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The map label for this gene is hmgA [H]

Identifier: 116625571

GI number: 116625571

Start: 8170917

End: 8172197

Strand: Reverse

Name: hmgA [H]

Synonym: Acid_6518

Alternate gene names: 116625571

Gene position: 8172197-8170917 (Counterclockwise)

Preceding gene: 116625573

Following gene: 116625570

Centisome position: 82.0

GC content: 61.51

Gene sequence:

>1281_bases
ATGCCGTCGTCCGAAGTGAAATACCAATCCGGCTTCGGGAATGAGTTCGCCACCGAAGCTGTGCCCGGGGCGCTCCCGGT
GGGTCAAAATTCCCCGCAAAAGGCGCCGCTCGGACTCTACACGGAACAACTCAGCGGCAGCGCCTTCACCGCGCCGCGCG
CCGTGAATCGCCGCACCTGGAGCTATCGGATTCGACCGTCCGTGACGCACAAACCGTACGTCGAGCATCCGGGCGGCCTG
ATTCGCGGTGTCTTTGACGAATTGCCGACACCGCCCAATCAATTGCGCTGGGACCCCTTCCCGATTCCCTCCGAGCCTAC
CGATTTTGTCGATGGCCTTATCACCATCGCGGGCAACGGCGACCCGGCCGCGCAGAGCGGCGTCGCCATCCACATCTACG
CCGCCAACGCCTCCATGCAGCGCCGCTACTTCTATACGGCGGATGGCGAGCTGCTGATCGTGCCGCAGCAGGGGCGCACC
GCGATCGCGACCGAACTGGGAATCCTCGAGGTCAAGCCCGGCGAGATCTGCGTGATCCCGCGCGGCATCAAATTCCGCGT
CGATCTCCCGGACGGTCCCTCGCGCGGCTACGTCTGCGAGAACAGCGCCGCGCCTTTCCGGCTGCCCGAACTCGGAGCCA
TCGGCGCCAACGGACTCGCGAATGCGCGCGACTTCCTGGCGCCCACCGCCGCATACGAAGATATCGACGCCGAATGCCAC
ATCGTCGCCAAATTCCTGGGCCGGCTCTGGACGGCGGAGATCGACCACTCGCCGCTTGACGTAGTGGCCTGGCATGGAAA
TTACGTGCCCTATAAATACGATCTCGCGCGTTTCAATTGCATCAACACGGTGAGCTTCGATCATCCGGATCCTTCGATCT
ACACAGTGTTGACCTCTCCGGCGAATGTCGATTTCGCCATCTTCCCGCCGCGCTGGCTGGTGGCCGAACACACCTTCCGT
CCGCCGTGGTTCCATCGCAACCTGATGAATGAATTCATGGGCCTGATATTCGGCCAGTATGACGCCAAGGCCGAGGGCTT
TCTTCCGGGCGGCGCCAGCCTGCACAACTGCATGTCCGGCCACGGACCCGATGCCGAGACTTACGAGCGCGCCAGCAACG
CCGAGCTCAAACCGGTGTACCTGGCGGATACGTTGGCCTTCATGTTCGAAACGCAACTCGTGCTGCGGCCCACGCGCTTC
GCCATGGAAAGCAAAATTCTTCAACACGAATATTACGAATGCTGGCAGGGATTAAGAAAGCACTTCAAAGGCAATGTCTA
A

Upstream 100 bases:

>100_bases
CATCGGGACAGCCGATAATAGTGAGTGCATGATCATTCGCATCCCAGTGTGCTAATCTCAAAACCCGAGCGCAAGCGGCT
ATCGCCGCTTTGAGGAGACT

Downstream 100 bases:

>100_bases
AGCTCTGCGCGCTCTCATGGAAGGTCTGATCGACTACGCCGGAATGTTTCCGCCGGCCGGCTTGGATATGGCCCAAGCGG
CCGTCAACTACGAGTCGTAC

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MPSSEVKYQSGFGNEFATEAVPGALPVGQNSPQKAPLGLYTEQLSGSAFTAPRAVNRRTWSYRIRPSVTHKPYVEHPGGL
IRGVFDELPTPPNQLRWDPFPIPSEPTDFVDGLITIAGNGDPAAQSGVAIHIYAANASMQRRYFYTADGELLIVPQQGRT
AIATELGILEVKPGEICVIPRGIKFRVDLPDGPSRGYVCENSAAPFRLPELGAIGANGLANARDFLAPTAAYEDIDAECH
IVAKFLGRLWTAEIDHSPLDVVAWHGNYVPYKYDLARFNCINTVSFDHPDPSIYTVLTSPANVDFAIFPPRWLVAEHTFR
PPWFHRNLMNEFMGLIFGQYDAKAEGFLPGGASLHNCMSGHGPDAETYERASNAELKPVYLADTLAFMFETQLVLRPTRF
AMESKILQHEYYECWQGLRKHFKGNV

Sequences:

>Translated_426_residues
MPSSEVKYQSGFGNEFATEAVPGALPVGQNSPQKAPLGLYTEQLSGSAFTAPRAVNRRTWSYRIRPSVTHKPYVEHPGGL
IRGVFDELPTPPNQLRWDPFPIPSEPTDFVDGLITIAGNGDPAAQSGVAIHIYAANASMQRRYFYTADGELLIVPQQGRT
AIATELGILEVKPGEICVIPRGIKFRVDLPDGPSRGYVCENSAAPFRLPELGAIGANGLANARDFLAPTAAYEDIDAECH
IVAKFLGRLWTAEIDHSPLDVVAWHGNYVPYKYDLARFNCINTVSFDHPDPSIYTVLTSPANVDFAIFPPRWLVAEHTFR
PPWFHRNLMNEFMGLIFGQYDAKAEGFLPGGASLHNCMSGHGPDAETYERASNAELKPVYLADTLAFMFETQLVLRPTRF
AMESKILQHEYYECWQGLRKHFKGNV
>Mature_425_residues
PSSEVKYQSGFGNEFATEAVPGALPVGQNSPQKAPLGLYTEQLSGSAFTAPRAVNRRTWSYRIRPSVTHKPYVEHPGGLI
RGVFDELPTPPNQLRWDPFPIPSEPTDFVDGLITIAGNGDPAAQSGVAIHIYAANASMQRRYFYTADGELLIVPQQGRTA
IATELGILEVKPGEICVIPRGIKFRVDLPDGPSRGYVCENSAAPFRLPELGAIGANGLANARDFLAPTAAYEDIDAECHI
VAKFLGRLWTAEIDHSPLDVVAWHGNYVPYKYDLARFNCINTVSFDHPDPSIYTVLTSPANVDFAIFPPRWLVAEHTFRP
PWFHRNLMNEFMGLIFGQYDAKAEGFLPGGASLHNCMSGHGPDAETYERASNAELKPVYLADTLAFMFETQLVLRPTRFA
MESKILQHEYYECWQGLRKHFKGNV

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=437, Percent_Identity=53.0892448512586, Blast_Score=459, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17507969, Length=430, Percent_Identity=55.5813953488372, Blast_Score=463, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24583650, Length=435, Percent_Identity=54.9425287356322, Blast_Score=462, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 47230; Mature: 47099

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSEVKYQSGFGNEFATEAVPGALPVGQNSPQKAPLGLYTEQLSGSAFTAPRAVNRRTW
CCCCCCEECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEHHHCCCCCCCCCCCCCCCEE
SYRIRPSVTHKPYVEHPGGLIRGVFDELPTPPNQLRWDPFPIPSEPTDFVDGLITIAGNG
EEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCEEEEEECCC
DPAAQSGVAIHIYAANASMQRRYFYTADGELLIVPQQGRTAIATELGILEVKPGEICVIP
CCCHHCCCEEEEEEECCCCEEEEEEECCCEEEEEECCCCEEEEEECCEEEECCCCEEEEE
RGIKFRVDLPDGPSRGYVCENSAAPFRLPELGAIGANGLANARDFLAPTAAYEDIDAECH
CCEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHCCCCHHH
IVAKFLGRLWTAEIDHSPLDVVAWHGNYVPYKYDLARFNCINTVSFDHPDPSIYTVLTSP
HHHHHHHHHHEECCCCCCCEEEEECCCCCCEEECHHEEEEEEECCCCCCCCCEEEEEECC
ANVDFAIFPPRWLVAEHTFRPPWFHRNLMNEFMGLIFGQYDAKAEGFLPGGASLHNCMSG
CCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCC
HGPDAETYERASNAELKPVYLADTLAFMFETQLVLRPTRFAMESKILQHEYYECWQGLRK
CCCCHHHHHHCCCCCCCEEEHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHH
HFKGNV
HHCCCC
>Mature Secondary Structure 
PSSEVKYQSGFGNEFATEAVPGALPVGQNSPQKAPLGLYTEQLSGSAFTAPRAVNRRTW
CCCCCEECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEHHHCCCCCCCCCCCCCCCEE
SYRIRPSVTHKPYVEHPGGLIRGVFDELPTPPNQLRWDPFPIPSEPTDFVDGLITIAGNG
EEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCEEEEEECCC
DPAAQSGVAIHIYAANASMQRRYFYTADGELLIVPQQGRTAIATELGILEVKPGEICVIP
CCCHHCCCEEEEEEECCCCEEEEEEECCCEEEEEECCCCEEEEEECCEEEECCCCEEEEE
RGIKFRVDLPDGPSRGYVCENSAAPFRLPELGAIGANGLANARDFLAPTAAYEDIDAECH
CCEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHCCCCHHH
IVAKFLGRLWTAEIDHSPLDVVAWHGNYVPYKYDLARFNCINTVSFDHPDPSIYTVLTSP
HHHHHHHHHHEECCCCCCCEEEEECCCCCCEEECHHEEEEEEECCCCCCCCCEEEEEECC
ANVDFAIFPPRWLVAEHTFRPPWFHRNLMNEFMGLIFGQYDAKAEGFLPGGASLHNCMSG
CCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCC
HGPDAETYERASNAELKPVYLADTLAFMFETQLVLRPTRFAMESKILQHEYYECWQGLRK
CCCCHHHHHHCCCCCCCEEEHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHH
HFKGNV
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA