Click here to switch to the map view.

The map label for this gene is ppx [H]

Identifier: 116625736

GI number: 116625736

Start: 8388414

End: 8389949

Strand: Reverse

Name: ppx [H]

Synonym: Acid_6686

Alternate gene names: 116625736

Gene position: 8389949-8388414 (Counterclockwise)

Preceding gene: 116625737

Following gene: 116625729

Centisome position: 84.19

GC content: 64.45

Gene sequence:

>1536_bases
GTGCCCCGCTACGCAGCTATCGATATCGGCAGTAACTCCATCCGAATGGAGGCCGCGGAGGTTGTGCCCGGGCTGCCGAC
GCGGATTCTGGCGTCCGACCGCGAGGTCACGCGGCTGGGGGAGAGCGTCTTCCGTACGGGTGCGGTCAGTGAAGAGTACA
TCAAGGCAACTTGCACCGTACTGTCGCGGATGGCGGAACTCTACCGCAAGCTGGATGTGGTGGGAGTGCGGGCGGTGGCC
ACGAGCGCGATCCGCGACACGCGCAATCAGCGCGAGTTTCTGGCGCGCGCGGCGGAGGCCGCGGGCACCTCGGTCGAAAT
CATCTCGGGCCGGGAAGAGGCGCGGCTGATTCACCTGGGGGTGGAGAGCGTCTGGCCGCAAGCCGATAAGCGCGTGTTGA
TCATCGACATCGGCGGCGGCAGCGCGGAGATCATCGCGGCCGATCGGGGGCGGCTCATCGAGGCGTACTCCAAGCCGCTG
GGCGCGGTACGGCTGCGCGAGAGTTTTCTGAAGGACGACCCACCAGGCGGCCGGCAACTGCACCAGATGCGGGAATACAT
TCAGGCCAAGCTGGATACCGCGGTACGGCGGCTGGGCCACACCGGATGGGATCGCGTGATCGCGACCTCGGCGACGGCAT
CGGCGGTGGCGAGCGCGGTGGCGCGTGCCCCCCGTTCCAAGCGCGACGAGGTAGACCGCCTGCGGGTCACCACCTCGCAA
GTGCGCAAGCTCTACGCGCGGATTTCTGAGTTGGGCCTCACGGCGCGGCGCAAGGTCACCGGCATTGGGCCGCGGCGCGC
GGAGATCATCGTGCCCGGTGTCGCGGTACTGCTCGAGTTTTTGCAGGAGTTCCACCTGCCGGCTTTTTCCTATTCGCGCG
CTGGGGTGCGAGACGGCATCATCGCCGACCTGGCCGCTCGCAATGTGGGGGCCGAGCTCTCGCGGCTGAATCGCGACCAG
CGCCGCGAGGTCGAGGAGTTGGGACGCCGGTATGGCGTGTCGCTGGAGCATGCGCGCAAAGTCGCCGATCTGGCCAACCT
TTTGTTCTGTGCGTTACAACCGCTGCACCACTTACCGACCGGTTGCGGCAAACTGTTGGAAGCGGCTGCGTATCTGCTGG
ACGTGGGCCATTACGTGAGTTCCGTGAGCCATCACAAGCACTCTTACTACGTTGTCTCGAATTCGGACATGGCAGGGTTC
ACGGATCGCGAGCGATTCCTGATCGCAGCGCTGTGCCGCTACCATCGCAAGTCCCTGCCCAGCCAGGTGCACGGAATTTA
TCAGGCGCTCTCGGCCGACGAGCGGCGCATGCTGATGTTACTCATCCCGATTCTGCGGCTGGCATATAATCTCAATCGCA
GTCGCGAACACCGGATTCGCGGGGTCGATTGCCGGTTGCGCGATGGCGAAGTTGTCCTGCAAGTGCGCTCCAATGGCGAT
ATCGATCTGGAGCAGTGGGCCGCCGAACGGGCGGGCGAGGTATTTCAGCAGATTTACAACCGCCCGATGACGGTGGTGAA
GTCCAAGGAGTCATGA

Upstream 100 bases:

>100_bases
TCTGAGCGGCGCGGCGAATTCTTTGCGGCCGCAACCGCTCCCGGGAATTACGGCGGAAATAACGGTGCTCTGGTTGTTGT
ATGTCGATTAGCATGGAAGG

Downstream 100 bases:

>100_bases
TGCGCGAGTATGTGCAGAAACAGACGGCGGTTCTATTGCGCAGGCTGGCGTTCCAAATCAACCGCGCCGCGCGCGCGGGC
GATGCCGATGCGGTTCACGA

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MPRYAAIDIGSNSIRMEAAEVVPGLPTRILASDREVTRLGESVFRTGAVSEEYIKATCTVLSRMAELYRKLDVVGVRAVA
TSAIRDTRNQREFLARAAEAAGTSVEIISGREEARLIHLGVESVWPQADKRVLIIDIGGGSAEIIAADRGRLIEAYSKPL
GAVRLRESFLKDDPPGGRQLHQMREYIQAKLDTAVRRLGHTGWDRVIATSATASAVASAVARAPRSKRDEVDRLRVTTSQ
VRKLYARISELGLTARRKVTGIGPRRAEIIVPGVAVLLEFLQEFHLPAFSYSRAGVRDGIIADLAARNVGAELSRLNRDQ
RREVEELGRRYGVSLEHARKVADLANLLFCALQPLHHLPTGCGKLLEAAAYLLDVGHYVSSVSHHKHSYYVVSNSDMAGF
TDRERFLIAALCRYHRKSLPSQVHGIYQALSADERRMLMLLIPILRLAYNLNRSREHRIRGVDCRLRDGEVVLQVRSNGD
IDLEQWAAERAGEVFQQIYNRPMTVVKSKES

Sequences:

>Translated_511_residues
MPRYAAIDIGSNSIRMEAAEVVPGLPTRILASDREVTRLGESVFRTGAVSEEYIKATCTVLSRMAELYRKLDVVGVRAVA
TSAIRDTRNQREFLARAAEAAGTSVEIISGREEARLIHLGVESVWPQADKRVLIIDIGGGSAEIIAADRGRLIEAYSKPL
GAVRLRESFLKDDPPGGRQLHQMREYIQAKLDTAVRRLGHTGWDRVIATSATASAVASAVARAPRSKRDEVDRLRVTTSQ
VRKLYARISELGLTARRKVTGIGPRRAEIIVPGVAVLLEFLQEFHLPAFSYSRAGVRDGIIADLAARNVGAELSRLNRDQ
RREVEELGRRYGVSLEHARKVADLANLLFCALQPLHHLPTGCGKLLEAAAYLLDVGHYVSSVSHHKHSYYVVSNSDMAGF
TDRERFLIAALCRYHRKSLPSQVHGIYQALSADERRMLMLLIPILRLAYNLNRSREHRIRGVDCRLRDGEVVLQVRSNGD
IDLEQWAAERAGEVFQQIYNRPMTVVKSKES
>Mature_510_residues
PRYAAIDIGSNSIRMEAAEVVPGLPTRILASDREVTRLGESVFRTGAVSEEYIKATCTVLSRMAELYRKLDVVGVRAVAT
SAIRDTRNQREFLARAAEAAGTSVEIISGREEARLIHLGVESVWPQADKRVLIIDIGGGSAEIIAADRGRLIEAYSKPLG
AVRLRESFLKDDPPGGRQLHQMREYIQAKLDTAVRRLGHTGWDRVIATSATASAVASAVARAPRSKRDEVDRLRVTTSQV
RKLYARISELGLTARRKVTGIGPRRAEIIVPGVAVLLEFLQEFHLPAFSYSRAGVRDGIIADLAARNVGAELSRLNRDQR
REVEELGRRYGVSLEHARKVADLANLLFCALQPLHHLPTGCGKLLEAAAYLLDVGHYVSSVSHHKHSYYVVSNSDMAGFT
DRERFLIAALCRYHRKSLPSQVHGIYQALSADERRMLMLLIPILRLAYNLNRSREHRIRGVDCRLRDGEVVLQVRSNGDI
DLEQWAAERAGEVFQQIYNRPMTVVKSKES

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=465, Percent_Identity=28.1720430107527, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI48994966, Length=445, Percent_Identity=27.1910112359551, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 56894; Mature: 56763

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRYAAIDIGSNSIRMEAAEVVPGLPTRILASDREVTRLGESVFRTGAVSEEYIKATCTV
CCCEEEEEECCCCCEEEHHHHCCCCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LSRMAELYRKLDVVGVRAVATSAIRDTRNQREFLARAAEAAGTSVEIISGREEARLIHLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEC
VESVWPQADKRVLIIDIGGGSAEIIAADRGRLIEAYSKPLGAVRLRESFLKDDPPGGRQL
HHHHCCCCCCEEEEEEECCCCEEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCCCCHHHH
HQMREYIQAKLDTAVRRLGHTGWDRVIATSATASAVASAVARAPRSKRDEVDRLRVTTSQ
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VRKLYARISELGLTARRKVTGIGPRRAEIIVPGVAVLLEFLQEFHLPAFSYSRAGVRDGI
HHHHHHHHHHHCCHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCH
IADLAARNVGAELSRLNRDQRREVEELGRRYGVSLEHARKVADLANLLFCALQPLHHLPT
HHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GCGKLLEAAAYLLDVGHYVSSVSHHKHSYYVVSNSDMAGFTDRERFLIAALCRYHRKSLP
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCH
SQVHGIYQALSADERRMLMLLIPILRLAYNLNRSREHRIRGVDCRLRDGEVVLQVRSNGD
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEECCEEEEEECCCCC
IDLEQWAAERAGEVFQQIYNRPMTVVKSKES
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCC
>Mature Secondary Structure 
PRYAAIDIGSNSIRMEAAEVVPGLPTRILASDREVTRLGESVFRTGAVSEEYIKATCTV
CCEEEEEECCCCCEEEHHHHCCCCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LSRMAELYRKLDVVGVRAVATSAIRDTRNQREFLARAAEAAGTSVEIISGREEARLIHLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEC
VESVWPQADKRVLIIDIGGGSAEIIAADRGRLIEAYSKPLGAVRLRESFLKDDPPGGRQL
HHHHCCCCCCEEEEEEECCCCEEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCCCCHHHH
HQMREYIQAKLDTAVRRLGHTGWDRVIATSATASAVASAVARAPRSKRDEVDRLRVTTSQ
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VRKLYARISELGLTARRKVTGIGPRRAEIIVPGVAVLLEFLQEFHLPAFSYSRAGVRDGI
HHHHHHHHHHHCCHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCH
IADLAARNVGAELSRLNRDQRREVEELGRRYGVSLEHARKVADLANLLFCALQPLHHLPT
HHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GCGKLLEAAAYLLDVGHYVSSVSHHKHSYYVVSNSDMAGFTDRERFLIAALCRYHRKSLP
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCH
SQVHGIYQALSADERRMLMLLIPILRLAYNLNRSREHRIRGVDCRLRDGEVVLQVRSNGD
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEECCEEEEEECCCCC
IDLEQWAAERAGEVFQQIYNRPMTVVKSKES
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]