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The map label for this gene is aroE [H]

Identifier: 116626199

GI number: 116626199

Start: 8983611

End: 8985140

Strand: Direct

Name: aroE [H]

Synonym: Acid_7159

Alternate gene names: 116626199

Gene position: 8983611-8985140 (Clockwise)

Preceding gene: 116626196

Following gene: 116626200

Centisome position: 90.15

GC content: 62.22

Gene sequence:

>1530_bases
ATGGCGCAGACCAGATCGCTCCCCCGCATATGCATCGCGTTGGGCCTGCCAGACGTTCCAACACTACTGGACCACGCTCG
TCGGGAAGCGGAGGCAGGGGAAGTTTTCCTCGAATTCCGTCTCGACTACCTGAGTAACCCGTGCAAGGGCGCGGAGGCTA
TCGGCAAGTTTCTGGAGGAGTTTCCGGAGTGTATCCTGCTCGCCACCTGCCGCCGCCACCAGAATCACGGCAAGTTCAAC
GGCAGCATCGAAGAGCAGCTTGCTGTCCTGGATTTGGCTGTGCGCAATGGCGCCCACGCGATCGACGTGGAAATTGAGAC
CGCCGAAATCGCGCAGGACCGGCTGAACCAGTTCCGCGGCCGTACCCAAGTAATCGTCTCCTATCACAATTTCGAAGCCA
CGCCGCCAATGGACACGGTAGTCAACCGCGTCATGAAGGTGCAGGCGGACGCCTATAAGATTGTCAGTACGGCGCGCAAG
CCGAGCGACAACGTCCGAGTGCTGGCCGTGGCCAAGGCGCTGACCAAACACCGCGTCATCGTGCTGGCGATGGGTGAGCT
TGGCTTCCCGACGCGAGTGCTTTCGCCGGTATTCGGCGGCGTGTTTACCTACGCGGCGCCGATTTACGCCGAAGGCACGG
CCGCCGGCCAGGTGAGCGCGCGGTACCTACGCCATCTGTACCGGGTCGAAAAGCTGGGCAAGTCGGCGAAGATTTACGGC
GTGATCGCCGATCCGATCCGGCATTCGATTTCGCCGGCGGTACACAATCGCGCGTTTCAATCGCGGCGCGTGGATGCGGT
GTACCTGCCGTTTCTTGTGGCGCCTGCGTGCCTGCGCGATTTCTTCTCGCTGGCGGCGAAGCTACCGCTATCGGGATTCA
GCGTCACGATTCCGCACAAGCAGAAGATCATCCGATATCTGGATATCGTGGACCCGCTGGCACGGCGCATCGGCGCTGTC
AACACGGTGTGGCGCAAGGCCGGCAAGTGGCGCGGCACCAATACCGATGCGGCTGGCGTGACCGGGCCGCTCTCGCGGCT
GCTGAAGATTTCCAAGGCAAGTGTGTTGATCGTGGGCAACGGTGGCGCGGCACGCAGCGCGGCCTGCGCGCTTTCCGACG
CGGGCGCGAAGATCTCGCTGGTGGGGCGCAATCCGGACCGCGTGCGCGCACTGAGCAAGATCTGCGGCGCCGAATCACTG
CTGCGCGAACAGCTCGATTCGCGGCATTTCGACGCTGTGGTGCACGCTACACCGCTCGGTATGTTCCCGCACGTGAACGA
ATGCTTCTTCGAAGATAAAATCCCCGCCGACATTGTCTTCGACATGGTCTACAATCCGCTCGAGACGGTGTTGGTGCAAC
GCGCCAAGGAGCAGGGGAAGATCGTGGTTCCGGGGTTGGATATGTTTATCGAACAGGCGGTGCGCCAGTTTGAAATCTGG
ACCGGCGAAACCGCGCCGCGCCCGGTGATGCTCAAAGCCGCCCTGGAAGCACTGAATGGCGGCGCGGGCCATGCGCCGGC
GCCGAAATAG

Upstream 100 bases:

>100_bases
TGAAAGCTTCATCCTAAGCTATGCAGTTTACCAAAGTACGACGAAACGCCGCGCGGCAGGGCGGGCGAGCCGTGCTATTC
TGAATCTTCTTATCGCTCCA

Downstream 100 bases:

>100_bases
TCGGAGGTGAACATGAAGTTGACGCGCCGCAAATTGGCCGTGGTGCTCGCATCCGGTTCCGTGGCCGCGGTGGCCGCCGC
GCAAACTCCGCAGCAGCCCG

Product: shikimate dehydrogenase/3-dehydroquinate dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MAQTRSLPRICIALGLPDVPTLLDHARREAEAGEVFLEFRLDYLSNPCKGAEAIGKFLEEFPECILLATCRRHQNHGKFN
GSIEEQLAVLDLAVRNGAHAIDVEIETAEIAQDRLNQFRGRTQVIVSYHNFEATPPMDTVVNRVMKVQADAYKIVSTARK
PSDNVRVLAVAKALTKHRVIVLAMGELGFPTRVLSPVFGGVFTYAAPIYAEGTAAGQVSARYLRHLYRVEKLGKSAKIYG
VIADPIRHSISPAVHNRAFQSRRVDAVYLPFLVAPACLRDFFSLAAKLPLSGFSVTIPHKQKIIRYLDIVDPLARRIGAV
NTVWRKAGKWRGTNTDAAGVTGPLSRLLKISKASVLIVGNGGAARSAACALSDAGAKISLVGRNPDRVRALSKICGAESL
LREQLDSRHFDAVVHATPLGMFPHVNECFFEDKIPADIVFDMVYNPLETVLVQRAKEQGKIVVPGLDMFIEQAVRQFEIW
TGETAPRPVMLKAALEALNGGAGHAPAPK

Sequences:

>Translated_509_residues
MAQTRSLPRICIALGLPDVPTLLDHARREAEAGEVFLEFRLDYLSNPCKGAEAIGKFLEEFPECILLATCRRHQNHGKFN
GSIEEQLAVLDLAVRNGAHAIDVEIETAEIAQDRLNQFRGRTQVIVSYHNFEATPPMDTVVNRVMKVQADAYKIVSTARK
PSDNVRVLAVAKALTKHRVIVLAMGELGFPTRVLSPVFGGVFTYAAPIYAEGTAAGQVSARYLRHLYRVEKLGKSAKIYG
VIADPIRHSISPAVHNRAFQSRRVDAVYLPFLVAPACLRDFFSLAAKLPLSGFSVTIPHKQKIIRYLDIVDPLARRIGAV
NTVWRKAGKWRGTNTDAAGVTGPLSRLLKISKASVLIVGNGGAARSAACALSDAGAKISLVGRNPDRVRALSKICGAESL
LREQLDSRHFDAVVHATPLGMFPHVNECFFEDKIPADIVFDMVYNPLETVLVQRAKEQGKIVVPGLDMFIEQAVRQFEIW
TGETAPRPVMLKAALEALNGGAGHAPAPK
>Mature_508_residues
AQTRSLPRICIALGLPDVPTLLDHARREAEAGEVFLEFRLDYLSNPCKGAEAIGKFLEEFPECILLATCRRHQNHGKFNG
SIEEQLAVLDLAVRNGAHAIDVEIETAEIAQDRLNQFRGRTQVIVSYHNFEATPPMDTVVNRVMKVQADAYKIVSTARKP
SDNVRVLAVAKALTKHRVIVLAMGELGFPTRVLSPVFGGVFTYAAPIYAEGTAAGQVSARYLRHLYRVEKLGKSAKIYGV
IADPIRHSISPAVHNRAFQSRRVDAVYLPFLVAPACLRDFFSLAAKLPLSGFSVTIPHKQKIIRYLDIVDPLARRIGAVN
TVWRKAGKWRGTNTDAAGVTGPLSRLLKISKASVLIVGNGGAARSAACALSDAGAKISLVGRNPDRVRALSKICGAESLL
REQLDSRHFDAVVHATPLGMFPHVNECFFEDKIPADIVFDMVYNPLETVLVQRAKEQGKIVVPGLDMFIEQAVRQFEIWT
GETAPRPVMLKAALEALNGGAGHAPAPK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=269, Percent_Identity=28.6245353159851, Blast_Score=112, Evalue=8e-26,
Organism=Escherichia coli, GI1789675, Length=261, Percent_Identity=29.1187739463602, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787984, Length=239, Percent_Identity=28.0334728033473, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320332, Length=492, Percent_Identity=27.4390243902439, Blast_Score=126, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 55642; Mature: 55511

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS01028 DEHYDROQUINASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQTRSLPRICIALGLPDVPTLLDHARREAEAGEVFLEFRLDYLSNPCKGAEAIGKFLEE
CCCCCCCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCHHHHHHHHHH
FPECILLATCRRHQNHGKFNGSIEEQLAVLDLAVRNGAHAIDVEIETAEIAQDRLNQFRG
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHCC
RTQVIVSYHNFEATPPMDTVVNRVMKVQADAYKIVSTARKPSDNVRVLAVAKALTKHRVI
CEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHCCEE
VLAMGELGFPTRVLSPVFGGVFTYAAPIYAEGTAAGQVSARYLRHLYRVEKLGKSAKIYG
EEEECCCCCCHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
VIADPIRHSISPAVHNRAFQSRRVDAVYLPFLVAPACLRDFFSLAAKLPLSGFSVTIPHK
EEHHHHHHHCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCH
QKIIRYLDIVDPLARRIGAVNTVWRKAGKWRGTNTDAAGVTGPLSRLLKISKASVLIVGN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEC
GGAARSAACALSDAGAKISLVGRNPDRVRALSKICGAESLLREQLDSRHFDAVVHATPLG
CCCCHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCHHHHHHHHHHCHHHHHHHEECCCC
MFPHVNECFFEDKIPADIVFDMVYNPLETVLVQRAKEQGKIVVPGLDMFIEQAVRQFEIW
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHC
TGETAPRPVMLKAALEALNGGAGHAPAPK
CCCCCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AQTRSLPRICIALGLPDVPTLLDHARREAEAGEVFLEFRLDYLSNPCKGAEAIGKFLEE
CCCCCCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCHHHHHHHHHH
FPECILLATCRRHQNHGKFNGSIEEQLAVLDLAVRNGAHAIDVEIETAEIAQDRLNQFRG
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHCC
RTQVIVSYHNFEATPPMDTVVNRVMKVQADAYKIVSTARKPSDNVRVLAVAKALTKHRVI
CEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHCCEE
VLAMGELGFPTRVLSPVFGGVFTYAAPIYAEGTAAGQVSARYLRHLYRVEKLGKSAKIYG
EEEECCCCCCHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
VIADPIRHSISPAVHNRAFQSRRVDAVYLPFLVAPACLRDFFSLAAKLPLSGFSVTIPHK
EEHHHHHHHCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCH
QKIIRYLDIVDPLARRIGAVNTVWRKAGKWRGTNTDAAGVTGPLSRLLKISKASVLIVGN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEC
GGAARSAACALSDAGAKISLVGRNPDRVRALSKICGAESLLREQLDSRHFDAVVHATPLG
CCCCHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCHHHHHHHHHHCHHHHHHHEECCCC
MFPHVNECFFEDKIPADIVFDMVYNPLETVLVQRAKEQGKIVVPGLDMFIEQAVRQFEIW
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHC
TGETAPRPVMLKAALEALNGGAGHAPAPK
CCCCCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA