECCEEEECCHHHHHHHHHHCCHHHHHHHHHEEC
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLAGPIGK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCHHHEECCCCC
VKTGDMLVIDAEAGVLDIEVDDAEWHARPVAQPRHQAENEVGFGRELFGVFRAAAAPAEQ
CCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCHHC
GASVFGTLVGETAAHVTA
CHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSLHPTLAKVTERVIVRSQSTRSAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGNDK
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
FAIKAIREPNIGIVSSYNEMLSAHAPYKDFPEIIKAAARENGGVAQFAGGVPAMCDGVTQ
EEEEEECCCCCCEEECHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHCCCCC
GNPGMELSLFSREAIAMGTAIALTHNMFDAALCLGICDKIVPGLLIGALQFGHLPTIFVP
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCEECCCEEEEEEECCCCCHHHHHHH
GLHLPGSAFVHPHTPLRTALTAEAARRVLDLTVERGHYTPIGHVIDEKAIVNGIVALLAT
CCCCCCCCEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCC
GGSTNHTLHLVAIARAAGILIDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLV
CCCCCCEEEEEEEEHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
RNLLEGGLLHEDVTTVAGKGLAHYTKEPKLIDGKLTWVDGAAESHDTKVLRGIRDPFQPD
HHHHCCCCCHHHHHHHHCCCHHHHCCCCCEECCEEEEECCCCCCHHHHHHHHHCCCCCCC
GGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQEAFDRGELKRDFVAVVRFQ
CCCEEECCCCCCCEEEEEEECCCCCCEECCEEEECCHHHHHHHHHHCCHHHHHHHHHEEC
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLAGPIGK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCHHHEECCCCC
VKTGDMLVIDAEAGVLDIEVDDAEWHARPVAQPRHQAENEVGFGRELFGVFRAAAAPAEQ
CCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCHHC
GASVFGTLVGETAAHVTA
CHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]