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The map label for this gene is hpd [H]

Identifier: 116688345

GI number: 116688345

Start: 366749

End: 367846

Strand: Reverse

Name: hpd [H]

Synonym: Bcen2424_0321

Alternate gene names: 116688345

Gene position: 367846-366749 (Counterclockwise)

Preceding gene: 116688347

Following gene: 116688343

Centisome position: 10.56

GC content: 63.21

Gene sequence:

>1098_bases
ATGCAGATCCCCACCTGGGACAACCCCGTCGGCACCGACGGCTTCGAATTCATCGAATACACGGCACCGGACCCGAAAGC
ACTCGGACAACTGTTCGAACGGATGGGTTTCACCGCGATCGCGCGCCACCGCCACAAGGACGTGACGGTGTACCGCCAGG
GCGACATCAACTTCATCATCAACGCCGAACCCGATTCGTTCGCGCAACGCTTCGCGCGGCTGCACGGCCCGTCGATCTGC
GCGATCGCGTTCCGCGTGCAGGACGCGGCAAAGGCGTACCAGCGTGCGCTCGAACTCGGCGCATGGGGCTTCGACAACAA
GACGGGCCCGATGGAGCTGAACATCCCGGCGATCAAGGGCATCGGCGATTCGCTGATCTATTTCGTCGACCGCTGGCGCG
GCAAGAACGGCGCGCAGCCGGGCGCGATCGGCGACATCAGCATCTATGACGTCGACTTCGAGCCGATTGCCGGCGCGAAC
CCGAATCCGGTCGGCCACGGCCTCACCTACATCGACCACCTGACGCACAACGTGCATCGCGGCCGCATGCAGGAATGGGC
CGAGTTCTACGAGCGCCTGTTCAACTTCCGCGAAGTGCGCTACTTCGACATCGAAGGCAAGGTGACGGGCGTGAAGTCGA
AGGCGATGACGTCGCCGTGCGGCAAGATCCGCATCCCGATCAACGAGGAAGGCTCGGACACGGCCGGCCAGATCCAGGAG
TACCTGGACGCGTATCACGGCGAAGGCATCCAGCACATCGCGCTCGGCGCGAGCGACATCTACCAGGCGGTCGACGGGCT
GCGCAGCAAGGAAGTGAAGCTGCTCGACACGATCGACACGTATTACGAGCTGGTCGATCGCCGCGTGCCGAACCACGGCG
AATCGCTGGACGAGCTGAAGAAGCGCAAGATCCTGATCGACGGCGCGCGCGACGACCTGCTGCTGCAGATCTTCACCGAG
AACCAGATCGGCCCGATCTTCTTCGAGATCATCCAGCGCAAGGGCAACCAGGGCTTCGGCGAAGGCAACTTCAAGGCGCT
GTTCGAATCGATCGAGCTCGACCAGATCCGTCGCGGCGTCGTGCAGGACAAGGCCTGA

Upstream 100 bases:

>100_bases
ACTCGTCGCGCACGCTCATGGCGGGCACGGCCGTCGACATCGAACCCCGCCGGGCACGCGCACGCCGCCCCGGCCGATCG
CCCCGCACAGGAGACACGAC

Downstream 100 bases:

>100_bases
CGCTTTCCGCCGCGCGGCGGCGGCGCCGGGCAACCCGGGCGGCCGCACCCTCCGCGCAGCGCAAAGAAAAAGGGCGGGAA
TCCGAGGATTCCCGCCCTTT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAIARHRHKDVTVYRQGDINFIINAEPDSFAQRFARLHGPSIC
AIAFRVQDAAKAYQRALELGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAQPGAIGDISIYDVDFEPIAGAN
PNPVGHGLTYIDHLTHNVHRGRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
YLDAYHGEGIQHIALGASDIYQAVDGLRSKEVKLLDTIDTYYELVDRRVPNHGESLDELKKRKILIDGARDDLLLQIFTE
NQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGVVQDKA

Sequences:

>Translated_365_residues
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAIARHRHKDVTVYRQGDINFIINAEPDSFAQRFARLHGPSIC
AIAFRVQDAAKAYQRALELGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAQPGAIGDISIYDVDFEPIAGAN
PNPVGHGLTYIDHLTHNVHRGRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
YLDAYHGEGIQHIALGASDIYQAVDGLRSKEVKLLDTIDTYYELVDRRVPNHGESLDELKKRKILIDGARDDLLLQIFTE
NQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGVVQDKA
>Mature_365_residues
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAIARHRHKDVTVYRQGDINFIINAEPDSFAQRFARLHGPSIC
AIAFRVQDAAKAYQRALELGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAQPGAIGDISIYDVDFEPIAGAN
PNPVGHGLTYIDHLTHNVHRGRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
YLDAYHGEGIQHIALGASDIYQAVDGLRSKEVKLLDTIDTYYELVDRRVPNHGESLDELKKRKILIDGARDDLLLQIFTE
NQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGVVQDKA

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=353, Percent_Identity=29.4617563739377, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI285002264, Length=350, Percent_Identity=29.1428571428571, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI14249394, Length=379, Percent_Identity=23.7467018469657, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17555220, Length=226, Percent_Identity=37.6106194690265, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17550752, Length=204, Percent_Identity=32.3529411764706, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21356105, Length=307, Percent_Identity=33.5504885993485, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24667510, Length=307, Percent_Identity=33.5504885993485, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 41137; Mature: 41137

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAIARHRHKDVTVYRQGDINFII
CCCCCCCCCCCCCCHHEEEECCCCHHHHHHHHHHHCHHHHHHHCCCCEEEEEECCEEEEE
NAEPDSFAQRFARLHGPSICAIAFRVQDAAKAYQRALELGAWGFDNKTGPMELNIPAIKG
ECCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHC
IGDSLIYFVDRWRGKNGAQPGAIGDISIYDVDFEPIAGANPNPVGHGLTYIDHLTHNVHR
CCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
GRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
HHHHHHHHHHHHHHCHHHEEEEEECCEEECCCHHHHCCCCCEEEEECCCCCCCHHHHHHH
YLDAYHGEGIQHIALGASDIYQAVDGLRSKEVKLLDTIDTYYELVDRRVPNHGESLDELK
HHHHHCCCCCEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
KRKILIDGARDDLLLQIFTENQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGV
HCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHHHHH
VQDKA
HCCCC
>Mature Secondary Structure
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAIARHRHKDVTVYRQGDINFII
CCCCCCCCCCCCCCHHEEEECCCCHHHHHHHHHHHCHHHHHHHCCCCEEEEEECCEEEEE
NAEPDSFAQRFARLHGPSICAIAFRVQDAAKAYQRALELGAWGFDNKTGPMELNIPAIKG
ECCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHC
IGDSLIYFVDRWRGKNGAQPGAIGDISIYDVDFEPIAGANPNPVGHGLTYIDHLTHNVHR
CCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
GRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
HHHHHHHHHHHHHHCHHHEEEEEECCEEECCCHHHHCCCCCEEEEECCCCCCCHHHHHHH
YLDAYHGEGIQHIALGASDIYQAVDGLRSKEVKLLDTIDTYYELVDRRVPNHGESLDELK
HHHHHCCCCCEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
KRKILIDGARDDLLLQIFTENQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGV
HCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHHHHH
VQDKA
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]