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The map label for this gene is proA [H]

Identifier: 116625823

GI number: 116625823

Start: 8494849

End: 8495586

Strand: Reverse

Name: proA [H]

Synonym: Acid_6774

Alternate gene names: 116625823

Gene position: 8495586-8494849 (Counterclockwise)

Preceding gene: 116625824

Following gene: 116625822

Centisome position: 85.25

GC content: 59.76

Gene sequence:

>738_bases
ATGCGAATGCGAGCCCAAATGAAACGATTGTCGTGTATCGGTGCCACTACCGCCGGATTTGCAGTCTTCTGGCTGATGGC
TCAACCCTCGGGAGATCCTTTGATTCAGGGGTATCGCGAAACCGAAGTAGCGTCAGTCTCAGATGCTATCGAGCAACTCT
ATGGCCAGCAGGCATTCATGTCGCATGAAATGCGGCCGATCGAAAAGACCAAATTCGCGGGTCCGGCCTGGACGGTGCTC
ATGAAGAAAGAGGAGGCCAAGGACGGCGGACCCGCGGTGCAGGGCATGCTTGACGCGATCGACGCCGCCCCGGCCGGCGC
CGTCTACGTCATGTCCGTGGAGAACGGTGCGGATTATGCGGGTATAGGCGGGCTGATGGCCACAGGCATGAAGGCCCGTG
GACTAGCGGGAGCGGTCATCGATGCCTCGATTCGCGACACACCGCACATCAAGAGGTTGCAGTTTCCGGTGTTCAGCCGC
GGCGTGGTGCCCTCCACCATGGTGGGCCACTACCGCTTCGCCGCTGTGAATGTGCCGGTGACGTGCGCAGGCGTGAAGGT
GAATCCCGGCGATATTGTCACCGCCGATGAAGACGGCATCGTAGTGGTGCCGAAGGCGCATGCCGCCGACGTCCTCAAGA
AGGCGCAGGACCTCGACTACCAGGAGCATTCGACCGTTCCCTTCATCGAAAAGTTCAAGTCGATCAAGGAAGCCGTCGCC
AAGTTCGGTCGAATCTAG

Upstream 100 bases:

>100_bases
GAAAGAGGCTGGCGCGCGGTACTGTGGAGATGAATGACGAGGTGGCGAAGAAAGCTCAACCCGGCACGCCGTGGTTCGAG
CCGGCCAGAAGGGGATGAGT

Downstream 100 bases:

>100_bases
GATATTACGGTGACCGGCTGGATAGTTCCCTGTGGAGCAGACTTTAGTCTGCTTCCAGCTTGCCGTCTGCATAGCGGGAA
CGCCGTCGATTGTTTGAGCT

Product: dimethylmenaquinone methyltransferase

Products: NA

Alternate protein names: 4-hydroxy-2-oxoglutarate aldolase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MRMRAQMKRLSCIGATTAGFAVFWLMAQPSGDPLIQGYRETEVASVSDAIEQLYGQQAFMSHEMRPIEKTKFAGPAWTVL
MKKEEAKDGGPAVQGMLDAIDAAPAGAVYVMSVENGADYAGIGGLMATGMKARGLAGAVIDASIRDTPHIKRLQFPVFSR
GVVPSTMVGHYRFAAVNVPVTCAGVKVNPGDIVTADEDGIVVVPKAHAADVLKKAQDLDYQEHSTVPFIEKFKSIKEAVA
KFGRI

Sequences:

>Translated_245_residues
MRMRAQMKRLSCIGATTAGFAVFWLMAQPSGDPLIQGYRETEVASVSDAIEQLYGQQAFMSHEMRPIEKTKFAGPAWTVL
MKKEEAKDGGPAVQGMLDAIDAAPAGAVYVMSVENGADYAGIGGLMATGMKARGLAGAVIDASIRDTPHIKRLQFPVFSR
GVVPSTMVGHYRFAAVNVPVTCAGVKVNPGDIVTADEDGIVVVPKAHAADVLKKAQDLDYQEHSTVPFIEKFKSIKEAVA
KFGRI
>Mature_245_residues
MRMRAQMKRLSCIGATTAGFAVFWLMAQPSGDPLIQGYRETEVASVSDAIEQLYGQQAFMSHEMRPIEKTKFAGPAWTVL
MKKEEAKDGGPAVQGMLDAIDAAPAGAVYVMSVENGADYAGIGGLMATGMKARGLAGAVIDASIRDTPHIKRLQFPVFSR
GVVPSTMVGHYRFAAVNVPVTCAGVKVNPGDIVTADEDGIVVVPKAHAADVLKKAQDLDYQEHSTVPFIEKFKSIKEAVA
KFGRI

Specific function: Plays a role in protocatechuate degradation. Has a broad substrate specificity and catalyzes the aldol cleavage of 4- hydroxy-4-methyl-2-oxoglutarate, 4-hydroxy-2-oxoglutarate and 4- carboxy-4-hydroxy-2-oxoadipate, and the decarboxylation of oxaloacetate.

COG id: COG0684

COG function: function code H; Demethylmenaquinone methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014165
- InterPro:   IPR005493 [H]

Pfam domain/function: PF03737 Methyltransf_6 [H]

EC number: =4.1.1.3; =4.1.3.16; =4.1.3.17 [H]

Molecular weight: Translated: 26230; Mature: 26230

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMRAQMKRLSCIGATTAGFAVFWLMAQPSGDPLIQGYRETEVASVSDAIEQLYGQQAFM
CCHHHHHHHHHHHCCCHHHEEEEEEEECCCCCHHHCCCCHHHHHHHHHHHHHHHCHHHHH
SHEMRPIEKTKFAGPAWTVLMKKEEAKDGGPAVQGMLDAIDAAPAGAVYVMSVENGADYA
HHCCCCCHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
GIGGLMATGMKARGLAGAVIDASIRDTPHIKRLQFPVFSRGVVPSTMVGHYRFAAVNVPV
CCCHHHHCCCHHCCCCCEEEECCCCCCCCCCEEECCHHCCCCCCCHHHCCEEEEEECCCE
TCAGVKVNPGDIVTADEDGIVVVPKAHAADVLKKAQDLDYQEHSTVPFIEKFKSIKEAVA
EEEEEEECCCCEEEECCCCEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
KFGRI
HHCCC
>Mature Secondary Structure
MRMRAQMKRLSCIGATTAGFAVFWLMAQPSGDPLIQGYRETEVASVSDAIEQLYGQQAFM
CCHHHHHHHHHHHCCCHHHEEEEEEEECCCCCHHHCCCCHHHHHHHHHHHHHHHCHHHHH
SHEMRPIEKTKFAGPAWTVLMKKEEAKDGGPAVQGMLDAIDAAPAGAVYVMSVENGADYA
HHCCCCCHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
GIGGLMATGMKARGLAGAVIDASIRDTPHIKRLQFPVFSRGVVPSTMVGHYRFAAVNVPV
CCCHHHHCCCHHCCCCCEEEECCCCCCCCCCEEECCHHCCCCCCCHHHCCEEEEEECCCE
TCAGVKVNPGDIVTADEDGIVVVPKAHAADVLKKAQDLDYQEHSTVPFIEKFKSIKEAVA
EEEEEEECCCCEEEECCCCEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
KFGRI
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11826967 [H]