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The map label for this gene is gpo [H]

Identifier: 116626290

GI number: 116626290

Start: 9100714

End: 9101256

Strand: Direct

Name: gpo [H]

Synonym: Acid_7250

Alternate gene names: 116626290

Gene position: 9100714-9101256 (Clockwise)

Preceding gene: 116626289

Following gene: 116626291

Centisome position: 91.32

GC content: 53.96

Gene sequence:

>543_bases
ATGATGAAAATGATGCTGCTGGGCATGGCTATGGGCGCGATGGCTTTCGGCGCTTCCAGCGTTTACGATTTCACTCTCAA
TTCCATCGATGGAGCGCCGACCCCGCTCTCCACGTTCAAAGGCAAGGTCGTACTCCTCGTCAACGTCGCCAGCAAATGCG
GCTTCACACCTCAATACGCCGGCCTCGAAAAACTCTACGAGAAGTACAAGGATCAGGGCCTCGTGCTCGTCGGCGTCCCT
GCCAACAATTTCGGCGCGCAGGAGCCCGGCAGCAACGAAGAAATCAAAACGTTTTGCAGCCGAAACTACAACGTCACTTT
TCCCATGATGAGCAAGGTTTCCGTCAAAGGCGCCGACAAAACTCCCCTTTACCAGTACTTGACCGACGCCTCCGCCAATC
CCAAGACCGCGGGCGAGATTAAATGGAACTTCACCAAGTTTCTGATCGATAAGAAAGGCAATGTTATCAATCGCTTCGAG
TCAGCCGTTACCCCGGAATCGGCGGATATGCTGAAGGCGATCGAGGCCGCTCTGGCTCAATAA

Upstream 100 bases:

>100_bases
GTACCTGGTCGCCAACTTCGGTGACGATAAGCCCGTCGCTCCCCCAGAGTTAACAACCGACGGCGCGGTGAAAAAATAGT
TCATCCGCTATTCTGGTTGC

Downstream 100 bases:

>100_bases
AGGTAGCCGCCCGTACCCCAAAGTCATTTTTATTTGGTCGGAATTCCTCCGTGTTGCGTCTATATAGCTTGAAGACCAAC
ATGGAGGTTCAGATGCAGAC

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MMKMMLLGMAMGAMAFGASSVYDFTLNSIDGAPTPLSTFKGKVVLLVNVASKCGFTPQYAGLEKLYEKYKDQGLVLVGVP
ANNFGAQEPGSNEEIKTFCSRNYNVTFPMMSKVSVKGADKTPLYQYLTDASANPKTAGEIKWNFTKFLIDKKGNVINRFE
SAVTPESADMLKAIEAALAQ

Sequences:

>Translated_180_residues
MMKMMLLGMAMGAMAFGASSVYDFTLNSIDGAPTPLSTFKGKVVLLVNVASKCGFTPQYAGLEKLYEKYKDQGLVLVGVP
ANNFGAQEPGSNEEIKTFCSRNYNVTFPMMSKVSVKGADKTPLYQYLTDASANPKTAGEIKWNFTKFLIDKKGNVINRFE
SAVTPESADMLKAIEAALAQ
>Mature_180_residues
MMKMMLLGMAMGAMAFGASSVYDFTLNSIDGAPTPLSTFKGKVVLLVNVASKCGFTPQYAGLEKLYEKYKDQGLVLVGVP
ANNFGAQEPGSNEEIKTFCSRNYNVTFPMMSKVSVKGADKTPLYQYLTDASANPKTAGEIKWNFTKFLIDKKGNVINRFE
SAVTPESADMLKAIEAALAQ

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=147, Percent_Identity=44.8979591836735, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI90903240, Length=147, Percent_Identity=44.8979591836735, Blast_Score=121, Evalue=3e-28,
Organism=Homo sapiens, GI15618997, Length=146, Percent_Identity=39.7260273972603, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI90903238, Length=135, Percent_Identity=43.7037037037037, Blast_Score=107, Evalue=5e-24,
Organism=Homo sapiens, GI192455698, Length=162, Percent_Identity=31.4814814814815, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI32967607, Length=189, Percent_Identity=31.2169312169312, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI6006001, Length=173, Percent_Identity=31.7919075144509, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI4557629, Length=180, Percent_Identity=29.4444444444444, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI41406084, Length=186, Percent_Identity=30.6451612903226, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI33186887, Length=178, Percent_Identity=29.2134831460674, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1788003, Length=181, Percent_Identity=42.5414364640884, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17535473, Length=161, Percent_Identity=39.7515527950311, Blast_Score=119, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17506887, Length=163, Percent_Identity=38.0368098159509, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17550320, Length=183, Percent_Identity=33.879781420765, Blast_Score=109, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI193209493, Length=183, Percent_Identity=31.1475409836066, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71993584, Length=147, Percent_Identity=35.3741496598639, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193210707, Length=153, Percent_Identity=35.2941176470588, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71999642, Length=77, Percent_Identity=45.4545454545455, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322228, Length=159, Percent_Identity=50.314465408805, Blast_Score=169, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6319721, Length=163, Percent_Identity=48.4662576687117, Blast_Score=165, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6322826, Length=159, Percent_Identity=42.7672955974843, Blast_Score=144, Evalue=8e-36,
Organism=Drosophila melanogaster, GI85726443, Length=148, Percent_Identity=40.5405405405405, Blast_Score=119, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24656772, Length=163, Percent_Identity=42.3312883435583, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24656767, Length=176, Percent_Identity=40.3409090909091, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24656777, Length=163, Percent_Identity=42.3312883435583, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 19537; Mature: 19537

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKMMLLGMAMGAMAFGASSVYDFTLNSIDGAPTPLSTFKGKVVLLVNVASKCGFTPQYA
CHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCCCHHHHCCCEEEEEEEHHHCCCCCCHH
GLEKLYEKYKDQGLVLVGVPANNFGAQEPGSNEEIKTFCSRNYNVTFPMMSKVSVKGADK
HHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCEEEECCCCC
TPLYQYLTDASANPKTAGEIKWNFTKFLIDKKGNVINRFESAVTPESADMLKAIEAALAQ
CHHHHHHHCCCCCCCCCCEEEECCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MMKMMLLGMAMGAMAFGASSVYDFTLNSIDGAPTPLSTFKGKVVLLVNVASKCGFTPQYA
CHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCCCHHHHCCCEEEEEEEHHHCCCCCCHH
GLEKLYEKYKDQGLVLVGVPANNFGAQEPGSNEEIKTFCSRNYNVTFPMMSKVSVKGADK
HHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCEEEECCCCC
TPLYQYLTDASANPKTAGEIKWNFTKFLIDKKGNVINRFESAVTPESADMLKAIEAALAQ
CHHHHHHHCCCCCCCCCCEEEECCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]