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The map label for this gene is tdcB [H]

Identifier: 116626543

GI number: 116626543

Start: 9401223

End: 9402242

Strand: Direct

Name: tdcB [H]

Synonym: Acid_7506

Alternate gene names: 116626543

Gene position: 9401223-9402242 (Clockwise)

Preceding gene: 116626540

Following gene: 116626545

Centisome position: 94.34

GC content: 65.1

Gene sequence:

>1020_bases
ATGGCACAACTGCGCCTCAACGAGCCCCTGAGTAACGCCGGACGCACCCCTCCGGTTAGACTCATAGGAATGGCTCTCGC
AATTCAGGCTGACGACGTACGCGCCGCTGCGGAACGGATCCGCCCCCTGGCGCGCAAAACCCCGGTCTTCACTTCGGCCG
GATTCGATACCGAAGCCGGCGCCCGCGTCTATTTCAAATGCGAGAACCTGCAGCGCGGAGGCGCCTTCAAGATTCGCGGG
GCAGCCAATCTCGTGCTTTCACTGCCACCCGAATCGCTAGCACGCGGCGTTGTCGCGTACTCCTCGGGCAATCACGCTCA
AGCCACCGCGATCGCCGCCCGCCATGTAGGCGTCGCTTCGACTATCGTCATGCCGGAGGATGCGCCGAAATCCAAAATGG
AAGCGACGCGTGCCCACGGCGCGCGGATCGTCACCTACAATCGCTTCACCGACAGCCGCGAAGCTATCGCGCAGAGCATC
CTCAAGGAAACCGGCGCCACCCTGATCCCGCCCTTCGACCACCCGATGATCATGGCCGGACAAGGCACCGCCGCTCTCGA
GTTGCTCGAAGAGACCGGCCCGCTGGACGCCCTGATCGCCCCCGTGGGCGGCGGCGGACTGCTCTCCGGCTGCGCTACTA
TCGCCAAAGCCCTTCACCCCACCGTTCGCGTCTTCGGCGCGGAACCGGCTGGCGCCAACGACACCTTCCTCTCCATGGTC
GCCGGAACCCGCATCGCGGTGCATCCCGACACCATCGCCGACGGGCTCCGTTCGCCCAAGCCCGGCGAGTTGACCTTCCC
CGTCATCCGCGAACTGGCCGAGCGCATCCTGCTGGTCAGCGAAGACGAGATCCGCGCTGCCGTCCGCTTCCTCCTGCTAC
GCCTGAAGATCCTCGTGGAACCAAGCGGCGCAGTGCCCGCGGCGGCCCTGTTGTTTCACAAGCTGCCCGAGGGCATCCGC
TCGGTCGGTGTGATTCTCTCCGGCGGGAATGTGGATTTCGAAGAACTCGCCCGCATGTAA

Upstream 100 bases:

>100_bases
GTCTTTGTAGCGTGCAGTCAAATCACTGGCGGCCGGGCCCCACCCGGCGATAAGACCGTATGTCCCCGGCCGCCGCAACG
AACAAGTATTCCCCCAACTA

Downstream 100 bases:

>100_bases
CTCCCCAACCGGGCCGGCTCGTTGGTGTCCACTCACTCGCCGCGCAGCGCATTCCACGGGTCAATGCGGCTTGCCCGCCA
GGCGGGAATCACGGCCGCCA

Product: pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MAQLRLNEPLSNAGRTPPVRLIGMALAIQADDVRAAAERIRPLARKTPVFTSAGFDTEAGARVYFKCENLQRGGAFKIRG
AANLVLSLPPESLARGVVAYSSGNHAQATAIAARHVGVASTIVMPEDAPKSKMEATRAHGARIVTYNRFTDSREAIAQSI
LKETGATLIPPFDHPMIMAGQGTAALELLEETGPLDALIAPVGGGGLLSGCATIAKALHPTVRVFGAEPAGANDTFLSMV
AGTRIAVHPDTIADGLRSPKPGELTFPVIRELAERILLVSEDEIRAAVRFLLLRLKILVEPSGAVPAAALLFHKLPEGIR
SVGVILSGGNVDFEELARM

Sequences:

>Translated_339_residues
MAQLRLNEPLSNAGRTPPVRLIGMALAIQADDVRAAAERIRPLARKTPVFTSAGFDTEAGARVYFKCENLQRGGAFKIRG
AANLVLSLPPESLARGVVAYSSGNHAQATAIAARHVGVASTIVMPEDAPKSKMEATRAHGARIVTYNRFTDSREAIAQSI
LKETGATLIPPFDHPMIMAGQGTAALELLEETGPLDALIAPVGGGGLLSGCATIAKALHPTVRVFGAEPAGANDTFLSMV
AGTRIAVHPDTIADGLRSPKPGELTFPVIRELAERILLVSEDEIRAAVRFLLLRLKILVEPSGAVPAAALLFHKLPEGIR
SVGVILSGGNVDFEELARM
>Mature_338_residues
AQLRLNEPLSNAGRTPPVRLIGMALAIQADDVRAAAERIRPLARKTPVFTSAGFDTEAGARVYFKCENLQRGGAFKIRGA
ANLVLSLPPESLARGVVAYSSGNHAQATAIAARHVGVASTIVMPEDAPKSKMEATRAHGARIVTYNRFTDSREAIAQSIL
KETGATLIPPFDHPMIMAGQGTAALELLEETGPLDALIAPVGGGGLLSGCATIAKALHPTVRVFGAEPAGANDTFLSMVA
GTRIAVHPDTIADGLRSPKPGELTFPVIRELAERILLVSEDEIRAAVRFLLLRLKILVEPSGAVPAAALLFHKLPEGIRS
VGVILSGGNVDFEELARM

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=310, Percent_Identity=42.9032258064516, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI19923959, Length=305, Percent_Identity=29.5081967213115, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI33469958, Length=310, Percent_Identity=29.0322580645161, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1789505, Length=323, Percent_Identity=38.6996904024768, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1790207, Length=301, Percent_Identity=34.5514950166113, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17508781, Length=315, Percent_Identity=38.0952380952381, Blast_Score=204, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI71991565, Length=313, Percent_Identity=34.185303514377, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17537387, Length=319, Percent_Identity=35.423197492163, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322631, Length=309, Percent_Identity=49.1909385113269, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6320930, Length=308, Percent_Identity=34.4155844155844, Blast_Score=152, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6319788, Length=281, Percent_Identity=23.4875444839858, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21355833, Length=307, Percent_Identity=36.8078175895765, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24645328, Length=211, Percent_Identity=36.0189573459716, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 35721; Mature: 35590

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLRLNEPLSNAGRTPPVRLIGMALAIQADDVRAAAERIRPLARKTPVFTSAGFDTEAG
CCCEECCCCHHHCCCCCCHHEEEEEEEEECHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
ARVYFKCENLQRGGAFKIRGAANLVLSLPPESLARGVVAYSSGNHAQATAIAARHVGVAS
CEEEEEECCCCCCCCEEEECCCEEEEECCHHHHHCCEEEECCCCCCHHHHHHHHHCCCEE
TIVMPEDAPKSKMEATRAHGARIVTYNRFTDSREAIAQSILKETGATLIPPFDHPMIMAG
EEECCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCEEECCCCCCEEEEC
QGTAALELLEETGPLDALIAPVGGGGLLSGCATIAKALHPTVRVFGAEPAGANDTFLSMV
CCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHH
AGTRIAVHPDTIADGLRSPKPGELTFPVIRELAERILLVSEDEIRAAVRFLLLRLKILVE
HCCEEEECCHHHHHHCCCCCCCCEEHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHEEC
PSGAVPAAALLFHKLPEGIRSVGVILSGGNVDFEELARM
CCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHCC
>Mature Secondary Structure 
AQLRLNEPLSNAGRTPPVRLIGMALAIQADDVRAAAERIRPLARKTPVFTSAGFDTEAG
CCEECCCCHHHCCCCCCHHEEEEEEEEECHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
ARVYFKCENLQRGGAFKIRGAANLVLSLPPESLARGVVAYSSGNHAQATAIAARHVGVAS
CEEEEEECCCCCCCCEEEECCCEEEEECCHHHHHCCEEEECCCCCCHHHHHHHHHCCCEE
TIVMPEDAPKSKMEATRAHGARIVTYNRFTDSREAIAQSILKETGATLIPPFDHPMIMAG
EEECCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCEEECCCCCCEEEEC
QGTAALELLEETGPLDALIAPVGGGGLLSGCATIAKALHPTVRVFGAEPAGANDTFLSMV
CCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHH
AGTRIAVHPDTIADGLRSPKPGELTFPVIRELAERILLVSEDEIRAAVRFLLLRLKILVE
HCCEEEECCHHHHHHCCCCCCCCEEHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHEEC
PSGAVPAAALLFHKLPEGIRSVGVILSGGNVDFEELARM
CCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA