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The map label for this gene is groEL

Identifier: 116625797

GI number: 116625797

Start: 8451550

End: 8453178

Strand: Direct

Name: groEL

Synonym: Acid_6747

Alternate gene names: 116625797

Gene position: 8451550-8453178 (Clockwise)

Preceding gene: 116625796

Following gene: 116625798

Centisome position: 84.81

GC content: 62.8

Gene sequence:

>1629_bases
ATGGCGAAACAGATTGTATATTCCGAAGCTTCCCGTCAGGCGATTCTGCGCGGTGTAAACCAGCTCGCGGATGCCGTGAA
GGTGACCCTCGGCCCGAAGGGCCGTAACGTTGTTCTGGAGAAGAAGTTTGGCGGCCCGACGATCACCAAAGACGGTGTGA
CGGTCGCGAAGGAAATCGAACTGAAGGATCCGCTGGAGAACATGGGCGCGCAGATGGTGCGCGAAGTGGCCTCCAAGACG
AGCGACGTGGCCGGCGACGGCACCACGACCGCGACGATTCTGGCGCAGAGCATCTACCGCGAAGGCGTTAAGGCCGTTGC
GGCGGGCGCGAACCCGATGGCGCTGAAGCGCGGCATCGACAAGGCCGTCGAGCTGGCGACCGAGGAAGTGAAGAAGCTCT
CCAAGCCCGTGTCGGGCGACATGATCGCGCAGGTTGGAACGATTTCGGCCAACAGCGATAAGACGATCGGCAACATCATC
GCCGACGCGATGAAGAAGGTCGGCAAGGATGGCGTGATCACGGTCGAGGAATCGAAGACCATGGTTACCGAACTGGACAC
CGTGGAAGGCATGCAGTTCGACCGCGGCTATCTCTCGCCCTACTTCGTGAGCGATGCGGAGCGGATGGAAGCCGTTCTCG
AGGATCCGTACATCCTGATCCACGAGAAGAAGATCAGCAACATGAAGGACCTGCTGCCGCTGCTCGAGCAGATCGCCCGT
TCCGGCAAGCCGCTCCTGATCATCGCGGAAGAAGTGGAAGGCGAAGCGCTGGCCACCCTCGTGGTGAACAAGCTGCGCGG
CACGCTGAACGCTTGCGCGGTGAAGGCTCCGGGCTTTGGCGATCGCCGCAAGGCGATGTTGGAAGACATCGGCATCCTGA
CCGGCGGCAAGCCGATCATGGAAGATATCGGCGTGAAGCTGGAAGGCGTTCGGCTCGAGGACCTGGGCCGCGCCAAGCGC
GTCACGGTGGACAAGGACAACACCACCATCGTTGACGGCGCCGGCAATCCGAAGGGAATCGAAGGGCGCATCAAGCAACT
GCGCGCGCAGATCGACGAGACCACCAGCGATTACGACCGCGAGAAGCTCCAGGAACGCCTGGCGAAGCTTGCCGGCGGCG
TGGCGGTGATCAAGGTCGGCGCGGCCACCGAGACCGAAATGAAGGAAAAGAAGGCTCGCGTGGAAGATGCTCTGCATGCG
ACCCGCGCCGCGGTTGAGGAAGGCATCGTTCCCGGCGGCGGCGTGGCGCTGCTCCGTGCGGCGAAGGCCCTGGCGACGTT
CAAGGTGGATGGCGATGAGCAGATCGGGGTGAGCATCGTGAAGCGCGCCTGCGAAGAGCCGCTGCGCCAGATCGTGTCCA
ACTCCGGCACGGAGGGTGCGATCGTGGTGGATAAGGTTCGCGAGAATGCGAACAACAACTACGGCTACAACGCGGCTACC
GACACCTATGAAGACCTGGTGGCAGCGGGCGTGATCGATCCGACGAAAGTGACGCGGTCTGCCCTGCAGCACGCGGCCTC
GATCGCCGGCTTGATGCTGACGACGGAAGCCATGATCGCCGAGATCCCGGAGAAGAAGTCTGCTCCGGCCGGCGGCCCCG
GCGGCCACGGTCCCGAGATGGACTACTAA

Upstream 100 bases:

>100_bases
ATGGCGATGAGTATTTGATTATGCGTGAGGACGAAGTCCTCGGGATTTTGGATGCTGCGCCCAAAGTGCAGAAGAAAGCT
AGCTAGGAGTCGATAACGAA

Downstream 100 bases:

>100_bases
GTAGTTCGTTAGTTAGGTAAGTTAAGGACGCCGCGCTCTGTAAGGGGCGCGGCGTTTTTGCGTTTGGAGGGCTGGAATCA
TCATCGCCGAAATTCGGAAG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MAKQIVYSEASRQAILRGVNQLADAVKVTLGPKGRNVVLEKKFGGPTITKDGVTVAKEIELKDPLENMGAQMVREVASKT
SDVAGDGTTTATILAQSIYREGVKAVAAGANPMALKRGIDKAVELATEEVKKLSKPVSGDMIAQVGTISANSDKTIGNII
ADAMKKVGKDGVITVEESKTMVTELDTVEGMQFDRGYLSPYFVSDAERMEAVLEDPYILIHEKKISNMKDLLPLLEQIAR
SGKPLLIIAEEVEGEALATLVVNKLRGTLNACAVKAPGFGDRRKAMLEDIGILTGGKPIMEDIGVKLEGVRLEDLGRAKR
VTVDKDNTTIVDGAGNPKGIEGRIKQLRAQIDETTSDYDREKLQERLAKLAGGVAVIKVGAATETEMKEKKARVEDALHA
TRAAVEEGIVPGGGVALLRAAKALATFKVDGDEQIGVSIVKRACEEPLRQIVSNSGTEGAIVVDKVRENANNNYGYNAAT
DTYEDLVAAGVIDPTKVTRSALQHAASIAGLMLTTEAMIAEIPEKKSAPAGGPGGHGPEMDY

Sequences:

>Translated_542_residues
MAKQIVYSEASRQAILRGVNQLADAVKVTLGPKGRNVVLEKKFGGPTITKDGVTVAKEIELKDPLENMGAQMVREVASKT
SDVAGDGTTTATILAQSIYREGVKAVAAGANPMALKRGIDKAVELATEEVKKLSKPVSGDMIAQVGTISANSDKTIGNII
ADAMKKVGKDGVITVEESKTMVTELDTVEGMQFDRGYLSPYFVSDAERMEAVLEDPYILIHEKKISNMKDLLPLLEQIAR
SGKPLLIIAEEVEGEALATLVVNKLRGTLNACAVKAPGFGDRRKAMLEDIGILTGGKPIMEDIGVKLEGVRLEDLGRAKR
VTVDKDNTTIVDGAGNPKGIEGRIKQLRAQIDETTSDYDREKLQERLAKLAGGVAVIKVGAATETEMKEKKARVEDALHA
TRAAVEEGIVPGGGVALLRAAKALATFKVDGDEQIGVSIVKRACEEPLRQIVSNSGTEGAIVVDKVRENANNNYGYNAAT
DTYEDLVAAGVIDPTKVTRSALQHAASIAGLMLTTEAMIAEIPEKKSAPAGGPGGHGPEMDY
>Mature_541_residues
AKQIVYSEASRQAILRGVNQLADAVKVTLGPKGRNVVLEKKFGGPTITKDGVTVAKEIELKDPLENMGAQMVREVASKTS
DVAGDGTTTATILAQSIYREGVKAVAAGANPMALKRGIDKAVELATEEVKKLSKPVSGDMIAQVGTISANSDKTIGNIIA
DAMKKVGKDGVITVEESKTMVTELDTVEGMQFDRGYLSPYFVSDAERMEAVLEDPYILIHEKKISNMKDLLPLLEQIARS
GKPLLIIAEEVEGEALATLVVNKLRGTLNACAVKAPGFGDRRKAMLEDIGILTGGKPIMEDIGVKLEGVRLEDLGRAKRV
TVDKDNTTIVDGAGNPKGIEGRIKQLRAQIDETTSDYDREKLQERLAKLAGGVAVIKVGAATETEMKEKKARVEDALHAT
RAAVEEGIVPGGGVALLRAAKALATFKVDGDEQIGVSIVKRACEEPLRQIVSNSGTEGAIVVDKVRENANNNYGYNAATD
TYEDLVAAGVIDPTKVTRSALQHAASIAGLMLTTEAMIAEIPEKKSAPAGGPGGHGPEMDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=50.4708097928437, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=50.4708097928437, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI38455427, Length=137, Percent_Identity=33.5766423357664, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI302058290, Length=522, Percent_Identity=23.9463601532567, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=65.9735349716446, Blast_Score=687, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=51.6068052930057, Blast_Score=535, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=52.132701421801, Blast_Score=219, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=51.1450381679389, Blast_Score=526, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6322350, Length=533, Percent_Identity=23.4521575984991, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322524, Length=131, Percent_Identity=29.0076335877863, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=51.2333965844402, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=51.2333965844402, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=48.952380952381, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=48.952380952381, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=48.952380952381, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI17864606, Length=524, Percent_Identity=44.2748091603053, Blast_Score=425, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24584129, Length=536, Percent_Identity=37.5, Blast_Score=322, Evalue=5e-88,
Organism=Drosophila melanogaster, GI19921262, Length=536, Percent_Identity=37.5, Blast_Score=322, Evalue=5e-88,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_SOLUE (Q01RQ2)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_827953.1
- ProteinModelPortal:   Q01RQ2
- SMR:   Q01RQ2
- STRING:   Q01RQ2
- GeneID:   4428452
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_6747
- NMPDR:   fig|234267.9.peg.6415
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   GFGENRR
- PhylomeDB:   Q01RQ2
- ProtClustDB:   PRK00013
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57550; Mature: 57419

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQIVYSEASRQAILRGVNQLADAVKVTLGPKGRNVVLEKKFGGPTITKDGVTVAKEIE
CCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCEEEHHCC
LKDPLENMGAQMVREVASKTSDVAGDGTTTATILAQSIYREGVKAVAAGANPMALKRGID
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAVELATEEVKKLSKPVSGDMIAQVGTISANSDKTIGNIIADAMKKVGKDGVITVEESKT
HHHHHHHHHHHHHHCCCCCCHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCH
MVTELDTVEGMQFDRGYLSPYFVSDAERMEAVLEDPYILIHEKKISNMKDLLPLLEQIAR
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEECHHHCCHHHHHHHHHHHHH
SGKPLLIIAEEVEGEALATLVVNKLRGTLNACAVKAPGFGDRRKAMLEDIGILTGGKPIM
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCCHHH
EDIGVKLEGVRLEDLGRAKRVTVDKDNTTIVDGAGNPKGIEGRIKQLRAQIDETTSDYDR
HHCCCEEECEEHHHCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHH
EKLQERLAKLAGGVAVIKVGAATETEMKEKKARVEDALHATRAAVEEGIVPGGGVALLRA
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AKALATFKVDGDEQIGVSIVKRACEEPLRQIVSNSGTEGAIVVDKVRENANNNYGYNAAT
HHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCCCCCCCCCC
DTYEDLVAAGVIDPTKVTRSALQHAASIAGLMLTTEAMIAEIPEKKSAPAGGPGGHGPEM
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DY
CC
>Mature Secondary Structure 
AKQIVYSEASRQAILRGVNQLADAVKVTLGPKGRNVVLEKKFGGPTITKDGVTVAKEIE
CCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCEEEHHCC
LKDPLENMGAQMVREVASKTSDVAGDGTTTATILAQSIYREGVKAVAAGANPMALKRGID
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAVELATEEVKKLSKPVSGDMIAQVGTISANSDKTIGNIIADAMKKVGKDGVITVEESKT
HHHHHHHHHHHHHHCCCCCCHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCH
MVTELDTVEGMQFDRGYLSPYFVSDAERMEAVLEDPYILIHEKKISNMKDLLPLLEQIAR
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEECHHHCCHHHHHHHHHHHHH
SGKPLLIIAEEVEGEALATLVVNKLRGTLNACAVKAPGFGDRRKAMLEDIGILTGGKPIM
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCCHHH
EDIGVKLEGVRLEDLGRAKRVTVDKDNTTIVDGAGNPKGIEGRIKQLRAQIDETTSDYDR
HHCCCEEECEEHHHCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHH
EKLQERLAKLAGGVAVIKVGAATETEMKEKKARVEDALHATRAAVEEGIVPGGGVALLRA
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AKALATFKVDGDEQIGVSIVKRACEEPLRQIVSNSGTEGAIVVDKVRENANNNYGYNAAT
HHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCCCCCCCCCC
DTYEDLVAAGVIDPTKVTRSALQHAASIAGLMLTTEAMIAEIPEKKSAPAGGPGGHGPEM
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DY
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA