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The map label for this gene is atoC [H]

Identifier: 116625833

GI number: 116625833

Start: 8512344

End: 8513732

Strand: Direct

Name: atoC [H]

Synonym: Acid_6786

Alternate gene names: 116625833

Gene position: 8512344-8513732 (Clockwise)

Preceding gene: 116625832

Following gene: 116625834

Centisome position: 85.42

GC content: 61.48

Gene sequence:

>1389_bases
ATGAGAAGAGTACTTGTCGTCGATGATGAGGCCAGCCAGCGGTCCGCAGTCGCGCGCATGATCGACCGTTGGGGTTTTTC
CACGGACACCGCGGCAGACGGCGCGGAGGCCTTCCGTAAGGCGCAGGAGTTCAACTTCGACGCTATCGTTACCGACCTGA
TGATGCCGGGTATGGATGGAATAGAACTCCTGCACCGTCTGCGTCAGGAATATCCGGTCGGGCCGTCCACCATTGTCGTG
ACCGCATACGGCAATATCGAAACCGCAATCAGCACTGTCCACGAGTACGGTGCGTTCTGGTTTATCGAAAAACCGATCCG
CCCCCGCGCGTTTCGCATTCTTCTGGAGCGGGCAATCGCCCAGCGGCAGCTTGTTCAAAGGAGCGAGCGCCTCGAGCGCC
AGCTCTGCAGTCATGGCTTTCTCGGCAAGCTGGTGGGCAACAGCGCCCCCATGCAGGAGGTGTTCTTTGTGGCCCTCCAG
GCGGCTCCAACCAATGTGACAGTCCTGGTGACCGGCGAGAGTGGAACCGGAAAGGAACTGGTGGCCCGCGCCATTCACGA
CCAGAGTCCGCGCTGCGCGGGGCCCTTCATCGCGGTAAACTGCGCGGCGATTCCCGAGACGCTAATCGAGAGCGAGCTTT
TTGGGCACGAGAAGGGAGCATTTACCGGCGCATTCGAGCGGAGGGCCGGCTGTTTCGAACTTGCTCAGGACGGAACGCTC
CTGCTCGACGAGATCGGAGACATGCCACTGGCGCTTCAGGCGAAATTGCTGCGGGTCCTCGAGGACCACCGCATCCGGCG
CGTGGGCGCGTCCAATGAAGTGCAGGTGGATGTCCGCGTCATCGCTTCCACCAACAAGGACCTCCAGCGGCTCTCGAGCG
ACGGCGGTTTCCGCGCGGATCTGTATTTTCGGCTGAGCGTGCTGCAGATCGCCTTACCCCCACTGCGTGACCACATGGAA
GATTTACCCGATCTCTGCGCGGCGCTTTTGGAGCAGATCAACAGCCGCCATCAGACCCGCGTGACGGGCATCGATCCTGC
AGCCCTCGGGGCGCTGGCCAGCCACGAGTGGCCCGGAAACGTGCGCGAATTGCGCAACGTTCTGGAGCGGGCAGCCGTTC
TCGCCCGCGAAGGCGAGATTGCCATCAGTCATCTCCCCAGTGGATTAGGCTGGGCTGCTCCGGAGCGAGTGATGCGCCAA
CTCGGTACACTCCCGAGCGTGACCCTGCCAGTGGGAATCACGCTCGAGCAGGCCGAACGCGAAATGATCGAGATCACGCT
GATGCACACCAGGCACAATCAGAGGAAGGCAGCGGAAATCCTGGGCATTAGCGCCAAGACTCTCTATAACAAACTGCGGG
ACTACGGCGGCGTGGTAGCGGAAGAGTGA

Upstream 100 bases:

>100_bases
CACGGTCGCTGCGCGCTTTTGGAAAACCGTGGCCACGAAATCGACTTCCGAACGGCAGCGCTCTGCCTGTTACGCTGGAT
AATTGGGTCGGGTACGAGGA

Downstream 100 bases:

>100_bases
TTAGAAAAGTCCATGCACCGTCACTGCAGGCCAGAATCACGATTCTGACGGTTGCCGTTACAACCAGCCTGGTGGGCGCT
CTACTTCTGGTGCAACTCAA

Product: two component sigma54-specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MRRVLVVDDEASQRSAVARMIDRWGFSTDTAADGAEAFRKAQEFNFDAIVTDLMMPGMDGIELLHRLRQEYPVGPSTIVV
TAYGNIETAISTVHEYGAFWFIEKPIRPRAFRILLERAIAQRQLVQRSERLERQLCSHGFLGKLVGNSAPMQEVFFVALQ
AAPTNVTVLVTGESGTGKELVARAIHDQSPRCAGPFIAVNCAAIPETLIESELFGHEKGAFTGAFERRAGCFELAQDGTL
LLDEIGDMPLALQAKLLRVLEDHRIRRVGASNEVQVDVRVIASTNKDLQRLSSDGGFRADLYFRLSVLQIALPPLRDHME
DLPDLCAALLEQINSRHQTRVTGIDPAALGALASHEWPGNVRELRNVLERAAVLAREGEIAISHLPSGLGWAAPERVMRQ
LGTLPSVTLPVGITLEQAEREMIEITLMHTRHNQRKAAEILGISAKTLYNKLRDYGGVVAEE

Sequences:

>Translated_462_residues
MRRVLVVDDEASQRSAVARMIDRWGFSTDTAADGAEAFRKAQEFNFDAIVTDLMMPGMDGIELLHRLRQEYPVGPSTIVV
TAYGNIETAISTVHEYGAFWFIEKPIRPRAFRILLERAIAQRQLVQRSERLERQLCSHGFLGKLVGNSAPMQEVFFVALQ
AAPTNVTVLVTGESGTGKELVARAIHDQSPRCAGPFIAVNCAAIPETLIESELFGHEKGAFTGAFERRAGCFELAQDGTL
LLDEIGDMPLALQAKLLRVLEDHRIRRVGASNEVQVDVRVIASTNKDLQRLSSDGGFRADLYFRLSVLQIALPPLRDHME
DLPDLCAALLEQINSRHQTRVTGIDPAALGALASHEWPGNVRELRNVLERAAVLAREGEIAISHLPSGLGWAAPERVMRQ
LGTLPSVTLPVGITLEQAEREMIEITLMHTRHNQRKAAEILGISAKTLYNKLRDYGGVVAEE
>Mature_462_residues
MRRVLVVDDEASQRSAVARMIDRWGFSTDTAADGAEAFRKAQEFNFDAIVTDLMMPGMDGIELLHRLRQEYPVGPSTIVV
TAYGNIETAISTVHEYGAFWFIEKPIRPRAFRILLERAIAQRQLVQRSERLERQLCSHGFLGKLVGNSAPMQEVFFVALQ
AAPTNVTVLVTGESGTGKELVARAIHDQSPRCAGPFIAVNCAAIPETLIESELFGHEKGAFTGAFERRAGCFELAQDGTL
LLDEIGDMPLALQAKLLRVLEDHRIRRVGASNEVQVDVRVIASTNKDLQRLSSDGGFRADLYFRLSVLQIALPPLRDHME
DLPDLCAALLEQINSRHQTRVTGIDPAALGALASHEWPGNVRELRNVLERAAVLAREGEIAISHLPSGLGWAAPERVMRQ
LGTLPSVTLPVGITLEQAEREMIEITLMHTRHNQRKAAEILGISAKTLYNKLRDYGGVVAEE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=40.5701754385965, Blast_Score=340, Evalue=2e-94,
Organism=Escherichia coli, GI1790299, Length=474, Percent_Identity=39.4514767932489, Blast_Score=308, Evalue=7e-85,
Organism=Escherichia coli, GI1790437, Length=454, Percent_Identity=38.9867841409692, Blast_Score=299, Evalue=3e-82,
Organism=Escherichia coli, GI1788905, Length=371, Percent_Identity=39.622641509434, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI87082117, Length=349, Percent_Identity=43.2664756446991, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=45.4545454545455, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1789087, Length=320, Percent_Identity=43.125, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI87082152, Length=297, Percent_Identity=43.0976430976431, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=38.0503144654088, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1786524, Length=327, Percent_Identity=39.7553516819572, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1787583, Length=320, Percent_Identity=39.375, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI87081858, Length=377, Percent_Identity=31.0344827586207, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1789828, Length=230, Percent_Identity=35.6521739130435, Blast_Score=124, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51034; Mature: 51034

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVLVVDDEASQRSAVARMIDRWGFSTDTAADGAEAFRKAQEFNFDAIVTDLMMPGMDG
CCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCH
IELLHRLRQEYPVGPSTIVVTAYGNIETAISTVHEYGAFWFIEKPIRPRAFRILLERAIA
HHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHH
QRQLVQRSERLERQLCSHGFLGKLVGNSAPMQEVFFVALQAAPTNVTVLVTGESGTGKEL
HHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHH
VARAIHDQSPRCAGPFIAVNCAAIPETLIESELFGHEKGAFTGAFERRAGCFELAQDGTL
HHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHCCCCE
LLDEIGDMPLALQAKLLRVLEDHRIRRVGASNEVQVDVRVIASTNKDLQRLSSDGGFRAD
EHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCHHHHHHHCCCCCEEE
LYFRLSVLQIALPPLRDHMEDLPDLCAALLEQINSRHQTRVTGIDPAALGALASHEWPGN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCCCCCCC
VRELRNVLERAAVLAREGEIAISHLPSGLGWAAPERVMRQLGTLPSVTLPVGITLEQAER
HHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHCCCCCEEEECCEEHHHHHH
EMIEITLMHTRHNQRKAAEILGISAKTLYNKLRDYGGVVAEE
HHEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRRVLVVDDEASQRSAVARMIDRWGFSTDTAADGAEAFRKAQEFNFDAIVTDLMMPGMDG
CCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCH
IELLHRLRQEYPVGPSTIVVTAYGNIETAISTVHEYGAFWFIEKPIRPRAFRILLERAIA
HHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHH
QRQLVQRSERLERQLCSHGFLGKLVGNSAPMQEVFFVALQAAPTNVTVLVTGESGTGKEL
HHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHH
VARAIHDQSPRCAGPFIAVNCAAIPETLIESELFGHEKGAFTGAFERRAGCFELAQDGTL
HHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHCCCCE
LLDEIGDMPLALQAKLLRVLEDHRIRRVGASNEVQVDVRVIASTNKDLQRLSSDGGFRAD
EHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCHHHHHHHCCCCCEEE
LYFRLSVLQIALPPLRDHMEDLPDLCAALLEQINSRHQTRVTGIDPAALGALASHEWPGN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCCCCCCC
VRELRNVLERAAVLAREGEIAISHLPSGLGWAAPERVMRQLGTLPSVTLPVGITLEQAER
HHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHCCCCCEEEECCEEHHHHHH
EMIEITLMHTRHNQRKAAEILGISAKTLYNKLRDYGGVVAEE
HHEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]