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The map label for this gene is hyi [C]

Identifier: 116626711

GI number: 116626711

Start: 9651657

End: 9652487

Strand: Direct

Name: hyi [C]

Synonym: Acid_7683

Alternate gene names: 116626711

Gene position: 9651657-9652487 (Clockwise)

Preceding gene: 116626709

Following gene: 116626713

Centisome position: 96.85

GC content: 62.21

Gene sequence:

>831_bases
GTGCTTCGAAACGGGCGCATCAAACAATCTCTGGCTTACTGGTGCCTGAACGCCACCAAGTGGAAGTGGGAGATCGATCG
GATCTGCGAGACCGCGGTGCGCCTGGGATGTCCCAGCGTGGAGCTCGCGCCGCCGGAGCTCTGGCCCGTGGTGGCCGCTC
ACGGGCTGAAGAATTCGCTCGTGCTCAACGGCATGCCCGACCCCGTGTTCTTGAAGGGCCTCAACAATCCCCGCTACCAG
GAGGAGGTCATCGGGCGCACCAAAAAGGTTATCGACCAGTGCCCCGAGTTCGCCATTCCCAACGTGATTTGCTTCACCGG
CTATAAGTGGTTGGATGCGGATGACCCGGCGTGCGGCGAAATTGCGCTGCGCCAGGGTGCTGAAAGTACCGTGAAGGGCA
TGCGCGAATTAGCCGTCTACGCGGCATCGCGAAACGTCACGATGGTGCTGGAGCAGTTGAACACGCGCGATACGTCACAC
CCGATGAAGGGCCACCCCGGCTATCAGGGCGACGATATCGATTACTGCGCCGAGATCGTCCGGCAGGTCGATTCTCCGCA
CGCCAAGCTGCTCTTCGATGTCTACCATGTGGCCATTATGAACGGCGACGTGATCCGCCGCATAAATCAGTACGGCAAGT
GGATCGGTCACGTCCACGTCGCCGGCGTTCCGGGCAGGGCGGAACTGGACGGCGCGCAGGAAATCCACTTCCCCGGCGTC
ATGCGCGCTCTCATCGATGTCGGCTATCAGGGCTATGTCGGCCAGGAGTTCATCCCCACGCGCGAGCCCGACCAGGGGCT
CGCCGAGGCGGTCGCGCTCTGCGACGTGTAA

Upstream 100 bases:

>100_bases
ACCCGAATAATGCGATCGCACCCGCGGCGATGCAAGCTGTGGCTATCCGATGCTGTGGCATTCCTGTTACATATATACTT
CGATTGCGGAGGAATAGCGA

Downstream 100 bases:

>100_bases
GGCCGACTACCGGAAGGTTACTGTCGCGACCCGGTACCAGGGCTGGCCGCTGGCGTCGTCCACACCCCAGAATTCGAAGT
ATTGATCGCCGGGAGGGTAC

Product: xylose isomerase domain-containing protein

Products: 2-Hydroxy-3-oxopropanoate [C]

Alternate protein names: ORF4 [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MLRNGRIKQSLAYWCLNATKWKWEIDRICETAVRLGCPSVELAPPELWPVVAAHGLKNSLVLNGMPDPVFLKGLNNPRYQ
EEVIGRTKKVIDQCPEFAIPNVICFTGYKWLDADDPACGEIALRQGAESTVKGMRELAVYAASRNVTMVLEQLNTRDTSH
PMKGHPGYQGDDIDYCAEIVRQVDSPHAKLLFDVYHVAIMNGDVIRRINQYGKWIGHVHVAGVPGRAELDGAQEIHFPGV
MRALIDVGYQGYVGQEFIPTREPDQGLAEAVALCDV

Sequences:

>Translated_276_residues
MLRNGRIKQSLAYWCLNATKWKWEIDRICETAVRLGCPSVELAPPELWPVVAAHGLKNSLVLNGMPDPVFLKGLNNPRYQ
EEVIGRTKKVIDQCPEFAIPNVICFTGYKWLDADDPACGEIALRQGAESTVKGMRELAVYAASRNVTMVLEQLNTRDTSH
PMKGHPGYQGDDIDYCAEIVRQVDSPHAKLLFDVYHVAIMNGDVIRRINQYGKWIGHVHVAGVPGRAELDGAQEIHFPGV
MRALIDVGYQGYVGQEFIPTREPDQGLAEAVALCDV
>Mature_276_residues
MLRNGRIKQSLAYWCLNATKWKWEIDRICETAVRLGCPSVELAPPELWPVVAAHGLKNSLVLNGMPDPVFLKGLNNPRYQ
EEVIGRTKKVIDQCPEFAIPNVICFTGYKWLDADDPACGEIALRQGAESTVKGMRELAVYAASRNVTMVLEQLNTRDTSH
PMKGHPGYQGDDIDYCAEIVRQVDSPHAKLLFDVYHVAIMNGDVIRRINQYGKWIGHVHVAGVPGRAELDGAQEIHFPGV
MRALIDVGYQGYVGQEFIPTREPDQGLAEAVALCDV

Specific function: Catalyzes The Reversible Isomerization Between Hydroxypyruvate And 2-Hydroxy-3-Oxopropanoate (Also Termed Tartronate Semialdehyde). [C]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=149, Percent_Identity=33.5570469798658, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI300068964, Length=135, Percent_Identity=34.0740740740741, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17530883, Length=102, Percent_Identity=34.3137254901961, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: 5.3.1.22 [C]

Molecular weight: Translated: 30709; Mature: 30709

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRNGRIKQSLAYWCLNATKWKWEIDRICETAVRLGCPSVELAPPELWPVVAAHGLKNSL
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCE
VLNGMPDPVFLKGLNNPRYQEEVIGRTKKVIDQCPEFAIPNVICFTGYKWLDADDPACGE
EECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEECCCCCCHHH
IALRQGAESTVKGMRELAVYAASRNVTMVLEQLNTRDTSHPMKGHPGYQGDDIDYCAEIV
HHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
RQVDSPHAKLLFDVYHVAIMNGDVIRRINQYGKWIGHVHVAGVPGRAELDGAQEIHFPGV
HHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHH
MRALIDVGYQGYVGQEFIPTREPDQGLAEAVALCDV
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MLRNGRIKQSLAYWCLNATKWKWEIDRICETAVRLGCPSVELAPPELWPVVAAHGLKNSL
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCE
VLNGMPDPVFLKGLNNPRYQEEVIGRTKKVIDQCPEFAIPNVICFTGYKWLDADDPACGE
EECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEECCCCCCHHH
IALRQGAESTVKGMRELAVYAASRNVTMVLEQLNTRDTSHPMKGHPGYQGDDIDYCAEIV
HHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
RQVDSPHAKLLFDVYHVAIMNGDVIRRINQYGKWIGHVHVAGVPGRAELDGAQEIHFPGV
HHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHH
MRALIDVGYQGYVGQEFIPTREPDQGLAEAVALCDV
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 10 {hydroxypyruvate}} [C]

Substrates: Hydroxypyruvate [C]

Specific reaction: Hydroxypyruvate <==> 2-Hydroxy-3-oxopropanoate [C]

General reaction: Intramolecular oxidoreduction; Isomerization [C]

Inhibitor: Cu2+; Fe2+; Hydroxy l amine; Iodoacetate; NaCN [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7851418 [H]