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The map label for this gene is tyrS [H]

Identifier: 116625757

GI number: 116625757

Start: 8407697

End: 8408893

Strand: Direct

Name: tyrS [H]

Synonym: Acid_6707

Alternate gene names: 116625757

Gene position: 8407697-8408893 (Clockwise)

Preceding gene: 116625756

Following gene: 116625758

Centisome position: 84.37

GC content: 63.16

Gene sequence:

>1197_bases
ATGACGATCGACGAACAACTGACATACCTGCGCAAAGGCATGGCGGAGATCATCCGCGAAGAGGATCTGCGCGAGCGCCT
GATTCAATCGGAGAAGACCGGTCGGAAGCTGCGCGTGAAGGCGGGCTTCGACCCGACGGCGCCGGACCTGCACCTGGGAC
ACACGGTGCTGCTGCGCAAGATGAAGCACTTTCAGGACTTGGGGCACACGGTCATCTTCCTGATCGGCGATATGACGGGG
ATGATCGGGGACCCCACGGGGCGCAACGTGACGCGGCCGCCGATGACCACGGAGGCGATCGAGCGCAATGCGGAGACGTA
CAAGCAGCAGGTATTCAAGATCCTGGATCCGGCGAAGACCGAGGTGCGGTTCAACAGCCACTGGCTGGCGCCGCTGCGGT
GGGAAGAGGTCATCAAGCTGACCAGCAAGTACACCGTGGCGCGGCTGTTGGAGCGCGACGATTTCGCCAAGCGGTACGCG
GCGAATGCTCCGATTTCGCTGCACGAGCTGATGTACCCGCTGGCGCAAGGCTACGATTCCGTCGCATTGGAAAGCGACGT
CGAGATGGGCGGGACGGACCAGAAGTTCAACCTGCTGGTGGGCCGCGAACTGCAGCGCGATTACGGGCAGCAGCCGCAGA
TTGTGGCGATGGTGCCGATTCTGGAAGGGCTGGACGGCGTCAATAAGATGTCGAAATCGCTGGGGAACTACATCGGGATC
ACGGAAGCTCCCGAGGTGATGTTCCGGAAGGTGATGCAGGTCTCCGACGACCTGATGTGGCGGTACTACGAGCTGCTGAC
GGACAAGAGCCTGGCGGAGATCGCGGCGATGCAGCGCTCCATGCACCCGATGGAGGCGAAGGTCGCGCTGGGCAAGCACA
TTGTCGCGGATTTCCACACGGCGGAGGATGCGGAGCGCGCGGCGGAGGTATTCAACGCGGTGGTCCGGCGCAAGGAAGTG
CCGTCCGACGTGCCGACAGTCCCGATGCCCGAGGGCGTGATGACGCAAGCAGGGCTGCGGGTCGATAAGCTGCTGGCGCG
CATCGGGCTGGTGGCGTCGGTGACGGACGCGGTGCGGAAGATCAAGGCGGGCGCGGTGGAGATCAACGGCGAGAAGGTTC
GCGAGGTGCTGATGGCTAATCCGCCGGCGGAGATGGTGATCCAGGTGGGGAAAAATTGGAAGAGGGTCGCGGGTTAG

Upstream 100 bases:

>100_bases
AAGCATTTCTCGCGGCCAAAGGCACGGAAACACCGGCCACACCGGAACAGGTGGAGGCCATCCAGAAATTCTCACGGGAT
TTGAGCACGGCACTGAGCCA

Downstream 100 bases:

>100_bases
ACTAGACAATACGGTGAGAAAACTCTTTTTTTGGAAATTGAAGCAGCACGAGATCCGCCTGGGCGAACGCACCGTGCTGA
TGGGCGTGCTCAATGTAACG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTIDEQLTYLRKGMAEIIREEDLRERLIQSEKTGRKLRVKAGFDPTAPDLHLGHTVLLRKMKHFQDLGHTVIFLIGDMTG
MIGDPTGRNVTRPPMTTEAIERNAETYKQQVFKILDPAKTEVRFNSHWLAPLRWEEVIKLTSKYTVARLLERDDFAKRYA
ANAPISLHELMYPLAQGYDSVALESDVEMGGTDQKFNLLVGRELQRDYGQQPQIVAMVPILEGLDGVNKMSKSLGNYIGI
TEAPEVMFRKVMQVSDDLMWRYYELLTDKSLAEIAAMQRSMHPMEAKVALGKHIVADFHTAEDAERAAEVFNAVVRRKEV
PSDVPTVPMPEGVMTQAGLRVDKLLARIGLVASVTDAVRKIKAGAVEINGEKVREVLMANPPAEMVIQVGKNWKRVAG

Sequences:

>Translated_398_residues
MTIDEQLTYLRKGMAEIIREEDLRERLIQSEKTGRKLRVKAGFDPTAPDLHLGHTVLLRKMKHFQDLGHTVIFLIGDMTG
MIGDPTGRNVTRPPMTTEAIERNAETYKQQVFKILDPAKTEVRFNSHWLAPLRWEEVIKLTSKYTVARLLERDDFAKRYA
ANAPISLHELMYPLAQGYDSVALESDVEMGGTDQKFNLLVGRELQRDYGQQPQIVAMVPILEGLDGVNKMSKSLGNYIGI
TEAPEVMFRKVMQVSDDLMWRYYELLTDKSLAEIAAMQRSMHPMEAKVALGKHIVADFHTAEDAERAAEVFNAVVRRKEV
PSDVPTVPMPEGVMTQAGLRVDKLLARIGLVASVTDAVRKIKAGAVEINGEKVREVLMANPPAEMVIQVGKNWKRVAG
>Mature_397_residues
TIDEQLTYLRKGMAEIIREEDLRERLIQSEKTGRKLRVKAGFDPTAPDLHLGHTVLLRKMKHFQDLGHTVIFLIGDMTGM
IGDPTGRNVTRPPMTTEAIERNAETYKQQVFKILDPAKTEVRFNSHWLAPLRWEEVIKLTSKYTVARLLERDDFAKRYAA
NAPISLHELMYPLAQGYDSVALESDVEMGGTDQKFNLLVGRELQRDYGQQPQIVAMVPILEGLDGVNKMSKSLGNYIGIT
EAPEVMFRKVMQVSDDLMWRYYELLTDKSLAEIAAMQRSMHPMEAKVALGKHIVADFHTAEDAERAAEVFNAVVRRKEVP
SDVPTVPMPEGVMTQAGLRVDKLLARIGLVASVTDAVRKIKAGAVEINGEKVREVLMANPPAEMVIQVGKNWKRVAG

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=391, Percent_Identity=26.0869565217391, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1787925, Length=388, Percent_Identity=27.319587628866, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25145802, Length=380, Percent_Identity=25, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325160, Length=389, Percent_Identity=22.879177377892, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI20130383, Length=377, Percent_Identity=25.4641909814324, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 44763; Mature: 44631

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDEQLTYLRKGMAEIIREEDLRERLIQSEKTGRKLRVKAGFDPTAPDLHLGHTVLLRK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHH
MKHFQDLGHTVIFLIGDMTGMIGDPTGRNVTRPPMTTEAIERNAETYKQQVFKILDPAKT
HHHHHHHCCEEEEHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHH
EVRFNSHWLAPLRWEEVIKLTSKYTVARLLERDDFAKRYAANAPISLHELMYPLAQGYDS
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
VALESDVEMGGTDQKFNLLVGRELQRDYGQQPQIVAMVPILEGLDGVNKMSKSLGNYIGI
HHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECHHHHCCCHHHHHHHHHCCCCCC
TEAPEVMFRKVMQVSDDLMWRYYELLTDKSLAEIAAMQRSMHPMEAKVALGKHIVADFHT
CCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AEDAERAAEVFNAVVRRKEVPSDVPTVPMPEGVMTQAGLRVDKLLARIGLVASVTDAVRK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
IKAGAVEINGEKVREVLMANPPAEMVIQVGKNWKRVAG
HHCCCEEECHHHHHHHHHCCCCHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
TIDEQLTYLRKGMAEIIREEDLRERLIQSEKTGRKLRVKAGFDPTAPDLHLGHTVLLRK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHH
MKHFQDLGHTVIFLIGDMTGMIGDPTGRNVTRPPMTTEAIERNAETYKQQVFKILDPAKT
HHHHHHHCCEEEEHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHH
EVRFNSHWLAPLRWEEVIKLTSKYTVARLLERDDFAKRYAANAPISLHELMYPLAQGYDS
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
VALESDVEMGGTDQKFNLLVGRELQRDYGQQPQIVAMVPILEGLDGVNKMSKSLGNYIGI
HHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECHHHHCCCHHHHHHHHHCCCCCC
TEAPEVMFRKVMQVSDDLMWRYYELLTDKSLAEIAAMQRSMHPMEAKVALGKHIVADFHT
CCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AEDAERAAEVFNAVVRRKEVPSDVPTVPMPEGVMTQAGLRVDKLLARIGLVASVTDAVRK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
IKAGAVEINGEKVREVLMANPPAEMVIQVGKNWKRVAG
HHCCCEEECHHHHHHHHHCCCCHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA