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The map label for this gene is 116625917

Identifier: 116625917

GI number: 116625917

Start: 8635226

End: 8636083

Strand: Reverse

Name: 116625917

Synonym: Acid_6874

Alternate gene names: NA

Gene position: 8636083-8635226 (Counterclockwise)

Preceding gene: 116625918

Following gene: 116625912

Centisome position: 86.66

GC content: 59.32

Gene sequence:

>858_bases
ATGCCCACTTTTTCCGTCCGCTGCGCTCTCATTGCGGCATTCGCTGCCGGGAGCGCAGCGCAGAGTTCCAGTAGCTGGAC
TGAGCCGTTCCCGCCGCATCGCATCGCCGGGAATTTGTATTATGTCGGATCGCGGGGGCTGGCCTCGTACCTGATCGCCA
CGCCCGAAGGGCACATCCTCATCAACAGCAGCCTGAAAACTTCCGTACCGCTGATCGAGACGAGTATCACGAAACTCGGC
TTCCAGCTCTCGGATGTGAAGATCCTCCTGGTCAGTCACGCACATTGGGATCACAACGCGGGTAGCGCAGATCTCAAAGG
CCGGACCGGCGCGAAGTACATGGTGATGGAGCCGGATGTACCCGTAACCGAAGACGGCGGCAAATCCGACTTCTTTTACG
GGGACTCGCCGGAGTCACTCTATCCACCGGCGAAGGTGGACCGCGTCTTACATGACGGAGACCAGGTGAAAATTGGGGGC
TCCGTCCTGACCGCCCATCTCACCCCCGGACACACAAAGGGTTGCACCACATGGACCATGAAGGTCAGCGAAGGCGGCAA
GACCTATGACGCCGTGATCGTGGGCAGCCCGAATGTGAATGCCGGGTTCCAGCTCGTGAACAACGCGAAATACCCCAGGA
TCGCAGACGATTATGTGCGGACCTTCGAGGTTTTGAGAGCGCTGCACTGCGACATTTTTCTGGGCGCCCACGGCGATTAC
TACGGGTTGGAGCGCAAGTTCAGCCGCTACGCCGCGAACGGACCGGGCGTCTTCATAGACCCCGATGGATATCGCGCCTA
TGTAGCCGAACGAGAGGAGGCCTTCCGACGCGAATTGGAGCGGCAGAAGAAGAAGTAG

Upstream 100 bases:

>100_bases
ATTCGAATCTGAGCAGCCCCAGCTTCGGCCGGATCATCTCCACGGCAGTCAATATGCGGCAGATGCAGTTTGCCATGAAG
TACGTGTTCTAATCGAACCC

Downstream 100 bases:

>100_bases
CATCGCCCTGCGGCAGGATGAAAAGGACGCCGCTGTTTCTCACAACACGACGTGGCAAGAGGCGGCTCGTCGTGATCATG
ATCGATGGTTTGCGTCATTT

Product: beta-lactamase

Products: NA

Alternate protein names: Beta-lactamase type II; Penicillinase [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MPTFSVRCALIAAFAAGSAAQSSSSWTEPFPPHRIAGNLYYVGSRGLASYLIATPEGHILINSSLKTSVPLIETSITKLG
FQLSDVKILLVSHAHWDHNAGSADLKGRTGAKYMVMEPDVPVTEDGGKSDFFYGDSPESLYPPAKVDRVLHDGDQVKIGG
SVLTAHLTPGHTKGCTTWTMKVSEGGKTYDAVIVGSPNVNAGFQLVNNAKYPRIADDYVRTFEVLRALHCDIFLGAHGDY
YGLERKFSRYAANGPGVFIDPDGYRAYVAEREEAFRRELERQKKK

Sequences:

>Translated_285_residues
MPTFSVRCALIAAFAAGSAAQSSSSWTEPFPPHRIAGNLYYVGSRGLASYLIATPEGHILINSSLKTSVPLIETSITKLG
FQLSDVKILLVSHAHWDHNAGSADLKGRTGAKYMVMEPDVPVTEDGGKSDFFYGDSPESLYPPAKVDRVLHDGDQVKIGG
SVLTAHLTPGHTKGCTTWTMKVSEGGKTYDAVIVGSPNVNAGFQLVNNAKYPRIADDYVRTFEVLRALHCDIFLGAHGDY
YGLERKFSRYAANGPGVFIDPDGYRAYVAEREEAFRRELERQKKK
>Mature_284_residues
PTFSVRCALIAAFAAGSAAQSSSSWTEPFPPHRIAGNLYYVGSRGLASYLIATPEGHILINSSLKTSVPLIETSITKLGF
QLSDVKILLVSHAHWDHNAGSADLKGRTGAKYMVMEPDVPVTEDGGKSDFFYGDSPESLYPPAKVDRVLHDGDQVKIGGS
VLTAHLTPGHTKGCTTWTMKVSEGGKTYDAVIVGSPNVNAGFQLVNNAKYPRIADDYVRTFEVLRALHCDIFLGAHGDYY
GLERKFSRYAANGPGVFIDPDGYRAYVAEREEAFRRELERQKKK

Specific function: Has a high activity against imipenem [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001018
- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 31133; Mature: 31002

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTFSVRCALIAAFAAGSAAQSSSSWTEPFPPHRIAGNLYYVGSRGLASYLIATPEGHIL
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCEEEEECCCCEEEEEECCCCCEE
INSSLKTSVPLIETSITKLGFQLSDVKILLVSHAHWDHNAGSADLKGRTGAKYMVMEPDV
ECCCCCCCCCHHHHHHHHHCEEECCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCC
PVTEDGGKSDFFYGDSPESLYPPAKVDRVLHDGDQVKIGGSVLTAHLTPGHTKGCTTWTM
CCCCCCCCCCCEECCCCCCCCCCHHHHHHHCCCCEEEECCEEEEEEECCCCCCCCEEEEE
KVSEGGKTYDAVIVGSPNVNAGFQLVNNAKYPRIADDYVRTFEVLRALHCDIFLGAHGDY
EECCCCCEEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCCC
YGLERKFSRYAANGPGVFIDPDGYRAYVAEREEAFRRELERQKKK
CCHHHHHHHHCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PTFSVRCALIAAFAAGSAAQSSSSWTEPFPPHRIAGNLYYVGSRGLASYLIATPEGHIL
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCEEEEECCCCEEEEEECCCCCEE
INSSLKTSVPLIETSITKLGFQLSDVKILLVSHAHWDHNAGSADLKGRTGAKYMVMEPDV
ECCCCCCCCCHHHHHHHHHCEEECCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCC
PVTEDGGKSDFFYGDSPESLYPPAKVDRVLHDGDQVKIGGSVLTAHLTPGHTKGCTTWTM
CCCCCCCCCCCEECCCCCCCCCCHHHHHHHCCCCEEEECCEEEEEEECCCCCCCCEEEEE
KVSEGGKTYDAVIVGSPNVNAGFQLVNNAKYPRIADDYVRTFEVLRALHCDIFLGAHGDY
EECCCCCEEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCCC
YGLERKFSRYAANGPGVFIDPDGYRAYVAEREEAFRRELERQKKK
CCHHHHHHHHCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8018721; 3931629; 9811546 [H]