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The map label for this gene is tuaD [H]

Identifier: 116626534

GI number: 116626534

Start: 9392351

End: 9393694

Strand: Direct

Name: tuaD [H]

Synonym: Acid_7497

Alternate gene names: 116626534

Gene position: 9392351-9393694 (Clockwise)

Preceding gene: 116626533

Following gene: 116626538

Centisome position: 94.25

GC content: 63.47

Gene sequence:

>1344_bases
ATGAAGGTATCGATCATCGGCCTAGGTAAACTAGGCGCTCCCATGGCCGCCGTGATGGCGCACAAAGGAAACTTCGTGGT
TGGTGTGGATATCAACCCGGAGTTTGTGAAGGCGATTCGCGAAGGCCGTCCACCGGTCAACGAACCGCAGCTGGCGGAGA
TGATAACCGCCAATCATGAGCGCCTCACCGCCACGGAGAGTTACGAAGACGCGATTCTGGCGACCGATCTGACGTTCATC
ATCGTGCCCACGCCTTCGGGTCCCGACGGGCGGTTTTCGCTGGACTACGTGCTTAAGGCCGTTGAGAAGATCGGCGCCGC
GGTGCGCAAGAAAGCCGCCTGGCATCTGGTCGTGCTCTCCAGCACGGTGATGCCGGGCTCGGTGGATTTGCACGTTCTGC
CCGCTCTGGAGAAGTACTCCGGGCTGAAATGCGGCGTGGATTTCGGGCTGTGCTACAACCCGGAATTCATCGCGCTGGGC
AGCGTCGTGCGCGACATGCTGAACCCGGACATGATCCTGATCGGGGAAGCCGAGCCGCGTTCCGGCGCCATGCTGGAAGA
GCTGTACACCGGCGTCTGCGAGAGCAATCCGCGCATTCAGCGCATGAATTACGTAAATGCCGAGCTCACCAAGCTCTCCG
TGAATACCTTCGTCACCACCAAGATCAGCTACGCCAATATGCTGGCCCAGATCTGCGAAACCCTCAACGGAGCGGATGCC
GACGTGGTCACCTCGGCGCTCGGCTGCGACACGCGTATCGGCCCCAAGTATTTGAAGGGCGCGCTCGGCTACGGCGGACC
CTGCTTCCCCCGCGACAACATTGCCTTCTCGGCGCTGGCCCGCGAGAACGGCGTTCCCGCGCTGCTGGCCGAGGCCACCG
ACGAATTGAATCGCCGCCAGGTGCCGCGCATGGCGGAGCTGCTGCTTTCGCATTTGCCCGCGGGCGGAACCGTCGGCATG
CTCGGCCTTTCGTATAAGCCGCACACCGAAGTCATTGAGGAATCGCAGGGCGTGGCGATCGCAAAGGAACTGGCGGCGCG
CGGCGCGCGCGTCGTGGTCTACGACCCCGCCGCGATGGATTCGACGCGGCGCGTGTTGGGCGATCGCATCGAGTACGCCG
CCACCGCCGCCGAATGCGCGGGCCAGGCCGACGTCCTGGCCATCACCACTCCGTGGCCGGAGTTCAAAAACCTGACGCCC
ACCGATTTGAAGCAGGGCGCGAAGCCCGCGATCGTCGATTGCTGGCGCGTATTGCCCCGCGCCGCTTTCGAGGGCGCATC
CGAATACATGACACTGGGCTTCGGCATGTCCGCCCTCGCCCTTGCCACCGCCGAAGGCGACTAA

Upstream 100 bases:

>100_bases
TCGCCGAGTTTAAACGAAAGCAGGCCGCCCCGGTCTTGAAGGTCACATCACGCGCCTTCGGCACCGGCTGGCGGATGCCC
ATTGTCAGACAGGAATAAGC

Downstream 100 bases:

>100_bases
ACCCCTGGCCCGCCGCAACCGTGAGGGAGCGATCGCTTTTTGCGTCTCGCCGCTCTCTATTACACTGCTCTTGTTTGCTC
GCAGGCCGCAAACTCAGAGC

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKVSIIGLGKLGAPMAAVMAHKGNFVVGVDINPEFVKAIREGRPPVNEPQLAEMITANHERLTATESYEDAILATDLTFI
IVPTPSGPDGRFSLDYVLKAVEKIGAAVRKKAAWHLVVLSSTVMPGSVDLHVLPALEKYSGLKCGVDFGLCYNPEFIALG
SVVRDMLNPDMILIGEAEPRSGAMLEELYTGVCESNPRIQRMNYVNAELTKLSVNTFVTTKISYANMLAQICETLNGADA
DVVTSALGCDTRIGPKYLKGALGYGGPCFPRDNIAFSALARENGVPALLAEATDELNRRQVPRMAELLLSHLPAGGTVGM
LGLSYKPHTEVIEESQGVAIAKELAARGARVVVYDPAAMDSTRRVLGDRIEYAATAAECAGQADVLAITTPWPEFKNLTP
TDLKQGAKPAIVDCWRVLPRAAFEGASEYMTLGFGMSALALATAEGD

Sequences:

>Translated_447_residues
MKVSIIGLGKLGAPMAAVMAHKGNFVVGVDINPEFVKAIREGRPPVNEPQLAEMITANHERLTATESYEDAILATDLTFI
IVPTPSGPDGRFSLDYVLKAVEKIGAAVRKKAAWHLVVLSSTVMPGSVDLHVLPALEKYSGLKCGVDFGLCYNPEFIALG
SVVRDMLNPDMILIGEAEPRSGAMLEELYTGVCESNPRIQRMNYVNAELTKLSVNTFVTTKISYANMLAQICETLNGADA
DVVTSALGCDTRIGPKYLKGALGYGGPCFPRDNIAFSALARENGVPALLAEATDELNRRQVPRMAELLLSHLPAGGTVGM
LGLSYKPHTEVIEESQGVAIAKELAARGARVVVYDPAAMDSTRRVLGDRIEYAATAAECAGQADVLAITTPWPEFKNLTP
TDLKQGAKPAIVDCWRVLPRAAFEGASEYMTLGFGMSALALATAEGD
>Mature_447_residues
MKVSIIGLGKLGAPMAAVMAHKGNFVVGVDINPEFVKAIREGRPPVNEPQLAEMITANHERLTATESYEDAILATDLTFI
IVPTPSGPDGRFSLDYVLKAVEKIGAAVRKKAAWHLVVLSSTVMPGSVDLHVLPALEKYSGLKCGVDFGLCYNPEFIALG
SVVRDMLNPDMILIGEAEPRSGAMLEELYTGVCESNPRIQRMNYVNAELTKLSVNTFVTTKISYANMLAQICETLNGADA
DVVTSALGCDTRIGPKYLKGALGYGGPCFPRDNIAFSALARENGVPALLAEATDELNRRQVPRMAELLLSHLPAGGTVGM
LGLSYKPHTEVIEESQGVAIAKELAARGARVVVYDPAAMDSTRRVLGDRIEYAATAAECAGQADVLAITTPWPEFKNLTP
TDLKQGAKPAIVDCWRVLPRAAFEGASEYMTLGFGMSALALATAEGD

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=469, Percent_Identity=28.997867803838, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI296040438, Length=321, Percent_Identity=30.8411214953271, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI296040443, Length=311, Percent_Identity=31.5112540192926, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1788340, Length=403, Percent_Identity=26.5508684863524, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI48994968, Length=440, Percent_Identity=27.0454545454545, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560350, Length=466, Percent_Identity=28.755364806867, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI17136908, Length=444, Percent_Identity=29.2792792792793, Blast_Score=156, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 47756; Mature: 47756

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVSIIGLGKLGAPMAAVMAHKGNFVVGVDINPEFVKAIREGRPPVNEPQLAEMITANHE
CEEEEEECCCCCCCHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHCCCC
RLTATESYEDAILATDLTFIIVPTPSGPDGRFSLDYVLKAVEKIGAAVRKKAAWHLVVLS
CEEECCCCCCEEEEECEEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHCCEEEEEEE
STVMPGSVDLHVLPALEKYSGLKCGVDFGLCYNPEFIALGSVVRDMLNPDMILIGEAEPR
CCCCCCCCCEEEECCHHHCCCCEECCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCCC
SGAMLEELYTGVCESNPRIQRMNYVNAELTKLSVNTFVTTKISYANMLAQICETLNGADA
CCHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEEEEEEEEHHHHHHHHHHHHHHCCCCH
DVVTSALGCDTRIGPKYLKGALGYGGPCFPRDNIAFSALARENGVPALLAEATDELNRRQ
HHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHC
VPRMAELLLSHLPAGGTVGMLGLSYKPHTEVIEESQGVAIAKELAARGARVVVYDPAAMD
CHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCC
STRRVLGDRIEYAATAAECAGQADVLAITTPWPEFKNLTPTDLKQGAKPAIVDCWRVLPR
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHCCCCCHHHHHHHHHHH
AAFEGASEYMTLGFGMSALALATAEGD
HHHCCCHHHEEECCCHHHHEEEECCCC
>Mature Secondary Structure
MKVSIIGLGKLGAPMAAVMAHKGNFVVGVDINPEFVKAIREGRPPVNEPQLAEMITANHE
CEEEEEECCCCCCCHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHCCCC
RLTATESYEDAILATDLTFIIVPTPSGPDGRFSLDYVLKAVEKIGAAVRKKAAWHLVVLS
CEEECCCCCCEEEEECEEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHCCEEEEEEE
STVMPGSVDLHVLPALEKYSGLKCGVDFGLCYNPEFIALGSVVRDMLNPDMILIGEAEPR
CCCCCCCCCEEEECCHHHCCCCEECCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCCC
SGAMLEELYTGVCESNPRIQRMNYVNAELTKLSVNTFVTTKISYANMLAQICETLNGADA
CCHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEEEEEEEEHHHHHHHHHHHHHHCCCCH
DVVTSALGCDTRIGPKYLKGALGYGGPCFPRDNIAFSALARENGVPALLAEATDELNRRQ
HHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHC
VPRMAELLLSHLPAGGTVGMLGLSYKPHTEVIEESQGVAIAKELAARGARVVVYDPAAMD
CHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCC
STRRVLGDRIEYAATAAECAGQADVLAITTPWPEFKNLTPTDLKQGAKPAIVDCWRVLPR
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHCCCCCHHHHHHHHHHH
AAFEGASEYMTLGFGMSALALATAEGD
HHHCCCHHHEEECCCHHHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]