Click here to switch to the map view.

The map label for this gene is macA [H]

Identifier: 116626959

GI number: 116626959

Start: 9947736

End: 9949163

Strand: Direct

Name: macA [H]

Synonym: Acid_7936

Alternate gene names: 116626959

Gene position: 9947736-9949163 (Clockwise)

Preceding gene: 116626958

Following gene: 116626960

Centisome position: 99.82

GC content: 59.45

Gene sequence:

>1428_bases
GTGAAGAGCAAGTGGAAGATTGTCATCGGCCTTGTGGTTGTTCTGCTCCTCGCCATCGGCGTTTACGCCAGCACGGTCCT
CAGCAAAAAGGGCCTGGTCACGGTTCAGACCGGCAATGTTGTGCGCCAGGATCTGACCAGCCTTGTGACTGCCTCCGGCG
AGGTTAAGCCTAAGAATTACATCAACATCGGCGCCAACGCACAGGGCGAGCTCAAAGAAATTCTCGTCAAGGAAGGCGAC
CGTGTCCGGCGTGGCCAGTTGCTGGCGCGCATCGAGAACGTGCAGCCCGAAGCGGACGTGGATGCCCAGCGCGCGACGCT
CAATTCCGCCGAGGCCGATTCGGCCGCGGCTGAGGCCGGCCTGAAGGCCGCCGACGAAAATCTTCGCACACTGCAGGCCC
AGATCGATAAGGATAAGGCCGACCTCGAACACACCAAGGCCGACTTCGATCGCAGCGAGTCGCTCTACAAGGAGCACTTG
CTGGCCAAACAGGATTGGGAGCTCAAGAAGTTTACATTTGAGGCGCAGCGGGCCACCGTGACGCAGAGCGAAATGCGGCT
GGTGCAGGCGCGCGCCCAGCGTGAACAGAGCCTGGCGCAGCTTGCCTCGGCGCAGAAGCGCATCGCGCAGTACAAGGCCG
TGCTCGTTCGTTTCAACGATATCCTGCAGAAACATAACGCCTTCGCCCCGTTGGACGGAGTCGTCACCAACCTGCCCGTG
CGAGTCGGTGAAACGGTTGTGCCCGGCGTGCAGAACTCGGCTGCCAGCACCATCATGACGATTGCCGACATGTCCCTGAT
CACCGCCGAGGTGAAGGTGGACGAGACCGATATCGTCAACGTGAAGCTATCCCAGGCCGTGGATGTCACGATAGACGCGA
TCCCGAACAAGACCTTCAAGGGTCATGTGGTCGAGATCGGCAATACTGCGATCCTGCGTTCCACCGGCGTCGCCGCCAGC
CAGAGCGCCATTTCCAGCCAGGAGGCCAAGGATTTTAAAGTCGTCGTCGCCCTGGATAACCCGCCGGATGAGATTCGTCC
GGGACTTTCTTGCACGGCAAAGATAACCACAGCCACCCGGAAGAACGTCCTTACTATTCCGATCCAAGCGCTCACCGTTC
GTCAGAAGGGGCAATTGGAGCCGAAACCGGCCGATGGAAAGGTCGCGCCGGTCGCCGCGAAACTGGATCCGGTCGCGGAA
AAGGCAAAGAAGGAAGAGCTTCAAGGCGTTTTTGTGGTTTCGGGAGGGAAAGCGGTCTTCAAGAAGGTGGAAACGGGAAT
TACCGGCGCCACCGACATCGAAGTGCTGGCCGGCCTGAATGAGGGCGACCAGATCGTCACCGGTACCTACCAGGTGATCC
GCACGATCCTGAACGATACGCAGGTAAAAGTGGATAATAAGGCTCCGGTCGTGCCGGCCAAGTCTTAG

Upstream 100 bases:

>100_bases
CATCGGTACTAACGGACGCCCGGGTGTAAAATGTTATCTGAACTCCCGGCACACATTTTACGTCTAAGCGGGTGAACAGT
AAAAAAGGGAGATTTTTGTC

Downstream 100 bases:

>100_bases
AAACGAGAACCATCCGATGTCAACAGCAGTTGAGAAGGAACTAATCCAGCGCGGTGAGCAGCTCAAGAAGGACGGAATCG
TTATCCGCACCTTCGATCTC

Product: secretion protein HlyD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MKSKWKIVIGLVVVLLLAIGVYASTVLSKKGLVTVQTGNVVRQDLTSLVTASGEVKPKNYINIGANAQGELKEILVKEGD
RVRRGQLLARIENVQPEADVDAQRATLNSAEADSAAAEAGLKAADENLRTLQAQIDKDKADLEHTKADFDRSESLYKEHL
LAKQDWELKKFTFEAQRATVTQSEMRLVQARAQREQSLAQLASAQKRIAQYKAVLVRFNDILQKHNAFAPLDGVVTNLPV
RVGETVVPGVQNSAASTIMTIADMSLITAEVKVDETDIVNVKLSQAVDVTIDAIPNKTFKGHVVEIGNTAILRSTGVAAS
QSAISSQEAKDFKVVVALDNPPDEIRPGLSCTAKITTATRKNVLTIPIQALTVRQKGQLEPKPADGKVAPVAAKLDPVAE
KAKKEELQGVFVVSGGKAVFKKVETGITGATDIEVLAGLNEGDQIVTGTYQVIRTILNDTQVKVDNKAPVVPAKS

Sequences:

>Translated_475_residues
MKSKWKIVIGLVVVLLLAIGVYASTVLSKKGLVTVQTGNVVRQDLTSLVTASGEVKPKNYINIGANAQGELKEILVKEGD
RVRRGQLLARIENVQPEADVDAQRATLNSAEADSAAAEAGLKAADENLRTLQAQIDKDKADLEHTKADFDRSESLYKEHL
LAKQDWELKKFTFEAQRATVTQSEMRLVQARAQREQSLAQLASAQKRIAQYKAVLVRFNDILQKHNAFAPLDGVVTNLPV
RVGETVVPGVQNSAASTIMTIADMSLITAEVKVDETDIVNVKLSQAVDVTIDAIPNKTFKGHVVEIGNTAILRSTGVAAS
QSAISSQEAKDFKVVVALDNPPDEIRPGLSCTAKITTATRKNVLTIPIQALTVRQKGQLEPKPADGKVAPVAAKLDPVAE
KAKKEELQGVFVVSGGKAVFKKVETGITGATDIEVLAGLNEGDQIVTGTYQVIRTILNDTQVKVDNKAPVVPAKS
>Mature_475_residues
MKSKWKIVIGLVVVLLLAIGVYASTVLSKKGLVTVQTGNVVRQDLTSLVTASGEVKPKNYINIGANAQGELKEILVKEGD
RVRRGQLLARIENVQPEADVDAQRATLNSAEADSAAAEAGLKAADENLRTLQAQIDKDKADLEHTKADFDRSESLYKEHL
LAKQDWELKKFTFEAQRATVTQSEMRLVQARAQREQSLAQLASAQKRIAQYKAVLVRFNDILQKHNAFAPLDGVVTNLPV
RVGETVVPGVQNSAASTIMTIADMSLITAEVKVDETDIVNVKLSQAVDVTIDAIPNKTFKGHVVEIGNTAILRSTGVAAS
QSAISSQEAKDFKVVVALDNPPDEIRPGLSCTAKITTATRKNVLTIPIQALTVRQKGQLEPKPADGKVAPVAAKLDPVAE
KAKKEELQGVFVVSGGKAVFKKVETGITGATDIEVLAGLNEGDQIVTGTYQVIRTILNDTQVKVDNKAPVVPAKS

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=445, Percent_Identity=24.4943820224719, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 51041; Mature: 51041

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKWKIVIGLVVVLLLAIGVYASTVLSKKGLVTVQTGNVVRQDLTSLVTASGEVKPKNY
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCE
INIGANAQGELKEILVKEGDRVRRGQLLARIENVQPEADVDAQRATLNSAEADSAAAEAG
EEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCHHHHHHHC
LKAADENLRTLQAQIDKDKADLEHTKADFDRSESLYKEHLLAKQDWELKKFTFEAQRATV
CHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHEEEHHHHHHH
TQSEMRLVQARAQREQSLAQLASAQKRIAQYKAVLVRFNDILQKHNAFAPLDGVVTNLPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCH
RVGETVVPGVQNSAASTIMTIADMSLITAEVKVDETDIVNVKLSQAVDVTIDAIPNKTFK
HCCCEECCCCCCHHHHHHHHHHHHHEEEEEEEECCCEEEEEEECCEEEEEEECCCCCCCC
GHVVEIGNTAILRSTGVAASQSAISSQEAKDFKVVVALDNPPDEIRPGLSCTAKITTATR
CEEEEECCEEEEEECCCCHHHHHHHCCCCCCEEEEEEECCCHHHHCCCCCEEEEEEECCC
KNVLTIPIQALTVRQKGQLEPKPADGKVAPVAAKLDPVAEKAKKEELQGVFVVSGGKAVF
CCEEEEEHHEEEECCCCCCCCCCCCCCEEEEHHHCCHHHHHHHHHHCCEEEEEECCHHHH
KKVETGITGATDIEVLAGLNEGDQIVTGTYQVIRTILNDTQVKVDNKAPVVPAKS
HHHHHCCCCCCCHHHEECCCCCCEEEHHHHHHHHHHHCCCEEEECCCCCCCCCCC
>Mature Secondary Structure
MKSKWKIVIGLVVVLLLAIGVYASTVLSKKGLVTVQTGNVVRQDLTSLVTASGEVKPKNY
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCE
INIGANAQGELKEILVKEGDRVRRGQLLARIENVQPEADVDAQRATLNSAEADSAAAEAG
EEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCHHHHHHHC
LKAADENLRTLQAQIDKDKADLEHTKADFDRSESLYKEHLLAKQDWELKKFTFEAQRATV
CHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHEEEHHHHHHH
TQSEMRLVQARAQREQSLAQLASAQKRIAQYKAVLVRFNDILQKHNAFAPLDGVVTNLPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCH
RVGETVVPGVQNSAASTIMTIADMSLITAEVKVDETDIVNVKLSQAVDVTIDAIPNKTFK
HCCCEECCCCCCHHHHHHHHHHHHHEEEEEEEECCCEEEEEEECCEEEEEEECCCCCCCC
GHVVEIGNTAILRSTGVAASQSAISSQEAKDFKVVVALDNPPDEIRPGLSCTAKITTATR
CEEEEECCEEEEEECCCCHHHHHHHCCCCCCEEEEEEECCCHHHHCCCCCEEEEEEECCC
KNVLTIPIQALTVRQKGQLEPKPADGKVAPVAAKLDPVAEKAKKEELQGVFVVSGGKAVF
CCEEEEEHHEEEECCCCCCCCCCCCCCEEEEHHHCCHHHHHHHHHHCCEEEEEECCHHHH
KKVETGITGATDIEVLAGLNEGDQIVTGTYQVIRTILNDTQVKVDNKAPVVPAKS
HHHHHCCCCCCCHHHEECCCCCCEEEHHHHHHHHHHHCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]