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The map label for this gene is proA [H]

Identifier: 116688680

GI number: 116688680

Start: 730748

End: 732055

Strand: Direct

Name: proA [H]

Synonym: Bcen2424_0657

Alternate gene names: 116688680

Gene position: 730748-732055 (Clockwise)

Preceding gene: 116688679

Following gene: 116688681

Centisome position: 20.97

GC content: 67.89

Gene sequence:

>1308_bases
ATGCCGCCCCGCGCGGCTCGCTTCTCGAGTCACACGATGGATATCGATCAGTACATGACCGACCTGGGCCGTCGCGCCCG
GCACGCTTCCCGCGCGATGGCGCGCGCCAGCACGGCCGCGAAGAACGCGGCGCTCGACGCCGTGGCCCGCGCGATCGAAC
GCGATGCGCAGGCGCTGAAGGACGCGAATGCGCGCGACGTCGCCCGTGCCCGTGAAAAGGGGCTCGATGCGGCGTTCATC
GACCGCCTGACGCTGTCGGACAAGGCGCTGAACACGATGGTCGAGGGGCTGCGCCAGGTCGCGTCGCTGGCCGATCCGAT
CGGCGAGATCGGCAACCTCAAGTTCCGCCCGAGCGGAATCCAGGTCGGCCAGATGCGCGTGCCGCTCGGCGTGATCGGCA
TCATCTACGAGTCGCGCCCGAACGTGACGATCGACGCGGCCGCGCTGTGCCTGAAGTCGGGCAACGCGACGATCCTGCGC
GGCGGCTCCGAGGCGCTCGAATCGAACGCGGCGCTCGCGAAGCTGATCGGCGAAGGGCTCGAGGCGGCCGGCCTGCCGCA
GGACGCGGTGCAGGTCGTCGCGACGGCCGATCGCGCGGCGGTCGGCAAGCTGATCACGATGACCGAATACGTCGACGTGA
TCGTGCCGCGCGGCGGCAAGAGCCTGATCGAACGGCTGATCAACGAGGCGCGCGTGCCGATGATCAAGCACCTCGACGGC
ATCTGCCACGTGTACGTCGACGATCGCGCCGATCTCGCGAAGGCGCTGACCGTCTGCGACAACGCGAAGACGCACCGCTA
CGGCACCTGCAACACGATGGAGACGCTGCTCGTCGCGAGCGGCATCGCCGCGAAGCTGCTGCCACCGCTCGGCAAGCTGT
ATCGCGACAAGCAGGTCGAGCTGCGCGTCGATGCGGCCGCGCGCGCGGTGCTCGCCGATGCGGGCGTCGGCCCGCTCGTC
GACGTGACGGAAGAAGACTGGCATACCGAATATCTGGCACCGGTGCTCGCGATCAAGGTCGTCGACGGGCTCGACGCCGC
GATCGAGCACATCAACCATTACGGCTCGCATCACACGGATGCGATCGTCACCGAGGATCACGACCGCGCGATGCGGTTCC
TGCGCGAAGTCGATTCGGCGAGCGTGATGGTCAATGCGTCGACGCGTTTCGCGGATGGCTTCGAATTCGGCCTCGGCGCG
GAAATCGGCATCTCGAACGACAAGCTGCACGCACGCGGCCCGGTCGGCCTGGAAGGGCTCACGTCGCTGAAGTACGTGGT
GCTCGGGCACGGCGAAGGCCGTCAGTAA

Upstream 100 bases:

>100_bases
CCGCTTACAATGTTTGGATGACCGGGGCGCCGCCCTGCGCGGCGCGGTTTTGCGGCCGTTACCCCGCCCGGGTGGCCGTC
CCCCGCTTCCCCACGAATTC

Downstream 100 bases:

>100_bases
GTCAACAGCGAGGCGCACAACCGATGGCAATGCTCTGGGTCAAGACGTTCCATGTCGTTCTGATCGCCGCGTGGTTCGCG
GGGCTGTTCTACCTGCCGCG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MPPRAARFSSHTMDIDQYMTDLGRRARHASRAMARASTAAKNAALDAVARAIERDAQALKDANARDVARAREKGLDAAFI
DRLTLSDKALNTMVEGLRQVASLADPIGEIGNLKFRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILR
GGSEALESNAALAKLIGEGLEAAGLPQDAVQVVATADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDG
ICHVYVDDRADLAKALTVCDNAKTHRYGTCNTMETLLVASGIAAKLLPPLGKLYRDKQVELRVDAAARAVLADAGVGPLV
DVTEEDWHTEYLAPVLAIKVVDGLDAAIEHINHYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGA
EIGISNDKLHARGPVGLEGLTSLKYVVLGHGEGRQ

Sequences:

>Translated_435_residues
MPPRAARFSSHTMDIDQYMTDLGRRARHASRAMARASTAAKNAALDAVARAIERDAQALKDANARDVARAREKGLDAAFI
DRLTLSDKALNTMVEGLRQVASLADPIGEIGNLKFRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILR
GGSEALESNAALAKLIGEGLEAAGLPQDAVQVVATADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDG
ICHVYVDDRADLAKALTVCDNAKTHRYGTCNTMETLLVASGIAAKLLPPLGKLYRDKQVELRVDAAARAVLADAGVGPLV
DVTEEDWHTEYLAPVLAIKVVDGLDAAIEHINHYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGA
EIGISNDKLHARGPVGLEGLTSLKYVVLGHGEGRQ
>Mature_434_residues
PPRAARFSSHTMDIDQYMTDLGRRARHASRAMARASTAAKNAALDAVARAIERDAQALKDANARDVARAREKGLDAAFID
RLTLSDKALNTMVEGLRQVASLADPIGEIGNLKFRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRG
GSEALESNAALAKLIGEGLEAAGLPQDAVQVVATADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDGI
CHVYVDDRADLAKALTVCDNAKTHRYGTCNTMETLLVASGIAAKLLPPLGKLYRDKQVELRVDAAARAVLADAGVGPLVD
VTEEDWHTEYLAPVLAIKVVDGLDAAIEHINHYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAE
IGISNDKLHARGPVGLEGLTSLKYVVLGHGEGRQ

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=412, Percent_Identity=37.8640776699029, Blast_Score=248, Evalue=8e-66,
Organism=Homo sapiens, GI21361368, Length=412, Percent_Identity=37.8640776699029, Blast_Score=248, Evalue=1e-65,
Organism=Escherichia coli, GI1786438, Length=411, Percent_Identity=45.7420924574209, Blast_Score=359, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17569969, Length=417, Percent_Identity=34.5323741007194, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17569967, Length=417, Percent_Identity=34.5323741007194, Blast_Score=245, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6324899, Length=434, Percent_Identity=37.5576036866359, Blast_Score=288, Evalue=2e-78,
Organism=Drosophila melanogaster, GI21357643, Length=418, Percent_Identity=38.0382775119617, Blast_Score=263, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 46525; Mature: 46394

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPRAARFSSHTMDIDQYMTDLGRRARHASRAMARASTAAKNAALDAVARAIERDAQALK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DANARDVARAREKGLDAAFIDRLTLSDKALNTMVEGLRQVASLADPIGEIGNLKFRPSGI
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCC
QVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNAALAKLIGEGL
EECEEECCCEEEEEEEECCCCEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCH
EAAGLPQDAVQVVATADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDG
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHCCC
ICHVYVDDRADLAKALTVCDNAKTHRYGTCNTMETLLVASGIAAKLLPPLGKLYRDKQVE
EEEEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEE
LRVDAAARAVLADAGVGPLVDVTEEDWHTEYLAPVLAIKVVDGLDAAIEHINHYGSHHTD
EEEHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHARGPVGLEGL
EEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHH
TSLKYVVLGHGEGRQ
CCEEEEEEECCCCCC
>Mature Secondary Structure 
PPRAARFSSHTMDIDQYMTDLGRRARHASRAMARASTAAKNAALDAVARAIERDAQALK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DANARDVARAREKGLDAAFIDRLTLSDKALNTMVEGLRQVASLADPIGEIGNLKFRPSGI
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCC
QVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNAALAKLIGEGL
EECEEECCCEEEEEEEECCCCEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCH
EAAGLPQDAVQVVATADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDG
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHCCC
ICHVYVDDRADLAKALTVCDNAKTHRYGTCNTMETLLVASGIAAKLLPPLGKLYRDKQVE
EEEEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEE
LRVDAAARAVLADAGVGPLVDVTEEDWHTEYLAPVLAIKVVDGLDAAIEHINHYGSHHTD
EEEHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHARGPVGLEGL
EEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHH
TSLKYVVLGHGEGRQ
CCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA