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The map label for this gene is fsr [H]

Identifier: 116625633

GI number: 116625633

Start: 8254456

End: 8255646

Strand: Direct

Name: fsr [H]

Synonym: Acid_6582

Alternate gene names: 116625633

Gene position: 8254456-8255646 (Clockwise)

Preceding gene: 116625632

Following gene: 116625634

Centisome position: 82.83

GC content: 62.05

Gene sequence:

>1191_bases
GTGATCACCGCGCAAAAGCAGAACGTCACCGCATTTCGCATTCTGGGGGCCATCAGCTTCTGTCATCTGTTGAACGACAT
GATGCAGTCGCTGATTCCCGCCGTGTACCCGATTCTCAAGCGGTCCTACCATCTGGACTTCGGACAGATTGGGTTGATCA
CGCTGACGTCGCAGCTTACCGCCTCCCTGCTGCAACCGCTGGTTGGCCTGTATACCGATCGACGGCCAACGCCCTACTCG
CTGCCGATGGGGATGAGCTTCACCATGATCGGACTCATCCTGGTCGCATCCGCGCCGACCTTCGGGCTGGTGCTGGCCGC
GGTCGGCATGGTCGGGATCGGCTCGGCGGTCTTCCATCCCGAGTCCTCGCGCGTGGCCCGCATGGCATCGGGCGGCCAGC
ATGGCCTCGCGCAATCGCTCTTCCAGGTAGGCGGCAACGCGGGATCGTCGCTAGGGCCGCTGCTGGCGGCATTCGTCGTG
TTGCCCGCGGGCCAGCGCAGCATCGCGTGGTTCTCAGGTGCCGCGCTGCTGGCCATCCTCATCCTTTTGCGCGTGGGCGG
CTGGTACAAACGCCATCAGCGGGTCGGCCCGAAATCGCGCATGGTGACCGATTCGCGGCCGCGCCTCTCAACGCGAACCA
TCGTAACTTCGATGGCGATTCTGATCGCCCTGATCTTTTCCAAGTACTTCTATCTCGCCAGCCTGGTGAGCTATTACACG
TTTTACCTGATGGCGAAATTCCATCTCACCGTGCAGAACGCGCAATTCCACCTCTTCCTGTTCCTGGGTGCGGTGGCCCT
CGGCACAATCGTAGGCGGCCCGGTCGGAGATCGCATCGGCCGCAAGTACGTGATCTGGGTCTCGATTCTCGGCGTGCTCC
CATTCACGCTGGCGCTACCCTACGCCAGCCTCTTCTGGACGGACATTCTGGTGGTGATCATCGGGCTGGTGCTGGCGTCC
GCTTTCTCGGCAATTCTGGTCTATGCGCAGGATCTGGTGCCCGGCAAGGTCGGCACAATCTCCGGCCTCTTCTTCGGACT
GGCCTTCGGAATGGGCGGCATCGGCGCCGCGCTGCTCGGTCAACTCGCCGACGCCACCAGCATCGAATTCGTCTACCGCG
TTTGCTCTTTCCTTCCCGTGATCGGACTGCTGACAGCCTTCCTGCCCAACCTCGAGCAACACCACCGGTAA

Upstream 100 bases:

>100_bases
AGTGGAGTTGCAGGTCAAAAATCCGCGTGCTGCGGCGACATTCAATATCGGCGGACCCATCTGTGCCAGCGTGTGCACGG
TGCTGCGCGCAGTAGAATAA

Downstream 100 bases:

>100_bases
AGTATTACAAGCCGTCGCGAAGCACTCCTCAACGACAACGAGCCGCTCTCAATCAGAGCCGGCGACCGCCAGGGAGCGAT
CCCGCATGATCCACGATTTT

Product: major facilitator transporter

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MITAQKQNVTAFRILGAISFCHLLNDMMQSLIPAVYPILKRSYHLDFGQIGLITLTSQLTASLLQPLVGLYTDRRPTPYS
LPMGMSFTMIGLILVASAPTFGLVLAAVGMVGIGSAVFHPESSRVARMASGGQHGLAQSLFQVGGNAGSSLGPLLAAFVV
LPAGQRSIAWFSGAALLAILILLRVGGWYKRHQRVGPKSRMVTDSRPRLSTRTIVTSMAILIALIFSKYFYLASLVSYYT
FYLMAKFHLTVQNAQFHLFLFLGAVALGTIVGGPVGDRIGRKYVIWVSILGVLPFTLALPYASLFWTDILVVIIGLVLAS
AFSAILVYAQDLVPGKVGTISGLFFGLAFGMGGIGAALLGQLADATSIEFVYRVCSFLPVIGLLTAFLPNLEQHHR

Sequences:

>Translated_396_residues
MITAQKQNVTAFRILGAISFCHLLNDMMQSLIPAVYPILKRSYHLDFGQIGLITLTSQLTASLLQPLVGLYTDRRPTPYS
LPMGMSFTMIGLILVASAPTFGLVLAAVGMVGIGSAVFHPESSRVARMASGGQHGLAQSLFQVGGNAGSSLGPLLAAFVV
LPAGQRSIAWFSGAALLAILILLRVGGWYKRHQRVGPKSRMVTDSRPRLSTRTIVTSMAILIALIFSKYFYLASLVSYYT
FYLMAKFHLTVQNAQFHLFLFLGAVALGTIVGGPVGDRIGRKYVIWVSILGVLPFTLALPYASLFWTDILVVIIGLVLAS
AFSAILVYAQDLVPGKVGTISGLFFGLAFGMGGIGAALLGQLADATSIEFVYRVCSFLPVIGLLTAFLPNLEQHHR
>Mature_396_residues
MITAQKQNVTAFRILGAISFCHLLNDMMQSLIPAVYPILKRSYHLDFGQIGLITLTSQLTASLLQPLVGLYTDRRPTPYS
LPMGMSFTMIGLILVASAPTFGLVLAAVGMVGIGSAVFHPESSRVARMASGGQHGLAQSLFQVGGNAGSSLGPLLAAFVV
LPAGQRSIAWFSGAALLAILILLRVGGWYKRHQRVGPKSRMVTDSRPRLSTRTIVTSMAILIALIFSKYFYLASLVSYYT
FYLMAKFHLTVQNAQFHLFLFLGAVALGTIVGGPVGDRIGRKYVIWVSILGVLPFTLALPYASLFWTDILVVIIGLVLAS
AFSAILVYAQDLVPGKVGTISGLFFGLAFGMGGIGAALLGQLADATSIEFVYRVCSFLPVIGLLTAFLPNLEQHHR

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=387, Percent_Identity=64.0826873385013, Blast_Score=461, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42546; Mature: 42546

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITAQKQNVTAFRILGAISFCHLLNDMMQSLIPAVYPILKRSYHLDFGQIGLITLTSQLT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
ASLLQPLVGLYTDRRPTPYSLPMGMSFTMIGLILVASAPTFGLVLAAVGMVGIGSAVFHP
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHCCC
ESSRVARMASGGQHGLAQSLFQVGGNAGSSLGPLLAAFVVLPAGQRSIAWFSGAALLAIL
CHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ILLRVGGWYKRHQRVGPKSRMVTDSRPRLSTRTIVTSMAILIALIFSKYFYLASLVSYYT
HHHHHCCHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYLMAKFHLTVQNAQFHLFLFLGAVALGTIVGGPVGDRIGRKYVIWVSILGVLPFTLALP
HHHHHHHHEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHH
YASLFWTDILVVIIGLVLASAFSAILVYAQDLVPGKVGTISGLFFGLAFGMGGIGAALLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
QLADATSIEFVYRVCSFLPVIGLLTAFLPNLEQHHR
HHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure
MITAQKQNVTAFRILGAISFCHLLNDMMQSLIPAVYPILKRSYHLDFGQIGLITLTSQLT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
ASLLQPLVGLYTDRRPTPYSLPMGMSFTMIGLILVASAPTFGLVLAAVGMVGIGSAVFHP
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHCCC
ESSRVARMASGGQHGLAQSLFQVGGNAGSSLGPLLAAFVVLPAGQRSIAWFSGAALLAIL
CHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ILLRVGGWYKRHQRVGPKSRMVTDSRPRLSTRTIVTSMAILIALIFSKYFYLASLVSYYT
HHHHHCCHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYLMAKFHLTVQNAQFHLFLFLGAVALGTIVGGPVGDRIGRKYVIWVSILGVLPFTLALP
HHHHHHHHEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHH
YASLFWTDILVVIIGLVLASAFSAILVYAQDLVPGKVGTISGLFFGLAFGMGGIGAALLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHH
QLADATSIEFVYRVCSFLPVIGLLTAFLPNLEQHHR
HHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]