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The map label for this gene is chuR [H]

Identifier: 116625697

GI number: 116625697

Start: 8334038

End: 8335213

Strand: Reverse

Name: chuR [H]

Synonym: Acid_6646

Alternate gene names: 116625697

Gene position: 8335213-8334038 (Counterclockwise)

Preceding gene: 116625698

Following gene: 116625694

Centisome position: 83.64

GC content: 59.61

Gene sequence:

>1176_bases
GTGTCACAGTTCCCCATTTTTGGCGAGGGACTGGTCGAAAGCGGACCGGTCCCTCGCATCACCTCTCTTCTGATCAAGCC
CGCGTCGGCGGTCTGCAATCTGGATTGCGAGTATTGCTTCTATCTGGATCGCGACGCAGACCCTTACAGCGCCCTGCCCG
GCCGGCGCATGACCACCGAGACCCTCGAGCGCCTGGTCGACACCTATCTCTTCTACTCCTACCCCAACAGTACCTTCGCT
TTCCAGGGCGGGGAACCGACCTTGGCGGGTTTGCCGTTCTTCGAGAAACTGGTTCGCCTGCAACAGCAGTACGGGCGCAA
TGGCCAATCGGTCAGCAATGCCCTGCAGACCAACGCGGTGCTGCTGGACAAGAACTGGTGCGACCTCTTCCACGAATACT
CCTGGCTGCTCGGCGTCTCACTCGACGGGCCGGAGGAGGTCAACGATCTCTATCGCTTCAATAAGGAAAAGCGCGGCACC
TGGAAGCGCGTGATGCAGAGTGTGGAACTGCTCAAAACGGAAAAAGTGGAGTTCAATATTCTCTGCGTGCTCAGCCAGGC
CAATGTCCACAAACCGCGCGAACTGTATAAGTTCTACAGGAGCCTGGGTATCGACAACATCCAGTTCATCCCGCTCGCCG
AATTCGCGCCCGACGGAACTCCTTTGCCTTTCACGATCACCGCAGAGGAGTACGGCCGCTTCATGTGCGAGATCTTCGAA
CTGTGGTGGCCGGAGCGCCGCAAGATGCGCATCCGCACCTTTGACAACATCGCCGAGGCACTGGCCGGCCAGAAGCCGGG
CAACTGCACGATGCACGAAACCTGCGACAGCTACGTGGTCGTGGAGTTCAACGGGGATGTGTACCCGTGCGATTTCTTCG
TGGAGGGCGGCTGGAAGCTCGGCAACATCAACGAGGATTCCTGGGGCGAAATCGCCCGCCGCACCCGCCGCTACTCATTC
GCCGCGAAAAAGACCATCGCGCATCCGGAGTGCCAGGTCTGCGAATTCCAGAGCATCTGCCACGGCGGCTGCCCCAAAGG
CCGCCACGGTCCCCACGGAAAATTCGAGGACCTGGACTATTTCTGCGGCGCCTACAAGATGTACTTCGCCAAAAGCGTCG
GTCCGCTGAAGAAGGAACTGCAGCGTCTCTATCCCGCCGGGCGGAGCCGCGAATAA

Upstream 100 bases:

>100_bases
GAGCTTCGGCAAAATCAGCGGCGTAGTCAGCAATCCTCGCCTGCTGCAAGGAGCCCTTCGCTTCGAGTGGTAAGGCGAAC
TCTTTACTAAAATAGGGGGA

Downstream 100 bases:

>100_bases
GAAAGACCTGCCTTTGTGTTATCTGCGTTCATCTGTGGCCCATTGTGCTTTAGAAAACCGATGGGCCGCAGATAAACGCA
GATAAGCGCAGATAACACAA

Product: radical SAM domain-containing protein

Products: NA

Alternate protein names: AnSME; Chondroitin sulfate/heparin utilization regulation protein; Ser-type sulfatase-activating enzyme [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSQFPIFGEGLVESGPVPRITSLLIKPASAVCNLDCEYCFYLDRDADPYSALPGRRMTTETLERLVDTYLFYSYPNSTFA
FQGGEPTLAGLPFFEKLVRLQQQYGRNGQSVSNALQTNAVLLDKNWCDLFHEYSWLLGVSLDGPEEVNDLYRFNKEKRGT
WKRVMQSVELLKTEKVEFNILCVLSQANVHKPRELYKFYRSLGIDNIQFIPLAEFAPDGTPLPFTITAEEYGRFMCEIFE
LWWPERRKMRIRTFDNIAEALAGQKPGNCTMHETCDSYVVVEFNGDVYPCDFFVEGGWKLGNINEDSWGEIARRTRRYSF
AAKKTIAHPECQVCEFQSICHGGCPKGRHGPHGKFEDLDYFCGAYKMYFAKSVGPLKKELQRLYPAGRSRE

Sequences:

>Translated_391_residues
MSQFPIFGEGLVESGPVPRITSLLIKPASAVCNLDCEYCFYLDRDADPYSALPGRRMTTETLERLVDTYLFYSYPNSTFA
FQGGEPTLAGLPFFEKLVRLQQQYGRNGQSVSNALQTNAVLLDKNWCDLFHEYSWLLGVSLDGPEEVNDLYRFNKEKRGT
WKRVMQSVELLKTEKVEFNILCVLSQANVHKPRELYKFYRSLGIDNIQFIPLAEFAPDGTPLPFTITAEEYGRFMCEIFE
LWWPERRKMRIRTFDNIAEALAGQKPGNCTMHETCDSYVVVEFNGDVYPCDFFVEGGWKLGNINEDSWGEIARRTRRYSF
AAKKTIAHPECQVCEFQSICHGGCPKGRHGPHGKFEDLDYFCGAYKMYFAKSVGPLKKELQRLYPAGRSRE
>Mature_390_residues
SQFPIFGEGLVESGPVPRITSLLIKPASAVCNLDCEYCFYLDRDADPYSALPGRRMTTETLERLVDTYLFYSYPNSTFAF
QGGEPTLAGLPFFEKLVRLQQQYGRNGQSVSNALQTNAVLLDKNWCDLFHEYSWLLGVSLDGPEEVNDLYRFNKEKRGTW
KRVMQSVELLKTEKVEFNILCVLSQANVHKPRELYKFYRSLGIDNIQFIPLAEFAPDGTPLPFTITAEEYGRFMCEIFEL
WWPERRKMRIRTFDNIAEALAGQKPGNCTMHETCDSYVVVEFNGDVYPCDFFVEGGWKLGNINEDSWGEIARRTRRYSFA
AKKTIAHPECQVCEFQSICHGGCPKGRHGPHGKFEDLDYFCGAYKMYFAKSVGPLKKELQRLYPAGRSRE

Specific function: Involved in 'Ser-type' sulfatase maturation under anaerobic conditions. Links the heparin and the chondroitin sulfate utilization pathways which contribute to the colonization of the intestinal tract. May catalyze the activation of chondro-6- sulfatase, i

COG id: COG0641

COG function: function code R; Arylsulfatase regulator (Fe-S oxidoreductase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081923, Length=364, Percent_Identity=37.9120879120879, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI48994973, Length=395, Percent_Identity=36.4556962025316, Blast_Score=235, Evalue=4e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 44914; Mature: 44782

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQFPIFGEGLVESGPVPRITSLLIKPASAVCNLDCEYCFYLDRDADPYSALPGRRMTTE
CCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHH
TLERLVDTYLFYSYPNSTFAFQGGEPTLAGLPFFEKLVRLQQQYGRNGQSVSNALQTNAV
HHHHHHHHHHEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCEE
LLDKNWCDLFHEYSWLLGVSLDGPEEVNDLYRFNKEKRGTWKRVMQSVELLKTEKVEFNI
EEECHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEE
LCVLSQANVHKPRELYKFYRSLGIDNIQFIPLAEFAPDGTPLPFTITAEEYGRFMCEIFE
EEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCEEEEHHHHHHHHHHHHH
LWWPERRKMRIRTFDNIAEALAGQKPGNCTMHETCDSYVVVEFNGDVYPCDFFVEGGWKL
HHCCHHHCEEHHHHHHHHHHHCCCCCCCCCHHCCCCCEEEEEECCCEEEEEEEEECCEEE
GNINEDSWGEIARRTRRYSFAAKKTIAHPECQVCEFQSICHGGCPKGRHGPHGKFEDLDY
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
FCGAYKMYFAKSVGPLKKELQRLYPAGRSRE
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SQFPIFGEGLVESGPVPRITSLLIKPASAVCNLDCEYCFYLDRDADPYSALPGRRMTTE
CCCCCCCCCCCCCCCCHHHHHHHHCCCHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHH
TLERLVDTYLFYSYPNSTFAFQGGEPTLAGLPFFEKLVRLQQQYGRNGQSVSNALQTNAV
HHHHHHHHHHEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCEE
LLDKNWCDLFHEYSWLLGVSLDGPEEVNDLYRFNKEKRGTWKRVMQSVELLKTEKVEFNI
EEECHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEE
LCVLSQANVHKPRELYKFYRSLGIDNIQFIPLAEFAPDGTPLPFTITAEEYGRFMCEIFE
EEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCEEEEHHHHHHHHHHHHH
LWWPERRKMRIRTFDNIAEALAGQKPGNCTMHETCDSYVVVEFNGDVYPCDFFVEGGWKL
HHCCHHHCEEHHHHHHHHHHHCCCCCCCCCHHCCCCCEEEEEECCCEEEEEEEEECCEEE
GNINEDSWGEIARRTRRYSFAAKKTIAHPECQVCEFQSICHGGCPKGRHGPHGKFEDLDY
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
FCGAYKMYFAKSVGPLKKELQRLYPAGRSRE
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1429442; 12663928 [H]