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The map label for this gene is mutM

Identifier: 116625750

GI number: 116625750

Start: 8402648

End: 8403442

Strand: Direct

Name: mutM

Synonym: Acid_6700

Alternate gene names: 116625750

Gene position: 8402648-8403442 (Clockwise)

Preceding gene: 116625749

Following gene: 116625751

Centisome position: 84.32

GC content: 61.64

Gene sequence:

>795_bases
GTGCCCGAACTTCCCGAAGTTGAAACTGTAGTCCGATCACTGGCGCCCCTGGTGGGCCGTCGCATCGCAACCGCGGAATT
CCGCAATCTGCGCATTCTGCGCGGCGGCGATCCCGACCTTATGTCGGCGCGGTTGGCCGGCCGGAAGATTCTATCGATCA
AGCGCTACGGCAAGTTCATCGTGGCGGTGATCGAGGGCGGCGGTCACCTCATGATCCATCTGGGGATGACAGGAAAACTG
CTGCTGGGCGGCCCCTCGGGGAAGCACACGCACGCGGTGCTGACGTTCGACCGGGGGACGCTGCTCTTCGACGACAGCCG
GCAGTTCGGCTGCATCGAGTACAGCGAGGAGTTTCCGAAGCGCGTGGCGCGGCTCGGTCCGGAGCCGATGGAGATTTCAT
TCGAGGATTTCGCCGCGGACCTGAAACGGAGAAAGACGCGGATCAAGTCGCTGCTCCTGAACCAGACGTTTATTCGCGGA
GTTGGCAATATTTATGCGGATGAAGCGCTGTTTCGCGCGGGGATTCATCCGCAGGCGCTTACGTCGCGGATTCGGATTGA
GCGGGCGCGCAAGCTGTACGATGCGATCGGCGAGGTGCTCACGGAGGCGATCGAGGCGGGCGGGTCTTCGATTTCCGACT
ATGTGGACGCAGAGGGCCGCAGCGGATTTTTCCAGTTCAGCCACCGTGTGTACCAGCGCACGGGCGAGCCGTGTTTGAAT
TGCAAGACACCGATTCGCCGCGTGATTGTGACCCAGCGCTCGTCGCATTTCTGCCCGCACTGCCAGAAGCGATAA

Upstream 100 bases:

>100_bases
CGATTGCGCCACGGGCGAGTACGACTATGACCCGGCCAGGCGTGTTCCGACCTACGAGGTAAAGGTAGAAGGCGATGAGA
TTTTCCTCCAGGTGCCCTGA

Downstream 100 bases:

>100_bases
GTCAAAAGAGCTACGGCAATTTGCCGCGTTTGAAAACATCTTTGCCGCCGTAACCCCGGCCCGGAATCGCACGTACACAC
GAGTAGGAAGTTTATCCTCA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MPELPEVETVVRSLAPLVGRRIATAEFRNLRILRGGDPDLMSARLAGRKILSIKRYGKFIVAVIEGGGHLMIHLGMTGKL
LLGGPSGKHTHAVLTFDRGTLLFDDSRQFGCIEYSEEFPKRVARLGPEPMEISFEDFAADLKRRKTRIKSLLLNQTFIRG
VGNIYADEALFRAGIHPQALTSRIRIERARKLYDAIGEVLTEAIEAGGSSISDYVDAEGRSGFFQFSHRVYQRTGEPCLN
CKTPIRRVIVTQRSSHFCPHCQKR

Sequences:

>Translated_264_residues
MPELPEVETVVRSLAPLVGRRIATAEFRNLRILRGGDPDLMSARLAGRKILSIKRYGKFIVAVIEGGGHLMIHLGMTGKL
LLGGPSGKHTHAVLTFDRGTLLFDDSRQFGCIEYSEEFPKRVARLGPEPMEISFEDFAADLKRRKTRIKSLLLNQTFIRG
VGNIYADEALFRAGIHPQALTSRIRIERARKLYDAIGEVLTEAIEAGGSSISDYVDAEGRSGFFQFSHRVYQRTGEPCLN
CKTPIRRVIVTQRSSHFCPHCQKR
>Mature_263_residues
PELPEVETVVRSLAPLVGRRIATAEFRNLRILRGGDPDLMSARLAGRKILSIKRYGKFIVAVIEGGGHLMIHLGMTGKLL
LGGPSGKHTHAVLTFDRGTLLFDDSRQFGCIEYSEEFPKRVARLGPEPMEISFEDFAADLKRRKTRIKSLLLNQTFIRGV
GNIYADEALFRAGIHPQALTSRIRIERARKLYDAIGEVLTEAIEAGGSSISDYVDAEGRSGFFQFSHRVYQRTGEPCLNC
KTPIRRVIVTQRSSHFCPHCQKR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Homo sapiens, GI157388969, Length=208, Percent_Identity=26.4423076923077, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1790066, Length=272, Percent_Identity=37.8676470588235, Blast_Score=171, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_SOLUE (Q01RU9)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_827906.1
- ProteinModelPortal:   Q01RU9
- SMR:   Q01RU9
- STRING:   Q01RU9
- GeneID:   4425170
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_6700
- NMPDR:   fig|234267.9.peg.6370
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- PhylomeDB:   Q01RU9
- ProtClustDB:   PRK14810
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 29581; Mature: 29450

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 253-253 BINDING 89-89 BINDING 107-107 BINDING 144-144

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVVRSLAPLVGRRIATAEFRNLRILRGGDPDLMSARLAGRKILSIKRYGKFI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHCCEE
VAVIEGGGHLMIHLGMTGKLLLGGPSGKHTHAVLTFDRGTLLFDDSRQFGCIEYSEEFPK
EEEEECCCEEEEEECCCCEEEEECCCCCCEEEEEEECCCEEEEECCCCCCEEHHHHHHHH
RVARLGPEPMEISFEDFAADLKRRKTRIKSLLLNQTFIRGVGNIYADEALFRAGIHPQAL
HHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
TSRIRIERARKLYDAIGEVLTEAIEAGGSSISDYVDAEGRSGFFQFSHRVYQRTGEPCLN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
CKTPIRRVIVTQRSSHFCPHCQKR
CHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVVRSLAPLVGRRIATAEFRNLRILRGGDPDLMSARLAGRKILSIKRYGKFI
CCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHCCEE
VAVIEGGGHLMIHLGMTGKLLLGGPSGKHTHAVLTFDRGTLLFDDSRQFGCIEYSEEFPK
EEEEECCCEEEEEECCCCEEEEECCCCCCEEEEEEECCCEEEEECCCCCCEEHHHHHHHH
RVARLGPEPMEISFEDFAADLKRRKTRIKSLLLNQTFIRGVGNIYADEALFRAGIHPQAL
HHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
TSRIRIERARKLYDAIGEVLTEAIEAGGSSISDYVDAEGRSGFFQFSHRVYQRTGEPCLN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
CKTPIRRVIVTQRSSHFCPHCQKR
CHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA