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The map label for this gene is zraS [H]

Identifier: 116625834

GI number: 116625834

Start: 8513729

End: 8515585

Strand: Direct

Name: zraS [H]

Synonym: Acid_6787

Alternate gene names: 116625834

Gene position: 8513729-8515585 (Clockwise)

Preceding gene: 116625833

Following gene: 116625835

Centisome position: 85.43

GC content: 61.44

Gene sequence:

>1857_bases
GTGATTAGAAAAGTCCATGCACCGTCACTGCAGGCCAGAATCACGATTCTGACGGTTGCCGTTACAACCAGCCTGGTGGG
CGCTCTACTTCTGGTGCAACTCAACAACGTGGTCGAGCTGTGGCTGAACAGTTCGCTGGGGGTTGCCGAAATCGCCGGAC
AGCAAGTCAAGACCCTGCTTTTGCTGCGGCTGCAGGAGCGCACTCCTCCGAGTGGTCGTGGCGGCGCGGAACGCAGACAG
GCCTGGGTGAACATCGTGAAGAATGACGGCAACCTCACGCTGCTGCTCGAGACCACCATGGCCCAGTCCCGCTCGATTAT
CGAGATTTCGATTACGGGCGAGAATGGAAACGTCATCGCTTCCTCCAATCCGATGCGACCCGGAACGCTGATGGTACGGC
GGCCTTCTGTGCGCAGTCTCATATCGACCAATCCACTGCAGCGAATCACCAGGGTTCTGACCCGTGGGCAGGATTTCGAA
CTCACCATCCCCCTGGGCGTGGAAGGCGAGGCGAGGCCGCTCTTCACCATTCAAACGCTCGTTTCCTGGGTGCTGCTCCG
CGAGGACCTGGTGCCGGCCATGCGGCGCGTCGCCCTGTGGGGCATGGCGGCGGTGCTCGCTTCTATCGTGCTGGCCTATG
TCTCCAGCCGGCTGGTGGTCCGCAATATTGGCCGCCTCGATGCAGTCATCGACCGCATCAGCAGCGGGGAAGCAGGAAAA
CTTGCGGACGAGACGACAGGCGCCGCCCGGGAGTTCGCTGTCATTGAATCGAAGCTCAGTATCCTCGGGCACCGGTTTCG
CGGTGCCGTCGAGGGAGCCACCGAGCTCCGCAACAACGTTAAGAAACTGCTCGATCACCTGGAGGAGGCGATCCTCCTGT
TTGACCCGGCCGGTCGCTTGATTCTTGCGGGAGGGGCCGCGGCACGGATTCTCCGCCTTCCCGTAGACGCCGCGACGGGC
CGCCTTATGACAGAAATATTCCCGACTAACACGCTTCTCGGCAGCTTCCTGCGAGAGGCCTGCGTGCTTGATAAAGGGGT
TCAAGAACAGAGGATCGGCCGGCTGCTCGTGACAGTCGAACTGATCCCCGCCTCGCCGGATCACGCTGCCCGGATGGCAC
TGGTACGGATTCGGGATGCGGCCGGTCCGCAACAGCTCGAATCCCAACTGCAGCTGTCGGCACGCCTAGACGCCATGCAC
CGCTTGATTGGGAGCGTCGCCCACGAGGTTAAAAATCCCTTGAATTCGATCGCAGTGCGCCTGGATTATCTGCAGTCCTG
GGCGGCCACGGCTTCCCCCGAAGCGGAGGAGGAGGTCCAGGTAATCGTTGAGGAGGTGAACCGGCTGGATCGCGTGGTGC
GAAATTTCCTGGATTTCACGCGCCCGGTGGAACTAGTCCGGGAGCGATTGGACATGGTCGCGCTGTCGCGTGAAGTGGCA
GAGCTGGTCCAGCCCGATGCGGAACGGCGCGGCGTATCCATCCGGTTCGATAGCGCGCGGCCCTCGGTTCCGGTCTGCGG
CGATCCCGACCTTCTGAAAGAAGCGATCATGAATGTGGTCACCAACGGAATCGAAGCGATGCCATCCGGTGGAGAACTCG
ACATCGCGGTTTCCGAAGCCGACATGCAGTGCCGAATCACGATCCGCGACACGGGTCCGGGAATCCCGGCGGGCCAACGG
GAAAAGGTTTTCGAGCTCTACTTCAGCACCAAGGCAAAGGGCTCCGGCCTTGGCCTCCCGATGGCATACCGGGCATTGCA
GTTGCACGGCGGCAGCATAGACCTCGCGAGCGAACCGGGCAAAGGCACGAGCTTTCACCTGAAACTCCCGGTGATGGAAA
GCGAGGGAATCGCGTGA

Upstream 100 bases:

>100_bases
ACACCAGGCACAATCAGAGGAAGGCAGCGGAAATCCTGGGCATTAGCGCCAAGACTCTCTATAACAAACTGCGGGACTAC
GGCGGCGTGGTAGCGGAAGA

Downstream 100 bases:

>100_bases
GACCGGGGCTGCACCTCCCGAGGCTGTTCCTGGTCGCGCTTTGCGTGAGTGATTTGGGCTGCTGGTGGAACCGGAAGCCG
GCGCGCACCACACCCCCACC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MIRKVHAPSLQARITILTVAVTTSLVGALLLVQLNNVVELWLNSSLGVAEIAGQQVKTLLLLRLQERTPPSGRGGAERRQ
AWVNIVKNDGNLTLLLETTMAQSRSIIEISITGENGNVIASSNPMRPGTLMVRRPSVRSLISTNPLQRITRVLTRGQDFE
LTIPLGVEGEARPLFTIQTLVSWVLLREDLVPAMRRVALWGMAAVLASIVLAYVSSRLVVRNIGRLDAVIDRISSGEAGK
LADETTGAAREFAVIESKLSILGHRFRGAVEGATELRNNVKKLLDHLEEAILLFDPAGRLILAGGAAARILRLPVDAATG
RLMTEIFPTNTLLGSFLREACVLDKGVQEQRIGRLLVTVELIPASPDHAARMALVRIRDAAGPQQLESQLQLSARLDAMH
RLIGSVAHEVKNPLNSIAVRLDYLQSWAATASPEAEEEVQVIVEEVNRLDRVVRNFLDFTRPVELVRERLDMVALSREVA
ELVQPDAERRGVSIRFDSARPSVPVCGDPDLLKEAIMNVVTNGIEAMPSGGELDIAVSEADMQCRITIRDTGPGIPAGQR
EKVFELYFSTKAKGSGLGLPMAYRALQLHGGSIDLASEPGKGTSFHLKLPVMESEGIA

Sequences:

>Translated_618_residues
MIRKVHAPSLQARITILTVAVTTSLVGALLLVQLNNVVELWLNSSLGVAEIAGQQVKTLLLLRLQERTPPSGRGGAERRQ
AWVNIVKNDGNLTLLLETTMAQSRSIIEISITGENGNVIASSNPMRPGTLMVRRPSVRSLISTNPLQRITRVLTRGQDFE
LTIPLGVEGEARPLFTIQTLVSWVLLREDLVPAMRRVALWGMAAVLASIVLAYVSSRLVVRNIGRLDAVIDRISSGEAGK
LADETTGAAREFAVIESKLSILGHRFRGAVEGATELRNNVKKLLDHLEEAILLFDPAGRLILAGGAAARILRLPVDAATG
RLMTEIFPTNTLLGSFLREACVLDKGVQEQRIGRLLVTVELIPASPDHAARMALVRIRDAAGPQQLESQLQLSARLDAMH
RLIGSVAHEVKNPLNSIAVRLDYLQSWAATASPEAEEEVQVIVEEVNRLDRVVRNFLDFTRPVELVRERLDMVALSREVA
ELVQPDAERRGVSIRFDSARPSVPVCGDPDLLKEAIMNVVTNGIEAMPSGGELDIAVSEADMQCRITIRDTGPGIPAGQR
EKVFELYFSTKAKGSGLGLPMAYRALQLHGGSIDLASEPGKGTSFHLKLPVMESEGIA
>Mature_618_residues
MIRKVHAPSLQARITILTVAVTTSLVGALLLVQLNNVVELWLNSSLGVAEIAGQQVKTLLLLRLQERTPPSGRGGAERRQ
AWVNIVKNDGNLTLLLETTMAQSRSIIEISITGENGNVIASSNPMRPGTLMVRRPSVRSLISTNPLQRITRVLTRGQDFE
LTIPLGVEGEARPLFTIQTLVSWVLLREDLVPAMRRVALWGMAAVLASIVLAYVSSRLVVRNIGRLDAVIDRISSGEAGK
LADETTGAAREFAVIESKLSILGHRFRGAVEGATELRNNVKKLLDHLEEAILLFDPAGRLILAGGAAARILRLPVDAATG
RLMTEIFPTNTLLGSFLREACVLDKGVQEQRIGRLLVTVELIPASPDHAARMALVRIRDAAGPQQLESQLQLSARLDAMH
RLIGSVAHEVKNPLNSIAVRLDYLQSWAATASPEAEEEVQVIVEEVNRLDRVVRNFLDFTRPVELVRERLDMVALSREVA
ELVQPDAERRGVSIRFDSARPSVPVCGDPDLLKEAIMNVVTNGIEAMPSGGELDIAVSEADMQCRITIRDTGPGIPAGQR
EKVFELYFSTKAKGSGLGLPMAYRALQLHGGSIDLASEPGKGTSFHLKLPVMESEGIA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=229, Percent_Identity=36.6812227074236, Blast_Score=157, Evalue=3e-39,
Organism=Escherichia coli, GI1788549, Length=240, Percent_Identity=31.6666666666667, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1790300, Length=371, Percent_Identity=28.3018867924528, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=265, Percent_Identity=25.6603773584906, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786600, Length=359, Percent_Identity=22.8412256267409, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790346, Length=250, Percent_Identity=26.8, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789149, Length=240, Percent_Identity=27.5, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI145693157, Length=227, Percent_Identity=28.1938325991189, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=26.7857142857143, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786783, Length=218, Percent_Identity=24.7706422018349, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=246, Percent_Identity=25.609756097561, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=24.0909090909091, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=293, Percent_Identity=22.5255972696246, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 67188; Mature: 67188

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRKVHAPSLQARITILTVAVTTSLVGALLLVQLNNVVELWLNSSLGVAEIAGQQVKTLL
CCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LLRLQERTPPSGRGGAERRQAWVNIVKNDGNLTLLLETTMAQSRSIIEISITGENGNVIA
HHHHHHCCCCCCCCCHHHHHHHHHEEECCCCEEEEEEECHHCCCCEEEEEEECCCCCEEE
SSNPMRPGTLMVRRPSVRSLISTNPLQRITRVLTRGQDFELTIPLGVEGEARPLFTIQTL
CCCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHH
VSWVLLREDLVPAMRRVALWGMAAVLASIVLAYVSSRLVVRNIGRLDAVIDRISSGEAGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LADETTGAAREFAVIESKLSILGHRFRGAVEGATELRNNVKKLLDHLEEAILLFDPAGRL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCE
ILAGGAAARILRLPVDAATGRLMTEIFPTNTLLGSFLREACVLDKGVQEQRIGRLLVTVE
EEECCHHHEEEECCCCHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHCEEEEEEE
LIPASPDHAARMALVRIRDAAGPQQLESQLQLSARLDAMHRLIGSVAHEVKNPLNSIAVR
EECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDYLQSWAATASPEAEEEVQVIVEEVNRLDRVVRNFLDFTRPVELVRERLDMVALSREVA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELVQPDAERRGVSIRFDSARPSVPVCGDPDLLKEAIMNVVTNGIEAMPSGGELDIAVSEA
HHHCCCHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCHHCCCCCCCEEEEEECC
DMQCRITIRDTGPGIPAGQREKVFELYFSTKAKGSGLGLPMAYRALQLHGGSIDLASEPG
CCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEECCCCC
KGTSFHLKLPVMESEGIA
CCCEEEEEEEEECCCCCC
>Mature Secondary Structure
MIRKVHAPSLQARITILTVAVTTSLVGALLLVQLNNVVELWLNSSLGVAEIAGQQVKTLL
CCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LLRLQERTPPSGRGGAERRQAWVNIVKNDGNLTLLLETTMAQSRSIIEISITGENGNVIA
HHHHHHCCCCCCCCCHHHHHHHHHEEECCCCEEEEEEECHHCCCCEEEEEEECCCCCEEE
SSNPMRPGTLMVRRPSVRSLISTNPLQRITRVLTRGQDFELTIPLGVEGEARPLFTIQTL
CCCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHH
VSWVLLREDLVPAMRRVALWGMAAVLASIVLAYVSSRLVVRNIGRLDAVIDRISSGEAGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LADETTGAAREFAVIESKLSILGHRFRGAVEGATELRNNVKKLLDHLEEAILLFDPAGRL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCE
ILAGGAAARILRLPVDAATGRLMTEIFPTNTLLGSFLREACVLDKGVQEQRIGRLLVTVE
EEECCHHHEEEECCCCHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHCEEEEEEE
LIPASPDHAARMALVRIRDAAGPQQLESQLQLSARLDAMHRLIGSVAHEVKNPLNSIAVR
EECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDYLQSWAATASPEAEEEVQVIVEEVNRLDRVVRNFLDFTRPVELVRERLDMVALSREVA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELVQPDAERRGVSIRFDSARPSVPVCGDPDLLKEAIMNVVTNGIEAMPSGGELDIAVSEA
HHHCCCHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCHHCCCCCCCEEEEEECC
DMQCRITIRDTGPGIPAGQREKVFELYFSTKAKGSGLGLPMAYRALQLHGGSIDLASEPG
CCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEECCCCC
KGTSFHLKLPVMESEGIA
CCCEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]