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The map label for this gene is adh [H]

Identifier: 116625367

GI number: 116625367

Start: 7929004

End: 7929978

Strand: Direct

Name: adh [H]

Synonym: Acid_6312

Alternate gene names: 116625367

Gene position: 7929004-7929978 (Clockwise)

Preceding gene: 116625366

Following gene: 116625372

Centisome position: 79.56

GC content: 55.79

Gene sequence:

>975_bases
ATGACTCAAACACTAAGTAAGACTATGAAGGCTGTGGCGATTAATCGGTTTGGTGGAATTGAAACGTTAGAAACTCAGGA
GCTTCCCATCCCGGCGGTTGGCGCCGATGAAGTGTTGGTTGATGTGGAAGCCGCTGGCGTCGGCGTTTGGGATCCCTTTG
AACGGGAAGGCGGGTTTGCGAAGGAGTTCAATACCACGCCCGTTTTTCCCCTTGTATTGGGATCCGATGGCGCAGGCACT
GTTGCAGCCGTGGGACCGCAAGTGAAGCGCTTTAAGAAAGGGGACCGCGTCTACGGAATTTCCTTTCTGAATCCGAAGGG
CGGATTTTATGCGGAATATGCTGTTGTGAAAGAAAATAGTCTAGCGCTCATCCCGGGAAAACTCACCATGCTGCAAGCCG
CTGCCATGGCCGTTGATGCGGTCACGGCTCTTGCGGGTCTTGACACAACGCTGGGCTTGAGGAATGGGGAGTCCCTACTG
ATCTTTGGCGCAAGCGGCGGCATTGGTCACTTGGCCGTGCAATTCGCCAAACGCATGGGCGCGCGCGTACTGGCCGTGGC
CTCGGGCGATGATGGTGTTTCTTTTGTGCGCGGCCTTGGCGCCGATAAGGTTGTGGATGGACATAAGGAAGACGTGCTCG
GCGCTGCAAGCCAGTTCGCACCCAACGGTCTTGATGCCGTGCTCCTAACGACCGGCGGTGAAGCAGCTGAAAAGTCTTTA
GCCGCTCTACGAACGGGTGGACGCGCCGCCTATCCTAACGGTGTCCAACCGGTTCCCAAAGAACGTGCCGGCATTAAACT
CCAAAACTACGATGGCGAATATAACCCGCCACCCTTCGACAAGGTCAACAGCCTTATCGACGCCGGTCCGTTCGAAGTCA
GAGTCGCCCGGGCATTCACTCTAGATCAAGCCGCCGAAGCTCAACGCGCGCTCGACGATCACTACCTAGGAAAACTCGCA
TTGATCATGGAGTAA

Upstream 100 bases:

>100_bases
GACCGTTATGAACCTGGAATGATGCAGTTGATCAACGGTTGAAAGACCCAACGAGCAGGGCCTGTTGAACCGGTCCTTCT
ATCGGATAAGGAGGATTTCG

Downstream 100 bases:

>100_bases
ACGACAGAGCAAATCCTATGGTTTGGGTCGCCCCGCATCCATCCTCGCTTGGCCGCATCGGCCACCCGTTGAACTGCGAC
TGGCATCTCCCAAGGCATAG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MTQTLSKTMKAVAINRFGGIETLETQELPIPAVGADEVLVDVEAAGVGVWDPFEREGGFAKEFNTTPVFPLVLGSDGAGT
VAAVGPQVKRFKKGDRVYGISFLNPKGGFYAEYAVVKENSLALIPGKLTMLQAAAMAVDAVTALAGLDTTLGLRNGESLL
IFGASGGIGHLAVQFAKRMGARVLAVASGDDGVSFVRGLGADKVVDGHKEDVLGAASQFAPNGLDAVLLTTGGEAAEKSL
AALRTGGRAAYPNGVQPVPKERAGIKLQNYDGEYNPPPFDKVNSLIDAGPFEVRVARAFTLDQAAEAQRALDDHYLGKLA
LIME

Sequences:

>Translated_324_residues
MTQTLSKTMKAVAINRFGGIETLETQELPIPAVGADEVLVDVEAAGVGVWDPFEREGGFAKEFNTTPVFPLVLGSDGAGT
VAAVGPQVKRFKKGDRVYGISFLNPKGGFYAEYAVVKENSLALIPGKLTMLQAAAMAVDAVTALAGLDTTLGLRNGESLL
IFGASGGIGHLAVQFAKRMGARVLAVASGDDGVSFVRGLGADKVVDGHKEDVLGAASQFAPNGLDAVLLTTGGEAAEKSL
AALRTGGRAAYPNGVQPVPKERAGIKLQNYDGEYNPPPFDKVNSLIDAGPFEVRVARAFTLDQAAEAQRALDDHYLGKLA
LIME
>Mature_323_residues
TQTLSKTMKAVAINRFGGIETLETQELPIPAVGADEVLVDVEAAGVGVWDPFEREGGFAKEFNTTPVFPLVLGSDGAGTV
AAVGPQVKRFKKGDRVYGISFLNPKGGFYAEYAVVKENSLALIPGKLTMLQAAAMAVDAVTALAGLDTTLGLRNGESLLI
FGASGGIGHLAVQFAKRMGARVLAVASGDDGVSFVRGLGADKVVDGHKEDVLGAASQFAPNGLDAVLLTTGGEAAEKSLA
ALRTGGRAAYPNGVQPVPKERAGIKLQNYDGEYNPPPFDKVNSLIDAGPFEVRVARAFTLDQAAEAQRALDDHYLGKLAL
IME

Specific function: Active with primary alcohols, including methanol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=247, Percent_Identity=32.7935222672065, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI13236495, Length=247, Percent_Identity=32.7935222672065, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI194239676, Length=208, Percent_Identity=36.0576923076923, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI47519420, Length=347, Percent_Identity=31.4121037463977, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI22538446, Length=242, Percent_Identity=30.9917355371901, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI22538444, Length=242, Percent_Identity=30.9917355371901, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI18379349, Length=243, Percent_Identity=28.3950617283951, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI28557745, Length=248, Percent_Identity=28.2258064516129, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI24308257, Length=242, Percent_Identity=28.099173553719, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1790485, Length=238, Percent_Identity=27.7310924369748, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17507255, Length=251, Percent_Identity=30.6772908366534, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71988145, Length=246, Percent_Identity=29.6747967479675, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17562584, Length=227, Percent_Identity=29.0748898678414, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=278, Percent_Identity=25.5395683453237, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17536829, Length=232, Percent_Identity=28.448275862069, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71987554, Length=194, Percent_Identity=29.8969072164948, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319520, Length=252, Percent_Identity=29.3650793650794, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324486, Length=272, Percent_Identity=30.5147058823529, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=271, Percent_Identity=29.1512915129151, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24581339, Length=266, Percent_Identity=29.6992481203008, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581341, Length=259, Percent_Identity=30.1158301158301, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 33801; Mature: 33670

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTLSKTMKAVAINRFGGIETLETQELPIPAVGADEVLVDVEAAGVGVWDPFEREGGFA
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHCCCCC
KEFNTTPVFPLVLGSDGAGTVAAVGPQVKRFKKGDRVYGISFLNPKGGFYAEYAVVKENS
CCCCCCCCEEEEECCCCCCCEEECCHHHHHHCCCCEEEEEEEECCCCCCEEEEEEEECCC
LALIPGKLTMLQAAAMAVDAVTALAGLDTTLGLRNGESLLIFGASGGIGHLAVQFAKRMG
EEEECCHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCEEEEEECCCCHHHHHHHHHHHCC
ARVLAVASGDDGVSFVRGLGADKVVDGHKEDVLGAASQFAPNGLDAVLLTTGGEAAEKSL
CEEEEEECCCCCHHHHHHCCCCHHCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHH
AALRTGGRAAYPNGVQPVPKERAGIKLQNYDGEYNPPPFDKVNSLIDAGPFEVRVARAFT
HHHHCCCCCCCCCCCCCCCCHHCCEEEECCCCCCCCCCHHHHHHHHCCCCCEEEEEEEEC
LDQAAEAQRALDDHYLGKLALIME
HHHHHHHHHHHHHHHHCEEEEEEC
>Mature Secondary Structure 
TQTLSKTMKAVAINRFGGIETLETQELPIPAVGADEVLVDVEAAGVGVWDPFEREGGFA
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHCCCCC
KEFNTTPVFPLVLGSDGAGTVAAVGPQVKRFKKGDRVYGISFLNPKGGFYAEYAVVKENS
CCCCCCCCEEEEECCCCCCCEEECCHHHHHHCCCCEEEEEEEECCCCCCEEEEEEEECCC
LALIPGKLTMLQAAAMAVDAVTALAGLDTTLGLRNGESLLIFGASGGIGHLAVQFAKRMG
EEEECCHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCEEEEEECCCCHHHHHHHHHHHCC
ARVLAVASGDDGVSFVRGLGADKVVDGHKEDVLGAASQFAPNGLDAVLLTTGGEAAEKSL
CEEEEEECCCCCHHHHHHCCCCHHCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHH
AALRTGGRAAYPNGVQPVPKERAGIKLQNYDGEYNPPPFDKVNSLIDAGPFEVRVARAFT
HHHHCCCCCCCCCCCCCCCCHHCCEEEECCCCCCCCCCHHHHHHHHCCCCCEEEEEEEEC
LDQAAEAQRALDDHYLGKLALIME
HHHHHHHHHHHHHHHHCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8049268 [H]