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The map label for this gene is mdtA [H]

Identifier: 116625994

GI number: 116625994

Start: 8739725

End: 8740942

Strand: Reverse

Name: mdtA [H]

Synonym: Acid_6952

Alternate gene names: 116625994

Gene position: 8740942-8739725 (Counterclockwise)

Preceding gene: 116625995

Following gene: 116625993

Centisome position: 87.71

GC content: 61.41

Gene sequence:

>1218_bases
GTGCCGGGCCACCGGTTAGCGCAGCCTCCACCTTCCCCGCCGAGAAAAATGCACCGTGCATGGACGTGGCTTTTGCTGCC
TCTCGCGATCGGGTTGTTCTTCGTCGTTCAACGTTATAAAGGTAACCGTCCTCCCAATGCTTCGCGGCTGATCATGCCGG
GAGCGGTGGCGATTACCACCGCCACTGCGAAGAAGGGCACGATCGGCGTCTATCTGGAATCGATCGGTACGGTCACGCCC
GTTTACACCTCATCCATCACTGCCCAGGTGAATGGGCTGGTGACCGCCGTCCACTACGCCGAAGGGCAAATGGTTCACAA
AGGCGATGCCCTGATCGATATCGATCCGCGGCCGTTTCAGGCTCAGGTGCTGCAGGCCCAGGGAACGCTCGATCGCGACA
CCAACCTCCTGGCTCAGGCCAAGATGGATCTTGACCGCTACCGGGCGGCATGGGCGCGCAACGCAATCCCCAAACAACAG
CTCGACGACCAGGAAAAGCTGGTTTTGCAGGATGAAGGACAGGTCAAGAGCGATCAGGGCAATCTCCAGTTTTTCCAGGT
ACAACTCGGCTGGTGCCACATCACGGCGCCCTTCACCGGACGCATCGGCCTCCGGCCGGTCGATCCCGGCAATGTGGTTG
TGCTCACCGCCGGAAATCAGGTGAACGCCACCACCAGCCTCGCGGTGATTACCCAGACCCAGCCCATCACGGTTGTATTT
ACCCTCGCGCAGGACAATCTAGGCGAAGTGCGCTCCCAGTTCCGGCGCCGCGGAACTCTGCCGGTGGCTGCATACGACCG
CGCGCTACAGACCAGGATCGCGTCCGGCTCCCTGACGGCGCTCGACAACCAGGTCGATACCACCACCGGCACGGTGAAAC
TCCGTGCCACGTTTGAAAACGGGGACGACGCGCTGTTCCCGAACCAATTCGTGAATACCCGGCTTCTGGTGACGACGCTG
AAGGGCGTCACGCTGGTCCCAGGCAATGTGATCCAACACAACGGCCAGGTGACTTTCGTTTATGTGATCAGCGACGGCGT
GGCGCACATGCAAACCGTCAAGGTCGGCACGAACGAGGGCGGTATGACGCAAGTCGAAGGGATCGCTCCGGGCACCGTCG
TAGCCGCCAGCAGTTTCGAAAGACTCCAGGACAACGTTCCCGTCACTGTCGTACGCACGCCGATGCCCGGCGCCACGGGC
GGAGCCGACACGCGATGA

Upstream 100 bases:

>100_bases
TGGGAACCGCCGTCCGATTTCTGCTGGGACTGGAAGATCTTCAGCTGTATTCAAGCCTGACGGAAGAAGGTCATTAAACT
TGGAGGAAACCCAGGACCAT

Downstream 100 bases:

>100_bases
GCCCCTCTCGCCCGTTCATTCTCCGGCCCGTAGCCACTTCATTGCTGATGGCCGCGATTCTTCTGGCCGGCATCGTCGCC
TATTTGCAATTGCCGGTTTC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MPGHRLAQPPPSPPRKMHRAWTWLLLPLAIGLFFVVQRYKGNRPPNASRLIMPGAVAITTATAKKGTIGVYLESIGTVTP
VYTSSITAQVNGLVTAVHYAEGQMVHKGDALIDIDPRPFQAQVLQAQGTLDRDTNLLAQAKMDLDRYRAAWARNAIPKQQ
LDDQEKLVLQDEGQVKSDQGNLQFFQVQLGWCHITAPFTGRIGLRPVDPGNVVVLTAGNQVNATTSLAVITQTQPITVVF
TLAQDNLGEVRSQFRRRGTLPVAAYDRALQTRIASGSLTALDNQVDTTTGTVKLRATFENGDDALFPNQFVNTRLLVTTL
KGVTLVPGNVIQHNGQVTFVYVISDGVAHMQTVKVGTNEGGMTQVEGIAPGTVVAASSFERLQDNVPVTVVRTPMPGATG
GADTR

Sequences:

>Translated_405_residues
MPGHRLAQPPPSPPRKMHRAWTWLLLPLAIGLFFVVQRYKGNRPPNASRLIMPGAVAITTATAKKGTIGVYLESIGTVTP
VYTSSITAQVNGLVTAVHYAEGQMVHKGDALIDIDPRPFQAQVLQAQGTLDRDTNLLAQAKMDLDRYRAAWARNAIPKQQ
LDDQEKLVLQDEGQVKSDQGNLQFFQVQLGWCHITAPFTGRIGLRPVDPGNVVVLTAGNQVNATTSLAVITQTQPITVVF
TLAQDNLGEVRSQFRRRGTLPVAAYDRALQTRIASGSLTALDNQVDTTTGTVKLRATFENGDDALFPNQFVNTRLLVTTL
KGVTLVPGNVIQHNGQVTFVYVISDGVAHMQTVKVGTNEGGMTQVEGIAPGTVVAASSFERLQDNVPVTVVRTPMPGATG
GADTR
>Mature_404_residues
PGHRLAQPPPSPPRKMHRAWTWLLLPLAIGLFFVVQRYKGNRPPNASRLIMPGAVAITTATAKKGTIGVYLESIGTVTPV
YTSSITAQVNGLVTAVHYAEGQMVHKGDALIDIDPRPFQAQVLQAQGTLDRDTNLLAQAKMDLDRYRAAWARNAIPKQQL
DDQEKLVLQDEGQVKSDQGNLQFFQVQLGWCHITAPFTGRIGLRPVDPGNVVVLTAGNQVNATTSLAVITQTQPITVVFT
LAQDNLGEVRSQFRRRGTLPVAAYDRALQTRIASGSLTALDNQVDTTTGTVKLRATFENGDDALFPNQFVNTRLLVTTLK
GVTLVPGNVIQHNGQVTFVYVISDGVAHMQTVKVGTNEGGMTQVEGIAPGTVVAASSFERLQDNVPVTVVRTPMPGATGG
ADTR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=364, Percent_Identity=38.1868131868132, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1789929, Length=347, Percent_Identity=26.8011527377522, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786668, Length=343, Percent_Identity=26.2390670553936, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789665, Length=268, Percent_Identity=27.9850746268657, Blast_Score=85, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43687; Mature: 43555

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGHRLAQPPPSPPRKMHRAWTWLLLPLAIGLFFVVQRYKGNRPPNASRLIMPGAVAITT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEEEEE
ATAKKGTIGVYLESIGTVTPVYTSSITAQVNGLVTAVHYAEGQMVHKGDALIDIDPRPFQ
ECCCCCEEEEEEECCCCCCCEEECEEEEEECEEEEEEEECCCCEEECCCEEEEECCCCCH
AQVLQAQGTLDRDTNLLAQAKMDLDRYRAAWARNAIPKQQLDDQEKLVLQDEGQVKSDQG
HHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEECCCCEECCCC
NLQFFQVQLGWCHITAPFTGRIGLRPVDPGNVVVLTAGNQVNATTSLAVITQTQPITVVF
CEEEEEEEEEEEEEECCCCCCCCCEECCCCCEEEEECCCCCCCCEEEEEEEECCCEEEEE
TLAQDNLGEVRSQFRRRGTLPVAAYDRALQTRIASGSLTALDNQVDTTTGTVKLRATFEN
EECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEEEEC
GDDALFPNQFVNTRLLVTTLKGVTLVPGNVIQHNGQVTFVYVISDGVAHMQTVKVGTNEG
CCCCCCCCHHCCCEEEEEEECCCEECCCHHEEECCCEEEEEEEECCCEEEEEEEECCCCC
GMTQVEGIAPGTVVAASSFERLQDNVPVTVVRTPMPGATGGADTR
CCEEECCCCCCEEEEHHHHHHHHCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
PGHRLAQPPPSPPRKMHRAWTWLLLPLAIGLFFVVQRYKGNRPPNASRLIMPGAVAITT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEEEEE
ATAKKGTIGVYLESIGTVTPVYTSSITAQVNGLVTAVHYAEGQMVHKGDALIDIDPRPFQ
ECCCCCEEEEEEECCCCCCCEEECEEEEEECEEEEEEEECCCCEEECCCEEEEECCCCCH
AQVLQAQGTLDRDTNLLAQAKMDLDRYRAAWARNAIPKQQLDDQEKLVLQDEGQVKSDQG
HHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEECCCCEECCCC
NLQFFQVQLGWCHITAPFTGRIGLRPVDPGNVVVLTAGNQVNATTSLAVITQTQPITVVF
CEEEEEEEEEEEEEECCCCCCCCCEECCCCCEEEEECCCCCCCCEEEEEEEECCCEEEEE
TLAQDNLGEVRSQFRRRGTLPVAAYDRALQTRIASGSLTALDNQVDTTTGTVKLRATFEN
EECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEEEEEC
GDDALFPNQFVNTRLLVTTLKGVTLVPGNVIQHNGQVTFVYVISDGVAHMQTVKVGTNEG
CCCCCCCCHHCCCEEEEEEECCCEECCCHHEEECCCEEEEEEEECCCEEEEEEEECCCCC
GMTQVEGIAPGTVVAASSFERLQDNVPVTVVRTPMPGATGGADTR
CCEEECCCCCCEEEEHHHHHHHHCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA