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The map label for this gene is folP [H]

Identifier: 116625758

GI number: 116625758

Start: 8408907

End: 8409752

Strand: Direct

Name: folP [H]

Synonym: Acid_6708

Alternate gene names: 116625758

Gene position: 8408907-8409752 (Clockwise)

Preceding gene: 116625757

Following gene: 116625759

Centisome position: 84.38

GC content: 63.95

Gene sequence:

>846_bases
GTGAGAAAACTCTTTTTTTGGAAATTGAAGCAGCACGAGATCCGCCTGGGCGAACGCACCGTGCTGATGGGCGTGCTCAA
TGTAACGCCCGATTCGTTTTCCGATGGGGGCAAGTACTCGGACCCGGACCGCGCTTTCGCGCGGGCGATCGAGCTGGAGG
AACAGGGCGCGGACATCATCGATATCGGCGCGGAATCCACCAAGCCGGGGTCCACGCGAGTATCGGTGGCCGAGGAGATG
CGCCGGCTGATCCCGGTGCTGAAGCGGTTGAAGGACCGGCTGGGCATTCCGATCTCGGTGGACACATACAAGGCCGAGGT
GGCCGAGCGCGCGCTAGAGCTGGGCGTGGAGATCATCAACGACCCTTCGGGACTGACGTTCGAACCGCAGCTGGCGCGGA
CCGCGGCCAACATGAATGCCGGATTGATTTTGAATCACATGCGCGGGACGCCGGAGACATGGGCGAAGCTGGGTCCGATG
CCGGATCCGCTCTCGACGATCGGGCGCGATCTGGATGCGATGATCAGCCGGGCGCGGCACGCGGGCGTGGACAAGGCCCA
CATGGTGATCGATCCGGGCCTCGGGTTCGGCAAGCGCAAGGAGCAGAACGCAGTGATCCTGGCCCGGCTGGGCGAATTGA
ATCCGCTGGACCTCCCGATTATGGTGGGGCCGTCGCGCAAGAGTTTTCTGGCTCATCCCGATCTGGAAGAGACGAAGTTC
GCAACGGCGGCGGCGGTAACTGCCGCGATTCTCGGCGGCGCTCACATCGTGCGTGTGCACGACGTCCGCGAGATGCGCGC
GGTGGCGGACGTGGCGGATGAGATCGTACGCGGCAGGCCCGAGTAG

Upstream 100 bases:

>100_bases
GAGAAGGTTCGCGAGGTGCTGATGGCTAATCCGCCGGCGGAGATGGTGATCCAGGTGGGGAAAAATTGGAAGAGGGTCGC
GGGTTAGACTAGACAATACG

Downstream 100 bases:

>100_bases
CCGCCCGAGTAGCCGTTAGATACTGTAACCGTAGGACCACACTTGCCCGTCTATGGAGTCGCCATGAAGCGAATTTCAGT
AGTGATGCTGCTGGTGACGG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MRKLFFWKLKQHEIRLGERTVLMGVLNVTPDSFSDGGKYSDPDRAFARAIELEEQGADIIDIGAESTKPGSTRVSVAEEM
RRLIPVLKRLKDRLGIPISVDTYKAEVAERALELGVEIINDPSGLTFEPQLARTAANMNAGLILNHMRGTPETWAKLGPM
PDPLSTIGRDLDAMISRARHAGVDKAHMVIDPGLGFGKRKEQNAVILARLGELNPLDLPIMVGPSRKSFLAHPDLEETKF
ATAAAVTAAILGGAHIVRVHDVREMRAVADVADEIVRGRPE

Sequences:

>Translated_281_residues
MRKLFFWKLKQHEIRLGERTVLMGVLNVTPDSFSDGGKYSDPDRAFARAIELEEQGADIIDIGAESTKPGSTRVSVAEEM
RRLIPVLKRLKDRLGIPISVDTYKAEVAERALELGVEIINDPSGLTFEPQLARTAANMNAGLILNHMRGTPETWAKLGPM
PDPLSTIGRDLDAMISRARHAGVDKAHMVIDPGLGFGKRKEQNAVILARLGELNPLDLPIMVGPSRKSFLAHPDLEETKF
ATAAAVTAAILGGAHIVRVHDVREMRAVADVADEIVRGRPE
>Mature_281_residues
MRKLFFWKLKQHEIRLGERTVLMGVLNVTPDSFSDGGKYSDPDRAFARAIELEEQGADIIDIGAESTKPGSTRVSVAEEM
RRLIPVLKRLKDRLGIPISVDTYKAEVAERALELGVEIINDPSGLTFEPQLARTAANMNAGLILNHMRGTPETWAKLGPM
PDPLSTIGRDLDAMISRARHAGVDKAHMVIDPGLGFGKRKEQNAVILARLGELNPLDLPIMVGPSRKSFLAHPDLEETKF
ATAAAVTAAILGGAHIVRVHDVREMRAVADVADEIVRGRPE

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=248, Percent_Identity=42.741935483871, Blast_Score=186, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324073, Length=319, Percent_Identity=31.974921630094, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30746; Mature: 30746

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLFFWKLKQHEIRLGERTVLMGVLNVTPDSFSDGGKYSDPDRAFARAIELEEQGADII
CCCEEEEEHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEE
DIGAESTKPGSTRVSVAEEMRRLIPVLKRLKDRLGIPISVDTYKAEVAERALELGVEIIN
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCHHEEC
DPSGLTFEPQLARTAANMNAGLILNHMRGTPETWAKLGPMPDPLSTIGRDLDAMISRARH
CCCCCEECHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCCCHHHHHHCCHHHHHHHHHH
AGVDKAHMVIDPGLGFGKRKEQNAVILARLGELNPLDLPIMVGPSRKSFLAHPDLEETKF
CCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCHHHHH
ATAAAVTAAILGGAHIVRVHDVREMRAVADVADEIVRGRPE
HHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRKLFFWKLKQHEIRLGERTVLMGVLNVTPDSFSDGGKYSDPDRAFARAIELEEQGADII
CCCEEEEEHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEE
DIGAESTKPGSTRVSVAEEMRRLIPVLKRLKDRLGIPISVDTYKAEVAERALELGVEIIN
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCHHEEC
DPSGLTFEPQLARTAANMNAGLILNHMRGTPETWAKLGPMPDPLSTIGRDLDAMISRARH
CCCCCEECHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCCCHHHHHHCCHHHHHHHHHH
AGVDKAHMVIDPGLGFGKRKEQNAVILARLGELNPLDLPIMVGPSRKSFLAHPDLEETKF
CCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCHHHHH
ATAAAVTAAILGGAHIVRVHDVREMRAVADVADEIVRGRPE
HHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]