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The map label for this gene is uvrB [H]

Identifier: 116625433

GI number: 116625433

Start: 7994584

End: 7996563

Strand: Reverse

Name: uvrB [H]

Synonym: Acid_6378

Alternate gene names: 116625433

Gene position: 7996563-7994584 (Counterclockwise)

Preceding gene: 116625434

Following gene: 116625432

Centisome position: 80.24

GC content: 60.25

Gene sequence:

>1980_bases
ATGGGCTTTCGACTGGCGGTTACGTACGAACCGCGCGGGGATCAGGTTAATGCGATCGCGGAGCTGACTCGGGGTCTCCG
CGAAGGCGAGCAGCACCAGGTGCTGCTTGGGGTCACAGGTTCCGGCAAAACGTTCACGATGGCGAAGGTGATCGAGGCGG
TCAACCGCCCGGCACTGGTATTGGCACACAACAAGACGCTGGCAGCGCAGCTGTACCACGAATTCAAGACGTTCTTCCCC
GAGAACGCGGTCGAATACTTCGTCAGCTACTACGATTATTACCAGCCGGAGGCTTACATTCCGGCGAGCGACGTTTACAT
CGAGAAGGACGCGACGGTCAACGACGAGCTCGACAAGCTGCGGCTCGCCGCGACCAAGAGCCTCTTTGAACGGCGGGACT
GTGTGATTGTATCCAGCGTGAGCTGCATCTACGGCCTGGGCTCTCCGGAAGCGTATTACGGCATGCTGCTGATGCTGGAG
AAGGGGCAGAAGATCTCGCGCAATCAGATTGTGACGCGCCTGGTGGAGATTTTGTACGACCGCAACGATGCGGATTTCCG
TCGTGGCACGTTTCGGGTGCGCGGCGACGTGATCGAGGTCTATCCGACTTACGACGACGACGCGTACCGGATTGAATTGT
GGGGCGACGAGATCGAGAATCTCTCGCAGATCGACCCGCTGCTGGGACAGGTGAAGCAGACCTACCAGCGGCTGCCGATT
TATCCGAAGACGCACTATGTGATGTCGGCGGAAACCAAAGAGGATGCGATGCAGAGCATCCGCAACGAGTTGGAGTGGTG
GCACAAGGAACTGGTGAACCAGGGCAAAGCGATCGAGGCGCAGCGATTGTTCCAGCGTACAATGTTCGATCTCGAAATGA
TGAAGGAGATCGGGTACTGCCATGGAATCGAAAACTACTCGCGCCATTTTTCGGGAAGGCTGCCGGGAGAAGCGCCGCCG
ACGCTGCTGGATTACCTGCCGAACGATGCGGTGATGTTCCTGGATGAGAGCCACCAGACGGTGCCGCAACTGCACGGCAT
GTATCACGGCGACCGTTCGCGAAAGGAAGTGCTGGTCGCGCACGGCTTCCGAATGCCGAGCGCGCTGGACAACCGGCCGC
TCACGTTCGAGGAGTTCGAGCACCGCGTGAATCAACTGGTTTACGTCTCGGCGACGCCGGGGCCGTACGAGCTGACGAAA
TCGAGCGGAGTGGTGGTGGAGCAGATCATCCGGCCGACGGGGCTGCTGGATCCGACGGTGGAGATCCGGCCGGTGAAAGG
GCAGGTGGACGACCTGCTGGGACAGATTCGCGCGCGCGTGGAAAACAATCAACGCATTCTGGTGACGACGCTGACCAAGC
GCATGGCGGAGGATCTTTCGGAATATTATTCCGAAGTGGGCGTGCGCTGCCGCTACCTGCACTCGGAAGTGACTACGCTG
GACCGCATCAAGATTCTGCGCGACCTGAGGCGCGGCGAATTCGACGTGCTGGTGGGTATCAACCTGCTGCGCGAAGGGTT
GGACCTGCCGGAGGTGTCGCTGGTGGCGATTCTGGATGCGGACAAGGAAGGCTTCCTGCGATCCTGGGGCGCGTTGATCC
AGACCATCGGACGCGCGGCCCGGCACGTGGAAGGGCATGCGATTCTGTACGCCGATGTAATGACGGACAGCATGCGCAAG
GCGCTGGCGGAGACGGCGAGGCGCCGGCAGACGCAGATCGAGTACAACGAGGAAAATCACATTACGCCGCAATCGATCAT
CAAAGCGATCGATATGAGCCTGGTGGCGGTAGCCGAGGGCGATTATGTCACGGTGCCGCTGGAGGACGATCCGGAAGTGG
AGGACCTGACACCGGACCAGCGGCTGCGTTTCATCGGCGAGTTGGAAGAACGGATGCGCGAAGCGGCCCGAAAGTTCGAG
TTCGAGCGCGCGGCGCAATTGCGGGACCGGGTCAAGGCGCTGAAGGCGGTTGGTGGATAA

Upstream 100 bases:

>100_bases
CGCAGAGATCGCGGAGAAAACTCTAACCCAAGACGAAAGAAAATAAATTAGCACCGCGTGGGGTGAAACGGCATCGGGGG
CGGTGTGGCAAAGTTAAGGG

Downstream 100 bases:

>100_bases
CCAAAAGCCACGGATGCGCGTTTAGAAAACCTTCGATATACTAGGCACCTTGAAGTTTGCAGCACCTTGAAGTTCGTTCC
CGGAGGGGGCACGAATATGT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 659; Mature: 658

Protein sequence:

>659_residues
MGFRLAVTYEPRGDQVNAIAELTRGLREGEQHQVLLGVTGSGKTFTMAKVIEAVNRPALVLAHNKTLAAQLYHEFKTFFP
ENAVEYFVSYYDYYQPEAYIPASDVYIEKDATVNDELDKLRLAATKSLFERRDCVIVSSVSCIYGLGSPEAYYGMLLMLE
KGQKISRNQIVTRLVEILYDRNDADFRRGTFRVRGDVIEVYPTYDDDAYRIELWGDEIENLSQIDPLLGQVKQTYQRLPI
YPKTHYVMSAETKEDAMQSIRNELEWWHKELVNQGKAIEAQRLFQRTMFDLEMMKEIGYCHGIENYSRHFSGRLPGEAPP
TLLDYLPNDAVMFLDESHQTVPQLHGMYHGDRSRKEVLVAHGFRMPSALDNRPLTFEEFEHRVNQLVYVSATPGPYELTK
SSGVVVEQIIRPTGLLDPTVEIRPVKGQVDDLLGQIRARVENNQRILVTTLTKRMAEDLSEYYSEVGVRCRYLHSEVTTL
DRIKILRDLRRGEFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSWGALIQTIGRAARHVEGHAILYADVMTDSMRK
ALAETARRRQTQIEYNEENHITPQSIIKAIDMSLVAVAEGDYVTVPLEDDPEVEDLTPDQRLRFIGELEERMREAARKFE
FERAAQLRDRVKALKAVGG

Sequences:

>Translated_659_residues
MGFRLAVTYEPRGDQVNAIAELTRGLREGEQHQVLLGVTGSGKTFTMAKVIEAVNRPALVLAHNKTLAAQLYHEFKTFFP
ENAVEYFVSYYDYYQPEAYIPASDVYIEKDATVNDELDKLRLAATKSLFERRDCVIVSSVSCIYGLGSPEAYYGMLLMLE
KGQKISRNQIVTRLVEILYDRNDADFRRGTFRVRGDVIEVYPTYDDDAYRIELWGDEIENLSQIDPLLGQVKQTYQRLPI
YPKTHYVMSAETKEDAMQSIRNELEWWHKELVNQGKAIEAQRLFQRTMFDLEMMKEIGYCHGIENYSRHFSGRLPGEAPP
TLLDYLPNDAVMFLDESHQTVPQLHGMYHGDRSRKEVLVAHGFRMPSALDNRPLTFEEFEHRVNQLVYVSATPGPYELTK
SSGVVVEQIIRPTGLLDPTVEIRPVKGQVDDLLGQIRARVENNQRILVTTLTKRMAEDLSEYYSEVGVRCRYLHSEVTTL
DRIKILRDLRRGEFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSWGALIQTIGRAARHVEGHAILYADVMTDSMRK
ALAETARRRQTQIEYNEENHITPQSIIKAIDMSLVAVAEGDYVTVPLEDDPEVEDLTPDQRLRFIGELEERMREAARKFE
FERAAQLRDRVKALKAVGG
>Mature_658_residues
GFRLAVTYEPRGDQVNAIAELTRGLREGEQHQVLLGVTGSGKTFTMAKVIEAVNRPALVLAHNKTLAAQLYHEFKTFFPE
NAVEYFVSYYDYYQPEAYIPASDVYIEKDATVNDELDKLRLAATKSLFERRDCVIVSSVSCIYGLGSPEAYYGMLLMLEK
GQKISRNQIVTRLVEILYDRNDADFRRGTFRVRGDVIEVYPTYDDDAYRIELWGDEIENLSQIDPLLGQVKQTYQRLPIY
PKTHYVMSAETKEDAMQSIRNELEWWHKELVNQGKAIEAQRLFQRTMFDLEMMKEIGYCHGIENYSRHFSGRLPGEAPPT
LLDYLPNDAVMFLDESHQTVPQLHGMYHGDRSRKEVLVAHGFRMPSALDNRPLTFEEFEHRVNQLVYVSATPGPYELTKS
SGVVVEQIIRPTGLLDPTVEIRPVKGQVDDLLGQIRARVENNQRILVTTLTKRMAEDLSEYYSEVGVRCRYLHSEVTTLD
RIKILRDLRRGEFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSWGALIQTIGRAARHVEGHAILYADVMTDSMRKA
LAETARRRQTQIEYNEENHITPQSIIKAIDMSLVAVAEGDYVTVPLEDDPEVEDLTPDQRLRFIGELEERMREAARKFEF
ERAAQLRDRVKALKAVGG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=663, Percent_Identity=59.8793363499246, Blast_Score=771, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75454; Mature: 75323

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFRLAVTYEPRGDQVNAIAELTRGLREGEQHQVLLGVTGSGKTFTMAKVIEAVNRPALV
CCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEHHHHHHHHHCCCEEE
LAHNKTLAAQLYHEFKTFFPENAVEYFVSYYDYYQPEAYIPASDVYIEKDATVNDELDKL
EEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHH
RLAATKSLFERRDCVIVSSVSCIYGLGSPEAYYGMLLMLEKGQKISRNQIVTRLVEILYD
HHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHHHHEEEECCCCCHHHHHHHHHHHHHHC
RNDADFRRGTFRVRGDVIEVYPTYDDDAYRIELWGDEIENLSQIDPLLGQVKQTYQRLPI
CCCCCHHCCEEEEECCEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
YPKTHYVMSAETKEDAMQSIRNELEWWHKELVNQGKAIEAQRLFQRTMFDLEMMKEIGYC
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
HGIENYSRHFSGRLPGEAPPTLLDYLPNDAVMFLDESHQTVPQLHGMYHGDRSRKEVLVA
CCCHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCCHHHHHHCCCCCCCCHHHHHHH
HGFRMPSALDNRPLTFEEFEHRVNQLVYVSATPGPYELTKSSGVVVEQIIRPTGLLDPTV
CCCCCCCCCCCCCCCHHHHHHHHCEEEEEEECCCCCEECCCCCHHHHHHHCCCCCCCCCE
EIRPVKGQVDDLLGQIRARVENNQRILVTTLTKRMAEDLSEYYSEVGVRCRYLHSEVTTL
EEEECCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHH
DRIKILRDLRRGEFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSWGALIQTIGRAA
HHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHH
RHVEGHAILYADVMTDSMRKALAETARRRQTQIEYNEENHITPQSIIKAIDMSLVAVAEG
HHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEEECC
DYVTVPLEDDPEVEDLTPDQRLRFIGELEERMREAARKFEFERAAQLRDRVKALKAVGG
CEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GFRLAVTYEPRGDQVNAIAELTRGLREGEQHQVLLGVTGSGKTFTMAKVIEAVNRPALV
CEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEHHHHHHHHHCCCEEE
LAHNKTLAAQLYHEFKTFFPENAVEYFVSYYDYYQPEAYIPASDVYIEKDATVNDELDKL
EEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHH
RLAATKSLFERRDCVIVSSVSCIYGLGSPEAYYGMLLMLEKGQKISRNQIVTRLVEILYD
HHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHHHHEEEECCCCCHHHHHHHHHHHHHHC
RNDADFRRGTFRVRGDVIEVYPTYDDDAYRIELWGDEIENLSQIDPLLGQVKQTYQRLPI
CCCCCHHCCEEEEECCEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
YPKTHYVMSAETKEDAMQSIRNELEWWHKELVNQGKAIEAQRLFQRTMFDLEMMKEIGYC
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
HGIENYSRHFSGRLPGEAPPTLLDYLPNDAVMFLDESHQTVPQLHGMYHGDRSRKEVLVA
CCCHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCCHHHHHHCCCCCCCCHHHHHHH
HGFRMPSALDNRPLTFEEFEHRVNQLVYVSATPGPYELTKSSGVVVEQIIRPTGLLDPTV
CCCCCCCCCCCCCCCHHHHHHHHCEEEEEEECCCCCEECCCCCHHHHHHHCCCCCCCCCE
EIRPVKGQVDDLLGQIRARVENNQRILVTTLTKRMAEDLSEYYSEVGVRCRYLHSEVTTL
EEEECCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHH
DRIKILRDLRRGEFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSWGALIQTIGRAA
HHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHH
RHVEGHAILYADVMTDSMRKALAETARRRQTQIEYNEENHITPQSIIKAIDMSLVAVAEG
HHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEEECC
DYVTVPLEDDPEVEDLTPDQRLRFIGELEERMREAARKFEFERAAQLRDRVKALKAVGG
CEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA