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The map label for this gene is pol [H]

Identifier: 116626444

GI number: 116626444

Start: 9291091

End: 9293445

Strand: Direct

Name: pol [H]

Synonym: Acid_7406

Alternate gene names: 116626444

Gene position: 9291091-9293445 (Clockwise)

Preceding gene: 116626443

Following gene: 116626445

Centisome position: 93.23

GC content: 70.06

Gene sequence:

>2355_bases
ATGAGCAGGGCTGAGGACGAGTGGTTGTGGGGGTGGGACCCGACGCCGGGAATCGTCTCGGTGTGGGTCGAGGCGGACGG
GCGCGCCACTATCTGGAGGCGGATTGCGGCCACTGGCGAACTGGTGCGCGAGGAGGCGCGGTTCCGTCCGTGGCTGCTGC
TGGACCGGCTTGACGACCTGCGACACCTGGGCTCGGAGCTATCGCAGGAGGGTGGGGCCGGGGCGCTGGTCACCTGGCGG
GAACTCGAGGGGCCAGGCGCGCTGCGCTACCTGGTTCGGGCGGCGGACGGGAAGACGTTGAGCTCGGCCATCCTGCAGGG
GGCGACGCAGCGGCTCGGGCGCCGGGTTGGGGCGCTGCGCGACCTGGGGAAGGAGGCGGTGCTGGCGCTGCCGCCGGAAG
AGCAGTACCTGGTGGCGACGGGCCGTAATTATTTTCGCGATCTCACCTTTGACCATCTGCGGCGGCTGCAGTTCGACCTG
GAGACAACGGGGCTCGACGCGGGGCGCGACCGGATCTTCATGGTGGCAGTGCGCGACCCTTCAGGCGCGGCGGAGACATT
GGAGGTGGAGGGCGAAGGCGATGCTGCGGAGGCGGACCTCATCCGCCGGCTGGTGGCGCGGATCCAGGCGGCCGATCCGG
ACGTGATCGAGAACCATAACCTGCACGGCTTCGACTTACCGTTCCTAGACCGGCGCGCGCGGCGGCTGGGCGTGCCGCTA
TCTCTGGGACGGATCGGGCCGGCGGGACTGCGGCAGCGCACAGCGCGCCGCGGGGCAGCGGCCGGGTTGGACGATCGCCG
AAAGGTGCGGTACGTGGCGCCGGGGCGGGAATTGATCGATACGCTCGACGCGGTGCTGCGGCATGATTTCTCGGAGCGCG
ATTTGCCGGGCCACGGGCTCAAGGCGGTAGCGCGCCACCTGGGGCTGGCCGGACCGGATCGTGAGCAGATCCCAGGCCGG
CAGATTTACGAAGTGTATCGACGCGATCCGGCGCGGGTGCGGCGGTATGCGACTGCGGACGTGGAGGAGGTCGCCGGCCT
GGCGCGGCTGCTGGGCGGGGCGGCATTCGCGCTGGCGCAGATGGCTCCCCGGCGCTACGAGCGGCTGGCCGATGCCGGGG
CCGCGACCGGCGTGATCGACCCGCTGCTGGTGCGCGCCTATCTGCATGCGGGAATGGCGCTGCCGGCGCATCAGCCCGGC
GACGGTACGGAGCACAGCGGCGCCGCGCTTCACCTGTTCGCCACCGGGGTGGCGCACCGGATCGTGAAGGCCGATGTCGC
CAGCCTGTATCCCTCGCTGATGCGGGCCTTCCGGATTGGTCCCGCGCGCGACCGTTTGGGGGCGATGCTGGCGCTGGTGG
ACCGGCTGGTGGAGTGGCGCCTGGCAGCGAAGGCGAGCGCCCGGGCGGCGCCGCGCGGATCGGCCGAGCGGTTCGCACAT
GAGGCGCGGTCGGCAGCGATGAAGCTGGTGGTGAACTCGGCGTACGGCTACCTGGCGGCGGGGGGCGGGCTGACGCGGTT
CGCCGACGTTCACGCGGCCAATAAAGTCACGCGGCGGGGACGGGAGACGCTCGACCTGATGTGCCGCGAGCTGGCGGCGC
GAGGGGTGACGCTGCTGGAGGCCGATACCGACGGCGTGTACTTCGCGGTTCCCGAAGGCTGGAGCGAGGACGAGGAGCGG
GGCGTGGTGGCGGAGGTCGCGAGCCTGCTGCCGCCGCTGGTGCAACTGGAATTCGACGGGCGCTACGCGGCGATGCTGTC
GCACGAGCCCAAGAATTACGCGCTGCTCAGCTACGACGACAAGCTGCTGCTGCGCGGCGTCGCGTTCCGGTCGAGCCGGG
CGGAGCCGTTCGGCGAGAATTTCCTGCGCAGGGCTATCGGACGGCTGCTGAAGGGCGATGTACCGGGGGTGCGGGATGCC
TACCTGGTAACGCTCGACGCGTTGCGCCGCCGCGAGCTTCCGACGCGCGATGTATCTTCGCTGGTGCGGCTGACGAAGAG
CCCGGAGCATTACCTGGAGACTCGCGAGGCTCGTCGAGAGCTGCCGTACGAGGCAATGCTCGCGGCCGGGCGGCGCCAGT
GGAGCGCGGGCGAGCGGGTCCGGGTCTATCGGACGAGAACGAGCGCGGGGGTGGTGGAGGAAACGGACGACGATGAGGAC
GCGATCGCGGGCGAGGATCCGCGCGACTACGATGTCGGGCATTACGCGCGCGTGTTGCGCGAGATTTTCGCGTCGCGGCT
GGAGCGTGCATTTACGCCGGAGGACTTTGCGGCGGTCTTCGCGGATCCCGGGCAAATGTCGCTCTTCGCGCCGGCGATCG
AAAATGTGCGTCCGGTGCTGAAGAGAACAGATTAG

Upstream 100 bases:

>100_bases
CATGCCAAGACGCCGCTTTCGCAGGTGCACCGGCAGCTGCTGGAGGGCCTGGTGACCGCCGGGTATGGCGACGCCGATAA
CAGCGCGATCATGATGGCGT

Downstream 100 bases:

>100_bases
GTGCACCGGCCGGCGTGCCTCTCGCACTGTGGTAACTTCGGGGAATAGGCGCATGAAAGTCTGGCTGGTGCTTCTGGGCG
CGATCGTGATTGCCGGGTGC

Product: DNA polymerase B region

Products: NA

Alternate protein names: Pfu polymerase [H]

Number of amino acids: Translated: 784; Mature: 783

Protein sequence:

>784_residues
MSRAEDEWLWGWDPTPGIVSVWVEADGRATIWRRIAATGELVREEARFRPWLLLDRLDDLRHLGSELSQEGGAGALVTWR
ELEGPGALRYLVRAADGKTLSSAILQGATQRLGRRVGALRDLGKEAVLALPPEEQYLVATGRNYFRDLTFDHLRRLQFDL
ETTGLDAGRDRIFMVAVRDPSGAAETLEVEGEGDAAEADLIRRLVARIQAADPDVIENHNLHGFDLPFLDRRARRLGVPL
SLGRIGPAGLRQRTARRGAAAGLDDRRKVRYVAPGRELIDTLDAVLRHDFSERDLPGHGLKAVARHLGLAGPDREQIPGR
QIYEVYRRDPARVRRYATADVEEVAGLARLLGGAAFALAQMAPRRYERLADAGAATGVIDPLLVRAYLHAGMALPAHQPG
DGTEHSGAALHLFATGVAHRIVKADVASLYPSLMRAFRIGPARDRLGAMLALVDRLVEWRLAAKASARAAPRGSAERFAH
EARSAAMKLVVNSAYGYLAAGGGLTRFADVHAANKVTRRGRETLDLMCRELAARGVTLLEADTDGVYFAVPEGWSEDEER
GVVAEVASLLPPLVQLEFDGRYAAMLSHEPKNYALLSYDDKLLLRGVAFRSSRAEPFGENFLRRAIGRLLKGDVPGVRDA
YLVTLDALRRRELPTRDVSSLVRLTKSPEHYLETREARRELPYEAMLAAGRRQWSAGERVRVYRTRTSAGVVEETDDDED
AIAGEDPRDYDVGHYARVLREIFASRLERAFTPEDFAAVFADPGQMSLFAPAIENVRPVLKRTD

Sequences:

>Translated_784_residues
MSRAEDEWLWGWDPTPGIVSVWVEADGRATIWRRIAATGELVREEARFRPWLLLDRLDDLRHLGSELSQEGGAGALVTWR
ELEGPGALRYLVRAADGKTLSSAILQGATQRLGRRVGALRDLGKEAVLALPPEEQYLVATGRNYFRDLTFDHLRRLQFDL
ETTGLDAGRDRIFMVAVRDPSGAAETLEVEGEGDAAEADLIRRLVARIQAADPDVIENHNLHGFDLPFLDRRARRLGVPL
SLGRIGPAGLRQRTARRGAAAGLDDRRKVRYVAPGRELIDTLDAVLRHDFSERDLPGHGLKAVARHLGLAGPDREQIPGR
QIYEVYRRDPARVRRYATADVEEVAGLARLLGGAAFALAQMAPRRYERLADAGAATGVIDPLLVRAYLHAGMALPAHQPG
DGTEHSGAALHLFATGVAHRIVKADVASLYPSLMRAFRIGPARDRLGAMLALVDRLVEWRLAAKASARAAPRGSAERFAH
EARSAAMKLVVNSAYGYLAAGGGLTRFADVHAANKVTRRGRETLDLMCRELAARGVTLLEADTDGVYFAVPEGWSEDEER
GVVAEVASLLPPLVQLEFDGRYAAMLSHEPKNYALLSYDDKLLLRGVAFRSSRAEPFGENFLRRAIGRLLKGDVPGVRDA
YLVTLDALRRRELPTRDVSSLVRLTKSPEHYLETREARRELPYEAMLAAGRRQWSAGERVRVYRTRTSAGVVEETDDDED
AIAGEDPRDYDVGHYARVLREIFASRLERAFTPEDFAAVFADPGQMSLFAPAIENVRPVLKRTD
>Mature_783_residues
SRAEDEWLWGWDPTPGIVSVWVEADGRATIWRRIAATGELVREEARFRPWLLLDRLDDLRHLGSELSQEGGAGALVTWRE
LEGPGALRYLVRAADGKTLSSAILQGATQRLGRRVGALRDLGKEAVLALPPEEQYLVATGRNYFRDLTFDHLRRLQFDLE
TTGLDAGRDRIFMVAVRDPSGAAETLEVEGEGDAAEADLIRRLVARIQAADPDVIENHNLHGFDLPFLDRRARRLGVPLS
LGRIGPAGLRQRTARRGAAAGLDDRRKVRYVAPGRELIDTLDAVLRHDFSERDLPGHGLKAVARHLGLAGPDREQIPGRQ
IYEVYRRDPARVRRYATADVEEVAGLARLLGGAAFALAQMAPRRYERLADAGAATGVIDPLLVRAYLHAGMALPAHQPGD
GTEHSGAALHLFATGVAHRIVKADVASLYPSLMRAFRIGPARDRLGAMLALVDRLVEWRLAAKASARAAPRGSAERFAHE
ARSAAMKLVVNSAYGYLAAGGGLTRFADVHAANKVTRRGRETLDLMCRELAARGVTLLEADTDGVYFAVPEGWSEDEERG
VVAEVASLLPPLVQLEFDGRYAAMLSHEPKNYALLSYDDKLLLRGVAFRSSRAEPFGENFLRRAIGRLLKGDVPGVRDAY
LVTLDALRRRELPTRDVSSLVRLTKSPEHYLETREARRELPYEAMLAAGRRQWSAGERVRVYRTRTSAGVVEETDDDEDA
IAGEDPRDYDVGHYARVLREIFASRLERAFTPEDFAAVFADPGQMSLFAPAIENVRPVLKRTD

Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity [H]

COG id: COG0417

COG function: function code L; DNA polymerase elongation subunit (family B)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA polymerase type-B family [H]

Homologues:

Organism=Homo sapiens, GI156616275, Length=693, Percent_Identity=25.3968253968254, Blast_Score=87, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006172
- InterPro:   IPR017964
- InterPro:   IPR006133
- InterPro:   IPR006134
- InterPro:   IPR004578
- InterPro:   IPR023211
- InterPro:   IPR012337 [H]

Pfam domain/function: PF00136 DNA_pol_B; PF03104 DNA_pol_B_exo [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 86659; Mature: 86528

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00037 MYB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAEDEWLWGWDPTPGIVSVWVEADGRATIWRRIAATGELVREEARFRPWLLLDRLDDL
CCCCCCCEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RHLGSELSQEGGAGALVTWRELEGPGALRYLVRAADGKTLSSAILQGATQRLGRRVGALR
HHHHHHHHHCCCCCEEEEEHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
DLGKEAVLALPPEEQYLVATGRNYFRDLTFDHLRRLQFDLETTGLDAGRDRIFMVAVRDP
HCCCCCEEECCCCCCEEEECCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEECC
SGAAETLEVEGEGDAAEADLIRRLVARIQAADPDVIENHNLHGFDLPFLDRRARRLGVPL
CCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCHHHHHHHHCCCCE
SLGRIGPAGLRQRTARRGAAAGLDDRRKVRYVAPGRELIDTLDAVLRHDFSERDLPGHGL
ECCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCH
KAVARHLGLAGPDREQIPGRQIYEVYRRDPARVRRYATADVEEVAGLARLLGGAAFALAQ
HHHHHHHCCCCCCHHCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
MAPRRYERLADAGAATGVIDPLLVRAYLHAGMALPAHQPGDGTEHSGAALHLFATGVAHR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHH
IVKADVASLYPSLMRAFRIGPARDRLGAMLALVDRLVEWRLAAKASARAAPRGSAERFAH
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
EARSAAMKLVVNSAYGYLAAGGGLTRFADVHAANKVTRRGRETLDLMCRELAARGVTLLE
HHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
ADTDGVYFAVPEGWSEDEERGVVAEVASLLPPLVQLEFDGRYAAMLSHEPKNYALLSYDD
ECCCCEEEECCCCCCCHHHCCHHHHHHHHCCHHEEEEECCCEEEEECCCCCCEEEEECCC
KLLLRGVAFRSSRAEPFGENFLRRAIGRLLKGDVPGVRDAYLVTLDALRRRELPTRDVSS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHH
LVRLTKSPEHYLETREARRELPYEAMLAAGRRQWSAGERVRVYRTRTSAGVVEETDDDED
HHHHHCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCC
AIAGEDPRDYDVGHYARVLREIFASRLERAFTPEDFAAVFADPGQMSLFAPAIENVRPVL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHH
KRTD
HCCC
>Mature Secondary Structure 
SRAEDEWLWGWDPTPGIVSVWVEADGRATIWRRIAATGELVREEARFRPWLLLDRLDDL
CCCCCCEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RHLGSELSQEGGAGALVTWRELEGPGALRYLVRAADGKTLSSAILQGATQRLGRRVGALR
HHHHHHHHHCCCCCEEEEEHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
DLGKEAVLALPPEEQYLVATGRNYFRDLTFDHLRRLQFDLETTGLDAGRDRIFMVAVRDP
HCCCCCEEECCCCCCEEEECCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEECC
SGAAETLEVEGEGDAAEADLIRRLVARIQAADPDVIENHNLHGFDLPFLDRRARRLGVPL
CCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCHHHHHHHHCCCCE
SLGRIGPAGLRQRTARRGAAAGLDDRRKVRYVAPGRELIDTLDAVLRHDFSERDLPGHGL
ECCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCH
KAVARHLGLAGPDREQIPGRQIYEVYRRDPARVRRYATADVEEVAGLARLLGGAAFALAQ
HHHHHHHCCCCCCHHCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
MAPRRYERLADAGAATGVIDPLLVRAYLHAGMALPAHQPGDGTEHSGAALHLFATGVAHR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHH
IVKADVASLYPSLMRAFRIGPARDRLGAMLALVDRLVEWRLAAKASARAAPRGSAERFAH
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
EARSAAMKLVVNSAYGYLAAGGGLTRFADVHAANKVTRRGRETLDLMCRELAARGVTLLE
HHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
ADTDGVYFAVPEGWSEDEERGVVAEVASLLPPLVQLEFDGRYAAMLSHEPKNYALLSYDD
ECCCCEEEECCCCCCCHHHCCHHHHHHHHCCHHEEEEECCCEEEEECCCCCCEEEEECCC
KLLLRGVAFRSSRAEPFGENFLRRAIGRLLKGDVPGVRDAYLVTLDALRRRELPTRDVSS
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHH
LVRLTKSPEHYLETREARRELPYEAMLAAGRRQWSAGERVRVYRTRTSAGVVEETDDDED
HHHHHCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCC
AIAGEDPRDYDVGHYARVLREIFASRLERAFTPEDFAAVFADPGQMSLFAPAIENVRPVL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHH
KRTD
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8441634; 1762925; 1579479 [H]