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The map label for this gene is lon [H]

Identifier: 116626097

GI number: 116626097

Start: 8871153

End: 8873525

Strand: Direct

Name: lon [H]

Synonym: Acid_7055

Alternate gene names: 116626097

Gene position: 8871153-8873525 (Clockwise)

Preceding gene: 116626096

Following gene: 116626104

Centisome position: 89.02

GC content: 62.37

Gene sequence:

>2373_bases
ATGCCCGAAGAACACGAAGCTTCCGCCAGTGAAAACCACGCAACACCTGAAGAACTTCCCGTGCTCACGGTACGCGACAC
CGTGATTTACCCGGGGGCACTGCTGCCGATCACCGTCGGCCGCCCCGCCTCGCTTGCTTTGGTGCAATCCCTTGGCGAAA
ATCGGACGCTCGCTATCGTCTCGCAACTCGACCCGCGGGTCGAGTCTCCGACGCCGGAGGATCTTTATCAGATTGGCACT
GTGTGCGTGATGCACAAAGCTATTAAGGTTCCCAAGGACAACCTGCTGCTTTTTTGCGAGGGCATCGCGCGCATCCGGAC
AGCGGAATTCACCGCAACCGAGCCCTTCCTGCGCGCACGCGTGGATCGCCTGCCGGACATCGAGCCGCCGGCGAGCGCCG
AGGTCGAAGCCCTGCGGCAGAACGTGGTGAGCCTGTTCCAGCAAATTGTGACCGCGTCACCCAATCTCTCTGATGAGCTT
GGCATTAACGCCGCCAACATCACCGAACCCGGACGGCTTGCGGACTACGTGGCGGGCACCCTGCCGGCCTTGGGGCATAT
AGAGCGGCAGAAGTTGCTCGAAGAACTCGACGGTATGGTGCGGCTCAACGAGATTCACCGCCACCTCACGCGGGAACTCG
AGCTGGTCGAACTCCGCTCTCGCATTCAGGACCAGGTACAAGGGCAACTCTCGCAGAACCAGCGCGAGTTTTACTTGCGC
GAGCAGCTGAAGGCCATCCAAAAGGAACTCGGCGAAGGCGACGACGCGTCGCGCGATGTGGAGGAATTGCGCAAAAAGCT
GGAAAGCGCCGGCATGAAAGAAGACGTCAAGATCGAGGCTCTGCGCGAGCTCAACCGCCTGGCGCGCATGTCCCCGGCGT
CGCCGGAATACGGCATGACGCGCACCTACCTCGAATGGATGGCCAATCTGCCGTGGAGCGTCTCTTCGGGTTCGCAGGTG
AACGTCAAGCGCGCGGCCGAGATTCTGGACGAGGATCACTACGACCTGGAGAAGGTCAAAGACCGCATTTTGGATTACCT
GGCGGTACTGCAATTGAAGCCAGTTCTCAAGGGACCGATTCTGTGTTTCGTGGGTGCGCCGGGAGTGGGAAAGACCTCGC
TCGGCCGGTCCATCGCGCGCTCCCTGGGGCGCAAGTTCGCCCGCATCTCGATGGGCGGCATGCACGATGAGGCGGAAATC
CGCGGACACCGGAGGACCTACATCGGAGCGCTTCCGGGCCAGATCGTGCAGGCACTGCGCCGCGCCGGCAGCAACGATCC
GGTCTTCATGCTGGACGAAGTGGATAAGCTGGGCCGCGATTTCCGCGGCGACCCTGCGAGCGCGCTGCTCGAAGTACTCG
ACCCGGAGCAGAACTCCACTTTCCGGGACAACTATCTGGACGTGCCGTTTGACCTCTCCAAGGTCCTCTTCATCACCACG
GCGAACGTGCTCGATCCAATTCCGGATGCGCTGCGCGACCGCATGGAAATCATCACGCTGGAGGGTTACACCGAGCAGGA
GAAGGTGATCATCGCTTTCCGCTACTTGATTCCGCGCCAGACCGCCGAGAACGGACTGGACGGGACCCAGGACATCGAGT
TCGGCGACGACGCGGTGCGTCACATCGTGCGCCGCTACACGCGTGAAGCAGGGGTGCGCAATCTGGAGCGGCTGATCGGC
ACGATCTGCCGCAAGCAGGCGCGCCGGATCGCGGAAGGGACGCGCGAGAAGATGACGGTCACTCCCGAACTGGTGGAGAA
GGACCTGGGTGCTCCGCGTTACCGCACCGATACCGAAGTGGCGGACCGGACGAGCCGCCCCGGTGTCGCGGTCGGCCTCG
CGTGGACGCCGGTGGGGGGCGACGTGCTGTTCATTGAAGCGGGACGAATGCCGGGCGGCAACAAGGGACTCATCATGACC
GGCCAGCTGGGTCCGGTGATGCAGGAATCGGTGCAGGCGGCGCTGACCTGGGTGCGCGGGAATGCGACAAAGTACGGGAT
TGATCCCGACCTGTTCAAGACCAGCGACATCCATATCCACGTGCCTGCCGGTGCGATCCCGAAGGACGGGCCGAGCGCCG
GCATCACGATGGCGACGGCGCTGCTTTCCATGCTGACCGAACGGCGTGTGCGCACCAACCTCGCGATGACCGGCGAAATC
ACGCTGACTGGCCAGGTGCTGCCCATCGGCGGTATCAAGGAGAAGGTGCTGGCGGCAAAGCGCAGCGGCGTCCGGGAAGT
CATTCTGCCGTTTGAGAACGAGGTCAACGTGATTGAAGATCTGAAGAGCGAGCAGATCGACGATATCCAGCTCCACTATG
TGAAGGCGATGGAGGAAGTGGTCGAACTCGCGCTTGAGCCGCCGGCGAAGTAA

Upstream 100 bases:

>100_bases
TCCGGATCCTGGGTTGTTATCCCAAGGGTGCCTAGAGCGAACAACGCTAACGAATCGCACACTGTGCGGCCCACCTGCCC
GTTACACTGAAGTTAGCGCC

Downstream 100 bases:

>100_bases
GCGCCGTCAGAGCAGGGCAGGCAGCAGTTCGCCCGCGGGCCCGCGCAGGGCGCAGTCCACGAGGTTGGTGAACGGTGTCT
CAGCGGTATTGATCTCGATC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 790; Mature: 789

Protein sequence:

>790_residues
MPEEHEASASENHATPEELPVLTVRDTVIYPGALLPITVGRPASLALVQSLGENRTLAIVSQLDPRVESPTPEDLYQIGT
VCVMHKAIKVPKDNLLLFCEGIARIRTAEFTATEPFLRARVDRLPDIEPPASAEVEALRQNVVSLFQQIVTASPNLSDEL
GINAANITEPGRLADYVAGTLPALGHIERQKLLEELDGMVRLNEIHRHLTRELELVELRSRIQDQVQGQLSQNQREFYLR
EQLKAIQKELGEGDDASRDVEELRKKLESAGMKEDVKIEALRELNRLARMSPASPEYGMTRTYLEWMANLPWSVSSGSQV
NVKRAAEILDEDHYDLEKVKDRILDYLAVLQLKPVLKGPILCFVGAPGVGKTSLGRSIARSLGRKFARISMGGMHDEAEI
RGHRRTYIGALPGQIVQALRRAGSNDPVFMLDEVDKLGRDFRGDPASALLEVLDPEQNSTFRDNYLDVPFDLSKVLFITT
ANVLDPIPDALRDRMEIITLEGYTEQEKVIIAFRYLIPRQTAENGLDGTQDIEFGDDAVRHIVRRYTREAGVRNLERLIG
TICRKQARRIAEGTREKMTVTPELVEKDLGAPRYRTDTEVADRTSRPGVAVGLAWTPVGGDVLFIEAGRMPGGNKGLIMT
GQLGPVMQESVQAALTWVRGNATKYGIDPDLFKTSDIHIHVPAGAIPKDGPSAGITMATALLSMLTERRVRTNLAMTGEI
TLTGQVLPIGGIKEKVLAAKRSGVREVILPFENEVNVIEDLKSEQIDDIQLHYVKAMEEVVELALEPPAK

Sequences:

>Translated_790_residues
MPEEHEASASENHATPEELPVLTVRDTVIYPGALLPITVGRPASLALVQSLGENRTLAIVSQLDPRVESPTPEDLYQIGT
VCVMHKAIKVPKDNLLLFCEGIARIRTAEFTATEPFLRARVDRLPDIEPPASAEVEALRQNVVSLFQQIVTASPNLSDEL
GINAANITEPGRLADYVAGTLPALGHIERQKLLEELDGMVRLNEIHRHLTRELELVELRSRIQDQVQGQLSQNQREFYLR
EQLKAIQKELGEGDDASRDVEELRKKLESAGMKEDVKIEALRELNRLARMSPASPEYGMTRTYLEWMANLPWSVSSGSQV
NVKRAAEILDEDHYDLEKVKDRILDYLAVLQLKPVLKGPILCFVGAPGVGKTSLGRSIARSLGRKFARISMGGMHDEAEI
RGHRRTYIGALPGQIVQALRRAGSNDPVFMLDEVDKLGRDFRGDPASALLEVLDPEQNSTFRDNYLDVPFDLSKVLFITT
ANVLDPIPDALRDRMEIITLEGYTEQEKVIIAFRYLIPRQTAENGLDGTQDIEFGDDAVRHIVRRYTREAGVRNLERLIG
TICRKQARRIAEGTREKMTVTPELVEKDLGAPRYRTDTEVADRTSRPGVAVGLAWTPVGGDVLFIEAGRMPGGNKGLIMT
GQLGPVMQESVQAALTWVRGNATKYGIDPDLFKTSDIHIHVPAGAIPKDGPSAGITMATALLSMLTERRVRTNLAMTGEI
TLTGQVLPIGGIKEKVLAAKRSGVREVILPFENEVNVIEDLKSEQIDDIQLHYVKAMEEVVELALEPPAK
>Mature_789_residues
PEEHEASASENHATPEELPVLTVRDTVIYPGALLPITVGRPASLALVQSLGENRTLAIVSQLDPRVESPTPEDLYQIGTV
CVMHKAIKVPKDNLLLFCEGIARIRTAEFTATEPFLRARVDRLPDIEPPASAEVEALRQNVVSLFQQIVTASPNLSDELG
INAANITEPGRLADYVAGTLPALGHIERQKLLEELDGMVRLNEIHRHLTRELELVELRSRIQDQVQGQLSQNQREFYLRE
QLKAIQKELGEGDDASRDVEELRKKLESAGMKEDVKIEALRELNRLARMSPASPEYGMTRTYLEWMANLPWSVSSGSQVN
VKRAAEILDEDHYDLEKVKDRILDYLAVLQLKPVLKGPILCFVGAPGVGKTSLGRSIARSLGRKFARISMGGMHDEAEIR
GHRRTYIGALPGQIVQALRRAGSNDPVFMLDEVDKLGRDFRGDPASALLEVLDPEQNSTFRDNYLDVPFDLSKVLFITTA
NVLDPIPDALRDRMEIITLEGYTEQEKVIIAFRYLIPRQTAENGLDGTQDIEFGDDAVRHIVRRYTREAGVRNLERLIGT
ICRKQARRIAEGTREKMTVTPELVEKDLGAPRYRTDTEVADRTSRPGVAVGLAWTPVGGDVLFIEAGRMPGGNKGLIMTG
QLGPVMQESVQAALTWVRGNATKYGIDPDLFKTSDIHIHVPAGAIPKDGPSAGITMATALLSMLTERRVRTNLAMTGEIT
LTGQVLPIGGIKEKVLAAKRSGVREVILPFENEVNVIEDLKSEQIDDIQLHYVKAMEEVVELALEPPAK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=839, Percent_Identity=39.5709177592372, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI21396489, Length=667, Percent_Identity=45.1274362818591, Blast_Score=551, Evalue=1e-157,
Organism=Escherichia coli, GI1786643, Length=773, Percent_Identity=46.1836998706339, Blast_Score=671, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=700, Percent_Identity=38.4285714285714, Blast_Score=472, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17556486, Length=796, Percent_Identity=35.0502512562814, Blast_Score=449, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6319449, Length=696, Percent_Identity=40.0862068965517, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24666867, Length=691, Percent_Identity=43.1259044862518, Blast_Score=529, Evalue=1e-150,
Organism=Drosophila melanogaster, GI221513036, Length=691, Percent_Identity=43.1259044862518, Blast_Score=529, Evalue=1e-150,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87538; Mature: 87406

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS01046 LON_SER ; PS00153 ATPASE_GAMMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEEHEASASENHATPEELPVLTVRDTVIYPGALLPITVGRPASLALVQSLGENRTLAIV
CCCCCCCCCCCCCCCHHHCCEEEEECCEECCCCEEEEECCCCHHHHHHHHCCCCCEEEEE
SQLDPRVESPTPEDLYQIGTVCVMHKAIKVPKDNLLLFCEGIARIRTAEFTATEPFLRAR
ECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHCCCCCCCHHHHHH
VDRLPDIEPPASAEVEALRQNVVSLFQQIVTASPNLSDELGINAANITEPGRLADYVAGT
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCHHHHHHHHHH
LPALGHIERQKLLEELDGMVRLNEIHRHLTRELELVELRSRIQDQVQGQLSQNQREFYLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQLKAIQKELGEGDDASRDVEELRKKLESAGMKEDVKIEALRELNRLARMSPASPEYGMT
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHH
RTYLEWMANLPWSVSSGSQVNVKRAAEILDEDHYDLEKVKDRILDYLAVLQLKPVLKGPI
HHHHHHHHCCCCCCCCCCEECHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCE
LCFVGAPGVGKTSLGRSIARSLGRKFARISMGGMHDEAEIRGHRRTYIGALPGQIVQALR
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHEEECCCHHHHHHHH
RAGSNDPVFMLDEVDKLGRDFRGDPASALLEVLDPEQNSTFRDNYLDVPFDLSKVLFITT
HCCCCCCEEEHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
ANVLDPIPDALRDRMEIITLEGYTEQEKVIIAFRYLIPRQTAENGLDGTQDIEFGDDAVR
HHHHCCCHHHHHCCEEEEEECCCCCCCCEEEEHHHHHCCHHHHCCCCCCCCCCCCHHHHH
HIVRRYTREAGVRNLERLIGTICRKQARRIAEGTREKMTVTPELVEKDLGAPRYRTDTEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCEEECHHHHHHHCCCCCCCCCCHH
ADRTSRPGVAVGLAWTPVGGDVLFIEAGRMPGGNKGLIMTGQLGPVMQESVQAALTWVRG
HHCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCC
NATKYGIDPDLFKTSDIHIHVPAGAIPKDGPSAGITMATALLSMLTERRVRTNLAMTGEI
CCEEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEE
TLTGQVLPIGGIKEKVLAAKRSGVREVILPFENEVNVIEDLKSEQIDDIQLHYVKAMEEV
EEEEEEEECCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
VELALEPPAK
HHHHCCCCCC
>Mature Secondary Structure 
PEEHEASASENHATPEELPVLTVRDTVIYPGALLPITVGRPASLALVQSLGENRTLAIV
CCCCCCCCCCCCCCHHHCCEEEEECCEECCCCEEEEECCCCHHHHHHHHCCCCCEEEEE
SQLDPRVESPTPEDLYQIGTVCVMHKAIKVPKDNLLLFCEGIARIRTAEFTATEPFLRAR
ECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHCCCCCCCHHHHHH
VDRLPDIEPPASAEVEALRQNVVSLFQQIVTASPNLSDELGINAANITEPGRLADYVAGT
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCHHHHHHHHHH
LPALGHIERQKLLEELDGMVRLNEIHRHLTRELELVELRSRIQDQVQGQLSQNQREFYLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQLKAIQKELGEGDDASRDVEELRKKLESAGMKEDVKIEALRELNRLARMSPASPEYGMT
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHH
RTYLEWMANLPWSVSSGSQVNVKRAAEILDEDHYDLEKVKDRILDYLAVLQLKPVLKGPI
HHHHHHHHCCCCCCCCCCEECHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCE
LCFVGAPGVGKTSLGRSIARSLGRKFARISMGGMHDEAEIRGHRRTYIGALPGQIVQALR
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHEEECCCHHHHHHHH
RAGSNDPVFMLDEVDKLGRDFRGDPASALLEVLDPEQNSTFRDNYLDVPFDLSKVLFITT
HCCCCCCEEEHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
ANVLDPIPDALRDRMEIITLEGYTEQEKVIIAFRYLIPRQTAENGLDGTQDIEFGDDAVR
HHHHCCCHHHHHCCEEEEEECCCCCCCCEEEEHHHHHCCHHHHCCCCCCCCCCCCHHHHH
HIVRRYTREAGVRNLERLIGTICRKQARRIAEGTREKMTVTPELVEKDLGAPRYRTDTEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCEEECHHHHHHHCCCCCCCCCCHH
ADRTSRPGVAVGLAWTPVGGDVLFIEAGRMPGGNKGLIMTGQLGPVMQESVQAALTWVRG
HHCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCC
NATKYGIDPDLFKTSDIHIHVPAGAIPKDGPSAGITMATALLSMLTERRVRTNLAMTGEI
CCEEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEE
TLTGQVLPIGGIKEKVLAAKRSGVREVILPFENEVNVIEDLKSEQIDDIQLHYVKAMEEV
EEEEEEEECCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
VELALEPPAK
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA